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WO1999007326A3 - Antimicrobial cement compositions - Google Patents

Antimicrobial cement compositions Download PDF

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Publication number
WO1999007326A3
WO1999007326A3 PCT/CA1998/000754 CA9800754W WO9907326A3 WO 1999007326 A3 WO1999007326 A3 WO 1999007326A3 CA 9800754 W CA9800754 W CA 9800754W WO 9907326 A3 WO9907326 A3 WO 9907326A3
Authority
WO
WIPO (PCT)
Prior art keywords
antimicrobial
composition
cement
glass ionomer
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA1998/000754
Other languages
French (fr)
Other versions
WO1999007326A2 (en
Inventor
Joseph Paul Santerre
Shimon Friedman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Toronto Innovations Foundation
University of Toronto
Original Assignee
University of Toronto Innovations Foundation
University of Toronto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Toronto Innovations Foundation, University of Toronto filed Critical University of Toronto Innovations Foundation
Priority to CA002268478A priority Critical patent/CA2268478A1/en
Priority to AU88463/98A priority patent/AU8846398A/en
Publication of WO1999007326A2 publication Critical patent/WO1999007326A2/en
Publication of WO1999007326A3 publication Critical patent/WO1999007326A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/30—Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/869—Zeolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A61K6/889—Polycarboxylate cements; Glass ionomer cements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants

Landscapes

  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Dental Preparations (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Antimicrobial cement compositions are disclosed which contain antimicrobial zeolites. Preferred are antimicrobial cement compositions having dental applications including fillers, adhesives, sealants and restorative materials, and medical applications such as bone cements, implant components and bone substitutes. A particularly preferred cement is an antimicrobial glass ionomer cement composition for dental use comprising a polyelectrolyte, glass ionomer particles, and antimicrobial zeolite particles. When the composition is cured to form a hardened cement, the glass ionomer particles and the zeolite particles form ionic bonds with the polyelectrolyte, the zeolite particles being present in the composition in an amount sufficient to prevent growth of bacteria in the composition and over the hardened cement formed by curing the composition. Preferably, the zeolite contains an antimicrobial metal ion such as silver ion, and is present in the glass ionomer cement composition in an amount of from about 0.2 % to about 20 % by weight of the glass ionomer particles.
PCT/CA1998/000754 1997-08-11 1998-08-07 Antimicrobial cement compositions Ceased WO1999007326A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002268478A CA2268478A1 (en) 1997-08-11 1998-08-07 Antimicrobial cement compositions
AU88463/98A AU8846398A (en) 1997-08-11 1998-08-07 Antimicrobial cement compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5536197P 1997-08-11 1997-08-11
US60/055,361 1997-08-11

Publications (2)

Publication Number Publication Date
WO1999007326A2 WO1999007326A2 (en) 1999-02-18
WO1999007326A3 true WO1999007326A3 (en) 1999-05-20

Family

ID=21997319

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1998/000754 Ceased WO1999007326A2 (en) 1997-08-11 1998-08-07 Antimicrobial cement compositions

Country Status (3)

Country Link
AU (1) AU8846398A (en)
CA (1) CA2268478A1 (en)
WO (1) WO1999007326A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8278368B2 (en) 2004-11-16 2012-10-02 3M Innnovatve Properties Company Dental fillers, methods, compositions including a caseinate
US8710114B2 (en) 2004-11-16 2014-04-29 3M Innovative Properties Company Dental fillers including a phosphorus containing surface treatment, and compositions and methods thereof
US8957126B2 (en) 2004-11-16 2015-02-17 3M Innovative Properties Company Dental compositions with calcium phosphorus releasing glass
US10131574B2 (en) 2013-06-17 2018-11-20 Corning Incorporated Antimicrobial glass articles and methods of making and using same
US10137061B2 (en) 2004-11-16 2018-11-27 3M Innovative Properties Company Dental fillers and compositions including phosphate salts

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582715B1 (en) * 1999-04-27 2003-06-24 Agion Technologies, Inc. Antimicrobial orthopedic implants
DE10111449A1 (en) 2001-03-09 2002-09-26 Schott Glas Use of bioactive glass in tooth filling material
US6924325B2 (en) * 2002-06-21 2005-08-02 Kerr Corporation Silver-containing dental composition
FR2896124A1 (en) * 2006-01-19 2007-07-20 Le Cam Soc Par Actions Simplif Preserving eggs comprises depositing a homogeneous composition containing a zeolite and metal ions on the eggshells
CN102387782B (en) * 2009-04-01 2013-10-30 扩散技术公司 Regulation of bone growth using zeolite in combination with bone graft substitutes
DE102009035970A1 (en) * 2009-08-04 2011-02-17 Heraeus Kulzer Gmbh Antimicrobially equipped dental materials, in particular for preventing plaque accumulation
GB2470088B (en) * 2009-11-10 2011-06-29 Landmark Innovations Ltd Root canal therapy
IN2012DN04965A (en) 2009-11-25 2015-09-25 Difusion Technologies Inc
EP2512538B1 (en) 2009-12-11 2017-02-22 Difusion Technologies, Inc. Method of manufacturing antimicrobial implants of polyetheretherketone
EP2571542B1 (en) 2010-05-07 2018-06-20 Difusion Technologies Inc. Medical implants with increased hydrophilicity
US10045801B2 (en) 2012-07-30 2018-08-14 The Governing Council Of The University Of Toronto Bone stabilization device and method of production
EP2724998A1 (en) * 2012-10-24 2014-04-30 Clariant S.A. Method for avoiding fungal growth in mineral construction materials
ITUB20156054A1 (en) * 2015-12-01 2017-06-01 Univ Degli Studi Di Messina Synthesis method of a scratch-resistant composite coating with anti-microbial / anti-fungal action, and composite coating material, for use in the medical / dental field.
CN111012951B (en) * 2019-12-31 2021-09-03 同济大学 Injectable composite bone cement with photothermal effect and preparation method and application thereof
US20210402052A1 (en) 2020-06-30 2021-12-30 Difusion, Inc. Medical Implants And Methods Of Manufacture
US11643574B2 (en) 2021-05-28 2023-05-09 Cohesys Inc. Adhesive devices and uses thereof
WO2024136824A1 (en) * 2022-12-23 2024-06-27 Atatürk Üni̇versi̇tesi̇ Fi̇kri̇ Mülki̇yet Haklari Koordi̇natörlüğü Döner Sermaye İşletmesi̇ Innovative glass ionomer cement material

