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WO1999016457A3 - Nouvelle composition pour traiter, prevenir et/ou retarder la mort cellulaire ischemique - Google Patents

Nouvelle composition pour traiter, prevenir et/ou retarder la mort cellulaire ischemique Download PDF

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Publication number
WO1999016457A3
WO1999016457A3 PCT/EP1998/006269 EP9806269W WO9916457A3 WO 1999016457 A3 WO1999016457 A3 WO 1999016457A3 EP 9806269 W EP9806269 W EP 9806269W WO 9916457 A3 WO9916457 A3 WO 9916457A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell death
delaying
treating
preventing
ischemic cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1998/006269
Other languages
English (en)
Other versions
WO1999016457A2 (fr
Inventor
Wolfgang Schaper
Patrik Htun
Miroslav Barancik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften
Publication of WO1999016457A2 publication Critical patent/WO1999016457A2/fr
Publication of WO1999016457A3 publication Critical patent/WO1999016457A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne la modulation de la mort cellulaire ischémique. L'invention traite, en particulier, de compositions pharmaceutiques comprenant un inhibiteur de phosphatases de protéines de mitogène (MKP) et/ou une molécule d'acide nucléique codant cet inhibiteur, qui présentent une grande utilité pour traiter, prévenir et/ou retarder la mort cellulaire ischémique. En outre, l'invention concerne des procédés pour traiter, prévenir et/ou retarder la mort cellulaire ischémique consistant à placer des organes, des tissus ou des cellules en contact avec un inhibiteur de phosphatases de protéines de mitogènes (MKP) et/ou une molécule d'acide nucléique codant cet inhibiteur.
PCT/EP1998/006269 1997-10-01 1998-10-01 Nouvelle composition pour traiter, prevenir et/ou retarder la mort cellulaire ischemique Ceased WO1999016457A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97117039.4 1997-10-01
EP97117039 1997-10-01

Publications (2)

Publication Number Publication Date
WO1999016457A2 WO1999016457A2 (fr) 1999-04-08
WO1999016457A3 true WO1999016457A3 (fr) 1999-07-22

Family

ID=8227424

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/006269 Ceased WO1999016457A2 (fr) 1997-10-01 1998-10-01 Nouvelle composition pour traiter, prevenir et/ou retarder la mort cellulaire ischemique

Country Status (1)

Country Link
WO (1) WO1999016457A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061039A2 (fr) * 1998-05-22 1999-12-02 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Nouvelle composition de modulation de la mort cellulaire ischemique
DE10038043B4 (de) * 2000-08-02 2006-09-07 Walter, Michael, Dr. Phamakologisch wirksame Substanz zur Behandlung kardiovaskulärer Erkrankungen

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0457295A2 (fr) * 1990-05-16 1991-11-21 The Rockefeller University Utilisation d'un modulateur de la phosphorylation des protéines comme médicament dans le traitement de l'amyloidose associé à la maladie d'Alzheimer
EP0551200A1 (fr) * 1992-01-07 1993-07-14 National University Of Singapore Protéine phosphatase inhibiteur pour l'utilisation en thérapeutique
WO1997003660A2 (fr) * 1995-07-21 1997-02-06 The Rockefeller University Modulation de l'activite de la phosphatase de la proteine et utilisation concernant la fecondite et la contraception

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0457295A2 (fr) * 1990-05-16 1991-11-21 The Rockefeller University Utilisation d'un modulateur de la phosphorylation des protéines comme médicament dans le traitement de l'amyloidose associé à la maladie d'Alzheimer
EP0551200A1 (fr) * 1992-01-07 1993-07-14 National University Of Singapore Protéine phosphatase inhibiteur pour l'utilisation en thérapeutique
WO1997003660A2 (fr) * 1995-07-21 1997-02-06 The Rockefeller University Modulation de l'activite de la phosphatase de la proteine et utilisation concernant la fecondite et la contraception

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARMSTRONG S C ET AL: "Effects of the protein phosphatase inhibitors okadaic acid and calyculin A on metabolically inhibited and ischaemic isolated myocytes.", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, (1992 AUG) 24 (8) 869-84. JOURNAL CODE: J72. ISSN: 0022-2828., ENGLAND: United Kingdom, XP002099207 *
ARMSTRONG S C ET AL: "Translocation of PKC, protein phosphatase inhibition and preconditioning of rabbit cardiomyocytes.", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, (1996 JUL) 28 (7) 1479-92. JOURNAL CODE: J72. ISSN: 0022-2828., ENGLAND: United Kingdom, XP002099208 *
ARMSTRONG, S. C. ET AL: "Protein phosphatase inhibitors calyculin A and fostriecin protect rabbit cardiomyocytes in late ischemia", J. MOL. CELL. CARDIOL. (1998), 30(1), 61-73 CODEN: JMCDAY;ISSN: 0022-2828, XP002099209 *

Also Published As

Publication number Publication date
WO1999016457A2 (fr) 1999-04-08

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WO1999016457A3 (fr) Nouvelle composition pour traiter, prevenir et/ou retarder la mort cellulaire ischemique

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