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WO1999056126A3 - Matrice d'immuno-adsorption, ses procedes de production et son utilisation - Google Patents

Matrice d'immuno-adsorption, ses procedes de production et son utilisation Download PDF

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Publication number
WO1999056126A3
WO1999056126A3 PCT/DE1999/001228 DE9901228W WO9956126A3 WO 1999056126 A3 WO1999056126 A3 WO 1999056126A3 DE 9901228 W DE9901228 W DE 9901228W WO 9956126 A3 WO9956126 A3 WO 9956126A3
Authority
WO
WIPO (PCT)
Prior art keywords
utilization
production
immuno
activated
adsorption matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1999/001228
Other languages
German (de)
English (en)
Other versions
WO1999056126A2 (fr
Inventor
Wolfgang Roenspeck
Frank Gebauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AFFINA IMMUNTECHNIK GmbH
Original Assignee
AFFINA IMMUNTECHNIK GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AFFINA IMMUNTECHNIK GmbH filed Critical AFFINA IMMUNTECHNIK GmbH
Priority to AU46000/99A priority Critical patent/AU4600099A/en
Publication of WO1999056126A2 publication Critical patent/WO1999056126A2/fr
Publication of WO1999056126A3 publication Critical patent/WO1999056126A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

L'invention concerne une nouvelle matrice d'immuno-adsorption, ses procédés de production et son utilisation pour la thérapie, le diagnostic, la réalisation de préparations, l'analyse, et dans la technique médicale. Par couplage avec un matériau support, des structures de liaison d'antigène sont dérivatisées et/ou activées, les sites de liaison d'antigène étant protégés, avec des groupes fonctionnels qui conviennent pour un couplage à une matrice chimiquement activée ou constituent eux-mêmes un groupe activé.
PCT/DE1999/001228 1998-04-27 1999-04-24 Matrice d'immuno-adsorption, ses procedes de production et son utilisation Ceased WO1999056126A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU46000/99A AU4600099A (en) 1998-04-27 1999-04-24 Immuno-adsorption matrix, a method for the production thereof, and the utilization thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1998118790 DE19818790A1 (de) 1998-04-27 1998-04-27 Immunadsorptionsmatrix, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19818790.4 1998-04-27

Publications (2)

Publication Number Publication Date
WO1999056126A2 WO1999056126A2 (fr) 1999-11-04
WO1999056126A3 true WO1999056126A3 (fr) 2000-01-13

Family

ID=7865940

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/001228 Ceased WO1999056126A2 (fr) 1998-04-27 1999-04-24 Matrice d'immuno-adsorption, ses procedes de production et son utilisation

Country Status (3)

