WO1999054448A2 - Human nucleic acid sequences, increased expression thereof in uterus myoma tissue - Google Patents

Abstract

The invention relates to human nucleic acid sequences (mRNA, cDNA, genomic sequences) of uterus myoma tissue, coding for genetic products or parts thereof, in addition to the use thereof. The invention also relates to the polypeptides obtained according to said sequences and to the use thereof.

Description

 Human nucleic acid sequences from uterine fibroid tissue

The invention relates to human nucleic acid sequences from uterine fibroid tissue which code for gene products or parts thereof, their functional genes, which code for at least one biologically active polypeptide, and their use. The invention further relates to the polypeptides obtainable via the sequences and their use. One of the main causes of cancer death in women is the uterine fibroid, for which new therapies are necessary to combat it. Therapies used so far, such as Chemotherapy, hormone therapy or surgical removal of the tumor tissue often do not lead to complete healing. The phenomenon of cancer is often associated with the over- or under-expression of certain genes in the degenerate cells, although it is still unclear whether these altered expression rates are the cause or the consequence of the malignant transformation. The identification of such genes would be an essential step in the development of new therapies for cancer. The spontaneous development of cancer is often preceded by a large number of mutations. These can have various effects on the expression pattern in the affected tissue, e.g. Under- or overexpression, but also expression of shortened genes. Several such changes through such cascade mutations can eventually lead to malignant degeneration. The complexity of such relationships makes the experimental approach very difficult.

A database consisting of so-called ESTs is used to search for candidate genes, ie genes that are more strongly expressed in normal tissue than tumor tissue. ESTs (Expressed Sequence Tags) are sequences of cDNAs, ie reverse-transcribed mRNAs, the molecules that reflect the expression of genes. The EST sequences are determined for normal and degenerate tissues. Various operators offer such databases commercially. The ESTs in the LifeSeq database used here are typically between 150 and 350 nucleotides long. They represent a pattern unmistakable for a specific gene, although this gene is usually much longer (> 2000 nucleotides). By comparing the expression patterns of normal and tumor tissue, ESTs can be identified that are important for tumor development and proliferation. However, there is the following problem: since, due to different constructions of the cDNA libraries, the EST sequences found can belong to different regions of an unknown gene, the result would be a completely wrong ratio of the occurrence of these ESTs in the respective tissue. This would only be noticed when the complete gene is known and the ESTs can thus be assigned to the same gene. It has now been found that this possibility of error can be reduced if all ESTs from the respective tissue type are assembled beforehand before the expression patterns are compared with one another. Overlapping ESTs of one and the same gene were thus combined into longer sequences (see FIG. 1, FIG. 2a and FIG. 3). By extending and thus covering a much larger gene range in each of the respective banks, the error described above should be avoided as far as possible. Since there were no existing software products for this purpose, programs for the assembly of genomic Sections used, which were used modified and supplemented by own programs. A flowchart of the assembly procedure is shown in Figures 2b1 - 2b4. The nucleic acid sequences Seq. ID No 1 to Seq. ID No. 31 and Seq. ID 52 can be found that play a role as candidate genes in uterine fibroids.

The nucleic acid sequences Seq are of particular interest. ID Nos. 14-18, 30, 31, 52.

The invention thus relates to nucleic acid sequences which encode a gene product or a part thereof, comprising a) a nucleic acid sequence selected from the group of the nucleic acid sequences Seq ID Nos. 14-18, 30, 31, 52.

b) an allelic variation of the nucleic acid mentioned under a)

Sequences

or c) a nucleic acid sequence which is complementary to the nucleic acid sequences mentioned under a) or b).

The invention further relates to a nucleic acid sequence according to one of the sequences Seq ID Nos 14-18, 30, 31 or a complementary or allelic variant thereof and the nucleic acid sequences thereof which have a 90% to 95% homology to a human nucleic acid Sequence.

The invention also relates to the nucleic acid sequences Seq. ID No. 1 to Seq. ID No. 31 and and Seq. ID 52, which are expressed increased in the uterine fibroid.

The invention further relates to nucleic acid sequences comprising a part of the above-mentioned nucleic acid sequences, in such a sufficient size that they can be combined with the sequences Seq. Hybridize ID Nos 14-18, 30, 31, 52.

The nucleic acid sequences according to the invention generally have a length of at least 50 to 4500 bp, preferably a length of at least 150 to 4000 bp, in particular a length of 450 to 3500 bp. With the partial sequences Seq. ID Nos. 14-18, 30, 31, 52, expression cassettes can also be constructed in accordance with current process practice, with at least one of the nucleic acid sequences according to the invention together with at least one control or regulatory sequence known to the person skilled in the art, such as eg B. a suitable promoter is combined. The sequences according to the invention can be inserted in sense or antisense orientation. A large number of expression cassettes or vectors and promoters are known in the literature which can be used.

Expression cassettes or vectors are to be understood: 1. bacterial, such as. B., phagescript, pBs, φX174, pBluescript SK, pBs KS, pNH8a, pNH16a, pNH18a, pNH46a (Stratagene), pTrc99A, pKK223-3, pKK233-3, pDR540, pRIT5 (Pharmacia), like eukaryont, 2nd eukaryont. B. pWLneo, pSV2cat, pOG44, pXT1, pSG (Stratagene), pSVK3, pBPV, pMSG, pSVL (Pharmacia).

Suitable control or regulatory sequence means suitable promoters. Two preferred vectors are the pKK232-8 and the PCM7 vector. The following promoters are specifically meant: lad, lacZ, T3, T7, gpt, lambda PR, trc, CMV, HSV thymidine kinase, SV40, LTRs from retrovirus and mouse metallothionein-I.

The DNA sequences on the expression cassette can encode a fusion protein which comprises a known protein and a biologically active polypeptide fragment.

The expression cassettes are also the subject of the present invention.

The nucleic acid fragments according to the invention can be used to produce full-length genes. The available genes are also the subject of the present invention.

The invention also relates to the use of the nucleic acid sequences according to the invention and the gene fragments obtainable from the use. The nucleic acid sequences according to the invention can be brought into host cells with suitable vectors, in which the heterologous part contains the genetic information contained on the nucleic acid fragments which is expressed. The host cells containing the nucleic acid fragments are also the subject of the present invention.

Suitable host cells are e.g. B. prokaryotic cell systems such as E. coli or eukaryotic cell systems such as animal or human cells or yeasts.

The nucleic acid sequences according to the invention can be used in sense or antisense form.

The polypeptides or their fragments are produced by cultivating the host cells in accordance with common cultivation methods and then isolating and purifying the peptides or fragments, likewise by means of conventional methods. The invention further relates to nucleic acid sequences which encode at least a partial sequence of a biologically active polypeptide. Furthermore, the present invention relates to partial polypeptide sequences, so-called ORF (open reading frame) peptides, according to the sequence protocols ORF ID Nos 32-51 and ORF ID Nos 53-55. The invention further relates to the polypeptide sequences which have at least 80% homology, in particular 90% homology, to the polypeptide partial sequences of the ORF according to the invention. ID Nos. 32-51 and ORF ID Nos 53-55. The invention also relates to antibodies which are directed against a polypeptide or fragment thereof which are of the nucleic acids of the sequences Seq. ID No. 1-31 and Seq.lD No. 52 can be encoded.

Antibodies are to be understood in particular as monoclonal antibodies.

The antibodies of the invention can include can be identified by a phage display method. These antibodies are also the subject of the invention.

The partial polypeptide sequences according to the invention can be used in a phage display method. The polypeptides identified by this method which bind to the partial polypeptide sequences according to the invention are also the subject of the invention.

The nucleic acid sequences according to the invention can also be used in a phage display method.

The polypeptides according to the invention of the sequences Seq. ID Nos. 32-51 and Seq. ID Nos 53-55 can also be used as a tool for finding active substances against the uterine fibroid, which is also the subject of the present invention.

The present invention also relates to the use of the nucleic acid sequences according to the sequences Seq. ID No. 1 to Seq. ID No. 31 and Seq. ID 52 for the expression of polypeptides that can be used as tools for finding active substances against the uterine fibroid.

The invention also relates to the use of the polypeptide partial sequences Seq found. ID No. 32 to Seq. ID No. 51 and Seq. ID Nos 53-55 as a drug in gene therapy for the treatment of the uterine fibroid, or for the manufacture of a drug for the treatment of the uterine fibroid.

The invention also relates to pharmaceutical compositions which contain at least one polypeptide partial sequence Seq. ID No. 32 to 51 and Seq. ID Nos 53-55 included. The nucleic acid sequences according to the invention found can also be genomic or mRNA sequences.

The invention also relates to genomic genes, their exon and intron structure and their splice variants, obtainable from the cDNAs of the sequences Seq. ID No. 1-31, 52, and their use together with suitable regulatory elements, such as suitable promoters and / or enhancers. With the nucleic acids (cDNA sequences) according to the invention Seq. ID. No. 1-31, 52 genomic BAC, PAC and cosmid libraries are screened and specifically human clones are isolated via complementary base pairing (hybridization). The BAC, PAC and cosmid clones isolated in this way are hybridized with the aid of fluorescence in situ hybridization to metaphase chromosomes and corresponding chromosome sections on which the corresponding genomic genes lie are identified. BAC, PAC and cosmid clones are sequenced in order to elucidate the corresponding genomic genes in their complete structure (promoters, enhancers, silencers, exons and introns). BAC, PAC and cosmid clones can be used as independent molecules for gene transfer (see FIG. 5).

The invention also relates to BAC, PAC and cosmid clones containing functional genes and their chromosomal localization, according to the sequences Seq. ID. No. 1-31, 52 for use as a vehicle for gene transfer.

Meanings of technical terms and abbreviations

Nucleic acids = nucleic acids are to be understood in the full invention: mRNA, partial cDNA, full length cDNA and genomic genes (chromosomes).

ORF = Open Reading Frame, a defined sequence of amino acids that can be derived from the cDNA sequence. Contig = a set of DNA sequences that can be combined into one sequence due to their very similarities (consensus)

Singieton = a contig that contains only one sequence

Module = domain of a protein with a defined sequence, which represents a structural unit and occurs in different proteins N = optionally the nucleotide A, T, G or C X = optionally one of the 20 naturally occurring amino acids

Explanation of the alignment parameters minimal initial match = minimum initial identity range maximum pads per read = maximum number of insertions maximum percent mismatch = maximum deviation in%

Explanation of the pictures

Fig. 1 shows the systematic gene search in the Incyte LifeSeq database.

Fig. 2a shows the principle of EST assembly. Fig. 2b1-2b4 shows the entire principle of EST assembly. Fig. 3 shows in silico subtraction of gene expression in different tissues

4a shows the determination of the tissue-specific expression via electronic Northern.

Fig. 4b shows the electronic Northern. Fig. 5 shows the isolation of genomic BAC and PAC clones. The following examples explain the preparation of the nucleic acid sequences according to the invention without restricting the invention to these examples and nucleic acid sequences.

example 1

Search for tumor-related candidate genes

First, all ESTs of the corresponding tissue were extracted from the LifeSeq database (from October 1997). These were then assembled using the program GAP4 of the Staden package with the parameters 0% mismatch, 8 pads per read and a minimum match of 20. The sequences (failures) not included in the GAP4 database were assembled with the database first at 1% mismatch and then again at 2% mismatch. Consensus sequences were calculated from the database contigs, which consisted of more than one sequence. The singletons of the database, which consisted of only one sequence, were reassembled with the sequences not included in the GAP4 database at 2% mismatch. Again, the consensus sequences were determined for the contigs. All other ESTs were reassembled at 4% mismatch. The consensus sequences were extracted again and finally assembled with the previous consensus sequences as well as the singletons and the sequences not included in the database at 4% mismatch. The consensus sequences were formed and used with the singletons and failures as the basis for the tissue comparisons. This procedure ensured that, under the parameters used, all sequences represented mutually independent gene regions. 2b1-2b4 illustrates the extension of the uterine fibroid tissue ESTs.

The sequences of the respective tissues assembled in this way were then compared using the same program (FIG. 3). For this purpose, all sequences of the first tissue were first entered in the database. (It was therefore important that they were independent of each other.)

Then all sequences of the second tissue were compared to all of the first. The result was sequences that were specific for the first and second tissues as well as those that occurred in both. In the latter, the ratio of the frequency of occurrence in the respective tissues was evaluated. All programs related to the evaluation of the assembled sequences were developed in-house.

All sequences that occurred more than four times in one of the compared tissues as well as all that occurred at least five times as frequently in one of the two tissues were examined further. These sequences were subjected to an electronic Northern (see Example 2.1), whereby the distribution in all tumor and normal tissues was examined (see FIGS. 4a and 4b). The relevant candidates were then extended using all Incyte ESTs and all ESTs in public databases (see Example 3). The sequences and their translation into possible proteins were then compared with all nucleotide and protein databases and examined for possible regions coding for proteins. Example 2

Algorithm for the identification and extension of partial cDNA sequences with a changed expression pattern

An algorithm for finding over- or underexpressed genes will be explained below. For the sake of clarity, the individual steps are also summarized in a flow chart (see FIG. 4b).

2.1 Electronic Northern blot

To a partial DNA sequence S, e.g. B. a single EST or a contig of ESTs are using a standard program for homology search, z. B. BLAST (Altschul, SF, Gish W., Miller, W., Myers, EW and Lipman, DJ (1990) J. Mol. Bio!., 215, 403-410), BLAST2 (Altschul, SF, Madden, T. L, Schäffer, AA, Zhang, J., Zhang, Z., Miller, W. and Lipman, DJ (1997) Nucleic Acids Research 25 3389-3402) or FASTA (Pearson, WR and Lipman, DJ (1988) Proc. Natl. Acad. Sci. USA 85 2444-2448), which determines homologous sequences in various EST libraries ordered by tissue (private or public). The (relative or absolute) tissue-specific occurrence frequencies of this partial sequence S determined in this way are referred to as electronic Northern blot.

2.1.1

Analogous to the procedure described under 2.1, the sequence Seq. ID No. 30 found that occurs more frequently in uterine fibroid tissue than in normal tissue.

The result is as follows: Electronic Northern for SEQ. ID. NO: 30

NORMAL TUMOR conditions

% Haeufιgkeιt% Frequency N / T T / N

Bubble 0.0078 0.0000 undef 0.0000

Breast 0.0013 0.0000 undef 0.0000

Small intestine 0.0092 0.0000 undef 0.0000

Ovary 0.0000 0.0000 undef undef

Endocrine tissue 0.0034 0.0000 undef 0.0000

Gastrom test times 0.0019 0.0000 undef 0.0000

Brain 0.0000 0.0000 undef undef

Haematopoetic 0.0000 0.0000 undef undef

Skin 0.0000 0.0000 undef undef

Hepatic 0.0000 0.0000 undef undef

Heart 0.0011 0.0000 undef 0.0000

Testicles 0.0000 0.0000 undef undef

Lungs 0.0010 0.0000 undef 0.0000

Stomach-ear of ear 0.0000 0.0000 undef undef

Musculoskeletal 0.0000 0.0000 undef undef

Kidney 0.0000 0.0000 undef undef

Pancreas 0.0000 0.0000 undef undef Penis 0.0000 0, .0000 undef undef

Prostate 0.0109 0.0021 5.11810.1954

Uterine endometrium 0.0000 0. .0000 undef undef

Uterine myometrium 0.0000 0., 0340 0.0000 undef

Uterus_general 0.0102 0., 0000 undef 0.0000

Breast hyperplasia 0.0000

Prostate hyperplasia 0.0000

Seminal vesicle 0.0089

Sensory organs 0.0000 ice blood 0.0000

Cervix 0.0000

FOETUS% frequency

Development 0.0000

Gastrointest time 0.0000

Brain 0.0000

Haematopoietic 0.0000

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0000

Lungs 0.0000

Adrenal gland 0.0000

Kidney 0.0000

Placenta 0.0000

Prostate 0.0000

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

% Frequency

Breast 0.0000

Ovary n 0.0000

Ovary t 0.0000

Endocrine tissue 0.0000

Fetal 0.0000

Gastro test times 0.0000

Haematopoietic 0.0000

Skin muscle 0.0000

Testicles 0.0000

Lungs 0.0000

Nerves 0.0000

Prostate 0.0068

Sensory organs 0.0000

Uterus n 0.0000

2.1.2

Analogous to the procedure described under 2.1, the sequence Seq. ID No. 31 found that occurs more frequently in uterine fibroid tissue than in normal tissue.

The result is as follows: Electronic Northern for SEQ. ID. NO: 31

NORMAL TUMOR conditions

% Frequency% frequency bit N / T T / N

Bubble 0.0000 0.0051 0.0000 undef

Breast 0.0038 0.0019 2.04160.4898

Small intestine 0.0031 0.0000 undef 0.0000

Ovary 0.0030 0.0104 0.28783.4745

Endocrine tissue 0.0034 0.0100 0.33962.9444

Gastrointestinal 0.0057 0.0046 1.24250.8048

Brain 0.0111 0.0051 2.15990.4630

Haematopoetic 0.0040 0.0000 undef 0.0000

Skin 0.0000 0.0000 undef undef

Hepatic 0.0048 0.0000 undef 0.0000

Heart 0.0095 0.0000 undef 0.0000

Testicles 0.0058 0.0000 undef 0.0000

Lungs 0.0042 0.0102 0.40642.4605

Stomach-ear of ear 0.0000 0.0000 undef undef

Musculoskeletal 0.0034 0.0060 0.57111.7510

Kidney 0.0163 0.0068 2.37910.4203

Pancreas 0.0017 0.0000 undef 0.0000

Penis 0.0090 0.0000 undef 0.0000

Prostate 0.0022 0.0021 1.02360.9769

Uterine endometrium 0.0135 0.0000 undef 0.0000

Uterine Myorαetnum 0.0000 0.0340 0.0000 undef

Uterus_allgemeιn 0.0000 0.0000 undef undef

Breast hyperplasia 0.0224

Prostate hyperplasia 0.0030

Seminal vesicle 0.0089

Sensory organs 0.0000

White blood cells 0.0061

Cervix 0.0213

FOETUS frequency

Development 0.0000

Gastromtenstmal 0.0028

Brain 0.0125

Haematopoietic 0.0000

Skin 0.0000

Hepatic 0.0000

Heart blood vessels 0.0036

Lungs 0.0036

Adrenal gland 0.0254

Kidney 0.0062

Placenta 0.0303

Prostate 0.0000

Sensory organs 0.0126

NORMALIZED / SUBTRACTED LIBRARIES

% Frequency

Breast 0.0000

Ovary n 0.0000

Ovary t 0.0000

Endocrine tissue 0.0000

Fetal 0.0000

Gastrointestinal 0.0000

Haematopoietic 0.0000

Skin muscle 0.0000

Testicles 0.0000

Lungs 0.0082

Nerves 0.0000

Prostate 0.0000

Sensory organs 0.0000

Uterus n 0.0000 The following Northerns were also found in an analogous procedure: Electronic Northern for SEQ. ID. NO: 1