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61232253A (en) * 1985-04-08 1986-10-16 株式会社イナックス Tile joint material
JPH0217107A (en) * 1988-07-04 1990-01-22 Yukiko Hirano Antibacterial cement for dental treatment
US4938958A (en) * 1986-12-05 1990-07-03 Shinagawa Fuel Co., Ltd. Antibiotic zeolite
JPH05321358A (en) * 1992-05-26 1993-12-07 Kubota Corp Mildewproof inorganic building material
JPH08109108A (en) * 1994-10-07 1996-04-30 Yuusuke Ogura Building material having antibacterial activity consisting of conjugate material obtained by using mordentite and its production
JPH09323912A (en) * 1996-06-05 1997-12-16 Shinagawa Fuel Co Ltd Dental restoration material

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61232253A (en) * 1985-04-08 1986-10-16 株式会社イナックス Tile joint material
US4938958A (en) * 1986-12-05 1990-07-03 Shinagawa Fuel Co., Ltd. Antibiotic zeolite
JPH0217107A (en) * 1988-07-04 1990-01-22 Yukiko Hirano Antibacterial cement for dental treatment
JPH05321358A (en) * 1992-05-26 1993-12-07 Kubota Corp Mildewproof inorganic building material
JPH08109108A (en) * 1994-10-07 1996-04-30 Yuusuke Ogura Building material having antibacterial activity consisting of conjugate material obtained by using mordentite and its production
JPH09323912A (en) * 1996-06-05 1997-12-16 Shinagawa Fuel Co Ltd Dental restoration material

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 106, no. 12, 23 March 1987, Columbus, Ohio, US; abstract no. 89333, XP002097681 *
CHEMICAL ABSTRACTS, vol. 113, no. 14, 1 October 1990, Columbus, Ohio, US; abstract no. 120855, XP002097678 *
CHEMICAL ABSTRACTS, vol. 127, no. 13, 29 September 1997, Columbus, Ohio, US; abstract no. 181109, K.WAKASA ET AL.: "Dental application of silver zeolite. Dental restorative materials" XP002097679 *
CHEMICAL ABSTRACTS, vol. 128, no. 6, 9 February 1998, Columbus, Ohio, US; abstract no. 66537, XP002097680 *
DATABASE WPI Section Ch Week 9402, Derwent World Patents Index; Class D22, AN 94-013060, XP002097682 *
DATABASE WPI Section Ch Week 9627, Derwent World Patents Index; Class D22, AN 96-263765, XP002097683 *
HIROSHIMA DAIGAKU SHIGAKU ZASSHI, vol. 29, no. 1, 1997, pages 87 - 98 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8278368B2 (en) 2004-11-16 2012-10-02 3M Innnovatve Properties Company Dental fillers, methods, compositions including a caseinate
US8710114B2 (en) 2004-11-16 2014-04-29 3M Innovative Properties Company Dental fillers including a phosphorus containing surface treatment, and compositions and methods thereof
US8957126B2 (en) 2004-11-16 2015-02-17 3M Innovative Properties Company Dental compositions with calcium phosphorus releasing glass
US9233054B2 (en) 2004-11-16 2016-01-12 3M Innovative Properties Company Dental fillers including a phosphorus-containing surface treatment, and compositions and methods thereof
US9414995B2 (en) 2004-11-16 2016-08-16 3M Innovative Properties Company Dental fillers including a phosphorus-containing surface treatment, and compositions and methods thereof
US9517186B2 (en) 2004-11-16 2016-12-13 3M Innovative Properties Company Dental compositions with calcium phosphorus releasing glass
US10137061B2 (en) 2004-11-16 2018-11-27 3M Innovative Properties Company Dental fillers and compositions including phosphate salts
US10131574B2 (en) 2013-06-17 2018-11-20 Corning Incorporated Antimicrobial glass articles and methods of making and using same

Also Published As

Publication number Publication date
AU8846398A (en) 1999-03-01
WO1999007326A2 (en) 1999-02-18
CA2268478A1 (en) 1999-02-18

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