Country Link
AU (1) AU4600099A (fr)
DE (1) DE19818790A1 (fr)
WO (1) WO1999056126A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006042507A1 (fr) * 2004-10-20 2006-04-27 Adexter Technology Limited Immunoadsorbants pour le traitement d'inflammations
EP1832600A1 (fr) 2006-03-09 2007-09-12 Max-Delbrück-Centrum Für Molekulare Medizin Peptides contre autoanticorps associees du glaucome et leur utilisation.
DE102007004909A1 (de) 2007-01-26 2008-07-31 Ga Generic Assays Gmbh Verfahren zum Nachweis von Antikörpern aus Körperflüssigkeiten durch eine Immunreaktion mit Glykoprotein 2(GP2) aus zymogenen Granula des Pankreas zur Differentialdiagnose von entzündlichen Darmerkrankungen und chronischer Pankreatitis
EP1950222A1 (fr) 2007-01-26 2008-07-30 GA Generic Assays GmbH Procédé à la vérification d'anticorps dans des liquides corporels par une réaction immunitaire avec les glycoprotéines 2 (GP2) à partir de granulés zymogènes du pancréas pour le diagnostic différentiel de maladies inflammatoires de l'intestin et de pancréatites chroniques
EP2199305A1 (fr) 2008-12-18 2010-06-23 Max-Delbrück-Centrum Peptides contre les anticorps associés au CRPS et utilisation de ces peptides
RU2014104690A (ru) 2011-08-12 2015-09-20 Е.Р.Д.Е.-ААК-Диагностик ГмбХ АГОНИСТИЧЕСКИЕ АУТОАНТИТЕЛА К α1- И β2-АДРЕНЕРГИЧЕСКИМ РЕЦЕПТОРАМ ПРИ БОЛЕЗНИ АЛЬЦГЕЙМЕРА И СОСУДИСТОЙ ДЕМЕНЦИИ
EP2913675B1 (fr) 2014-02-28 2020-02-12 GA Generic Assays GmbH Isoformes GP2 et leur utilisation dans la capture d'auto-anticorps
WO2016061632A1 (fr) 2014-10-23 2016-04-28 La Trobe University Protéines de liaison à fn14 et leurs utilisations
EP3242685B1 (fr) 2015-01-09 2022-05-04 AdAlta Limited Molécules de liaison cxcr4
EP3299818B1 (fr) 2016-09-26 2019-12-04 GA Generic Assays GmbH Procédé de diagnostic de pancréatite aigüe (ap) par détection de glycoprotéine 2 alpha isoforme (gp2a)
WO2019015814A1 (fr) 2017-07-20 2019-01-24 Ga Generic Assays Gmbh Utilisation de protéine-1 de type chitinase-3 (chi3l1) en tant qu'auto-antigène dans des troubles auto-immuns du système digestif
KR102755742B1 (ko) 2017-09-11 2025-01-15 모나쉬 유니버시티 인간 트롬빈 수용체 par4 결합 단백질
CN114144427A (zh) 2019-07-16 2022-03-04 德国神经退行性疾病中心 用于检测和分离nmdar自身抗体的nmda受体构建体
EP3872492A1 (fr) 2020-02-28 2021-09-01 Seramun Diagnostica GmbH Identification d'infection par le virus de la maladie de borna (bodv) grâce à la détection d'anticorps contre la glycoprotéine bodv
WO2021239949A1 (fr) 2020-05-29 2021-12-02 Deutsches Zentrum Für Neurodegenerative Erkrankungen E. V. (Dzne) Anticorps monoclonal recombinant humain dirigé contre la glycoprotéine de spicule de sars-cov-2
EP4308933A1 (fr) 2021-03-19 2024-01-24 Charité - Universitätsmedizin Berlin Procédé d'analyse directe de l'avidité fonctionnelle de lymphocytes t
EP4183409A1 (fr) 2021-11-17 2023-05-24 Charité - Universitätsmedizin Berlin Vaccin contre les coronavirus mutants présentant une meilleure immunogénicité
WO2024235842A1 (fr) 2023-05-12 2024-11-21 B.R.A.H.M.S Gmbh Dosage immunologique de fragment régional moyen de proadrénomédulline avec des anticorps monoclonaux
WO2025073733A1 (fr) 2023-10-06 2025-04-10 Ga Generic Assays Gmbh Méthode de diagnostic de la dysbiose du microbiote par détection de la glycoprotéine 2 (gp2) dans les selles

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19653669A1 (de) * 1996-12-13 1998-06-18 Affina Immuntechnik Gmbh Adsorptionsmatrix, ihre Herstellung und ihre Verwendung zur Entfernung von Immunglobulinen aus biologischen Flüssigkeiten

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19653669A1 (de) * 1996-12-13 1998-06-18 Affina Immuntechnik Gmbh Adsorptionsmatrix, ihre Herstellung und ihre Verwendung zur Entfernung von Immunglobulinen aus biologischen Flüssigkeiten

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 115, no. 21, 25 November 1991, Columbus, Ohio, US; abstract no. 223755, XP002121981 *
L.I. SURVILO ET AL.: "Production of immunoaffinity sorbent with biospecific protected antigen - binding centers and its use for separation of human thyrotropin", VESTSI AKAD. NAVUK BSSR, SER. KHIM. NAVUK, vol. 4, 1991, Minsk USSR, pages 79 - 83 *

Also Published As

Publication number Publication date
AU4600099A (en) 1999-11-16
WO1999056126A2 (fr) 1999-11-04
DE19818790A1 (de) 1999-10-28

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