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0468 0.0562 0.83211.2018

Breast 0.0576 0.0752 0.76561.3062

Small intestine 0.0766 0.0662 1.15860.8631

Ovary 0.0509 0.0650 0.78291.2774

Endokπnes_Gewebe 0.0596 0.0702 0.84911.1778

Gastrointestinal 0.0690 0.1203 0.57351.7438

Brain 0.0850 0.0873 0.97411.0266

Haematopoetic 0.0722 0.0379 1.90560.5248

Skin 0.0918 0.0000 undef 0.0000

Hepatic 0.0143 0.1100 0.12987.7066

Heart 0.1123 0.0275 4.08620.2447

Testis 0.0518 0.0819 0.63251.5809

Lungs 0.1080 0.0879 1.22870.8138

Gastric food tube 0.0676 0.0307 2.20590.4533

Musculoskeletal system 0.0737 0.0780 0.94451.0587

Kidney 0.0407 0.0890 0.45752.1857

Pancreas 0.0463 0.0552 0.83761.1939

Penis 0.0449 0.0000 undef 0.0000

Prostate 0.0436 0.0554 0.78741.2700

Uterus_Endometnum 0.0338 0.0000 undef 0.0000

Uterus_Myometrιum 0.0534 0.1426 0.37412.6732

Uterus_general 0.0255 0.0000 undef 0.0000

Breast hyperplasia 0.0863

Prostate hyperplasia 0.0535

Seminal vesicle 0.0890

Sensory organs 0.0588 eιsse_Blutkoerperchen 0.0772

Cervix 0.1171

FETUS

% Freight

Development 0.0139

Guest romtenst times 0.0583

Brain 0.0500

Haematopoetic 0.0590

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0462

Lungs 0.0578

Adrenal gland 0.0254

Kidney 0.0679

Placenta 0.0545

Prostate 0.2493

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

% Haeufιgkeιt

Breast 0.0204

Eιerstock_n 0.1595

Eιerstock_t 0.0051

Endocrine tissue 0.0000

Fetal 0.0256

Gastrointestinal 0.0488

Haematopoietic 0.0000

Skin muscle 0.0227

Testicles 0.0154

Lungs 0.0082

Nerves 0.0191

Prostate 0.0068

Sensory organs 0.0000

Uterus n 0.0000 Electronic Northern for SEQ. ID. NO: 2

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0039 0.0102 0.38142.6222

Breast 0.0128 0.0038 3.40260.2939

Small intestine 0.0031 0.0165 0.18545.3946

Ovary 0.0000 0.0000 undef undef

Endocrine tissue 0.0017 0.0075 0.22644.4166

Gastrointestinal 0.0019 0.0093 0.20714.8289

Brain 0.0022 0.0103 0.21604.6299

Haematopoetic 0.0040 0.0000 undef 0.0000

Skin 0.0000 0.0000 undef undef

Hepatic 0.0000 0.0065 0.0000 undef

Heart 0.0011 0.0137 0.077112.9706

Testicles 0.0058 0.0000 undef 0.0000

Lungs 0.0021 0.0082 0.25403.9367

Stomach-ear of ear 0.0000 0.0000 undef undef

Musculoskeletal 0.0000 0.0120 0.0000 undef

Kidney 0.0054 0.0000 undef 0.0000

Pancreas 0.0000 0.0055 0.0000 undef

Penis 0.0030 0.0000 undef 0.0000

Prostate 0.0000 0.0021 0.0000 undef

Uterus Endometπum 0.0000 0.0528 0.0000 undef

Uterus Myometπum 0.0000 0.0408 0.0000 undef

General uterus 0.0051 0.0954 0.053418.7357

Breast hyperplasia 0.0064

Prostate hyperplasia 0.0000

Seminal vesicle 0.0089

Sensory organs 0.0000

White blood cells 0.0009

Cervix 0.0000

FOETUS% frequency

Development 0.0974

Gastromtenst al 0.0333

Brain 0.0063

Haematopoetic 0.0157

Skin 0.0000

Hepatic 0.0000

Heart blood vessels 0.0249

Lungs 0.0325

Adrenal gland 0.0761

Kidney 0.0618

Placenta 0.0727

Prostate 0.0249

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

%Frequency

Breast 0.0000

Ovary n 0.0000

Ovary t 0.0000

Endocrine tissue 0.0000

Fetal 0.0384

Gastrointestinal 0.0122

Haematopoietic 0.0000

Skin muscle 0.0259

Testicles 0.0000

Lungs 0.0328

Nerves 0.0171

Prostate 0.0137

Sensory organs 0.0000

Uterus n 0.0083 Electronic Northern for SEQ. ID. NO: 3

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0000 0.0000 undef undef

Breast 0.0000 0.0000 undef undef

Small intestine 0.0000 0.0000 undef undef

Ovary 0.0000 0.0000 undef undef

Endocrine tissue 0.0000 0.1103 0.0000 undef

Gastrointestinal 0.0000 0.0000 undef undef

Brain 0.0140 0.0010 13.6792 0.0731

Haematopoetic 0.0000 0.0000 undef undef

Skin 0.0000 0.0000 undef undef

Hepatic 0.0000 0.0000 undef undef

Heart 0.0000 0.0000 undef undef

Testicles 0.0000 0.0000 undef undef

Lung 0.0000 0.0000 undef undef

Stomach-ear of ear 0.0000 0.0000 undef undef

Musculoskeletal 0.0000 0.0000 undef undef

Kidney 0.0000 0.0000 undef undef

Pancreas 0.0000 0.0000 undef undef

Penis 0.0000 0.0000 undef undef

Prostate 0.0000 0.0000 undef undef

Uterine endometrium 0.0000 0.0000 undef undef

Uterine myometrium 0.0000 0.0815 0.0000 undef

General uterus 0.0000 0.0000 undef undef

Breast hyperplasia 0.0000

Prostate hyperplasia 0.0030

Seminal vesicle 0.0000

Sensory organs 0.0000

White blood cells 0.0000

Cervix 0.0000

FOETUS

Development 0.0000

Gastromtenst al 0.0028

Brain 0.0000

Haematopoietic 0.0000

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0000

Lungs 0.0000

Adrenal gland 0.0000

Kidney 0.0000

Placenta 0.0000

Prostate 0.0000

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

Frequent

Breast 0.0000

Ovary n 0.0000

Ovary t 0.0000

Endocrine tissue 0.0000

Fetal 0.0000

Gastrointestinal 0.0000

Haematopoietic 0.0000

Skin muscle 0.0000

Testicles 0.0000

Lungs 0.0000

Nerves 0.0090

Prostate 0.0137

Sensory organs 0.0000

Uterus n 0.0000 Electronic Northern for SEQ. ID. NO: 4

NORMAL TUMOR BEHAVIOR

% Frequency% frequency N / T T / N

Bubble 0.0078 0.0077 1.01700.9833

Breast 0.0026 0.0038 0.68051.4694

Small intestine 0.0031 0.0165 0.18545.3946

Ovary 0.0060 0.0026 2.30250.4343

Endocrine tissue 0.0000 0.0000 undef undef

Gastrointestinal 0.0000 0.0046 0.0000 undef

Brain 0.0007 0.0031 0.24004.1669

Haematopoetic 0.0000 0.0000 undef undef

Skin 0.0000 0.1695 0.0000 undef

Hepatic 0.0000 0.0065 0.0000 undef

Heart 0.0095 0.0412 0.23134.3235

Testicles 0.0000 0.0000 undef undef

Lungs 0.0021 0.0041 0.50801.9684

Gastro-ear of ear 0.0000 0.0077 0.0000 undef

Musculoskeletal system 0.0017 0.0120 0.14287.0040

Kidney 0.0027 0.0000 undef 0.0000

Pancreas 0.0033 0.0055 0.59831.6714

Penis 0.0030 0.0000 undef 0.0000

Prostate 0.0000 0.0021 0.0000 undef

Uterine endometrium 0.0068 0.0000 undef 0.0000

Uterus Myometπum 0.0152 0.0883 0.17275.7919

General uterus 0.0051 0.0000 undef 0.0000

Breast hyperplasia 0.0032

Prostate hyperplasia 0.0030

Seminal vesicle 0.0000

Sensory organs 0.0118

'' blood corpuscles 0.0000

Cervix 0.0000

FOETUS% Haeufιgkeιt

Development 0.0278

Gastromtenstmal 0.0139

Brain 0.0000

Haematopoietic 0.0000

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0213

Lungs 0.0253

Adrenal gland 0.0000

Kidney 0.0185

Placenta 0.0061

Prostate 0.0000

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

% Frequency

Breast 0. 0068

Eιerstock_n 0. 0000

Eιerstock_t 0. 0000

Endoknnes_Gewebe 0. 0000

Fetal 0.0093

Gastrointestinal 0. 0122

Haematopoetic 0. 0000

Skin muscle 0. 0130

Testicles 0. 0000

Lungs 0.0000

Nerves 0. 0000

Prostate 0. 0000

Sensory organs 0. 0000

Uterus n 0. 0000 Electronic Northern for SEQ. ID. NO: 5

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0390 0.0332 1.17340.8522

Breast 0.0345 0.0414 0.83521.1973

Small intestine 0.0399 0.0662 0.60241.6599

Ovary 0.0359 0.0546 0.65791.5201

Endocrine tissue 0.0528 0.0351 1.50400.6649

Gastrointestinal 0.0172 0.0185 0.93191.0731

Brain 0.0214 0.0359 0.59651.6763

Haematopoetic 0.0294 0.0379 0.77631.2881

Skin 0.0257 0.1695 0.15166.5954

Hepatic 0.0476 0.0323 1.47060.6800

Heart 0.0276 0.0000 undef 0.0000

Testis 0.0633 0.0234 2.70590.3696

Lungs 0.0312 0.0266 1.17240.8530

Stomach-ear of ear 0.0387 0.0153 2.52110.3967

Musculoskeletal system 0.0308 0.0360 0.85671.1673

Kidney 0.0326 0.0548 0.59481.6813

Pancreas 0.0132 0.0221 0.59831.6714

Penis 0.0479 0.0000 undef 0.0000

Prostate 0.0153 0.0319 0.47772.0934

Uterine endometer 0.0473 0.0528 0.89621.1158

Uterine myometrium 0.0305 0.1019 0.29933.3415

General uterus 0.0560 0.1908 0.29363.4065

Breast hyperplasia 0.0448

Pros ata hyperplasia 0.0446

Bubble 0.1513

Sensory organs 0.0235

White blood cells 0.0061

Cervix 0.0426

FOETUS% Haeufιgkeιt

Development 0.0974

Gastromtenst al 0.0222

Brain 0.0000

Haematopoetic 0.0197

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0356

Lungs 0.0325

Adrenal gland 0.0000

Kidney 0.0185

Placenta 0.0909

Prostate 0.1496

Sensory organs 0.0126

STANDARDIZED / SUBTRACTED LIBRARIES% Haeufιgkeιt

Breast 0, .0136

Ovary n 0, .0000

Ovary t 0, .0051

Indocrm tissue 0, .0000

Fetal 0, 0099

Gastrointestinal 0, .0122

Haematopoetic 0. 0000

Skin muscle 0, .0324

Testicles 0, 0231

Lungs 0., 0328

Nerves 0, .0131

Prostate 0, 0068

Sensory organs 0 .0077

Uterus n 0, 0208 Electronic Northern for SEQ. ID. NO: 6

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0429 0.1278 0.33562.9798

Breast 0.1036 0.1203 0.86131.1610

Small intestine 0.0215 0.0992 0.21634.6240

Ovary 0.0599 0.0702 0.85281.1726

Endocrine tissue 0.0783 0.0426 1.83800.5441

Gastrointestinal 0.0249 0.0786 0.31673.1574

Brain 0.0429 0.1284 0.33412.9935

Haematopoetic 0.0227 0.1136 0.20005.0008

Skin 0.0844 0.1695 0.49822.0073

Hepatic 0.0523 0.0712 0.73531.3600

Heart 0.0922 0.1649 0.55901.7890

Testis 0.0460 0.0585 0.78721.2704

Lungs 0.0447 0.0797 0.56011.7853

Gastro-ear of ear 0.0000 0.0537 0.0000 undef

Musculoskeletal 0.1490 0.1380 1.08010.9258

Kidney 0.0489 0.0479 1.01960.9808

Pancreas 0.0149 0.1049 0.14177.0571

Penis 0.0509 0.1333 0.38192.6187

Prostate 0.0196 0.0319 0.61421.6282

Uterine endometrium 0.0676 0.1583 0.42682.3432

Uterine myometrium 0.0381 0.3260 0.11698.5541

General uterus 0.0560 0.0000 undef 0.0000

Breast hyperplasia 0.0863

Prostate hyperplasia 0.0297

Seminal vesicle 0.0089

Sensory organs 0.0353 release blood cells 0.0078

Cervix 0.0213

FOETUS% frequency

Development 0.1670

Gastromtenstmal 0.1444

Brain 0.0125

Haematopoetic 0.0629

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0889

Lungs 0.0759

Adrenal gland 0.2535

Kidney 0.1112

Placenta 0.1091

Prostate 0.1247

Sensory organs 0.1004

STANDARDIZED / SUBTRACTED LIBRARIES% Frequency

Breast 0, 0476

Ovary n0. .1595

Ovary t0.0203

, ndocrιnes tissue 0., 0000

Fetal 0 .0379

Gastrointestinal 0 .0122

Haematopoetic 0. 0000

Skin muscle 0, .0486

Testicles 0. 0077

Lungs 0, .0164

Nerves 0, 0251

Prostate 0, .0068

Sensory organs 0, .0155

Uterus n 0, .0167 Electronic Northern for SEQ. ID. NO: 7

NORMAL TUMOR conditions

% Frequency% Frequency N / T T / N Bubble 0.0117 0.0051 2.2882 0.4370

Breast 0.0128 0.0075 1.7013 0.5878

Small intestine 0.0153 0.0331 0.4634 2.1579

Ovary 0.0150 0.0104 1.4391 0.6949

Endocrine tissue 0.0085 0.0050 1.6981 0.5889 Gastrointestinal 0.0096 0.0278 0.34512.8974

Brain 0.0059 0.0113 0.5236 1.9098

Haematopoetic 0.0254 0.0000 undef 0.0000

Skin 0.0257 0.0000 undef 0.0000

Hepatic 0.0143 0.0194 0.7353 1.3600 heart 0.0106 0.0000 undef 0.0000

Testicles 0.0058 0.0234 0.2460 4.0652

Lungs 0.0104 0.0245 0.4234 2.3620

Stomach-ear of ear 0.0000 0.0000 undef undef

Musculoskeletal 0.0051 0.0360 0.1428 7.0040 Kidney 0.0244 0.0068 3.5687 0.2802

Pancreas 0.0083 0.0000 undef 0.0000

Penis 0.0180 0.0000 undef 0.0000

Prostate 0.0218 0.0064 3.4121 0.2931

Uterus_Endometrιum 0.0135 0.0000 undef 0.0000 Uterus_Myometrιum 0.0000 0.0408 0.0000 undef

Uterus_general 0.0000 0.0000 undef undef

Breast hyperplasia 0.0192

Prostate hyperplasia 0.0030

Seminal vesicle 0.0089 sensory organs 0.0235

Weιsse_Blutkoerperchen 0.0208

Cervix 0.0213

FETUS

% Frequency

Development 0. 0278

Gastromtenstmal 0. 0083

Brain 0. 0125

Haematopoetic 0. 0000

Skin 0. 0000

Hepatic 0. 0000

Cardiac blood vessels 0. 0071

Lungs 0. 0036

Adrenal gland 0. 0000

Kidney 0. 0309

Placenta 0. 0061

Prostate 0. 0249

Sensory organs 0. 0000

NORMALIZED / SUBTRACTED LIBRARIES

%Frequency

Breast 0.0000

Eιerstock_n 0.0000

Eιerstock_t 0.0101

Endokrmes_Gewebe 0245

Fetal 0093

Gastrointestinal 0122

Haematopoetic 0342

Skin muscle 0097

Testis 0154

Lungs 0082

Nerves 0.0080

Prostate 0.0000

Sensory organs 0.0000

Uterus n 0.0042 Electronic Northern for SEQ. ID. NO: 8

NORMAL TUMOR conditions

% Haeufιgkeit% Haeufιgkeιt N / T T / N

Bubble 0.0312 0.0460 0.67801.4750

Breast 0.0192 0.0282 0.68051.4694

Small intestine 0.0368 0.0000 undef 0.0000

Ovary 0.0210 0.0364 0.57561.7372

Endocrine tissue 0.0290 0.0326 0.88821.1258

Gastrointestinal 0.0460 0.0231 1.98800.5030

Brain 0.0532 0.0585 0.90941.0996

Haematopoetic 0.0361 0.0379 0.95281.0496

Skin 0.0367 0.0000 undef 0.0000

Hepatic 0.0048 0.0647 0.073513.5999

Heart 0.0699 0.0412 1.69610.5896

Testis 0.0288 0.4210 0.068314.6349

Lungs 0.0343 0.0368 0.93141.0737

Gastric ear of ear 0.0773 0.0230 3.36140.2975

Musculoskeletal system 0.0497 0.0660 0.75281.3283

Kidney 0.0353 0.1575 0.22414.4619

Pancreas 0.0165 0.0939 0.17605.6828

Penis 0.0299 0.0267 1.12320.8903

Prostate 0.0196 0.0298 0.65801.5197

Uterine endometrium 0.0270 0.1583 0.17075.8579

Uterine myometrium 0.0229 0.0679 0.33672.9702

General uterus 0.0051 0.0954 0.053418.7357

Breast hyperplasia 0.0192

Prostate hyperplasia 0.0505

Seminal vesicle 0.0890

Sensory organs 0.0353

White blood cells 0.0399

Cervix 0.0319

FOETUS% frequency

Development 0.0417

Gastromtenstmal 0.0333

Brain 0.0313

Haematopoetic 0.0197

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0783

Lungs 0.0217

Adrenal gland 0.0507

Kidney 0.0309

Placenta 0.0727

Prostate 0.0997

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

% Frequency

Breast 0.0000

Ovary n 0.0000

Ovary t 0.0152

Endocrine tissue 0.0000

Fetal 0.0082

Gastrointestinal 0.0244

Haematopoietic 0.0057

Skin muscle 0.0032

Testicles 0.0077

Lungs 0.0082

Nerves 0.0141

Prostate 0.0000

Sensory organs 0.0310

Uterus n 0.0125 Electronic Northern for SEQ. ID. NO: 9

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0468 0.0204 2.28820.4370

Breast 0.0205 0.0451 0.45372.2042

Small intestine 0.0307 0.0331 0.92681.0789

Ovary 0.0539 0.0468 1.15130.8686

Endocrine tissue 0.0562 0.0527 1.06740.9369

Gastrointestinal 0.0249 0.0324 0.76921.3001

Brain 0.0333 0.0318 1.04510.9568

Haematopoetic 0.0388 0.0379 1.02340.9772

Skin 0.0257 0.1695 0.15166.5954

Hepatic 0.0095 0.0259 0.36762.7200

Heart 0.0540 0.0000 undef 0.0000

Testis 0.0173 0.0702 0.24604.0652

Lungs 0.0291 0.0491 0.59271.6872

Gastro-ear of ear 0.0000 0.0230 0.0000 undef

Musculoskeletal system 0.0206 0.1140 0.18035.5448

Kidney 0.0733 0.0274 2.67650.3736

Pancreas 0.0264 0.0331 0.79771.2536

Penis 0.0269 0.0533 0.50541.9786

Prostate 0.0501 0.0341 1.47150.6796

Endometrial uterus 0.0541 0.2639 0.20494.8816

Uterine myometrium 0.0152 0.0611 0.24944.0097

Uterus_general 0.0204 0.0000 undef 0.0000

Breast hyperplasia 0.0512

Prostate hyperplasia 0.0386

Seminal vesicle 0.0623

Sensory organs 0.0470 ιsse_Blutkoerperchen 0.0286

Cervix 0.0426

FOETUS% Haeufιgkeιt

Development 0.0557

Gastromtenstmal 0.0666

Brain 0.0626

Haematopoetic 0.0786

Skin 0.0000

Hepatic 0.0260

Cardiac blood vessels 0.0818

Lungs 0.0867

Adrenal gland 0.0761

Kidney 0.0432

Placenta 0.0606

Prostate 0.0249

Sensory organs 0.0628

NORMALIZED / SUBTRACTED LIBRARIES

%Frequency

Breast 0.0068

Ovary 0.1595

Ovary t 0.0051

Endocrine tissue 0.0245

Fetal 0.0256

Gastrointestinal 0.0732

Haematopoietic 0.0057

Skin muscle 0.0551

Testis 0.0309

Lungs 0.0737

Nerves 0.0231

Prostate 0.0137

Sensory organs 0.0310

Uterus n 0.0333 Electronic Northern for SEQ. ID. NO: 10

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.1131 0.1431 0.79001 .2659

Breast 0.1356 0.1692 0.80151 .2476

Small intestine 0.1962 0.0165 11.8636 0.0843

Ovary 0.1827 0.2446 0.74711. .3385

Endocrine tissue 0.1090 0.1329 0.82021 .2192

Gastrointestinal 0.1878 0.2590 0.72481, .3797

Brain 0.1035 0.1325 0.78141, .2798

Haematopoetic 0.2700 0.1894 1.42570,, 7014

Skin 0.1358 0.0847 1.60280, .6239

Hepatic 0.0428 0.1812 0.23634, .2311

Heart 0.2586 0.0137 18.8118 0.0532

Testis 0.0633 0.1403 0.45102. .2174

Lungs 0.3231 0.2229 1.44950. .6899

Gastric ear of ear 0.1643 0.2147 0.76531. , 3066

Musculoskeletal 0.1970 0.0960 2.05240, .4872

Kidney 0.1222 0.2328 0.52481. , 9055

Pancreas 0.0876 0.1767 0.49552. , 0183

Penis 0.1407 0.1600 0.87981. 1366

Prostate 0.1003 0.0766 1.30800. , 7645

Uterine endometrium 0.1824 0.0528 3.45690. 2893

Uterine myometrium 0.1677 0.3804 0.44092. 2681

General uterus 0.2292 0.0000 undef 0. 0000

Breast hyperplasia 0.0735

Prostate hyperplasia 0.0684

Seminal vesicle 0.1335

Sensory organs 0.0470

Weιsse_Blutkoerperchen 0.2749

Cervix 0.0958

FOETUS% frequency

Development 0.0139

Gastromtenstmal 0.0639

Brain 0.1063

Haematopoietic 0.1258

Skin 0.2513

Hepatic 0.0260

Cardiac blood vessels 0.0712

Lungs 0.1517

Adrenal gland 0.0000

Kidney 0.0988

Placenta 0.0909

Prostate 0.1745

Sensory organs 0.0377

NORMALIZED / SUBTRACTED LIBRARIES

%Frequency

Breast 0.0136

Ovary n 0.3190

Ovary t 0.0709

Endocrine tissue 0.0000

Fetal 0.0326

Gastrointestinal 0.1464

Haematopoietic 0.0000

Skin muscle 0.1328

Testicles 0.0154

Lungs 0.2211

Nerves 0.0311

Prostate 0.0410

Sensory organs 0.0000

Uterus n 0.0333 Electronic Northern for SEQ. ID. NO: 11

NORMAL TUMOR Ratios% Haeufιgkeιt% Haeufιgkeιt N / T T / N

Bubble 0.0156 0 .0051 3.05090.3278

Breast 0.0064 0..0113 0.56711.7633

Small intestine 0.0031 0, .0000 undef 0.0000

Ovary 0.0240 0 .0234 1.02330.9772

Endocrine tissue 0.0068 0 .0100 0.67921.4722

Gastrointestinal 0.0096 0, .0046 2.07080.4829

Brain 0.0022 0, .0257 0.086411.5747

Haematopoetic 0.0147 0, .0000 undef 0.0000

Skin 0.0110 0, .0000 undef 0.0000

Hepatic 0.0238 0 .0065 3.67650.2720

Heart 0.0276 0, .0275 1.00230.9977

Testicles 0.0000 0, .0117 0.0000 undef

Lungs 0.0083 0, .0245 0.33872.9526

Stomach-ear of ear 0.0000 0, .0077 0.0000 undef

Musculoskeletal system 0.0086 0. .0060 1.42780.7004

Kidney 0.0081 0, .0616 0.13227.5658

Pancreas 0.0165 0. .0000 undef 0.0000

Penis 0.0120 0, .0267 0.44932.2259

Prostate 0.0065 0, .0085 0.76771.3026

Uterine endometrium 0.0270 0, .0000 undef 0.0000

Uterine myometrium 0.0076 0 .0951 0.080212.4748

General uterus 0.0968 0. .0000 undef 0.0000

Breast hyperplasia 0.0096

Prostate hyperplasia 0.0089

Seminal vesicle 0.0089

Sensory organs 0.0706

White blood body 0.0000

Cervix 0.0106

FOETUS% frequency

Development 0.0139

Gastromtenstmal 0.0278

Brain 0.0000

Haematopoetic 0.0708

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0320

Lungs 0.0036

Adrenal gland 0.0000

Kidney 0.0124

Placenta 0.2121

Prostate 0.0000

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

%Frequency

Breast 0.0000

Ovary n 0.0000

Ovary t 0.0000

Endocrine tissue 0.0000

Fetal 0.0233

Gastrointestinal 0.0244

Haematopoietic 0.0000

Skin muscle 0.0648

Testicles 0.0000

Lungs 0.0164

Nerves 0.0010

Prostate 0.0068

Sensory organs 0.0000

Uterus n 0.0083 Electronic Northern for SEQ. ID. NO: 12

NORMAL TUMOR conditions

% Haeuf_ .gkeit% Haeufιgkιeit N / T T / N

Bubble 0.0351 0.3093 0.11358.8135

Breast 0.0269 0.0470 0.57161.7493

Small intestine 0.0092 0.0662 0.13907.1929

Ovary 0.0569 0.0182 3.12480.3200

Endocrine tissue 0.0528 0.0502 1.05280.9498

Gastrointestinal 0.0019 0.0093 0.20714.8289

Brain 0.0022 0.0873 0.025439.3541

Haematopoetic 0.0147 0.0000 undef 0.0000

Skin 0.0220 0.5085 0.043323.0839

Hepatic 0.0285 0.0582 0.49022.0400

Heart 0.0191 0.0000 undef 0.0000

Testicles 0.0115 0.0000 undef 0.0000

Lungs 0.0114 0.0061 1.86280.5368

Stomach-ear of ear 0.0193 0.0077 2.52110.3967

Musculoskeletal system 0.0771 0.0540 1.42780.7004

Kidney 0.0489 0.0137 3.56870.2802

Pancreas 0.0264 0.0442 0.59831.6714

Penis 0.0090 0.1066 0.084211.8713

Prostate 0.0000 0.0064 0.0000 undef

Uterine endometrium 0.0743 0.0000 undef 0.0000

Uterine myometrium 0.0381 0.1494 0.25513.9206

General uterus 0.0153 0.0954 0.16016.2452

Breast hyperplasia 0.0096

Prostate hyperplasia 0.0059

Seminal vesicle 0.0000

Sensory organs 0.0118

White blood body 0.0000

Cervix 0.0000

FOETUS% frequency

Development 0.0696

Gastromtenstmal 0.4387

Brain 0.0000

Haematopoetic 0.2713

Skin 0.0000

Hepatic 1.6121

Cardiac blood vessels 0.0605

Lungs 0.1770

Adrenal gland 1.1663

Kidney 0.8092

Placenta 0.7635

Prostate 0.0499

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

.Frequency

Breast 0.0612

Ovary n 0.0000

Ovary t 0.1114

Endocrine tissue 0.0000

Fetal 0.4665

Gastrointestinal 0.0000

Haematopoietic 0.0000

Skin muscle 0.0000

Testicles 0.0000

Lungs 0.0000

Nerves 0.0030

Prostate 0.0068

Sensory organs 0.0000

Uterus n 0.0291 Electronic Northern for SEQ. ID. NO: 13

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0078 0.0204 0.38142.6222

Breast 0.0256 0.0432 0.59181.6899

Small intestine 0.0000 0.0000 undef undef

Ovary 0.0060 0.0078 0.76751.3029

Endocrine tissue 0.0000 0.0050 0.0000 undef

Gastrointestinal 0.0000 0.0000 undef undef

Brain 0.0074 0.0216 0.34282.9168

Haematopoetic 0.0013 0.0000 undef 0.0000

Skin 0.0073 0.0000 undef 0.0000

Hepatic 0.0000 0.0000 undef undef

Heart 0.0021 0.0000 undef 0.0000

Testicles 0.0115 0.0468 0.24604.0652

Lungs 0.0031 0.0082 0.38102.6245

Stomach-ear of ear 0.0580 0.0000 undef 0.0000

Musculoskeletal 0.0000 0.0300 0.0000 undef

Kidney 0.0027 0.0000 undef 0.0000

Pancreas 0.0033 0.0276 0.11978.3571

Penis 0.0210 0.1066 0.19665.0877

Prostate 0.0022 0.0043 0.51181.9538

Uterine endometrium 0.0135 0.0000 undef 0.0000

Uterine myometrium 0.0305 0.0883 0.34532.8959

General uterus 0.0102 0.0000 undef 0.0000

Breast hyperplasia 0.0160

Prostate hyperplasia 0.0059

Seminal vesicle 0.0356

Sensory organs 0.0000 blood corpuscles 0.0035

Cervix 0.0639

FOETUS% frequency

Development 0.0000

Gastromtenstmal 0.0028

Brain 0.0000

Haematopoietic 0.0000

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0000

Lungs 0.0145

Adrenal gland 0.0761

Kidney 0.0247

Placenta 0.0061

Prostate 0.0000

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

%Frequency

Breast 0.0408

Eierstöck _e n 0.0000

Eιerstock_t 0.1266

Endokrmes_Gewebe 0.0000

Fetal 0.0047

Gastrointestinal 0.0000

Haematopoietic 0.0057

Skin muscle 0.0032

Testicles 0.0000

Lungs 0.0000

Nerves 0.0030

Prostate 0.0000

Sensory organs 0.0000

Uterus n 0.0208 Electronic Northern for SEQ. ID. NO: 14

NORMAL TUMOR conditions

% Haeufι .gkea t% Haeufιgkιeit N / T T / N

Bubble 0.0195 0.0051 3.81360.2622

Breast 0.0051 0.0132 0.38892.5715

Small intestine 0.0061 0.0000 undef 0.0000

Ovary 0.0150 0.0130 1.15130.8686

Endocrine tissue 0.0153 0.0150 1.01890.9815

Gastrom test times 0.0115 0.0000 undef 0.0000

Brain 0.0133 0.0133 0.99691.0031

Haematopoetic 0.0174 0.0000 undef 0.0000

Skin 0.0147 0.0000 undef 0.0000

Hepatic 0.0000 0.0194 0.0000 undef

Heart 0.0265 0.0000 undef 0.0000

Testicles 0.0058 0.0000 undef 0.0000

Lungs 0.0042 0.0164 0.25403.9367

Gastro-ear of ear 0.0000 0.0077 0.0000 undef

Musculoskeletal system 0.0069 0.0540 0.12697.8795

Kidney 0.0217 0.0274 0.79301.2610

Pancreas 0.0165 0.0055 2.99150.3343

Penis 0.0090 0.0000 undef 0.0000

Prostate 0.0087 0.0170 0.51181.9538

Uterine endometrium 0.0338 0.2111 0.16006.2484

Uterine myometrium 0.0076 0.0475 0.16036.2374

General uterus 0.0000 0.0000 undef undef

Breast hyperplasia 0.0320

Prostate hyperplasia 0.0238

Seminal vesicle 0.0267

Sensory organs 0.0000

White blood cells 0.0069

Cervix 0.0213

FOETUS% frequency

Development 0.0417

Gastromtenstmal 0.0139

Brain 0.0125

Haematopoetic 0.0157

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0427

Lungs 0.0253

Adrenal gland 0.0000

Kidney 0.0124

Placenta 0.0121

Prostate 0.0000

Sensory organs 0.0126

NORMALIZED / SUBTRACTED LIBRARIES

% Frequency

Breast 0.0068

Ovary n 0.0000

Ovary t 0.0051

Endocrine tissue 0.0245

Fetal 0.0035

Gastrointestinal 0.0244

Haematopoietic 0.0000

Skin muscle 0. 0065

Testicles 0. 0000

Lungs 0. 0082

Nerves 0. 0050

Prostate 0. 0137

Sensory organs 0. 0155

Uterus n 0. 0042 Electronic Northern for SEQ. ID. NO: 15

NORMAL TUMOR conditions

% Frequency% frequency N / D T / N

Bubble 0.0078 0.0102 0.76271.3111

Breast 0.0026 0.0150 0.17015.8778

Small intestine 0.0184 0.0496 0.37072.6973

Ovary 0.0000 0.0052 0.0000 undef

Endocrine tissue 0.0000 0.0025 0.0000 undef

Gastrointestinal 0.0000 0.0093 0.0000 undef

Brain 0.0007 0.0072 0.10299.7228

Haematopoetic 0.0000 0.0000 undef undef

Skin 0.0037 0.0000 undef 0.0000

Hepatic 0.0000 0.0000 undef undef

Heart 0.0032 0.0000 undef 0.0000

Testicles 0.0058 0.0000 undef 0.0000

Lungs 0.0021 0.0041 0.50801.9684

Gastro-ear of ear 0.0000 0.0307 0.0000 undef

Musculoskeletal 0.0086 0.0240 0.35692.8016

Kidney 0.0027 0.0000 undef 0.0000

Pancreas 0.0000 0.0055 0.0000 undef

Penis 0.0240 0.0000 undef 0.0000

Prostate 0.0065 0.0021 3.07090.3256

Uterine endometrium 0.0000 0.0000 undef undef

Uterine myometrium 0.0000 0.0340 0.0000 undef

General uterus 0.0000 0.0000 undef undef

Breast hyperplasia 0.0096

Prostate hyperplasia 0.0000

Seminal vesicle 0.0000

Sensory organs 0.0118

White blood cells 0.0000

Cervix 0.0000

FOETUS% frequency

Development 0.0139

Gastromtenstmal 0.0000

Brain 0.0000

Haematopoietic 0.0039

Skin 0.0000

Hepatic 0.0000

Heart blood vessels 0.0036

Lungs 0.0036

Adrenal gland 0.0000

Kidney 0.0000

Placenta 0.0000

Prostate 0.0249

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

% Frequency

Breast 0.0000

Ovary n 0.0000

Ovary t 0.0000

Endocrine tissue 0.0000

Fetal 0.0000

Gastrointestinal 0.0000

Haematopoietic 0.0000

Skin muscle 0.0000

Testicles 0.0000

Lungs 0.0000

Nerves 0.0020

Prostate 0.0000

Sensory organs 0.0000

Uterus n 0.0125 Electronic Northern for SEQ. ID. NO: 16

NORMAL TUMOR conditions

% Frequency ..% frequency N / D T / N

Bubble 0.0039 0.0153 0.25423.9333

Breast 0.0077 0.0038 2.04160.4898

Small intestine 0.0123 0.0000 undef 0.0000

Ovary 0.0060 0.0026 2.30250.4343

Endocrine tissue 0.0119 0.0251 0.47552.1032

Gastro test times 0.0096 0.0139 0.69031.4487

Brain 0.0163 0.0246 0.66001.5152

Haematopoetic 0.0040 0.0000 undef 0.0000

Skin 0.0110 0.0000 undef 0.0000

Hepatic 0.0095 0.0065 1.47060.6800

Heart 0.0180 0.0000 undef 0.0000

Testicles 0.0000 0.0117 0.0000 undef

Lungs 0.0135 0.0082 1.65110.6057

Gastro-ear of ear 0.0000 0.0153 0.0000 undef

Musculoskeletal 0.0069 0.0060 1.14220.8755

Kidney 0.0000 0.0000 undef undef

Pancreas 0.0033 0.0276 0.11978.3571

Penis 0.0090 0.0267 0.33692.9678

Prostate 0.0196 0.0128 1.53540.6513

Uterus endometnum 0.0068 0.0000 undef 0.0000

Uterus_Myometπum 0.0000 0.0408 0.0000 undef

General uterus 0.0357 0.0000 undef 0.0000

Breast hyperplasia 0.0128

Prostate hyperplasia 0.0089

Seminal vesicle 0.0267

Sensory organs 0.0000

White blood cells 0.0000

Cervix 0.0000

FOETUS% frequency

Development 0.0000

Gastromtenstmal 0.0000

Brain 0.0375

Haematopoietic 0.0039

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0071

Lungs 0.0036

Adrenal gland 0.0507

Kidney 0.0124

Placenta 0.0061

Prostate 0.0249

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

% Frequency

Breast 0.0000

Ovary n 0.0000

Ovary t 0.0000

Endocrine tissue 0.0000

Fetal 0.0012

Gastrointestinal 0.0122

Haematopoietic 0.0000

Skin muscle 0.0097

Testicles 0.0000

Lungs 0.0082

Nerves 0.0050

Prostate 0.0000

Sensory organs 0.0000

Uterus n 0.0083 Electronic Northern for SEQ. ID. NO: 17

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0195 0.0179 1.08960.9178

Breast 0.0307 0.0338 0.90741.1021

Small intestine 0.0184 0.0165 1.11220.8991

Ovary 0.0509 0.0286 1.77920.5620

Endocrine tissue 0.0375 0.0301 1.24530.8030

Gastrointestinal 0.0153 0.0093 1.65670.6036

Brain 0.0222 0.0452 0.49092.0372

Haematopoetic 0.0160 0.0000 undef 0.0000

Skin 0.0661 0.0000 undef 0.0000

Hepatic 0.0143 0.0518 0.27573.6266

Heart 0.0636 0.0000 undef 0.0000

Testis 0.0173 0.0117 1.47590.6775

Lungs 0.0177 0.0532 0.33223.0104

Gastric ear of ear 0.0483 0.0000 undef 0.0000

