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WO1999057315A3 - Polymorphismes du gene de mmp-9 - Google Patents

Polymorphismes du gene de mmp-9 Download PDF

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Publication number
WO1999057315A3
WO1999057315A3 PCT/GB1999/001447 GB9901447W WO9957315A3 WO 1999057315 A3 WO1999057315 A3 WO 1999057315A3 GB 9901447 W GB9901447 W GB 9901447W WO 9957315 A3 WO9957315 A3 WO 9957315A3
Authority
WO
WIPO (PCT)
Prior art keywords
mmp
gene
prognosis
oligonucleotides
diagnosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1999/001447
Other languages
English (en)
Other versions
WO1999057315A2 (fr
Inventor
Bai Ping Zhang
Shu Ye
Adriano Henney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Priority to CA002327538A priority Critical patent/CA2327538A1/fr
Priority to AU39385/99A priority patent/AU3938599A/en
Priority to EP99922273A priority patent/EP1075547A2/fr
Publication of WO1999057315A2 publication Critical patent/WO1999057315A2/fr
Publication of WO1999057315A3 publication Critical patent/WO1999057315A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention se rapporte à une méthode visant à établir un diagnostic ou un pronostic de maladie ou une caractérisation d'un génotype ou d'une séquence génétique. Ladite méthode consiste à utiliser un échantillon d'acide nucléique et à définir la nature d'un ou de plusieurs variants d'un gène de MMP-9. L'invention se rapporte également à des oligonucléotides qui s'hybrident à des variants d'une séquence polymorphe dans le gène de MMP-9 ou son complément inverse. Ladite méthode et lesdits oligonucléotides s'avèrent particulièrement utiles pour établir le diagnostic ou le pronostic de maladies caractérisées par une transformation vasculaire à médiation assurée par des métalloprotéases, du type athérosclérose, métastase et invasion tumorale ou maladie inflammatoire.
PCT/GB1999/001447 1998-05-07 1999-05-07 Polymorphismes du gene de mmp-9 Ceased WO1999057315A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002327538A CA2327538A1 (fr) 1998-05-07 1999-05-07 Polymorphismes du gene de mmp-9
AU39385/99A AU3938599A (en) 1998-05-07 1999-05-07 Mmp-9 gene polymorphisms
EP99922273A EP1075547A2 (fr) 1998-05-07 1999-05-07 Polymorphismes du gene de mmp-9

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9809764.5A GB9809764D0 (en) 1998-05-07 1998-05-07 MMP-9 Gene polymorphisms
GB9809764.5 1998-05-07

Publications (2)

Publication Number Publication Date
WO1999057315A2 WO1999057315A2 (fr) 1999-11-11
WO1999057315A3 true WO1999057315A3 (fr) 2000-03-02

Family

ID=10831610

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/001447 Ceased WO1999057315A2 (fr) 1998-05-07 1999-05-07 Polymorphismes du gene de mmp-9

Country Status (5)

Country Link
EP (1) EP1075547A2 (fr)
AU (1) AU3938599A (fr)
CA (1) CA2327538A1 (fr)
GB (1) GB9809764D0 (fr)
WO (1) WO1999057315A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713257B2 (en) 2000-08-25 2004-03-30 Rosetta Inpharmatics Llc Gene discovery using microarrays
US7807447B1 (en) 2000-08-25 2010-10-05 Merck Sharp & Dohme Corp. Compositions and methods for exon profiling
WO2002046462A2 (fr) * 2000-12-07 2002-06-13 Isis Innovation Limited Variants genetiques fonctionels
EP1383797A2 (fr) * 2001-02-07 2004-01-28 Universiteit Maastricht Marqueurs de plaques d'atherosclerose instables
CA2475690A1 (fr) * 2002-03-01 2003-09-12 Flammer, Josef Procede servant a diagnostiquer le glaucome
WO2004081186A2 (fr) * 2003-03-10 2004-09-23 Applera Corporation Polymorphismes genetiques associes a la stenose, procedes de detection et utilisations associees
EP1644031A1 (fr) * 2003-06-19 2006-04-12 CTT Cancer Targeting Technologies OY Inhibiteurs du complexe prommp-9 leucocytaire /integrine beta (2)
WO2005017113A2 (fr) * 2003-08-11 2005-02-24 Lovelace Respiratory Research Institute, Et Al. Polymorphisme genique de la metalloproteinase dans une bronchopneumopathie chronique obstructive
CA2675606A1 (fr) * 2007-01-15 2008-07-24 Centre De Recherche Public De La Sante Marqueur de diagnostic et plate-forme de conception de medicament dans les cas d'infarctus du myocarde et d'insuffisance cardiaque
JP2011506614A (ja) 2007-12-17 2011-03-03 ダイアックス コーポレーション Ｍｍｐ−１４結合タンパク質を含む、骨溶解性障害を処置するための組成物および方法
US8008445B2 (en) 2008-03-03 2011-08-30 Dyax Corp. Metalloproteinase 9 binding proteins
JP2011517320A (ja) * 2008-03-03 2011-06-02 ダイアックス コーポレーション メタロプロテアーゼ９結合タンパク質およびメタロプロテアーゼ２結合タンパク質
US10314909B2 (en) 2011-10-21 2019-06-11 Dyax Corp. Combination therapy comprising an MMP-14 binding protein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038314A1 (fr) * 1996-04-09 1997-10-16 British Biotech Pharmaceuticals Limited Diagnostic et surveillance des affections neurologiques

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038314A1 (fr) * 1996-04-09 1997-10-16 British Biotech Pharmaceuticals Limited Diagnostic et surveillance des affections neurologiques

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DAY I N M ET AL.: "High-throughput genotyping using horizontal polyacrylamide gels with wells arranged for microplate array diagonal gel electrophoresis (MADGE)", BIOTECHNIQUES, vol. 19, no. 5, 1995, pages 830 - 834, XP002126918 *
LINN R ET AL.: "Reassignment of the 92-kDa type IV collagenase gene (CLG4B) to human chromosome 20", CYTOGENETICS AND CELL GENETICS, vol. 72, 1996, pages 159 - 161, XP000857425 *
YE S ET AL.: "Matrix metalloproteinases: implications in vascular matrix remodelling during artherosclerosis", CLINICAL SCIENCE, vol. 94, 1998, pages 103 - 110, XP000857426 *
ZHANG B ET AL.: "Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis", CIRCULATION, vol. 99, 1999, pages 1788 - 1794, XP000862964 *

Also Published As

Publication number Publication date
CA2327538A1 (fr) 1999-11-11
WO1999057315A2 (fr) 1999-11-11
EP1075547A2 (fr) 2001-02-14
AU3938599A (en) 1999-11-23
GB9809764D0 (en) 1998-07-08

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