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WO1999056727A3 - Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems - Google Patents

Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems Download PDF

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Publication number
WO1999056727A3
WO1999056727A3 PCT/IE1999/000031 IE9900031W WO9956727A3 WO 1999056727 A3 WO1999056727 A3 WO 1999056727A3 IE 9900031 W IE9900031 W IE 9900031W WO 9956727 A3 WO9956727 A3 WO 9956727A3
Authority
WO
WIPO (PCT)
Prior art keywords
preconcentrate
solvent
emulsion
drug delivery
delivery systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IE1999/000031
Other languages
French (fr)
Other versions
WO1999056727A2 (en
Inventor
Zebunnissa Ramtoola
Nuala Marie Clarke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Corp PLC
Original Assignee
Elan Corp PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Corp PLC filed Critical Elan Corp PLC
Priority to JP2000546754A priority Critical patent/JP2002513750A/en
Priority to AU38439/99A priority patent/AU3843999A/en
Priority to CA002331640A priority patent/CA2331640A1/en
Priority to EP99921098A priority patent/EP1075252A2/en
Publication of WO1999056727A2 publication Critical patent/WO1999056727A2/en
Publication of WO1999056727A3 publication Critical patent/WO1999056727A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Self-emulsifying microemulsion or emulsion preconcentrate pharmaceutical compositions capable of forming an oil-in-water microemulsion or emulsion upon dilution with an aqueous solution are disclosed. The preconcentrate contains a therapeutically effective amount of a poorly water soluble therapeutic agent; a pharmaceutically effective amount of a low HLB oil component; and a surfactant system consisting essentially of at least one surfactant having an HLB of from about 10 to 20 and is substantially free or contains only minor amounts of a hydrophilic solvent system. Microemulsions or emulsions formed by diluting the self-emulsifying preconcentrate with an aqueous solution are also provided.
PCT/IE1999/000031 1998-05-07 1999-05-07 Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems Ceased WO1999056727A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000546754A JP2002513750A (en) 1998-05-07 1999-05-07 Solvent / co-solvent free microemulsion and emulsion pre-concentrate drug delivery system
AU38439/99A AU3843999A (en) 1998-05-07 1999-05-07 Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems
CA002331640A CA2331640A1 (en) 1998-05-07 1999-05-07 Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems
EP99921098A EP1075252A2 (en) 1998-05-07 1999-05-07 Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8451898P 1998-05-07 1998-05-07
US60/084,518 1998-05-07

Publications (2)

Publication Number Publication Date
WO1999056727A2 WO1999056727A2 (en) 1999-11-11
WO1999056727A3 true WO1999056727A3 (en) 2000-03-02

Family

ID=22185451

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IE1999/000031 Ceased WO1999056727A2 (en) 1998-05-07 1999-05-07 Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems

Country Status (5)

Country Link
EP (1) EP1075252A2 (en)
JP (1) JP2002513750A (en)
AU (1) AU3843999A (en)
CA (1) CA2331640A1 (en)
WO (1) WO1999056727A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026290B1 (en) 1998-12-30 2006-04-11 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosprin
US7582785B2 (en) 2002-04-01 2009-09-01 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
US7709669B2 (en) 2000-02-16 2010-05-04 The Brigham And Women's Hospital, Inc. Aspirin-triggered lipid mediators
US7741368B2 (en) 2001-12-18 2010-06-22 The Brigham And Women's Hospital, Inc. Approach to antimicrobial host defense with molecular shields with EPA and DHA analogs
US7759395B2 (en) 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
US9364454B2 (en) 2005-10-03 2016-06-14 The Brigham And Women's Hospital, Inc. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers

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US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
WO2001028518A1 (en) * 1999-10-20 2001-04-26 Vesifact Ag Microemulsion preconcentrates which contain cyclosporines and corresponding microemulsions
SE0000773D0 (en) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0000774D0 (en) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
US6596306B1 (en) * 2000-07-07 2003-07-22 David Ho Sue San Ho Drug delivery system:formulation for fat-soluble drugs
MY120392A (en) * 2000-06-08 2005-10-31 Hovid Berhad A novel drug delivery system : formulation for fat-soluble drugs
WO2002030414A1 (en) * 2000-10-11 2002-04-18 Cephalon, Inc. Compositions comprising modafinil compounds
FR2818905A1 (en) * 2000-12-28 2002-07-05 Cll Pharma MICELLAR COLLOIDAL PHARMACEUTICAL COMPOSITIONS COMPRISING A LIPOPHILIC ACTIVE INGREDIENT
MXPA03007141A (en) * 2001-02-11 2003-11-18 Aquanova Ger Solubilisate Tech Method for producing an active ingredient concentrate, and an active ingredient concentrate.
DK1361864T3 (en) * 2001-02-14 2014-03-03 Gw Pharma Ltd FLYLDENDE SPRAY FORMULATIONS FOR buccal administration of cannabinoids
PT1249231E (en) * 2001-04-12 2004-06-30 Vesifact Ag Pharmaceutical formulations containing active anti-inflammatory substances and their use
SE0102993D0 (en) * 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
KR100441167B1 (en) * 2001-12-27 2004-07-21 씨제이 주식회사 Composition of microemulsion preconcentrate
NZ537829A (en) 2002-07-30 2006-09-29 Wyeth Corp Parenteral formulations containing a rapamycin hydroxyester
CA2495260C (en) 2002-08-12 2012-05-29 Brigham And Women's Hospital Resolvins: biotemplates for novel therapeutic interventions
CA2504329C (en) 2002-11-01 2013-08-20 Biodelivery Sciences International, Inc. Geodate delivery vehicles
US7842791B2 (en) 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
FR2853527B1 (en) * 2003-04-11 2006-06-23 Oreal COMPOSITION IN THE FORM OF OIL-IN-WATER EMULSION CONTAINING AN AMPHIPHILIC POLYMER, AND ITS PARTICULARLY COSMETIC USES
US7879345B2 (en) 2003-04-11 2011-02-01 L'oreal Composition containing an amphiphilic polymer, uses thereof
DE602005014227D1 (en) * 2004-03-10 2009-06-10 Bayer Schering Pharma Ag COMPOSITIONS OF DROSPIRENONE IN MOLECULAR DISPERSION
CA2562388A1 (en) * 2004-03-24 2005-09-29 Takeda Pharmaceutical Company Limited Emulsion-stabilized preparation
US20050232974A1 (en) * 2004-04-19 2005-10-20 Gore Makarand P System and a method for pharmaceutical dosage preparation using jettable microemulsions
US20090149533A1 (en) * 2004-08-06 2009-06-11 Transform Pharmaceuticals, Inc. Novel fenofibrate formulations and related methods of treatment
CN100361656C (en) 2004-08-27 2008-01-16 石药集团中奇制药技术（石家庄）有限公司 Butylbenzene phthalein self emulsifying releasing medicine system, preparation method and application
GT200500310A (en) 2004-11-19 2006-06-19 ORGANIC COMPOUNDS
EP1951200A2 (en) * 2005-08-09 2008-08-06 Nanobio Corporation Nanoemulsion compositions having anti-inflammatory activity
WO2007059431A1 (en) * 2005-11-14 2007-05-24 The Trustees Of Columbia University In The City Of New York Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs
US20140287004A1 (en) * 2005-11-14 2014-09-25 The Trustees Of Columbia University In The City Of New York Use of an Omega-3 Lipid-Based Emulsion Following Ischemic Injury to Provide Protection and Recovery in Human Organs
US20090196861A1 (en) * 2005-11-17 2009-08-06 Bioavailability, Inc. Biocompatible Latent Emulsifiers
MY153288A (en) * 2006-06-28 2015-01-29 Hovid Berhad An effective pharmaceutical carrier for poorly bioavailable drugs
EP2068825B1 (en) * 2006-10-04 2011-01-26 M & P Patent Aktiengesellschaft Controlled release delivery system for nasal application of neurotransmitters
KR101493546B1 (en) * 2007-08-21 2015-02-16 바실리어 파마슈티카 아게 Antifungal composition
US20090130198A1 (en) * 2007-11-21 2009-05-21 Innopharmax Inc. Pharmaceutical composition with enhanced bioavailability
FR2925855B1 (en) 2007-12-26 2010-11-05 Virbac Sa FLORFENICOL SELF-CONTAINING LIQUID COMPOSITION FOR INCORPORATING BEVERAGE WATER IN ANIMAL BREEDING ANIMALS.
KR102118478B1 (en) * 2009-03-09 2020-06-04 바스프 에이에스 Compositions comprising a fatty acid oil mixture and a surfactant, and methods and uses thereof
EP2433630A4 (en) 2009-05-22 2014-01-08 Mochida Pharm Co Ltd Self-emulsifying composition of 3 fatty acid
JP2011006380A (en) * 2009-05-22 2011-01-13 Mochida Pharmaceut Co Ltd EMULSIFIED COMPOSITION OF ω3 FATTY ACID
ES2661812T3 (en) 2009-10-16 2018-04-04 Mochida Pharmaceutical Co., Ltd. Compositions
CN102724972A (en) * 2009-10-23 2012-10-10 普罗诺瓦生物医药挪威公司 Coated capsules and coated tablets of fatty acid oil blend
DK2366408T3 (en) 2010-03-01 2012-10-22 Salvat Lab Sa Aqueous clear solutions of fluocinolone acetonide to treat inflammation of the ear
WO2011139899A2 (en) 2010-05-03 2011-11-10 Teikoku Pharma Usa, Inc. Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
JP2013537186A (en) * 2010-09-08 2013-09-30 プロノヴァ・バイオファーマ・ノルゲ・アーエス Composition comprising fatty acid oil mixture, free fatty acid and statin
AR082930A1 (en) * 2010-09-08 2013-01-16 Pronova Biopharma Norge As COMPOSITIONS THAT INCLUDE AN OILY MIXTURE OF FATTY ACIDS, A TENSIOACTIVE AND A STATIN
WO2012032415A2 (en) * 2010-09-08 2012-03-15 Pronova Biopharma Norge As Compositions comprising a fatty acid oil mixture comprising epa and dha in free acid form, a surfactant, and a statin
JO3337B1 (en) * 2010-12-13 2019-03-13 Debiopharm Sa Pharmaceutical Compositions Comprising Alisporivir
JO3685B1 (en) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc Non-aqueous taxane nanodispersion formulations and methods of using the same
ES2969933T3 (en) 2012-12-31 2024-05-23 Jrx Biotechnology Inc Liquid topical pharmaceutical formulations in nanoemulsion
US10070643B2 (en) 2013-03-28 2018-09-11 The Trustees Of Columbia University In The City Of New York Reperfusion with omega-3 glycerides promotes donor organ protection for transplantation
US11400048B2 (en) 2014-06-25 2022-08-02 Synergia Bio Sciences Private Limited Pharmaceutical oil-in-water nano-emulsion
US10736842B2 (en) 2014-06-25 2020-08-11 Synergia Bio Sciences Private Limited Pharmaceutical oil-in-water nano-emulsion
CN108024914A (en) 2015-09-17 2018-05-11 Jrx生物技术有限公司 Method of improving hydration or moisturization of the skin
EP3849516A2 (en) * 2018-09-13 2021-07-21 FTF Pharma Private Limited Non-aqueous chemotherapeutic suspensions for oral dosage
US20200147032A1 (en) 2018-11-14 2020-05-14 Robert K. Prud'homme Dihydromyricetin hot melt extrusion formulations and methods for forming them
US20200215027A1 (en) * 2018-12-28 2020-07-09 Robert K. Prud'homme Dihydromyricetin nanoemulsion formulations and methods for forming them
US11465107B2 (en) * 2019-01-31 2022-10-11 Hong Ngoc Thi Dang Process for producing a nano omega-3 microemulsion system
PE20221323A1 (en) 2019-11-07 2022-09-09 Chugai Pharmaceutical Co Ltd COMPOSED OF CYCLIC PEPTIDES THAT HAVE INHIBITOR ACTION OF KRAS
CZ309587B6 (en) * 2021-01-22 2023-05-03 Oncora S.R.O. Microemulsion preconcentrate containing cladribine and preparing it

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Patent Citations (13)

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SHAH N H ET AL: "SELF-EMULSIFYING DRUG DELIVERY SYSTEMS (SEDDS) WITH POLYGLYCOLYZED GLYCERIDES FOR IMPROVING IN VITRO DISSOLUTION AND ORAL ABSORPTION OF LIPOPHILIC DRUGS", INTERNATIONAL JOURNAL OF PHARMACEUTICS,NL,AMSTERDAM, vol. 106, no. 1, pages 15-23, XP000561369, ISSN: 0378-5173 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026290B1 (en) 1998-12-30 2006-04-11 Dexcel Ltd. Dispersible concentrate for the delivery of cyclosprin
US7709669B2 (en) 2000-02-16 2010-05-04 The Brigham And Women's Hospital, Inc. Aspirin-triggered lipid mediators
US7741368B2 (en) 2001-12-18 2010-06-22 The Brigham And Women's Hospital, Inc. Approach to antimicrobial host defense with molecular shields with EPA and DHA analogs
US7582785B2 (en) 2002-04-01 2009-09-01 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
US7759395B2 (en) 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
US7872152B2 (en) 2002-08-12 2011-01-18 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
US9364454B2 (en) 2005-10-03 2016-06-14 The Brigham And Women's Hospital, Inc. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers

Also Published As

Publication number Publication date
EP1075252A2 (en) 2001-02-14
JP2002513750A (en) 2002-05-14
AU3843999A (en) 1999-11-23
CA2331640A1 (en) 1999-11-11
WO1999056727A2 (en) 1999-11-11

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