Musculoskeletal system 0.0137 0.0960 0.14287.0040

Kidney 0.0217 0.0685 0.31723.1524

Pancreas 0.0264 0.0055 4.78640.2089

Penis 0.0449 0.0000 undef 0.0000

Prostate 0.0283 0.0341 0.83171.2024

Uterine endometrium 0.0135 0.0000 undef 0.0000

Uterine myometrium 0.0229 0.0679 0.33672.9702

General uterus 0.0051 0.0000 undef 0.0000

Breast hyperplasia 0.0671

Prostate hyperplasia 0.0476

Seminal vesicle 0.0356

Sensory organs 0.0353

White blood cells 0.0121

Cervix 0.0532

FOETUS frequency

Development 0.0557

Gastromtenstmal 0.0278

Brain 0.0688

Haematopoetic 0.0275

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0534

Lungs 0.0831

Adrenal gland 0.1014

Kidney 0.0741

Placenta 0.0182

Prostate 0.1247

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

%Frequency

Breast 0.0000

Ovary n 0.0000

Eιerstock_t 0.0203

Endocrine tissue 0.0490

Fetal 0.0169

Gastrointestinal 0. 0122

Haematopoetic 0. 0000

Skin muscle 0. 0259

Testicles 0.0000

Lungs 0. 0082

Nerves 0050

Prostate 0. 0068

Sensory organs 0. 0000

Uterus n 0. 0167 Electronic Northern for SEQ. ID. NO: 18

NORMAL TUMOR Behavior

% Frequency% frequency N / D T / N

Bubble 0.0195 0, .0179 1.08960.9178

Breast 0.0371 0 .0357 1.03870.9627

Small intestine 0.0245 0, .0331 0.74151.3487

Ovary 0.0479 0 .0390 1.22800.8143

Endocrine tissue 0.0358 0 .0326 1.09720.9114

Guest romtest times 0.0153 0, .0093 1.65670.6036

Brain 0.0229 0, .0524 0.43762.2851

Haematopoetic 0.0147 0, .0000 undef 0.0000

Skin 0.0587 0, .0000 undef 0.0000

Hepatic 0.0143 0.0518 0.2757 3.6266

Heart 0.0593 0, .0000 undef 0.0000

Testes 0.0115 0 .0117 0.98391.0163

Lungs 0.0145 0 .0491 0.2964 3.3743

Gastric ear of ear 0.0290 0, .0000 undef 0.0000

Musculoskeletal 0.0120 0, .1140 0.10529.5055

Kidney 0.0299 0, .0616 0.48462.0634

Pancreas 0.0281 0 .0055 5.08550.1966

Penis 0.0449 0, .0000 undef 0.0000

Prostate 0.0349 0 .0319 1.09190.9159

Uterine endometer 0.0203 0, .0000 undef 0.0000

Uterine myometrium 0.0152 0 .0679 0.22454.4553

Uterus_general 0.0051 0, .0000 undef 0.0000

Breast hyperplasia 0.0576

Prostate hyperplasia 0.0446

Seminal vesicle 0.0356

Sensory organs 0.0235

White blood corpuscles 0.0130

Cervix 0.0532

FOETUS% frequency

Development 0.0417

Gastromtenstmal 0.0333

Brain 0.0688

Haematopoetic 0.0275

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0427

Lungs 0.0867

Adrenal gland 0.1268

Kidney 0.0741

Placenta 0.0182

Prostate 0.1247

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

%Frequency

Breast 0.0000

Ovary 0.0000

Eιerstock_t 0.0253

Endocrmes_Tissue 0.0245

Fetal 0.0326

Gastrointestinal 0.0122

Haematopoietic 0.0000

Skin muscle 0.0518

Testicles 0.0000

Lungs 0.0082

Nerves 0.0090

Prostate 0.0137

Sensory organs 0.0000

Uterus n 0.0208 Electronic Northern for SEQ. ID. NO: 19

NORMAL TUMOR conditions

% Haeufι .gkeit% Haeufιgkι Bit N / T T / N

Bubble 0.0351 0.0332 1.05610.9469

Breast 0.0269 0.0376 0.71461.3995

Small intestine 0.0337 0.0992 0.33982.9425

Ovary 0.0240 0.0312 0.76751.3029

Endocrine tissue 0.0409 0.0075 5.43400.1840

Gastrointestinal 0.0268 0.0971 0.27613.6217

Brain 0.0059 0.0113 0.52361.9098

Haematopoetic 0.0013 0.2273 0.0059170.0273

Skin 0.0330 0.0000 undef 0.0000

Hepatic 0.0095 0.0388 0.24514.0800

Heart 0.0223 0.0000 undef 0.0000

Testis 0.0173 0.0351 0.49202.0326

Lungs 0.0395 0.0900 0.43882.2792

Gastro-ear of ear 0.0000 0.0077 0.0000 undef

Musculoskeletal system 0.0857 0.1920 0.44622.2413

Kidney 0.0136 0.0205 0.66091.5132

Pancreas 0.0198 0.0221 0.89741.1143

Penis 0.0629 0.0800 0.78621.2719

Prostate 0.0087 0.0106 0.81891.2211

Uterine endometrium 0.0676 0.0000 undef 0.0000

Uterine myometrium 0.0686 0.1630 0.42082.3761

General uterus 0.0153 0.0000 undef 0.0000

Breast hyperplasia 0.0735

Prostate hyperplasia 0.0416

Seminal vesicle 0.0000

Sensory organs 0.0235

'' blood corpuscles 0.0000

Cervix 0.0426

FOETUS% frequency

Development 0.1113

Gastromtenstmal 0.0056

Brain 0.0000

Haematopoietic 0.0039

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0356

Lungs 0.0289

Adrenal gland 0.0000

Kidney 0.0062

Placenta 0.1333

Prostate 0.0249

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

% Frequency

Breast 0.0204

Ovary n 0.0000

Ovary t 0.0000

Endocrine tissue 0.0000

Fetal 0.0111

Gastrointestinal 0.0244

Haematopoietic 0.0000

Skin muscle 0.0065

Testicles 0.0000

Lungs 0.0000

Nerves 0.0000

Prostate 0.0068

Sensory organs 0.0077

Uterus n 0.0125 Electronic Northern for SEQ. ID. NO: 20

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0858 0..1048 0.81851 .2217

Breast 0.1036 0, .1729 0.59921. .6690

Small intestine 0.1226 0, .1158 1.05930 .9441

Ovary 0.0958 0, .1197 0.80091, .2486

Endocrine tissue 0.0954 0, .1128 0.84531. .1830

Gastrointestinal 0.0900 0, .1573 0.57251, .7466

Brain 0.0658 0. .0924 0.71201. .4046

Haematopoietic 0.1109 0, .0758 1.46450, .6828

Skin 0.0918 0, .0000 undef 0. .0000

Hepatic 0.0333 0.0906 0.367627200

Heart 0.2120 0. .0412 5.13980, .1946

Testis 0.0690 0. .3625 0.19045, .2509

Lungs 0.0696 0. .1186 0.58691, .7040

Stomach-ear of ear 0.0483 0 .0460 1.05040, .9520

Musculoskeletal system 0.0702 0., 2820 0.24914, .0145

Kidney 0.0652 0 .1027 0.63441., 5762

Pancreas 0.1140 0. .1270 0.89741. .1143

Penis 0.1018 0., 0000 undef 0., 0000

Prostate 0.1090 0., 1277 0.85301. , 1723

Uterine endometrium 0.1149 0., 0000 undef 0., 0000

Uterine myometrium 0.0686 0, .2106 0.32583. , 0692

General uterus 0.0458 0., 1908 0.24024. , 1635

Breast hyperplasia 0.1279

Prostate hyperplasia 0.1159

Bubble 0.1157

Sensory organs 0.1059 ιsse_Blutkoerperchen 0.0832

Cervix 0.1278

FOETUS% Haeufιgkeιt

Development 0.0557

Gastromtenstmal 0.2471

Brain 0.2189

Haematopoietic 0.1612

Skin 0.0000

Hepatic 0.1560

Cardiac blood vessels 0.2633

Lungs 0.1012

Adrenal gland 0.1014

Kidney 0.1112

Placenta 0.0848

Prostate 0.3740

Sensory organs 0.0126

NORMALIZED / SUBTRACTED LIBRARIES

%Frequency

Breast 0.0136

Eιerstock_n 0.1595

Eιerstock_t 0.0658

Endokrmes_Gewebe 0000

Fetal 0216

Gastrointestinal 0732

Haematopoetic 0057

Skin muscle 0259

Testicles 0.0000

Lungs 0.1638

Nerves 0.0211

Prostate 0.0205

Sensory organs 0.0000

Uterus n 0.0333 Electronic Northern for SEQ. ID. NO: 21

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0273 0.0102 2.66950.3746

Breast 0.0051 0.0019 2.72210.3674

Small intestine 0.0276 0.0000 undef 0.0000

Ovary 0.0180 0.0000 undef 0.0000

Endocrine tissue 0.0136 0.0000 undef 0.0000

Gastrointestinal 0.0134 0.0046 2.89920.3449

Brain 0.0015 0.0164 0.090011.1117

Haematopoetic 0.0053 0.0000 undef 0.0000

Skin 0.0147 0.0000 undef 0.0000

Hepatic 0.0048 0.0000 undef 0.0000

Heart 0.0106 0.0412 0.25703.8912

Testicles 0.0000 0.0117 0.0000 undef

Lungs 0.0052 0.0102 0.50801.9684

Stomach-ear of ear 0.0000 0.0000 undef undef

Musculoskeletal system 0.0223 0.0060 3.71220.2694

Kidney 0.0081 0.0000 undef 0.0000

Pancreas 0.0033 0.0276 0.11978.3571

Penis 0.0030 0.0267 0.11238.9035

Prostate 0.0022 0.0043 0.51181.9538

Uterine endometrium 0.0135 0.0000 undef 0.0000

Uterine myometrium 0.0381 0.1019 0.37412.6732

General uterus 0.0102 0.0000 undef 0.0000

Breast hyperplasia 0.0032

Prostate hyperplasia 0.0000

Seminal vesicle 0.0089

Sensory organs 0.0000

White blood cells 0.0130

Cervix 0.0106

FOETUS% frequency

Development 0.0000

Gastromtenstmal 0.0111

Brain 0.0000

Haematopoetic 0.0157

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0107

Lungs 0.0000

Adrenal gland 0.0000

Kidney 0.0247

Placenta 0.0000

Prostate 0.0000

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

%Frequency

Breast 0.0204

Ovary n 0.0000

Eιerstock_t 0.0101

Endokrmes_Gewebe 0490

Fetal 0093

Gastrointestinal 0122

Haematopoetic 0057

Skin muscle 0421

Testicles 0.0154

Lungs 0.0000

Nerves 0.0010

Prostate 0.0274

Sensory organs 0.0000

Uterus n 0.0000 Electronic Northern for SEQ. ID. NO: 22

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0000 0.0102 0.0000 undef

Breast 0.0064 0.0207 0.30933.2328

Small intestine 0.0153 0.0662 0.23174.3157

Ovary 0.0180 0.0156 1.15130.8686

Endocrine tissue 0.0204 0.0351 0.58221.7176

Gastric test times 0.0153 0.0231 0.66271.5090

Brain 0.0510 0.0257 1.98710.5032

Haematopoetic 0.0134 0.0000 undef 0.0000

Skin 0.0367 0.0000 undef 0.0000

Hepatic 0.0095 0.0000 undef 0.0000

Heart 0.0466 0.0000 undef 0.0000

Testicles 0.0000 0.0117 0.0000 undef

Lungs 0.0249 0.0348 0.71721.3943

Stomach-ear of ear 0.0193 0.0077 2.52110.3967

Musculoskeletal system 0.0377 0.0300 1.25640.7959

Kidney 0.0244 0.0274 0.89221.1209

Pancreas 0.0083 0.0166 0.49862.0057

Penis 0.0329 0.0267 1.23550.8094

Prostate 0.0131 0.0149 0.87741.1397

Uterine endometrium 0.0338 0.0000 undef 0.0000

Uterine myometrium 0.0000 0.0340 0.0000 undef

General uterus 0.0153 0.0000 undef 0.0000

Breast hyperplasia 0.0256

Prostate hyperplasia 0.0238

Seminal vesicle 0.0000

Sensory organs 0.0000

Weιsse_Blutkoerperchen 0.0069

Cervix 0.0213

FOETUS% frequency

Development 0.0139

Gastromtenstmal 0.0194

Brain 0.0125

Haematopoietic 0.0039

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0320

Lungs 0.0434

Adrenal gland 0.0000

Kidney 0.0124

Placenta 0.0061

Prostate 0.0000

Sensory organs 0.0251

NORMALIZED / SUBTRACTED LIBRARIES

% Frequency

Breast 0.0000

Ovary n 0. 3190

Eιerstock_t 0. 0000

Endocrm tissue 0. 0000

Fetal 0. 0373

Gastrointestinal 0. 0000

Haematopoetic 0. 0114

Skin muscle 0. 0680

Testicles 0.0231

Lungs 0. 0000

Nerves 0. 0211

Prostate 0. 0205

Sensory organs 0. 0077

Uterus n 0. 0458 Electronic Northern for SEQ. ID. NO: 23

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0741 0.0639 1.15930.8626

Breast 0.0691 0.0827 0.83521.1973

Small intestine 0.0245 0.0496 0.49432.0230

Ovary 0.0689 0.0494 1.39360.7176

Endocrine tissue 0.2487 0.5191 0.47912.0873

Gastrointestinal 0.0421 0.0879 0.47962.0852

Brain 0.1700 0.1037 1.63950.6099

Haematopoetic 0.0695 0.0758 0.91751.0899

Skin 0.0367 0.4237 0.086611.5419

Hepatic 0.0143 0.0388 0.36762.7200

Heart 0.0668 0.1375 0.48572.0588

Testis 0.0460 0.0468 0.98391.0163

Lungs 0.0592 0.0470 1.25900.7943

Stomach-ear of ear 0.1160 0.0690 1.68070.5950

Musculoskeletal system 0.0754 0.0960 0.78531.2735

Kidney 0.0706 0.0479 1.47280.6790

Pancreas 0.0677 0.0552 1.22650.8153

Penis 0.0988 0.0267 3.70640.2698

Prostate 0.0697 0.0660 1.05660.9464

Uterine endometrium 0.0608 0.0000 undef 0.0000

Uterine myometrium 0.0152 0.0611 0.24944.0097

General uterus 0.1120 0.0000 undef 0.0000

Breast hyperplasia 0.0480

Prostate hyperplasia 0 .0565

Seminal vesicle 0 .0445

Sensory organs 0 .0823

White blood cells 0, .0824

Cervix 0. .0852

FETUS

%Frequency

Development 0.1113

Gastromtenstmal 0.0805

Brain 0.1376

Haematopoietic 0.1140

Skin 0.0000

Hepatic 0.0520

Cardiac blood vessels 0.0996

Lungs 0.1951

Adrenal gland 0.1268

Kidney 0.1359

Placenta 0.1030

Prostate 0.0748

Sensory organs 0.0879

NORMALIZED / SUBTRACTED LIBRARIES

%Frequency

Breast 0.0544

Eιerstock_n 0.0000

Eιerstock_t 0.0203

Endoknnes_Gewebe 0.0245

Fetal 0.0309

Gastrointestinal 0.0610

Haematopoietic 0.0000

Skin muscle 0.0356

Testicles 0.0077

Lungs 0.0655

Nerves 0.0783

Prostate 0.0547

Sensory organs 0.0000

Uterus n 0.0083 Electronic Northern for SEQ. ID. NO: 24

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0546 0.0332 1.64280.6087

Breast 0.0269 0.0320 0.84071.1896

Small intestine 0.0276 0.0000 undef 0.0000

Ovary 0.0479 0.0546 0.87711.1401

Endocrmes_Tissue 0.0324 0.0176 1.84370.5424

Gastrointestinal 0.0211 0.0463 0.45562.1950

Brain 0.0229 0.0277 0.82661.2097

Haematopoetic 0.0348 0.0379 0.91751.0899

Skin 0.0184 0.0000 undef 0.0000

Hepatic 0.0190 0.0000 undef 0.0000

Heart 0.0477 0.0000 undef 0.0000

Testicles 0.0230 0.1169 0.19685.0816

Lungs 0.0156 0.0307 0.50801.9684

Gastro-ear of ear 0.0000 0.0460 0.0000 undef

Musculoskeletal 0.0120 0.0480 0.24994.0023

Kidney 0.0163 0.0068 2.37910.4203

Pancreas 0.0182 0.0331 0.54841.8234

Penis 0.0180 0.0800 0.22464.4517

Prostate 0.0174 0.0170 1.02360.9769

Uterine endometrium 0.0541 0.0000 undef 0.0000

Uterus_Myometrιum 0.0229 0.0679 0.33672.9702

Uterus_general 0.0102 0.0000 undef 0.0000

Breast hyperplasia 0.0576

Prostate hyperplasia 0.0208

Seminal vesicle 0.0089

Sensory organs 0.0118

White blood cells 0.0277

Cervix 0.0213

FETUS

%Frequency

Development 0.0278

Gastromtenstmal 0.0639

Brain 0.0438

Haematopoetic 0.0275

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0925

Lungs 0.0831

Adrenal gland 0.0000

Kidney 0.0803

Placenta 0.0667

Prostate 0.0249

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

% Haeufιgkeιt

Breast 0.0000

Ovary n 0.0000

Eιerstock_t 0.0000

Endocrine tissue 0.0000

Fetal 0.0006

Gastrointestinal 0.0122

Haematopoietic 0.0000

Skin muscle 0.0000

Testicles 0.0077

Lungs 0.0000

Nerves 0.0040

Prostate 0.0000

Sensory organs 0.0000

Uterus n 0.0000 Electronic Northern for SEQ. ID. NO: 25

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0429 0.0486 0.88321.1323

Breast 0.0435 0.0771 0.56431.7720

Small intestine 0.0307 0.0000 undef 0.0000

Ovary 0.0389 0.0833 0.46772.1381

Endocrine tissue 0.0460 0.0301 1.52830.6543

Gastrointestinal 0.0287 0.0971 0.29583.3803

Brain 0.0347 0.0534 0.65071.5367

Haematopoetic 0.0869 0.0000 undef 0.0000

Skin 0.0551 0.0847 0.64981.5389

Hepatic 0.0143 0.0194 0.73531.3600

Heart 0.0466 0.0137 3.39230.2948

Testis 0.0173 0.0935 0.18455.4203

Lungs 0.0457 0.0613 0.74511.3421

Gastric esophagus 0.0290 0.0153 1.89080.5289

Musculoskeletal system 0.0223 0.1140 0.19545.1183

Kidney 0.0407 0.0137 2.97390.3363

Pancreas 0.0314 0.0442 0.71051.4075

Penis 0.0779 0.0533 1.46010.6849

Prostate 0.0458 0.0617 0.74121.3491

Uterus_Endometnum 0.0473 0.0000 undef 0.0000

Uterine myometrium 0.0305 0.1087 0.28063.5642

Uterus_general 0.0357 0.0954 0.37362.6765

Breast hyperplasia 0.0256

Prostate hyperplasia 0.0803

Seminal vesicle 0.0801

Sensory organs 0.0118

White blood cells 0.0494

Cervix 0.0426

FOETUS% frequency

Development 0.0417

Gastromtenstmal 0.0611

Brain 0.0626

Haematopoetic 0.0708

Skin 0.0000

Hepatic 0.0260

Cardiac blood vessels 0.0534

Lungs 0.0542

Adrenal gland 0.0761

Kidney 0.0988

Placenta 0.0303

Prostate 0.0000

Sensory organs 0.0251

STANDARDIZED / SUBTRACTED LIBRARIES% Frequency

Breast 0, 0204

Ovary n 0, .1595

Ovary t 0., 0101

Endocrine tissue 0 .0000

Fetal 0. 0332

Gastrointestinal test 0 .0000

Haematopoetic 0 .0000

Skin muscle 0, 0194

Testicles 0, .0077

Lungs 0, .0328

Nerves 0, .0161

Prostate 0, .0068

Sensory organs 0, .0000

Uterus n 0, .0291 Electronic Northern for SEQ. ID. NO: 26

NORMAL TUMOR conditions

% Frequency% frequency N / D T / N

Bubble 0.0000 0.0000 undef undef

Breast 0.0000 0.0000 undef undef

Small intestine 0.0000 0.0000 undef undef

Ovary 0.0000 0.0000 undef undef

Endokrmes_Gewebe 3.0675 0.0000 undef 0.0000

Gastrom test times 0.0000 0.0000 undef undef

Brain 0.0015 0.0000 undef 0.0000

Haematopoetic 0.0000 0.0000 undef undef

Skin 0.0000 0.0000 undef undef

Hepatic 0.0000 0.0000 undef undef

Heart 0.0000 0.0000 undef undef

Testicles 0.0000 0.0000 undef undef

Lung 0.0000 0.0000 undef undef

Stomach-ear of ear 0.0000 0.0000 undef undef

Musculoskeletal 0.0000 0.0000 undef undef

Kidney 0.0000 0.0000 undef undef

Pancreas 0.0000 0.0000 undef undef

Penis 0.0000 0.0000 undef undef

Prostate 0.0000 0.0000 undef undef

Uterine endometrium 0.0000 0.0000 undef undef

Uterine myometrium 0.0000 0.0340 0.0000 undef

General uterus 0.0000 0.0000 undef undef

Breast hyperplasia 0.0000

Prostate hyperplasia 0.0000

Seminal vesicle 0.0000

Sensory organs 0.0000

White blood cells 0.0000

Cervix 0.0000

FOETUS% frequency

Development 0.0000

Gastromtenstmal 0.0028

Brain 0.0000

Haematopoietic 0.0000

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0000

Lungs 0.0000

Adrenal gland 0.0000

Kidney 0.0000

Placenta 0.0061

Prostate 0.0000

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

% Frequency

Breast 0.0000

Ovary n 0.0000

Ovary t 0.0000

Endocrine tissue 0.0000

Fetal 0.0070

Gastro test times 0.0000

Haematopoietic 0.0000

Skin muscle 0.0000

Testicles 0.0000

Lungs 0.0000

Nerves 0.0000

Prostate 0.0000

Sensory organs 0.0155

Uterus n 0.0250 Electronic Northern for SEQ. ID. NO: 27

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0039 0.0230 0.16955.8999

Breast 0.0179 0.0395 0.45372.2042

Small intestine 0.0061 0.0000 undef 0.0000

Ovary 0.0300 0.0130 2.30250.4343

Endocrmes_Tissue 0.0068 0.0251 0.27173.6805

Gastrointestinal 0.0077 0.0093 0.82831.2072

Brain 0.0015 0.0092 0.16006.2504

Haematopoetic 0.0053 0.0000 undef 0.0000

Skin 0.0000 0.0000 undef undef

Hepatic 0.0000 0.0194 0.0000 undef

Heart 0.0032 0.0000 undef 0.0000

Testicles 0.0000 0.0000 undef undef

Lungs 0.0083 0.0368 0.22584.4288

Gastric ear of ear 0.0290 0.0230 1.26050.7933

Musculoskeletal 0.0000 0.0060 0.0000 undef

Kidney 0.0136 0.0068 1.98260.5044

Pancreas 0.0000 0.0276 0.0000 undef

Penis 0.0030 0.0000 undef 0.0000

Prostate 0.0065 0.0128 0.51181.9538

Uterine endometrium 0.0473 0.0000 undef 0.0000

Uterine myometrium 0.0000 0.0340 0.0000 undef

General uterus 0.0051 0.0000 undef 0.0000

Breast hyperplasia 0.0000

Prostate hyperplasia 0.0030

Seminal vesicle 0.0089

Sensory organs 0.0000

White blood cells 0.0000

Cervix 0.0213

FOETUS% frequency

Development 0.0139

Gastromtenstmal 0.0278

Brain 0.0125

Haematopoietic 0.0079

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0320

Lungs 0.0289

Adrenal gland 0.0000

Kidney 0.0185

Placenta 0.0000

Prostate 0.0997

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

%Frequency

Breast 0.0000

Ovary n 0.0000

Ovary t 0.0304

Endocrmes_Tissue 0.0245

Fetal 0.0029

Gastrointestinal 0.0122

Haematopoietic 0.0114

Skin muscle 0.0097

Testicles 0.0000

Lungs 0.0164

Nerves 0.0020

Prostate 0.0068

Sensory organs 0.0000

Uterus n 0.0000 Electronic Northern for SEQ. ID. NO: 28

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0195 0 .0383 0.50851.9666

Breast 0.0256 0. .0714 0.35822.7919

Small intestine 0.0552 0 .0331 1.66830.5994

Ovary 0.0270 0 .0468 0.57561.7372

Endocrine tissue 0.0477 0 .0451 1.05660.9464

Gastrointestinal 0.0326 0, .0324 1.00580.9942

Brain 0.0503 0, .0277 1.81320.5515

Haematopoetic 0.0201 0, .1894 0.10599.4460

Skin 0.0367 0, .2542 0.14446.9252

Hepatic 0.0476 0 .0388 1.22550.8160

Heart 0.0699 0. .0550 1.27210.7861

Testis 0.0173 0 .1403 0.12308.1305

Lungs 0.0395 0 .0818 0.48262.0720

Stomach-ear of ear 0.0676 0. .0613 1.10300.9066

Musculoskeletal system 0.0394 0 .0300 1.31350.7613

Kidney 0.0462 0 .0616 0.74901.3351

Pancreas 0.0347 0. 0607 0.57111.7510

Penis 0.0509 0..1600 0.31823.1424

Prostate 0.0327 0 .0149 2.19350.4559

Uterine endometrium 0.0000 0., 0000 undef undef

Uterine myometrium 0.0076 0. .0543 0.14037.1284

General uterus 0.0357 0, .0000 undef 0.0000

Breast hyperplasia 0.0192

Prostate hyperplasia 0.0565

Seminal vesicle 0.0445

Sensory organs 0.0941

White blood cells 0.0390

Cervix 0.0319

FOETUS% Haeufιgkeιt

Development 0.0557

Gastromtenstmal 0.0194

Brain 0.0188

Haematopoetic 0.0197

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0320

Lungs 0.0325

Adrenal gland 0.0000

Kidney 0.0371

Placenta 0.0242

Prostate 0.0997

Sensory organs 0.0000

STANDARDIZED / SUBTRACTED LIBRARIES%

Breast 0 .0340

Ovary n 0., 0000

Ovary t 0., 0101

Indocrm tissue 0, .0000

Fetal 0, 0396

Gastrointestinal 0, .0244

Haematopoetic 0 .0000

Skin muscle 0 .0778

Testes 0, .0000

Lungs 0, .0000

Nerves 0, .0231

Prostate 0, .0479

Sensory organs 0, .0697

Uterus n 0, .0291 Electronic Northern for SEQ. ID. NO: 29

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0663 0.0358 1.85230.5399

Breast 0.0512 0.0489 1.04700.9551

Small intestine 0.0368 0.0496 0.74151.3487

Ovary 0.0779 0.0728 1.06900.9354

Endocrine tissue 0.0562 0.0326 1.72420.5800

Gastrointestinal 0.0345 0.0370 0.93191.0731

Brain 0.0392 0.0524 0.74821.3366

Haematopoetic 0.0602 0.0379 1.58800.6297

Skin 0.0587 0.0000 undef 0.0000

Hepatic 0.0095 0.0647 0.14716.7999

Heart 0.0583 0.0550 1.06010.9433

Testis 0.0173 0.1520 0.11358.8080

Lungs 0.0208 0.0491 0.42342.3620

Stomach-ear of ear 0.0387 0.0460 0.84041.1900

Musculoskeletal system 0.0360 0.0420 0.85671.1673

Kidney 0.0380 0.0616 0.61681.6213

Pancreas 0.0314 0.0884 0.35522.8150

Penis 0.0689 0.0267 2.58330.3871

Prostate 0.0436 0.0490 0.89011.1235

Uterine endometrium 0.0541 0.0000 undef 0.0000

Uterine myometrium 0.0381 0.1155 0.33013.0296

Uterus_general 0.0815 0.0000 undef 0.0000

Breast hyperplasia 0.0831

Prostate hyperplasia 0.0446

Seminal vesicle 0.0801

Sensory organs 0.0353 ιsse_Blutkoerperchen 0.0520

Cervix 0.0532

FOETUS% frequency

Development 0.0000

Gastromtenstmal 0.0389

Brain 0.0188

Haematopoetic 0.0472

Skin 0.0000

Hepatic 0.0260

Cardiac blood vessels 0.0498

Lungs 0.0614

Adrenal gland 0.0254

Kidney 0.0741

Placenta 0.0364

Prostate 0.0499

Sensory organs 0.0000

STANDARDIZED / SUBTRACTED LIBRARIES Frequently

Breast 0. 0000

Ovary n 0. 1595

Eιerstock_t 0. 0203

Endokrmes_Gewebe 0. 0000

Fetal 0.0093

Gastrointestinal 0. 0366

Haematopoetic 0. 0000

Skin muscle 0. 0130

Testicles 0. 0000

Lungs 0. 0164

Nerves 0. 0120

Prostate 0.0205

Sensory organs 0. 0000

Uterus n 0. 0208 Electronic Northern for SEQ. ID. NO: 30

NORMAL TUMOR RELATIONSHIPS

% Frequency% frequency N / D T / N

Bubble 0.0078 0.0000 undef 0.0000

Breast 0.0013 0.0000 undef 0.0000

Small intestine 0.0092 0.0000 undef 0.0000

Ovary 0.0000 0.0000 undef undef

Endocrine tissue 0.0034 0.0000 undef 0.0000

Gastrointestinal 0.0019 0.0000 undef 0.0000

Brain 0.0000 0.0000 undef undef

Haematopoetic 0.0000 0.0000 undef undef

Skin 0.0000 0.0000 undef undef

Hepatic 0.0000 0.0000 undef undef

Heart 0.0011 0.0000 undef 0.0000

Testicles 0.0000 0.0000 undef undef

Lungs 0.0010 0.0000 undef 0.0000

Stomach-ear of ear 0.0000 0.0000 undef undef

Musculoskeletal 0.0000 0.0000 undef undef

Kidney 0.0000 0.0000 undef undef

Pancreas 0.0000 0.0000 undef undef

Penis 0.0000 0.0000 undef undef

Prostate 0.0109 0.0021 5.1181 0.1954

Uterine endometrium 0.0000 0.0000 undef undef

Uterine myometrium 0.0000 0.0340 0.0000 undef

General uterus 0.0102 0.0000 undef 0.0000

Breast hyperplasia 0.0000

Prostate hyperplasia 0.0000

Seminal vesicle 0.0089

Sensory organs 0.0000

White blood cells 0.0000

Cervix 0.0000

FOETUS% frequency

Development 0.0000

Gastromtenstmal 0.0000

Brain 0.0000

Haematopoietic 0.0000

Skin 0.0000

Hepatic 0.0000

Cardiac blood vessels 0.0000

Lungs 0.0000

Adrenal gland 0.0000

Kidney 0.0000

Placenta 0.0000

Prostate 0.0000

Sensory organs 0.0000

NORMALIZED / SUBTRACTED LIBRARIES

% Frequency

Breast 0.0000

Ovary n 0.0000

Ovary t 0.0000

Endocrine tissue 0.0000

Fetal 0.0000

Gastrointestinal 0.0000

Haematopoietic 0.0000

Skin muscle 0.0000

Testicles 0.0000

Lungs 0.0000

Nerves 0.0000

Prostate 0.0068

Sensory organs 0.0000

Uterus n 0.0000 Electronic Northern for SEQ. ID. NO: 31

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

Bubble 0.0000 0.0051 0.0000 undef

Breast 0.0038 0.0019 2.04160.4898

Small intestine 0.0031 0.0000 undef 0.0000

Ovary 0.0030 0.0104 0.28783.4745

Endocrine tissue 0.0034 0.0100 0.33962.9444

Gastrointestinal 0.0057 0.0046 1.24250.8048

Brain 0.0111 0.0051 2.15990.4630

Haematopoetic 0.0040 0.0000 undef 0.0000

Skin 0.0000 0.0000 undef undef

Hepatic 0.0048 0.0000 undef 0.0000

Heart 0.0095 0.0000 undef 0.0000

Testicles 0.0058 0.0000 undef 0.0000

Lungs 0.0042 0.0102 0.40642.4605

Stomach-ear of ear 0.0000 0.0000 undef undef

Musculoskeletal 0.0034 0.0060 0.57111.7510

Kidney 0.0163 0.0068 2.37910.4203

Pancreas 0.0017 0.0000 undef 0.0000

Penis 0.0090 0.0000 undef 0.0000

Prostate 0.0022 0.0021 1.02360.9769

Uterine endometrium 0.0135 0.0000 undef 0.0000

Uterine myometrium 0.0000 0.0340 0.0000 undef

General uterus 0.0000 0.0000 undef undef

Breast hyperplasia 0.0224

Prostate hyperplasia 0.0030

Seminal vesicle 0.0089

Sensory organs 0.0000

White blood cells 0.0061

Cervix 0.0213

FOETUS% frequency

Development 0.0000

Gastromtenstmal 0.0028

Brain 0.0125

Haematopoietic 0.0000

Skin 0.0000

Hepatic 0.0000

Heart blood vessels 0.0036

Lungs 0.0036

Adrenal gland 0.0254

Kidney 0.0062

Placenta 0.0303

Prostate 0.0000

Sensory organs 0.0126

STANDARDIZED / SUBTRACTED LIBRARIES% Frequency

Breast 0, .0000

Ovary n 0., 0000

Ovary t 0, .0000 indoknnes tissue 0, .0000

Fetal 0, .0000

Gastrointestinal 0, .0000

Haematopoetic 0 .0000

Skin muscle 0, .0000

Testes 0, .0000

Lungs 0, .0082

Nerves 0, .0000

Prostate 0, .0000

Sensory organs 0, .0000

Uterus n 0 .0000 Electronic Northern for SEQ. ID. NO: 52

NORMAL TUMOR conditions

% Frequency% frequency N / T T / N

B Lymphoma 0.0599 0.0543 1.10370.9060

Bubble 0.0507 0.0282 1.79790.5562

Breast 0.0326 0.0450 0.72401.3811

Colon 0.0268 0.0313 0.85631.1679

Small intestine 0.0439 0.0426 1.03060.9703

Ovary 0.0564 0.0453 1.24430.8037

Endocrine tissue 0.0642 0.0530 1.21130.8255

Brain 0.0380 0.0379 1.00220.9978

Skin 0.0330 0.0789 0.41902.3868

Hepatic 0.0093 0.0508 0.18315.4614

Heart 0.0589 0.0000 undef 0.0000

Testis 0.0482 0.0533 0.90471.1054

Lungs 0.0389 0.0499 0.77961.2828

Stomach-ear of ear 0.0072 0.0256 0.28333.5296

Musculoskeletal system 0.0240 0.0702 0.34182.9256

Kidney 0.0694 0.0289 2.39840.4169

Pancreas 0.0297 0.0331 0.89741.1143

Prostate 0.0443 0.0287 1.54570.6470

T lymphoma 0.0505 0.1643 0.30743.2533

Uterus 0.0325 0.0690 0.47152.1210

White blood cells 0.0363 0.0304 1.19480.8370

Haematopoetic 0.0495

Penis 0.0322

Seminal vesicle 0.0493

Sensory organs 0.0470

FOETUS% frequency

Development 0.0696

Gastromtenstmal 0.0750

Brain 0.0876

Haematopoetic 0.0904

Skin 0.0000

Hepatic 0.0260

Cardiac blood vessels 0.0854

Lungs 0.0867

Adrenal gland 0.0761

Kidney 0.0556

Placenta 0.0606

Prostate 0.0499

Sensory organs 0.0628

NORMALIZED / SUBTRACTED LIBRARIES

% Frequency breast 0.0068

Breast_t 0.0000

Dιckdarm_t 0000

Ovary n 1595

Eιerstock_t 0101 Endokrmes_Gewebe 0245

Foetal 0284

Gastrointestinal 0732

Haematopoietic 0.0000

Skin muscle 0.0616 testicles n 0.0293

Testicle_t 0.0000

Lungs n. 0195

Lung_t .0000

Nerves .0261 Nιere_t .0000

Ovarian Uterus, 0293

Prostate 0.0121

Sensory organs 0.0310

White blood body 0.0000 2.2 Fisher test

In order to decide whether a partial sequence S of a gene occurs significantly more frequently or less frequently in a library for normal tissues than in a library for degenerate tissues, Fisher's exact test, a standard statistical method (Hays, W. L, (1991) Statistics, Harcourt Brace College Publishers, Fort Worth).

The null hypothesis is that the two libraries cannot be distinguished in terms of the frequency of sequences homologous to S. If the null hypothesis can be rejected with sufficient certainty, the gene belonging to S will be accepted as an interesting candidate for a cancer gene and the next step will be to try to extend its sequence.

Example 3

Automatic extension of the partial sequence

The automatic extension of the partial sequence S takes place in three steps:

1. Determination of all sequences homologous to S from the total amount of available sequences using BLAST

2. Assemble these sequences using the standard program GAP4 (Bonfield, J.K., Smith, K.F., and Staden R. (1995), Nucleic Acids Research 23 4992-4999) (Contig formation).

3. Calculation of a consensus sequence C from the assembled sequences

The consensus sequence C will generally be longer than the starting sequence S. Your electronic Northern blot will therefore differ from that for S. A renewed Fisher test decides whether the alternative hypothesis of the deviation from a uniform expression can be maintained in both libraries. If this is the case, an attempt is made to extend C in the same way as S. This iteration is continued with the respectively obtained consensus sequences Cj (/ ^' : index of the iteration) until the alternative hypothesis is rejected (if Ho Exit; termination criterion I) or until automatic extension is no longer possible (while Cj> Cj- f, termination criterion II).

In the case of termination criterion II, the consensus sequence after the last iteration provides a complete or almost complete sequence of a gene that can be associated with cancer with a high degree of statistical certainty.

Analogously to the examples described above, the nucleic acid sequences described in Table I from uterine fibroid tissue could be found. It was also possible to determine the peptide sequences (ORF's) for the individual nucleic acid sequences which are listed in Table II, it being possible for a few nucleic acid sequences to be unable to assign a peptide and for some nucleic acid sequences to be able to assign more than one peptide. As already mentioned above, both the nucleic acid sequences determined and the peptide sequences assigned to the nucleic acid sequences are the subject of the present invention.

Example 4

Mapping of nucleic acid sequences on the human genome

Human genes were mapped using the Stanford G3 hybrid panel (Stewart et al., 1997), which is sold by Research Genetics, Huntsville, Alabama. This panel consists of 83 different genomic DNAs from human-hamster hybrid cell lines and allows a resolution of 500 kilobases. The hybrid cell lines were obtained by fusion of irradiated diploid human cells with Chinese hamster cells. The retention pattern of the human chromosome fragments is determined using a gene-specific primer in a polymerase chain reaction and analyzed using the software available from the Stanford RH server (http://www.stanford.edu/RH/rhserver_form2.html). This program determines the STS marker that is closest to the gene you are looking for. The corresponding cytogenetic band was determined using the "Mapview" program from the Genome Database (GDB), (http://gdbwww.dkfz-heidelberg.de).

In addition to mapping genes on the human cromosome set using various experimental methods, it is possible to determine the location of genes on this using bioinformatic methods. The well-known program e-PCR was used for this (Schuler GD (1998) Electronic PCR: bridging the gap between genome mapping and genome sequencing. Trends Biotechnol 16; 456-459, Schuler GD (1997). Sequence mapping by electronic PCR. Genome Res 7; 541-550). The database used no longer corresponds to the one specified in the literature, but is a further development, which includes data from the public database RHdb (http://www.ebi.ac.uk/RHdb/index.html). Analogous to the mapping by the hybrid panels, the results were evaluated using the software mentioned above and the software from the Whitehead Institute (http: //carbon.wi. Mit.edu:8000/cgi-bin/contig/rhmapper.pl) .

TABLE I

Legend for the modules:

Pfam: Protein families database of alignments and HMMs (pfam@sanger.ac.uk) PROSITE: The PROSITE database, its Status in 1999. Nucleic Acids Res. 27: 215-219 (http://www.expasy.ch/sprot /prosite.html)

33 34

15 35

36 37

16 38

39

17 40

50 51

50 51

The inventive nucleic acid sequences Seq. ID No. 1 to Seq. ID No. 31 of the determined candidate genes and the determined amino acid sequences Seq. ID No 32 to Seq. ID No. 51 are described in the following Sequ protocol.

Sequence listing

(i) ANMELDER:(1) GENERAL INFORMATION:

(i) APPLICANT:

(A) NAME: metaGen - Gesellschaft für Genomforschung mbH

(B) STREET: Ihnestrasse 63

(C) CITY: Berlin

(F) POST CODE (ZIP): D-14195(E) COUNTRY: Germany

(F) POST CODE (ZIP): D-14195

(G) TELEPHONE: (030) -8413 1673 (H) TELEFAX: (030) -8413 1674

(ii) TITLE OF THE INVENTION: Human nucleic acid sequences from

Uterine fibroid tissue

(iii) Number of sequences: 55

(iv) COMPUTER READABLE FORM:

(A) MEDIUM TYPE: floppy disk

(B) COMPUTER: IBM PC compatible

(C) OPERATING SYSTEM: PC-DOS / MS-DOS (D) SOFTWARE: Patentin Release # 1.0, Version # 1.25 (EPO)

(2) INFORMATION ABOUT SEQ ID NO: 1:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 779 base pairs

(A) LIBRARY: cDNA library (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1

agcgagcagc ggcggcggcg cggagagacg cagcggaggt tttcctggtt tcggacccca 60 gcggccggat ggtgaaatcc tccctgcagc ggatcctcaa tagccactgc ttcgccagagl20 agaaggaagg ggataaaccc agcgccacca tccacgccag ccgcaccatg ccgctcctaalδO gcctgcacag ccgcggcggc agcagcagtg agagttccag ggtctccctc cactgctgta240 gtaacccggg tccggggcct cggtggtgct cctgatgccc ctcacccacc cctgaagatc300 ccaggtgggc gagggaatag tcaaagggac cacaatcttt cagctaactt attctactcc360 gatgatcggc tgaatgtaac agaggaacta acgtccaacg acaagacgag gattctcaac420 gtccagtcca ggctcacaga cgccaaacgc attaactggc gaacagtgct gagtggcggc480 actgctctac atcgagatcc cgggcggcgc gctgcccgag gggagcaagg acagctttgc540 agttctcctg ggagttcgct gaggagcagc tgcgaggccg accatgtctt aatttgcttcδOO cacaagaacc ccgaggacag agccgccttg ctccgaacct tcagcttttt cgggcttgag660 attttgagac cggggcatcc cctttgttcc ccaagagacc cgacgcttgc ttcatgggcc720 tacaagtttc gagagagagt ctttggggag aggaagaagg attaggggcc gcgtcgggt 779

(2) INFORMATION ABOUT SEQ ID NO: 2:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2310 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN: (A) ORGANISM: HUMAN

