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WO1999058565A8 - Proteine relative a la cystatine - Google Patents

Proteine relative a la cystatine

Info

Publication number
WO1999058565A8
WO1999058565A8 PCT/SE1999/000764 SE9900764W WO9958565A8 WO 1999058565 A8 WO1999058565 A8 WO 1999058565A8 SE 9900764 W SE9900764 W SE 9900764W WO 9958565 A8 WO9958565 A8 WO 9958565A8
Authority
WO
WIPO (PCT)
Prior art keywords
protein
testis
nucleic acid
acid sequence
cystatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SE1999/000764
Other languages
English (en)
Other versions
WO1999058565A1 (fr
Inventor
Katarina Nordqvist
Virpi Toehoenen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Karolinska Innovations AB
Original Assignee
Karolinska Innovations AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karolinska Innovations AB filed Critical Karolinska Innovations AB
Publication of WO1999058565A1 publication Critical patent/WO1999058565A1/fr
Publication of WO1999058565A8 publication Critical patent/WO1999058565A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Un gène codant une nouvelle protéine relative à la cystatine a été isolé de la gonade foetale d'une souris mâle et d'une testicule d'un homme adulte. Cette nouvelle protéine a le potentiel d'induire la formation des testicules dans les gonades foetales. Il est aussi fort probable que cette protéine inhibe la croissance de la tumeur des testicules en raison des similitudes structurales et fonctionnelles avec les cystatines inhibant la tumeur. L'invention concerne également la séquence d'acide nucléique correspondante, les vecteurs et les cellules hôtes contenant la séquence d'acide nucléique ainsi que des compositions pharmaceutiques contenant cette protéine.
PCT/SE1999/000764 1998-05-08 1999-05-06 Proteine relative a la cystatine Ceased WO1999058565A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9801617A SE9801617D0 (sv) 1998-05-08 1998-05-08 New compound
SE9801617-3 1998-05-08

Publications (2)

Publication Number Publication Date
WO1999058565A1 WO1999058565A1 (fr) 1999-11-18
WO1999058565A8 true WO1999058565A8 (fr) 2000-01-06

Family

ID=20411238

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1999/000764 Ceased WO1999058565A1 (fr) 1998-05-08 1999-05-06 Proteine relative a la cystatine

Country Status (2)

Country Link
SE (1) SE9801617D0 (fr)
WO (1) WO1999058565A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7109292B2 (en) * 1999-03-08 2006-09-19 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001046421A2 (fr) * 1999-12-23 2001-06-28 Zymogenetics, Inc. Zcys5:membre de la superfamille de cystatine
AU2001279182A1 (en) * 2000-08-07 2002-02-18 Zymogenetics Inc. Zcys9: a member of the cystatin superfamily
US20020142396A1 (en) * 2000-09-01 2002-10-03 Holloway James L. Mammalian cystatin-8 and its use to inhibit cancer procoagulant protein
WO2002050105A1 (fr) * 2000-12-19 2002-06-27 Smithkline Beecham Corporation Composes
CN100368018C (zh) * 2005-05-26 2008-02-13 福建医科大学 蛇毒半胱氨酸蛋白酶抑制剂抗肿瘤侵袭与转移作用及应用

Also Published As

Publication number Publication date
SE9801617D0 (sv) 1998-05-08
WO1999058565A1 (fr) 1999-11-18

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DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WR Later publication of a revised version of an international search report
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase