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WO1999061064A8 - Mammalian genes encoding 3'-5' exonuclease - Google Patents

Mammalian genes encoding 3'-5' exonuclease

Info

Publication number
WO1999061064A8
WO1999061064A8 PCT/US1999/010578 US9910578W WO9961064A8 WO 1999061064 A8 WO1999061064 A8 WO 1999061064A8 US 9910578 W US9910578 W US 9910578W WO 9961064 A8 WO9961064 A8 WO 9961064A8
Authority
WO
WIPO (PCT)
Prior art keywords
exonuclease
genes encoding
mammalian genes
dna
exonucleases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/010578
Other languages
French (fr)
Other versions
WO1999061064A1 (en
Inventor
Fred W Perrino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wake Forest University
Original Assignee
Wake Forest University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wake Forest University filed Critical Wake Forest University
Priority to AU40773/99A priority Critical patent/AU4077399A/en
Publication of WO1999061064A1 publication Critical patent/WO1999061064A1/en
Publication of WO1999061064A8 publication Critical patent/WO1999061064A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Genes encoding 3'-5' exonucleases have been isolated and identified. A human exonuclease independent of DNA polymerase is produced in host cells from recombinant vectors. Methods of use include inhibition of exonuclease activity to increase incorporation of nucleotide analogs into DNA in rapidly dividing cells.
PCT/US1999/010578 1998-05-22 1999-05-14 Mammalian genes encoding 3'-5' exonuclease Ceased WO1999061064A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU40773/99A AU4077399A (en) 1998-05-22 1999-05-14 Mammalian genes encoding 3'-5' exonuclease

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8361798A 1998-05-22 1998-05-22
US09/083,617 1998-05-22
US19147098A 1998-11-12 1998-11-12
US09/191,470 1998-11-12

Publications (2)

Publication Number Publication Date
WO1999061064A1 WO1999061064A1 (en) 1999-12-02
WO1999061064A8 true WO1999061064A8 (en) 2000-01-27

Family

ID=26769499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/010578 Ceased WO1999061064A1 (en) 1998-05-22 1999-05-14 Mammalian genes encoding 3'-5' exonuclease

Country Status (2)

Country Link
AU (1) AU4077399A (en)
WO (1) WO1999061064A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632665B1 (en) 1999-08-09 2003-10-14 Wake Forest University Human gene encoding 3′-5′ exonuclease
WO2009140676A2 (en) * 2008-05-16 2009-11-19 Immune Disease Institute, Inc. Compositions and methods for inhibition of retroviruses
CA2999500A1 (en) * 2015-09-24 2017-03-30 Editas Medicine, Inc. Use of exonucleases to improve crispr/cas-mediated genome editing

Also Published As

Publication number Publication date
WO1999061064A1 (en) 1999-12-02
AU4077399A (en) 1999-12-13

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