(C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2

gttctccgaa acatggagtc ctgtaggcaa ggtcttacct gaatcaggat gagggagtgg 60 tgggtccagg tggggctgct ggccgtgccc ctgcttgctg cgtacctgca catcccaccc 120 cctcagcgct cccctgccct tcactcatgg aagtcttcag gcaagttttt cacttacaag 180 ggactgcgta tcttctacca agactctgtg ggtgtggttg gaagtccaga gatagttgtg 240 cttttacacg gttttccaac atccagctac gactggtaca agatttggga aggtctgacc 300 ttgaggtttc atcgggtgat tgcccttgat ttcttaggct ttggcttcag tgacaaaccg 360 agaccacatc actattccat atttgagcag gccagcatcg tggaagcgct tttgcggcat 420 ctggggctcc agaaccgcag gatcaacctt ctttctcatg actatggaga tattgttgct 480 caggagcttc tctacaggta caagcagaat cgatctggtc ggcttaccat aaagagtctc 540 tgtctgtcaa atggaggtat ctttcctgag actcaccgtc cactccttct ccaaaagcta 600 ctcaaagatg gaggtgtgct gtcacccatc ctcacacgac tgatgaactt ctttgtattc 660 tctcgaggtc tcaccccagt ctttgggccg tatactcggc cctctgagag tgagctgtgg 720 gacatgtggg cagggatccg caacaatgac gggaacttag tcattgacag tctcttacag 780 tacatcaatc agaggaagaa gttcagaagg cgctgggtgg gagctcttgc ctctgtaact 840 atccccattc attttatcta tgggccattg gatcctgtaa atccctatcc agagtttttg 900 gagctgtaca ggaaaacgct gccgcggtcc acagtgtcga ttctggatga ccacattagc 960 cactatccac agctagagga tcccatgggc ttcttgaatg catatatggg cttcatcaacl020 tccttctgag ctggaaagag tagcttccct gtattacctc ccctactccc ttatgtgttgl080 tgtattccac ttaggaagaa atgcccaaaa gaggtcctgg ccatcaaaca taattctctcll40 acaaagtcca ctttactcaa attggtgaac agtgtatagg aagaagccag caggagctctl200 gactaaggtt gacataatag tccacctccc attactttga tatctgatca aatgtatagal260 cttggctttg ttttttgtgc tattaggaaa ttctgatgag cattactatt cactgatgcal320 gaaagacgtt cttttgcata aaagactttt tttaacactt tggacttctc tgaaatatttl380 agaagtgcta atttctggcc cacccccaac aggaattcta tagtaagggg gaggagaaggl440 ggggctcctt ccctctcctc gaatgacgtt atgggcacat gccttttaaa agttctttaal500 gcaacacaga gctgagtcct ctttgtcata cctttggatt tagtgtttca tcagctgtttl560 ttagttataa acattttgtt aaaatagata ttggtttaaa tgatacagta ttttaggtatl620 gatttaagac tatgattta c ctatacatta tatatatttt ataaagatac taaaccagcal680 tacccttact ctgccagagt agtgaagcta attaaacacg tttggtttct gaataaattgl740 aactaaatcc aaactatttc ctaaaatcac aggacattaa ggaccaatag catctgtgcclδOO agagatgtac tgttattagc tgggaagacc aattctaaca gcaaataaca gtctgagactl860 cctcatacct cagtggttag aagcatgtct ctcttgagct acagtagagg ggaagggattl920 gttgtgtagt caagtcacca tgctgaatgt acactgattc ctttatgatg actgcttaacl980 tccccactgc ctgtcccaga gaggctttcc aatgtagctc agtaattcct gttactttac2040 agacaggaaa gttccagaaa ctttaagaac aaactctgaa agacctatga gcaaatggtg2100 ctgaatactt tttttttaaa gccacatttc attgtcttag tcaaagcagg attattaagt2160 gattatttaa aattcgtttt tttaaattag caacttcaag tataacaact ttgaaactgg2220 aataagtgtt tattttctat taataaaaat gaattgtgac aaaaaaaaaaa aaaggctttggg2280gctgt10g

(2) INFORMATION ABOUT SEQ ID NO: 3:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 854 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN: (A) ORGANISM: HUMAN

(C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3

ctgcacgggg gctcgggctc actataaaag gtgggagcgc gtggtgcccc agcaacgacg 60 agtttcagaa cgatggagag ctcccgcgtg aggctgctgc ccctcctggg cgccgccctgl20 ctgctgatgc tacctctgtt gggtacccgt gcccaggagg acgccgagct ccagccccgal80 gccctggaca tctactctgc cgtggatgat gcctcccacg agaaggagct gatcgaagcg240 ctgcaagaag tcttgaagaa gctcaagagt aaacgtgttc ccatctatga gaagaagtat300 ggccaagtcc ccatgtgtga cgccggtgag cagtgtgcag tgaggaaagg ggcaaggatc360 gggaagctgt gtgactgtcc ccgaggaacc tcctgcaatt ccttcctcct gaagtgctta420 tgaaggggcg tccattctcc tccatacatc cccatccctc tactttcccc agaggaccac480 accttcctcc ctggagtttg gcttaagcaa cagataaagt ttttattttc ctctgaaggg540 aaagggctct tttcctgctg tttcaaaaat aaaagaacac attagatgtt actgtgtgaa600 gaataatgcc ttgtatggtg ttgatacgtg tgtgaagtat tcttatttta tttgtctgac660 aaactcttgt gtacctttgt gtaaagaagg gaagctttgt ttgaaaattg tatttttgta720 tgtggcatgg cagaatgaaa attagatcta gctaatctcg gtagatgtca ttacaacctg780 gaaaataaat caccctaagt gacacaaatt gaagcatgta caaattatac ataataaagt840 gtttttaata attg 854

(2) INFORMATION ABOUT SEQ ID NO: 4: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1112 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4

cgccagcccc gtcgggggcc cggaggggac tcggagcggg ccaaggggcg gctccggcgg 60 gcggactcgg agcgggcggc ggagtgaccc ggacagctgt cctctctgac accaccccgg 120 cctgcctctt tgttgccatg agagctgcct acctcttcct gctattcctg cctgcaggct 180 tgctggctca gggccagtat gacctggacc cgctgccgcc gttccctgac cacgtccagt 240 acacccacta tagcgaccag atcgacaacc cagactacta tgattatcaa gaggtgactc 300 ctcggccctc cgaggaacag ttccagttcc agtcccagca gcaagtccaa caggaagtca 360 tcccagcccc aaccccagaa ccaggaaatg cagagctgga gcccacagag cctgggcctc 420 ttgactgccg tgaggaacag tacccgtgca cccgcctcta ctccatacac aggccttgca 480 aacagtgtct caacgaggtc tgcttctaca gcctccgccg tgtgtacgtc attaacaagg 540 agatctgtgt tcgtacagtg tgtgcccatg aggagctcct ccgagctgac ctctgtcggg 600 acaagttctc caaatgtggc gtgatggcca gcagcggcct gtgccaatcc gtggcggcct 660 cctgtgccag gagctgtggg agctgctagg gtggtgctgg catcctgagt cctggccctc 720 ctgggatctg gggccctcgg gccctgcctg acctggtgct tttttcccca tccccatgtt 780 ccttttattc tgtaaaaagt tagtggactg cagccctggg ggttgcaggc tgcggtgcct 840 caggcccctc cttcagcctg tggccacctc tggggcacga tgggggctcc ccactgccca 900 gtctgcccct cgggttgggg gagtatccca ggcctctctg tgggaccctg ggccctgacg 960 ggccttctca gcccgttttg aggacagaca gtcccccgag gtaggctaca tccccccaccl020 ccagctggtc tgcttggatt tcctacagcc cccgtgggca tggaccacct ttattttatal080 caaaattaaa aacaagtttt tacaaaaaaa aa 1112 (2) INFORMATION ABOUT SEQ ID NO: 5:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1051 base pairs (B) TYPE: nucleic acid

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN

(C) ORGAN: (vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 5

gcgcaggcgc gaagaagctg gcaggggcac gagccggggg cgggtttgaa gacgcgtcgt 60 tgggttttgg aggccgtgaa acagccgttt gagtttggct gcgggtggag aacgtttgtc 120 aggggcccgg ccaagaagga ggcccgcctg ttacgatggt gtccatgagt ttcaagcgga 180 accgcagtga ccggttctac agcacccggt gctgcggctg ttgccatgtc cgcaccggga 240 cgatcatcct ggggacctgg tacatggtag taaacctatt gatggcaatt ttgctgactg 300 tggaagtgac tcatccaaac tccatgccag ctgtcaacat tcagtatgaa gtcatcggta 360 attactattc gtctgagaga atggctgata atgcctgtgt tctttttgcc gtctctgttc 420 ttatgtttat aatcagttca atgctggttt atggagcaat ttcttatcaa gtgggttggc 480 tgattccatt cttctgttac cgactttttg acttcgtcct cagttgcctg gttgctatta 540 gttctctcac ctatttgcca agaatcaaag aatatctgga tcaactacct gattttccct 600 acaaagatga cctcctggcc ttggactcca gctgcctcct gttcattgtt cttgtgttct 660 ttgccttatt catcattttt aaggcttatc taattaactg tgtttggaac tgctataaat 720 acatcaacaa ccgaaacgtg ccggagattg ctgtgtaccc tgcctttgaa gcacctcctc 780 agtacgtttt gccaacctat gaaatggccg tgaaaatgcc tgaaaaagaa ccaccacctc 840 cttacttacc tgcctgaaga aattctgcct ttgacaataa atcctatacc agctttttgt 900 ttgtttatgt tacagaatgc tgcaattcag ggctcttcaa acttgtttag atataaaata 960 tggtggccct ttggttttaa agcaatttat tttccaaaac actaagggttacctctggttt20 cctctgggtt0 cctctgggtt20 cctctgggtt20 cctctgggtt0 cctctggttt20

(2) INFORMATION ABOUT SEQ ID NO: 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1516 base pairs

(B) TYPE: nucleic acid (C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing (iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6

gttgtcctca tccctctcat acagggtgac caggacgttc ttgagccagt cccgcatgcg 60 cagggggaag aagatccatg agaaggagaa gcgcctggag gcaggagacc accccgtgga 120 gctgctggcc cgggacttcg agaagaacta taacatgtac atcttccctg tacactggca 180 gttcggccag ctggaccagc accccattga cgggtacctc tcccacaccg agctggctcc 240 actgcgtgct cccctcatcc ccatggagca ttgcaccacc cgctttttcg agacctgtga 300 cctggacaat gacaagtaca tcgccctgga tgagtgggcc ggctgcttcg gcatcaagca 360 gaaggatatc gacaaggatc ttgtgatcta aatccactcc ttccacagta ccggattctc 420 tctttaaccc tccccttcgt gtttccccca atgtttaaaa tgtttggatg gtttgttgtt 480 ctgcctggag acaaggtgct aacatagatt taagtgaata cattaacggt gctaaaaatg 540 aaaattctaa cccaagaaca tgacattctt agctgtaact taactattaa ggccttttcc 600 acacgcatta atagtcccat ttttctcttg ccatttgtag ctttgcccat tgtcttattg 660 ggcacatggg gtggacacgg atctgctggg ctctgcctta aacacacatt gcagcttcaa 720 cttttctctt tagtgttctg tttgaaacta atacttaccg agtcagactt tgtgttcatt 760 tcatttcagg gtcttggctg cctgtgggct tccccaggtg gcctggaggt gggcaaaggg 840 aagtaacaga cacacgatgt tgtcaaggat ggttttggga ctagaggctc agtggtggga 900 gagatccctg cagaacccac caaccagaac gtggtttgcc tgaggctgta actgagagaa 960 agattctggg gctgtgttat gaaaatatag acattctcac ataagcccag ttcatcaccal020 tttcctcctt tacctttcag tgcagtttct tttcacatta ggctgttggt tcaaacttttlOδO gggagcacgg actgtcagtt ctctgggaag tggtcagcgc atcctgcagg gcttctcctcll40 ctctgtcttt tggagaacca gggctcttct caggggctct agggactgcc aggctgtttcl200 agccaggaag gccaaaatca agagtgagat gtagaaagtt gtaaaataga aaaagtggagl260 ttggtgaatc ggttgttctt tcctcacatt tggatgattg tcataaggtt tttagcatgtl320 tcctcctttt ctccaccctc cccttttttc ccccaagaat acagagaaaa ctcaaagttal380 atggggaggg tcggatccta caggcctgag aatcggtcaa ctccaagcat ttcatggaaal440 aggcggcttc ctaattaatc ctacaaaccc tcacccaggaaa ta 500g

(2) INFORMATION ABOUT SEQ ID NO: 7:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2367 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO (vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 7

cgccgggact cttggcgggt gaaggtgtgt gtcagctttt gcgtcactcg agccctgggc 60 gctgcttgct aaagagccga gcacgcgggt ctgtcatcat gtcgcgttac gggcggtacg 120 gaggagaaac caaggtgtat gttggtaacc tgggaactgg cgctggcaaa ggagagttag 180 aaagggcttt cagttattat ggtcctttaa gaactgtatg gattgcgaga aatcctccag 240 gatttgcctt tgtggaattc gaagatccta gagatgcaga agatgcagta cgaggactgg 300 atggaaaggt gatttgtggc tcccgagtga gggttgaact atcgacaggc atgcctcgga 360 gatcacgttt tgatagacca cctgcccgac gtccctttga tccaaatgat agatgctatg 420 agtgtggcga aaagggacat tatgcttatg attgtcatcg ttacagccgg cgaagaagaa 480 gcaggtcacg gtctagatca cattctcgat ccagaggaag gcgatactct cgctcacgca 540 gcaggagcag gggacgaagg tcaaggtcag catctcctcg acgatcaaga tctatctctc 600 ttcgtagatc aagatcagct tcactcagaa gatctaggtc tggttctata aaaggatcga 660 ggtatttcca atccccgtcg aggtcaagat caagatccag gtctatttca cgaccaagaa 720 gcagccgatc aaagtccaga tctccatctc caaaaagaag tcgttcccca tcaggaagtc 780 ctcgcagaag tgcaagtcct gaaagaatgg actgaagctc tcaagttcac cctttaggga 640 aaagttattt tgtttacatt attataaggg atttgtgatg tctgtaaagt gtaacctagg 900 aaagataatt caaccatcta atcaaaatgg atctggatta ctatgtaaat tcacagcagt 960 aagataatat aaattttgtt gaatgtatta acatcatatg gtctgaaaat gtgggtttttl020 atttggcaca tttaaataaa atgtttctaa ctagattttt gatttgtgtt caatattaacl080 acttcttaat ttgatatatt tgagagtcag acattataat tgttaacctt attcatacatll40 acctacattc agaattgaaa ggtgttggtt aagtcttgaa catcactatt ctatgcataal200 aacttggcca ggatcttaag ggactttgaa aattccatct tacccttgta gctctgggtal260 agatgacctg agtcccttat gatacagcct gaatgcatca tgacagatcc ttaagttagcl320 taatccgttt gaagttggtg ttagtaggta ttgtatgatc agtggtgaag caagtaggacl380 cactgatgtg tctaaatgag catgacagga actaaacgaa actgattaaa tgtatgagaal440 atagaaactg atttctggat gatctttata ctaattgcag ctttcaggct actaggtggcl500 atagtgttaa ttaggactcc ccaagatatg gggagttcta ctctcaatgg tcttgtttctl560 ttgctttcta cattagttaa ccagttttat accaaaaaat gcatgtttga ggaattgtctl620 gaaattggga caaaacacct tcatgtaaac cagctttgca aaattttcca gcccagatacl680 tcttcatcta ttcaaatgga ttgtcttatt ctgagcaa ag acctgttgtt aatcttcaagl740 ctaggttttg cagttcccaa ccacaacatt cttctatttt gccaggctgg tgcaaagtaalδOO ttaaagatgt caatcagaaa tgtcaatgag actaaagtgg ttttgtaaat ctcagctatal860 tttagcaaca ctccatgtag ctaatatttt ttggtagcat ctggtagacc ttagaatgttl920 acatagccag taggttcttt attcaaattt taagtatctt aagaatagta gggcagtaacl980 agttactttt gagagttttc tggtcaagct tttaccaggc attctctagc cttggtacaa2040 aaaaaaaaaa aacctgctgg ttgcgcagat acctaggctt gtccatttta tgcatttcag2100 caaagtcatt ggatactatt gcaacttggg aatactggtc tgcatcaagt ttattcggta2160 gtttgaccgc tagtatgttg gaagttattt ggattgtttt tggaattttg actggctgaa2220 ttatggttgg tataaagtta tgtgtataac tggcaggctt atttatctgt tgcacttggt2260 tagctttaat tgttctgtat tatttaaaga taagtttact caacaataaa tctgcagaga2340 ttgaacaaat aaaaaaaaaaa67aaaaaaaa67a

(2) INFORMATION ABOUT SEQ ID NO: 8:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 568 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN: (A) ORGANISM: HUMAN

(C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 8

ctcgagccgt gggcagtggc cgcgaatgcg cggagacact gaccttcagc gcctcggctc 60 cagcgccatg gcgccctcca ggaagttctt cgttggggga aactggaaga tgaacgggcgl20 gaagcagagt ctgggggagc tcatcggcac tctgaacgcg gccaaggtgc cggccgacaclδO cgaggtggtt tgtgctcccc ctactgccta tatcgacttc gcccggcaga agctagatcc240 caagattgct gtggctgcgc agaactgcta caaagtgact aatggggctt ttactgggga300 gatcagccct ggcatgatca aagactgcgg agccacgtgg gtggtcctgg ggcactcaga360 gagaaggcat gtctttgggg agtcagatga gctgattggg cagaaagtgg cccatgctct420 ggcagaggga ctcggagtaa tcgcctgcat tggggagaag ctagatgaaa gggaagctgg480 catcactgag aatgttgttt tcgagcagac aaaggtcatc ggggatgact tgaaggactg540 gatcaagttc gtcctggcct gttggcct 568

(2) INFORMATION ABOUT SEQ ID NO: 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1775 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN: (A) ORGANISM: HUMAN

(C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 9

ctcgggggcc attttgtgaa gagacgaaga ctgagcggtt gtggccgcgt tgccgacctc 60 cagcagcagt cggcttctct acgcagaacc cgggagtagg agactcagaa tcgaatctct 120 tctccctccc cttcttgtga gatttttttg atcttcagct acattttcgg ctttgtgaga 180 aaccttacca tcaaacacga tggccagcaa cgttaccaac aagacagatc ctcgctccat 240 gaactcccgt gtattcattg ggaatctcaa cactcttgtg gtcaagaaat ctgatgtgga 300 ggcaatcttt tcgaagtatg gcaaaattgt gggctgctct gttcataagg gctttgcctt 360 cgttcagtat gttaatgaga gaaatgcccg ggctgctgta gcaggagagg atggcagaat 420 gattgctggc caggttttag atattaacct ggctgcagag ccaaaagtga accgaggaaa 480 agcaggtgtg aaacgatctg cagcggagat gtacggctcc tcttttgact tggactatga 540 ctttcaacgg gactattatg ataggatgta cagttaccca gcacgtgtac ctcctcctcc 600 tcctattgct cgggctgtag tgccctcgaa acgtcagcgt gtatcaggaa acacttcacg 660 aaggggcaaa agtggcttca attctaagag tggacagcgg ggatcttcca agtctggaaa 720 gttgaaagga gatgaccttc aggccattaa gaaggagctg acccagataa aacaaaaagt 780 ggattctctc ctggaaaacc tggaaaaaat tgaaaaggaa cagagcaaac aagcagtaga 840 gatgaagaat gataagtcag aagaggagca gagcagcagc tccgtgaaga aagatgagac 900 taatgtgaag atggagtct g aggggggtgc agatgactct gctgaggagg gggacctact 960 ggatgatgat gataatgaag atcgggggga tgaccagctg gagttgatca aggatgatgal020 aaaagaggct gaggaaggag aggatgacag agacagcgcc aatggcgagg atgactcttalOδO agcacatagt ggggtttaga aatcttatcc cattatttct ttacctaggc gcttgtctaall40 gatcaaattt ttcaccagat cctctcccct agtatcttca gcacatgctc actgttctccl200 ccatccttgt ccttcccatg ttcattaatt catattgccc cgcgcctagt cccattttcal260 cttcctttga cgctcctagt agttttgtta agtcttaccc tgtaattttt gcttttaattl320 ttgatacctc tttatgactt aacaataaaa aggatgtatg gtttttatca actgtctccal3δ0 aaataatctc ttgttatgca gggagtacag ttcttttcat tcatacataa gttcagtagtl440 tgcttcccta actgcaaagg caatctcatt tagttgagta gctcttgaaa gcagctttgal500 gttagaagta tgtgtgttac accctcacat tagtgtgctg tgtggggcag ttcaacacaal560 atgtaacaat gtatttttgt gaatgagagt tggcatgtca aatgcatcct ctagaaaaatl620 aattagtgtt atagtcttaa gatttgtttt ctaaagttga tactgtgggt tatttttgtglδδO aacagcctga tgtttgggac cttttttcct caaaataaac aagtccttat taaaccaggal740 atttggagaa aaaaaaaaaa aaaaaaaaaa aaa aa 1775

(2) INFORMATION ABOUT SEQ ID NO: 10:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 509 base pairs (B) TYPE: nucleic acid

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN: (vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 10

caggtcgagt ggccactgcg cagaccagac ttcgctcgta ctcgtgcgcc tcgcttcgct 60 tttcctccgc aaccatgtct gacaaacccg atatggctga gatcgagaaa ttcgataagtl20 cgaaactgaa gaagaccaa actatacaaga gaaccccaga aacaggagaa gcaagcaggc gaatcgtaat gaggcgtgcg ccgccaatat gcactgtaca240 ttccacaagc attgccttct tattttactt cttttagctg tttaactttg taagatgcaa300 agaggttgga tcaagtttaa atgactgtgc tgcccctttc acatcaaagg gactacttga360 acaacggaag ggccgcggcc tacctttccc atctgtctat ctatctggct ggcagggaag420 ggaagagttg caggttggtg aggaagaagt ggggtggaag aagttggatg ggccgccagt480 aaaacttggg taaaccgaac ttggccaag 509

(2) INFORMATION ABOUT SEQ ID NO: 1 1: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2191 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1 1

actgagcgag ggccagccgt gcggcatcta caccgagcgc tgtggctccg gccttcgctg 60 ccagccgtcg cccgacgagg cgcgaccgct gcaggcgctg ctggacggcc gcgggctctg 120 cgtcaacgct agtgccgtca gccgcctgcg cgcctacctg ctgccagcgc cgccagctcc 180 aggaaatgct agtgagtcgg aggaagaccg cagcgccggc agtgtggaga gcccgtccgt 240 ctccagcacg caccgggtgt ctgatcccaa gttccacccc ctccattcaa agataatcat 300 catcaagaaa gggcatgcta aagacagcca gcgctacaaa gttgactacg agtctcagag 360 cacagatacc cagaacttct cctccgagtc caagcgggag acagaatatg gtccctgccg 420 tagagaaatg gaagacacac tgaatcacct gaagttcctc aatgtgctga gtcccagggg 460 tgtacacatt cccaactgtg acaagaaggg attttataag aaaaagcagt gtcgcccttc 540 caaaggcagg aagcggggct tctgctggtg tgtggataag tatgggcagc ctctcccagg 600 ctacaccacc aaggggaagg aggacgtgca ctgctacagc atgcagagca agtagacgcc 660 tgccgcaagg ttaatgtgga gctcaaatat gccttatttt gcacaaaaga ctgccaagga 720 catgaccagc agctggctac agcctcgatt tatatttctg tttgtggtga actgattttt 760 tttaaaccaa agtttagaaa gaggtttttg aaatgcctat ggtttctttg aatggtaaac 840 ttgagcatct tttcactttc cagtagtcag caaagagcag tttgaatttt cttgtcgctt 900 cctatcaaaa tattcagaga ctcgagcaca gcacccagac ttcatgcgcc cgtggaatgc 960 tcaccacatg ttggtcgaag cggccgacca ctgactttgt gacttaggcg gctgtgttgcl020 ctatgtagag aacacgcttc acccccactc cccgtacagt gcgcacaggc tttatcgagal080 ataggaaaac ctttaaaccc cggtcatccg gacatcccaa cgcatgctcc tggagctcacll40 agccttctgt ggtgtcattt ctgaaacaag ggcgtggatc cctcaaccaa gaagaatgttl200 tatgtcttca agtgacctgt actgcttggg gactattgga gaaaataagg tggagtcctal260 cttgtttaaa aaatatgtat ctaagaatgt tctagggcac tctgggaacc tataaaggcal320 ggtatttcgg gccctcctct tcaggaatct tcctgaagac atggcccagt cgaaggcccal380 ggatggcttt tgctgcggcc ccgtggggta ggagggacag agagacaggg agagtcagccl440 tccacattca gaggcatcac aagtaatggc acaattcttcca ga ga gtc tca ga ga gtc aagctttatt ttcatctctc atcttttgtc ctccttagca caatgtaaaa aagaatagtal620 atatcagaac aggaaggagg aatggcttgc tggggagccc atccaggaca ctgggagcacl680 atagagattc acccatgttt gttgaactta gagtcattct catgcttttc tttataattcl740 acacatatat gcagagaaga tatgttcttg ttaacattgt atacaacata gccccaaatalδOO tagtaagatc tatactagat aatcctagat gaaatgttag agatgctata tgatacaactl860 gtggccatga ctgaggaaag gagctcacgc ccagagactg ggctgctctc ccggaggccal920 aacccaagaa ggtctggcaa agtcaggctc agggagactc tgccctgctg cagacctcggl980 tgtggacaca cgctgcatag agctctcctt gaaaacagag gggtctcaag acattctgcc2040 tacctattag cttttcttta tttttttaac tttttggggg gaaaagtatt tttgagaagt2100 ttgtcttgca atgtatttat aaatagtaaa taaagttttt accattaaaa aaaaaaggag2160 taaaaagaaa aaaaagggcg gccgccgact a 2191

(2) INFORMATION ABOUT SEQ ID NO: 12:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1769 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN: (A) ORGANISM: HUMAN

(C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12

attatttaca tttcaaaata attcccctta atcgttttac tcctaagttc attaccattg 60 ttggcccacc ttaggttcca ccacttggtt gttaccccag ccctgggttc aaacagggac 120 atggcaaggg gacacaggac agaggggtcc ccagctgcca cctcacccac cgcaattcat 180 ttagtagcag gcacaggggc agctccggca cggctttctc aggcctatgc cggagcctcg 240 agggctggag agcgggaaga caggcagtgc tcggggagtt gcagcaggac gtcaccagga 300 gggcgaacgg ccacgggagg ggggccccgg gacattgcgc agcaaggagg ctgcaggggc 360 tcggcctgcg ggcgccggtc ccacgaggca ctgcggccca gggtctggtg cggagagggc 420 ccacagtgga cttggtgacg ctgtatgccc tcaccgctca gcccctgggg ctggcttggc 480 agacagtaca gcatccaggg gagtcaaggg catggggcga gaccagacta ggcgaggcgg 540 gcggggcgga gtgaatgagc tctcaggagg gaggatggtg caggcagggg tgaggagcgc 600 agggggcggc gagcgggagg cactggcctc cagagcccgt ggccaaggcg ggcctcgcgg 660 gcggcgacgg agccgggatc ggtgcctcag cgttcgggct ggagacgagg ccaggtctcc 720 agctggggtg gacgtgccca ccagctgccg aaggcaagac gccaggtccg gtggacgtga 780 caagcaggac atgacatggt ccggtgtgac ggcgaggaca gaggaggcgc gtccggcctt 840 cctgaacacc ttaggctggt ggggctgcgg caagaagcgg gtctgtttct ttacttcctc 900 cacggagtcg gcacactatg gctgccctct gggctcccag aacccacaac atgaaagaaa 960 tggtgctacc cagctcaagc ctgggccttt gaatccggac acaaaaccct ctagcttggal020 aatgaatatg ctgcacttta caaccactgc actacctgac tcaggaatcg gctctggaagl080 gtgaagctag aggaaccaga cctcatcagc ccaacatcaa agacaccatc ggaacagcagll40 cgcccgcagc acccaccccg caccggcgac tccatcttca tggccacccc ctgcggcggal200 cggttgacca ccagccacca catcatccca gagctgagct cctccagcgg gatgacgccgl260 tccccaccac ctccctcttc ttctttttca tccttctgtc tctttgtttc tgagctttccl320 tgtctttcct tttttctgag agattcaaag cctccacgac tctgtttccc ccgtcccttcl380 tgaatttaat ttgcactaag tcatttgcac tggttggagt tgtggagacg gccttgagtcl440 tcagtacgag tgtgcgtgag tgtgagccac cttggcaagt gcctgtgcag ggcccggccgl500 ccctccatct gggccgggtg actgggcgcc ggctgtgtgc ccgaggcctc accctgccctl560 cgcctagtct ggaagctccg accgacatca cggagcagcc ttcaagcatt ccattacgccl620 ccatctcgct ctgtgcccct ccccaccagg gcttcagcag gagccctgga ctcatcatcal680 ataaacactg ttacagcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaal740 aaaaaaaaaa aaaaaaaaaa aaaaaaaag 1769

(2) INFORMATION ABOUT SEQ ID NO: 13: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1026 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13

aaaagctgtc cgcgcgggga gcccagggcc agctttgggg ttgtccctgg acttgtcttg 60 gttccagaac ctgacgaccc ggcgacggcg acgtctcttt tgactaaaag acagtgtcca 120 gtgctccagc ctaggagtct acggggaccg cctcccgcgc cgccaccatg cccaacttct 180 ctggcaactg gaaaatcatc cgatcggaaa acttcgagga attgctcaaa gtgctggggg 240 tgaatgtgat gctgaggaag attgctgtgg ctgcagcgtc caagccagca gtggagatca 300 aacaggaggg agacactttc tacatcaaaa cctccaccac cgtgcgcacc acagagatta 360 acttcaaggt tggggaggag tttgaggagc agactgtgga tgggaggccc tgtaagagcc 420 tggtgaaatg ggagagtgag aataaaatgg tctgtgagca gaagctcctg aagggagagg 480 gccccaagac ctcgtggacc agagaactga ccaacgatgg ggaactgatc ctgaccatga 540 cggcggatga cgttgtgtgc accagggtct acgtccgaga gtgagtggcc acaggtagaa 600 ccgcggccga agcccaccac tggccatgct caccgccctg cttcactgcc ccctccgtcc 660 caccccctcc ttctaggata gcgctcccct taccccagtc acttctgggg gtcactggga 720 tgcctcttgc agggtcttgc tttctttgac ctcttctctc ctcccctaca ccaacaaaga 780 ggaatggctg caagagccca gatcacccat tccgggttca ctccccgcct ccccaagtca 840 gcagtcctag ccccaaacca gcccagagca gggtctctct aaaggggact tgagggcctg 900 agcaggaaag actggccctc tagcttctac cctttgtccc tgtagcctat acagtttaga 960 atatttattt gttaatttta ttaaaatatct ttaaaaaaaat aaaaaaaa20aaaaaaaaaaaaaaaaa20a (2) INFORMATION ABOUT SEQ ID NO: 14:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 676 base pairs (B) TYPE: nucleic acid

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN: (vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14

ggccattttg tgaagagacg aagactgagc ggttgtggcc gcgttgccga cctccagcag 60 cagtcggctt ctctacgcag aacccgggag taggagactc agaatcgaat ctcttctcccl20 tccccttctt gggcagcaag gcgaacccca tccctactca ctggagctca gctttgatttlδO ttaacctccc ttccccaccc ttccagaaca cacacattcc attccaaaac tgattttata240 aagacatttt aaacataatg atgcaacttg gtgtgcacta cagcaaatgt acaggtgttt300 tttttttaat tgtttccaaa accgggacct ggatttaaga tgtaattttt aaaatttcta360 tttctatttt ttcggcagca gttgggttag aggaggagga gccttttagc ctcccagaaa420 ctgacctctc tacttcctcg tgtattttta agattgattg atgatgtgga aagggctttg480 cttgtctgct actgaaaact ttatccttgc ggtttttgtg gaactgcgtt tggaaagaga540 aaagaaatga actttactga cttgacattt tgcacctccc ggttttcgaa tctgggcaat600 tttaattttg gttttacagt gagagttttt gatttatcccacagaga6

(2) INFORMATION ABOUT SEQ ID NO: 15:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1254 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO (vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 15

cggctcgagc agctcgagcg gctcaaacac ctcatttgac cttgccagct gaccttcaaa 60 ccctgcattt gaaccgacca acattaagtc cagagagtaa acttgaatgg aataacgaca 120 ttccagaagt taatcatttg aattctgaac actggagaaa aaccgaaaaa tggacggggc 180 atgaagagac taatcatctg gaaaccgatt tcagtggcga tggcatgaca gagctagagc 240 tcgggcccag ccccaggctg cagcccattc gcaggcaccc gaaagaactt ccccagtatg 300 gtggtcctgg aaaggacatt tttgaagatc aactatatct tcctgtgcat tccgatggaa 360 tttcagttca tcagatgttc accatggcca ccgcagaaca ccgaagtaat tccagcatag 420 cggggaagat gttgaccaag gtggagaaga atcacgaaaa ggagaagtca cagcacctag 480 aaggcagcgc ctcctcttca ctctcctctg attagatgaa actgttacct taccctaaac 540 acagtatttc tttttaactt ttttatttgt aaactaataa aggtaatcac agccaccaac 600 attccaagct accctgggta cctttgtgca gtagaagcta gtgagcatgt gagcaagcgg 660 tgtgcacacg gagactcatc gttataattt actatctgcc aagagtagaa agaaaggctg 720 gggatatttg ggttggcttg gttttgattt tttgcttgtt tgtttgtttt gtactaaaac 780 agtattatct tttgaatatc gtagggacat aagtatatac atgttatcca atcaagatgg 840 ctagaatggt gcctttctga gtgtctaaaa cttgacaccc ctggtaaatc tttcaacaca 900 cttccactgc ctgcgtaatg aagttttgat tcatttttaa ccactggaat ttttcaatgc 960 cgtcattttc agttagatga ttttgcactt tgagattaaa atgccatgtc tatttgattal020 gtcttatttt tttattttta caggcttatc agtctcactg ttggctgtca ttgtgacaaal080 gtcaaataaa cccccaagga cgacacacag tatggatcac atattgtttg acattaagctll40 tttgccagaa aatgttgcat gtgttttacc tcgacttgct aaaatcgatt agcagaaaggl200 catggctaat aatgttggtg gtgaaaataa ataaataagt aaacaaaaag aaaa 1254

(2) INFORMATION ABOUT SEQ ID NO: 16:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 537 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 16 ggcccgggcc cccaccctcg acatgcgctt ccggcgacgc cttagcgctg acccccacgc 60 aacccagcga aactccgcgg aggcgcgcgg cacgatggac ggtcgggtgc agctgatgaal20 ggccctcctg gccgggcccc tccggcccgc ggcgcgtcgc tggaggaacc cgattcccttlδO tcccgagacg tttgacggag ataccgaccg actcccggag ttcatcgtgc agacgtgctc240 ctacatgttc gtggacgaga acacgttctc caacgacgcc ctgaaggtga cgttcctcat300 cacccgcctc acggggccag ccctgcagtg ggtgatcccc tacatcagga aggagagccc360 cctgctcaat gattaccggg gctttctggc cgagatgaag cgagtctttg gatgggagga420 ggacgaggac ttctaggccg ggagaccctc gggcctgggg gcgggtgctc tgggaagagt460 tcgctgtgcc agtggccacc gctagggtct ccacaggcgc cctccccagg gaatgct 537

(2) INFORMATION ABOUT SEQ ID NO: 17:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 823 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: partial cDNA produced from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO (iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 17

tagactgaac aggaggggga gtcctgggta gcgcgccggt ctaaatcgtt acttggcgga 60 aagttcccat gagtctttgc cagcgtcccc ctccttttgt gaggattggg atattccgacl20 tccttaaggg cctggcgcac ataaggtgtg accttttcat tcccgttgtt atggagggccl80 acatctgcca gagcctggag tctgcgaagg ccgggacccg gttccccggc ccacagtggg240 ggtgtgcaaa cccgagagaa ctgggttgca aattcgtgaa gaatcagcat catgtttggc300 agctgagtat tggagccagg agcctgccat gaggttttga gaacagagtg ctgttttaga360 gctggcagca gcatctcagc ccaagagaag gttatattcc cagaggatgt cagtcccaag420 gaccagtagc tgccatcagt ttggattctg aaaactaact ggcatcaaca ctgggtgtag480 aaacatgctt gccttatgta tcagaggaca tgctcagcag atccaagaga tatatttggc540 aactttttct agaaaaggca cattgggtat cattcattac attcttgagg tttttttgggβOO tttttttttt ttttttttga gacagtcttg ctgtattgcc caggctggga gtgtggtggc660 acaatcacag ctcattgcat cctcaatcac ccagggccta agcaatcctc ccaccttgta720 gctgggacta cagctcacag cacaccgggc taaaattttt ttttgttgag acggtttttc760 tatgttgccc gggtggtttt cagggtccgg ggttcagatg gtc 823

(2) INFORMATION ABOUT SEQ ID NO: 18:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1082 base pairs (B) TYPE: nucleic acid (C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN

(C) ORGAN: (vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 18

gggcgcacat aaggtgtgac cttttcattc ccgttgttat ggagggccac atctgccaga 60 gcctggagtc tgcgaaggcc gggacccggt tccccggccc acagtggggg tgtgcaaacc 120 cgagagaact ggtcgctgaa acctctacaa cttagttgac cgtaactgcc agagccctgc 180 cctgaattcc tgtccttact ccctctttaa gattgcgtac ccactgcaga gtgctgaaga 240 cggggtagcc acgaggttgc aaattcgtga agaatcagca tcatgtttgg cagctgagta 300 ttggagccag gagcctgcca tgaggttttg agaacagagt gctgttttag agctggcagc 360 agcatctcag cccaagagaa ggttatattc ccagaggatg tcagtcccaa ggaccagtag 420 ctgccatcag tttggattct gaaaactaac tggcatcaac actgggtgta gaaacatgct 480 tgccttatgt atcagaggac atgctcagca gatccaagag atatatttgg caactttttc 540 tagaaaaggc acattgggta tcattcatta cattcttgag tttttttggg tttttttttt 600 ttttttttga gacagtcttg ctgtattgcc caggctggag tgtggtggca caatcacagc 660 tcattgcatc ctcaatcacc caggcctaag caatcctccc accttgtagc tgggactaca 720 gctcacagca cacctggcta aaattttttt tttgttgaga cggattctct atgttgccca 780 ggctggtctc aggctcctgg gctcagatgg tcctcctgcc tcagcttcca aaggcacagg 840 ccaagttgta gctttgtccc ttgccatcat gcccaacaag aggttctata ccttttaatg 900 aattgacttt cataaattgg ttatgttggt gggcaagttc tttaagctgg aaattgtaaa 960 ttcctcctga aatgtttttt catgcagtta ccatgaacta atactacaat aaaggatggtl020 cttgggtgtc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaagaaaa aaaaaaaaaalOδO aa 1082 (2) INFORMATION ABOUT SEQ ID NO: 19:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1548 base pairs

(B) TYPE: nucleic acid (C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO (iii) ANTI-SENSE: NO (vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 19

cccattccat agggaatgag ctgggctgtc ctttctcccc acgttcacct gcacttcgtt 60 agagagcagt gttcacatgc cacaccacaa gatccccaca atgacataac tccattcaga 120 gactggcgtg actgggctgg gtctccccac cccccccttc agctcttgta tcactcagaa 180 tctggcagcc agttccgtcc tgacagagtt cacagcatat attggtggat tcttgtccat 240 agtgcatctg ctttaagaat taacgaaagc agtgtcaaga cagtaaggat tcaaaccatt 300 tgccaaaaat gagtctaagt gcatttactc tcttcctggc attgattggt ggtaccagtg 360 gccagtacta tgattatgat tttcccctat caatttatgg gcaatcatca ccaaactgtg 420 caccagaatg taactgccct gaaagctacc caagtgccat gtactgtgat gagctgaaat 480 tgaaaagtgt accaatggtg cctcctggaa tcaagtatct ttaccttagg aataaccaga 540 ttgaccatat tgatgaaaag gcctttgaga atgtaactga tctgcagtgg ctcattctag 600 atcacaacct tctagaaaac tccaagataa aagggagagt tttctctaaa ttgaaacaac 660 tgaagaagct gcatataaac cacaacaacc tgacagagtc tgtgggccca cttcccaaat 720 ctctggagga tctgcagctt actcataaca agatcacaaa gctgggctct tttgaaggat 780 tggtaaacct gaccttcatc catctccagc acaatcggct gaaagaggat gctgtttcag 840 ctgcttttaa aggtcttaaa tcactcgaat accttgactt gagcttcaat cagatagcca 900 gactgccttc tggtctccct gtctctcttc taactctcta cttagacaac aataagatca 960 gcaacatccc tgatgagtat ttcaagcgtt ttaatgcatt gcagtatctg cgtttatctcl020 acaacgaact ggctgatagt ggaatacctg gaaattcttt caatgtgtca tccctggttglOδO agctggatct gtcctataac aagcttaaaa acataccaac tgtcaatgaa aaccttgaaall40 actattacct ggaggtcaat caacttgaga agtttgacat aaagagcttc tgcaagatccl200 tggggccatt atcctactcc aagatcaagc atttgcgttt ggatggcaat cgcatctcagl260 aaaccagtct tccaccggat atgtatgaat gtctacgtgt tgctaacgaa gtcactcttal320 attaatatct gtatcctgga acaatatttt atggttatgt ttttctgtgt gtcagttttcl360 atagtatcca tattttatta ctgtttatta cttccatgaa ttttaaaatc tgagggaaatl440 gttttgtaaa catttatttt tttttaaagg aaaaggatcattgaatt gattcccccggga gattaaccacccgclatt

(2) INFORMATION ABOUT SEQ ID NO: 20: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 844 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN: (vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 20

acctgcagag gggtccatac ggcgttgttc tggattcccg tcgtaactta aagggaaatt 60 ttcacaatgt ccggagccct tgatgtcctg caaatgaagg aggaggatgt ccttaagttcl20 cttgcagcag gaacccactt aggtggcacc aatcttgact tccagatgga acagtacatcl80 tataaaagga aaagtgatgg catctatatc ataaatctca agaggacctg ggagaagctt240 ctgctggcag ctcgtgcaat tgttgccatt gaaaaccctg ctgatgtcag tgttatatcc300 tccaggaata ctggccagag ggctgtgctg aagtttgctg ctgccactgg agccactcca360 attgctggcc gcttcactcc tggaaccttc actaaccaga tccaggcagc cttccgggag420 ccacggcttc ttgtggttac tgaccccagg gctgaccacc agcctctcac ggaggcatct480 tatgttaacc tacctaccat tgcgctgtgt aacacagatt ctcctctgcg ctatgtggac540 attgcaatcc catgcaacaa caaggtaatg attttaggat ctagagtttg tgaatgcgtg600 ctctagaaaa aacattcctg tgcacattgt tagagcttgg agttgaggct actgactggc660 cgatgaactc gcaagtgtag gtagtgtgct acatgagggg caagttttcg ctaacaccac720 aagggtctct ggcccaatga gtggagtttg atagtaattc ttgctacaag tataacatta780 ctgcatgaca gctttgtgga gaaatgaaaa catttggaaa atagtgtgtt ctctgccttg640 TCCA 844

(2) INFORMATION ABOUT SEQ ID NO: 21:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 862 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: partial cDNA produced from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO (iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 21

gagcaagaga gaaggaggcc cagacagtga gggcaggagg gagagaagag acgcagaagg 60 agagcgagcg agagagaaag ggttctggat tgggggggag agcaagggag ggaggaaggcl20 ggtgagagag gcgggggcct cgggagggtg aaagggggga ggagaagggc ggggcacggal80 ggcccgagcg agggacaaga ctccgactcc agctctgact tttttcgcgg ctctcggctt240 ccactgcagc catgtcactc ctcttgctgg tggtctcagc ccttcacatc ctcattctta300 tactgctttt cgtggccact ttggacaagt cctggtggac tctccctggg aaagagtccc360 tgaatctctg gtacgactgc acgtggaaca acgacaccaa aacatgggcc tgcagtaatg420 tcagcgagaa tggctggctg aaggcggtgc aggtcctcat ggtgctctcc ctcattctct480 gctgtctctc cttcatcctg ttcatgttcc agctctacac catgcgacga ggaggtctct540 tctatgccac cggcctctgc cagctttgca ccagcgtggc ggtgtttact ggcgccttga600 tctatgccat tcacgccgag gagatcctgg agaagcaccc gcgagggggc agcttcggat660 actgcttcgc cctggcctgg gtggccttcc ccctcgccct ggtcagcggc atcatctaca720 tccacctacg gaagcgggag tgagcgcccc gcctcgctcg gctgcccccg ccccttcccg780 gcccccctcg ccgcgcgtcc tccaaaaaat aaaaccttaa ccgcggggaa aaaaaaaaaa840 aaaaaggaag gaaaaaaaaa aa 862

(2) INFORMATION ABOUT SEQ ID NO: 22:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 546 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 22

cccagccaag ggtccttcag gtaggaggtc ctgggtgact ttggaagtcc gtagtgtctc 60 attgcagata atttttagct tagggcctgg tggctaggtc ggttctctcc tttccagtcgl20 gagacctctg ccgcaaacat gctccgccag atcatcggtc aggccaagaa gcatccgagcl80 ttgatccccc tctttgtatt tattggaact ggagctactg gagcaacact gtatctcttg240 cgtctggcat tgttcaatcc agatgtttgt tgggacagaa ataacccaga gccctggaac300 aaactgggtc ccaatgatca atacaagttc tactcagtga atgtggatta cagcaagctg360 aagaaggaac gtccagattt ctaaatgaaa tgtttcacta taacgctgct ttagaatgaa420 ggtcttccag aagccacatc cgcacaattt tccacttaac caggaaatat ttctcctctt460 aaatgaatga aatcaatggt ggggggcgct attggaagcc ctattggggt tcaagtgttg540 aataaa 546

(2) INFORMATION ABOUT SEQ ID NO: 23:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1591 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing (iii) HYPOTHETICAL: NO (iii) ANTI-SENSE: NO (vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN: (A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 23

gccgaggagc cgagcccgcc acccccccgc ccgcccgccg ccgccatggg ctgcctcggg 60 aacagtaaga ccgaggacca gcgcaacgag gagaaggcgc aggtgaggcc aacaaaaaga 120 tcgagaagca gctgcagaag gacaagcagg tctaccgggc cacgcaccgc ctgctgctgc 180 tgggtgctgg agaatctggt aaaagcacca ttgtgaagca gatgaggatc ctgcatgtta 240 atgggtttaa tggagacagt gagaaggcaa ccaaagtgca ggacatcaaa aacaacctga 300 aagaggcgat tgaaaccatt gtggccgcca tgagcaacct ggtgcccccc gtggagctgg 360 ccaaccccga gaaccagttc agagtggact acattctgag tgtgatgaac gtgcctgact 420 ttgacttccc tcccgaattc tatgagcatg ccaaggctct gtgggaggat gaaggagtgc 480 gtgcctgcta cgaacgctcc aacgagtacc agctgattga ctgtgcccag tacttcctgg 540 acaagatcga cgtgatcaag caggctgact atgtgccgag cgatcaggac ctgcttcgct 600 gccgtgtcct gacttctgga atctttgaga ccaagttcca ggtggacaaa gtcaacttcc 660 acatgtttga cgtgggtggc cagcgcgatg aacgccgcaa gtggatccag tgcttcaacg 720 atgtgactgc catcatcttc gtggtggcca gcagcagcta caacatggtc atccgggagg 780 acaaccagac caaccgcctg caggaggctc tgaacctctt caagagcatc tggaacaaca 840 gatggctgcg caccatctct gtgatcctgt tcctcaacaa gcaagatctg ctcgctgaga 900 aagtccttgc tgggaaatcg aagattgagg actactttcc agaatttgct cgctacacta 960 ctcctgagga tgctactccc gagcccggag aggacccacg cgtgacccgg gccaagtactl020 tcattcgaga tgagtttctg aggatcagca ctgccagtgg agatgggcgt cactactgctlOδO accctcattt cacctgcgct gtggacactg agaacatccg ccgtgtgttc aacgactgccll40 gtgacatcat tcagcgcatg caccttcgtc agtacgagct gctctaagaa gggaacccccl200 aaatttaatt aaagccttaa gcacaattaa ttaaaagtga aacgtaattg tacaagcagtl260 taatcaccca ccatagggca tgattaacaa agcaaccttt cccttccccc gagtgattttl320 gcgaaacccc cttttccctt cagcttgctt agatgttcca aatttagaaa gcttaaggcgl380 gcctacagaa aaaggaaaaa aggccacaaa agttccctct cactttcagt aaaaataaatl440 aaaacagcag cagcaaacaa ataaaatgaa ataaaagaaa caaatgaaat aaatattgtgl500 ttgtgcagca ttaaaaaaaa tcaaaataaa aattaaatgt gagcaaagga aaaaaaaaaal560 ggcaaaaggg gaaagaagaa aagggggggg 1591 g

(2) INFORMATION ABOUT SEQ ID NO: 24:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 441 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO (vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN: (vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 24

ggcaggcaga tacgttcgtc agcttgctcc tttctgcccg tggacgccgc cgaagaagca 60 tcgttaaagt ctctcttcac cctgccgtca tgtctaagtc agagtctcct aaagagcccgl20 aacagctgag gaagctcttc attggagggt tgagctttga aacaactgat gagagcctgal80 ggagccattt tgagcaatgg ggaacgctca cggactgtgt ggtaatgaga gatccaaaca240 ccaagcgctc caggggcttt gggtttgtca catatgccac tgtggaggag gtggatgcag300 ctatgaatgc aaggccacac aaggtggatg gaagagttgt ggaaccaaag agagctgttt360 cagagaagat ttgaaaagcc aggtgccact tacctgtgaa aaggtatttg ttggtggatt420 aaggagcact tgagacatca c 441

(2) INFORMATION ABOUT SEQ ID NO: 25:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1131 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN: (A) ORGANISM: HUMAN

(C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 25

cgggaggtga aatccggttc taaccggtcc ggggctccca gcgctataaa aactttataa 60 accccccgga gcccgagcag tgtgaagaag aggcgagaac gacccccgga ccgaccaaag 120 cccgcgcgcc gctgcatccc gcgtccagca cctacgtccc gctgccgtcg ccgccgccac 180 catgcccaag agaaaggctg aaggggatgc taagggagat aaagcaaagg tgaaggacga 240 accacagaga agatccgcga ggttgtctgc taaacctgct cctccaaagc cagagcccaa 300 gcctaaaaag gcccctgcaa agaagggaga gaaggtaccc aaagggaaaa agggaaaagc 360 tgatgctggc aaggagggga ataaccctgc agaaaatgga gatgccaaaa cagaccaggc 420 acagaaagct gaaggtgctg gagatgccaa gtgaagtgtg tgcatttttg ataactgtgt 480 acttctggtg actgtacagt ttgaaatact attttttatc aagttttata aaaatgcaga 540 attttgtttt actttttttt tttttttaaa agctatgttg ttagcacaca gaacacttca 600 ttgttgtttt tgggggaagg ggcatatgtc actaatagaa tgtctccaaa gctggattga 660 tgtggagaaa acacctttcc cttctagttt tgagagactt cctcttggct cccaggagga 720 gggattccct gactttgaca cacatggcca ccttggcaca aaagccttgt ggtatagaaa 780 aacaaatttg tttttatgtc ctcttctccc tttccatctt tcagcataga cttaactccc 840 ttaagcccag acatctgttg agacctgacc cctagtcatt ggttaccagt gtgtcaggca 900 atctggactt tccagtgatg ccactgagat ggcacctgtc aaaagagcag tggttccatt 960 tctagattgt ggatcttcag ataaattctg ccattttcat ttcacttcct gaaagtcaggl020 gtcggcttgt gaaaagttgt taaacaacat gctaaatgtg aaatgtcaac cctcactctalOδO aaacttttcc crgggtcaga ggatccgatg gaggacttca attgggggtt t 1131

(2) INFORMATION ABOUT SEQ ID NO: 26:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 1071 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: Partial cDNA made from individual ESTs by assembly and editing. (iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN: (A) ORGANISM: HUMAN

(C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 26

gtaccctcaa agacagagac accaagaaga atcggaacat acaggctttg atatcaaagg 60 tttataaagc caatatctgg gaaagagaaa accgtgagac ttccagatct tctctggtga 120 agtgttgttt cctgcaacga tcacgaacat gaacatcaaa ggatcgccat ggaaagggtc 180 cctcctgctg crgctggtgt caaacctgct cctgtgccag agcgtggccc ccttgcccat 240 ctgtcccggc ggggctgccc gatgccaggt gacccttcga gacctgtttg accgcgccgt 300 cgtcctgtcc cactacatcc ataacctctc ctcagaaatg ttcagcgaat tcgataaacg 360 gtatacccat ggccgggggt tcattaccaa ggccatcaac agctgccaca cttcttccct 420 tgccaccccc gaagacaagg agcaagccca acagatgaat caaaaagact ttctgagcct 480 gatagtcagc atattgcgat cctggaatga gcctctgtat catctggtca cggaagtacg 540 tggtatgcaa gaagccccgg aggctatcct atccaaagct gtagagattg aggagcaaac 600 caaacggctt cragagggca tggagctgat agtcagccag gttcatcctg aaaccaaaga 660 aaatgagatc taccctgtct ggtcgggact tccatccctg cagatggctg atgaagagtc 720 tcgcctttct gcttattata acctgctcca ctgcctacgc agggattcac ataaaatcga 780 caattatctc aagctcctga agtgccgaat catccacaac aacaactgct aagcccacat 840 ccatttcatc tatttctgag aaggtcctta atgatccgtt ccattgcaag cttcttttag 900 ttgtatctct tttgaatcca tgcttgggtg taacaggtct cctcttaaaa aataaaaact 960 gactccttag agacatcaaa atctaaaaaaa acttaatggg ccggggggggg0c

(2) INFORMATION ABOUT SEQ ID NO: 27:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 896 base pairs (B) TYPE: nucleic acid

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 27

gtgaccggct cagaccggtt ctggagacaa aaggggccgc ggcggccgga gcgggacggg 60 cccggcgcgg gagggagcga agagcgcggg cagcgagcga gatgcagcac cgaggcttccl20 tcctcctcac cctcctcgcc ctgctggcgc tcacctccgc ggtcgccaaa aagaaagatalδO aggtgaagaa gggcggcccg gggagcgagt gcgctgagtg ggcctggggg ccctgcaccc240 ccagcagcaa ggattgcggc gtgggtttcc gcgagggcac ctgcggggcc cagacccagc300 gcatccggtg cagggtgccc tgcaactgga agaaggagtt tggagccgac tgcaagtaca360 agtttgagaa ctggggtgcg tgtgatgggg gcacaggcac caaagtccgc caaggcaccc420 tgaagaaggc gcgctacaat gctcagtgcc aggagaccat ccgcgtcacc aagccctgca480 cccccaagac caaagcaaag gccaaagcca agaaagggaa gggaaaggac tagacgccaa540 gcctggatgc caaggagccc ctggtgtcac atggggcctg gcccacgccc tccctctccc600 aggcccgaga tgtgacccac cagtgccttc tgtctgctcg ttagctttaa tcaatcatgc660 cctgccttgt ccctctcact ccccagcccc acccctaagt gcccaaagtg gggagggaca720 agggattctg ggaagcttga gcctccccca aagcaatgtg agtcccagag cccgcttttg780 ttcttcccca caattccatt actaagaaac acatcaaata aactgacttt ttccccccaa840 aaaaagctct tcttttttaa tataaaaaaa aaaaaaaaaa aaaaaaaaaa aagaaa 696

(2) INFORMATION ABOUT SEQ ID NO: 28:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1050 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: partial cDNA produced from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN: (vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 28

ttttcatttt tttttttttt tttttctcag ttcaagttta atacaaacta caaaagatta 60 atgggttgct ctactaatac atcatacaaa ccagtagcct gcccacaacg ccaactcagg 120 ccattcctac caaaggaaga aaggctggtc tctccacccc ctgtaggaaa ggcctgcctt 180 gtaagacacc acaattcggc tgaatctgaa gtcttgtgtt ttactaatgg aaaaaaaaaa 240 tacagaagag gttttgttct catggctgcc caccgcagcc tggcactaaa acagcccagc 300 gctcacttct gcttggagaa atattctttg ctcttttgga catcaggctt gatggtatca 360 ctgccaggtt tccagccagc tgggcacact tccccatgtt tgtcagtgaa ctggaaggcc 420 tgaactagtc tcaaagtctc atccacagag cggccaacag ggaggtcatt tacagtgatc 480 tgccgaagaa tacccttatc atcaatgata aaaaggcccc tgaacgagat gccttcatca 540 gcctttaaga ccccataatc ctgagcaatg gtgcgcttcg ggtctgatac caaaggaatg 600 ttcatgggtc ccagtcctcc ttgtttctta ggtgtattga cccatgctag atgacagaag 660 tgagaatcca cagaagcacc aatcacttgg cagttgagtt tcttaaattc ttctgcccta 720 tcactgaaag caatgatctc cgtggggcac acaaaggtga agtcaagagg gtaaaagaag 780 aacacaacat attttccttt gtagtcagac aggctgatat ctttaaactg accatctggc 840 ataacagctg tggctttgaa gttgggggca gggtgcccaa ttttagcatt tcctgaagac 900 atcttcctat cagcagtccc aacacaagtc gcagaaacta accaccgaca ccaggcaaga 960 acaagacgcg caagagctct ccggggcgct gcctttatag ccagtcgggggggcccccaggggggggcccccccgggggggcccccccgggggggcccccccgggggggcccccggggggggcccccccgggggggcccccgggggggccccccggggggc

(2) INFORMATION ABOUT SEQ ID NO: 29:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 581 base pairs (B) TYPE: nucleic acid

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN: (vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 29

caggcttcct tctggcaaca ggcgtgggtc acgctctcgc tcggtctttc tgccgccatc 60 ttggttccgc gttccctgca caaaatgccc ggcgaacacc agaaaccgtc cctgctacagl20 agcaggagtt gccgcagccc caggctgaga cagggtctgg aacagaatct gacagtgatglδO aatcagtacc agagcttgaa gaacaggatt ccacccaggc aaccacacaa caagcccagc240 tggcggcagc agctgaaatc gatgaagaac cagtcagtaa agcaaaacag agtcggagtg300 aaaagaaggc acggaaggct atgtccaaac tgggtcttcg gcaggttaca ggagttacta360 gagtcactat ccggaaatct aagaatatcc tctttgtcat cacaaaacca gttgtctaca420 agagccctgc ttcagatacg tacatagttt ttggggaagc cagatcgaag attatcccag480 caagcacaggggggtcggccggc40g

(2) INFORMATION ABOUT SEQ ID NO: 30:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 264 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: partial cDNA produced from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO (iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 30

gggactatgt tgtgagcctg cgaaagaagt ttgtgtgggg actgtgggca gtgaatgcgt 60 tgggaacaat atggaaaact gggagctgcc ctcagtttct ccccaagttg gactcactttl20 cggggtgtcc caaaagcctg attccagggc ctgctagccc gaccccggtg acgcctccaclδO ccgcgcctgg ccccagcctt cacccgcgat cgccgccctc cggggcacac cctccgccag240 aaaacagccg gcgggcggcg agac 264

(2) INFORMATION ABOUT SEQ ID NO: 31:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 111 base pairs

(B) TYPE: nucleic acid

(C) STRAND: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: partial cDNA produced from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO (iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN (C) ORGAN:

(vii) OTHER ORIGIN:

(A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 31

cggcgaatca cttataaatg gcgccgaagc aggagcccga aggctaaatt gcaggagggg 60 tgagcgaatg ctgtgctttc atgggcctct tacgttgatg aggcaaagta t 111

(2) INFORMATION ABOUT SEQ ID NO: 32:

(A) LENGTH: 76 amino acids (B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF

(iii) HYPOTHETICAL: yes

(vi) ORIGIN: (A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 32: PFCEETKTER LWPRCRPPAA VGFSTQNPGV GDSESNLFSL PFLGSKANPI PTHWSSALIF60 NLPSPPFQNT HIPFQN 76

(2) INFORMATION ABOUT SEQ ID NO: 33: (A) LENGTH: 72 amino acids

(B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF

(iii) HYPOTHETICAL: yes

(vi) ORIGIN:

(A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 33:

SSFLFSFQTQ FHKNRKDKVF SSRQAKPFPH HQSILKIHEE VERSVSGRLK GSSSSNPTAA60 EKIEIEILKI TS 72 (2) INFORMATION ABOUT SEQ ID NO: 34:

(A) LENGTH: 70 amino acids

(B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes

(vi) ORIGIN:

(A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 34:

KKLDYFCAEI KNSHCKTKIK lAQIRKPGGA KCQVSKVHFF SLSKRSSTKT ARIKFSVADK60 QSPFHIINQS 70

(2) INFORMATION ABOUT SEQ ID NO: 35:

(A) LENGTH: 60 amino acids (B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF

(iii) HYPOTHETICAL: yes

(vi) ORIGIN: (A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 35: SSGPAPGCSP FAGTRKNFPS MVVLERTFLK INYIFLCIPM EFQFIRCSPW PPQNTEVIPA60

(2) INFORMATION ABOUT SEQ ID NO: 36:

(A) LENGTH: 63 amino acids (B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes (vi) ORIGIN:

(A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 36:

ASGVHTETHR YNLLSAKSRK KGWGYLGWLG FDFLLVCLFC TKTVLS FEYR RDI S IYMLSN 60 QDG 63 (2) INFORMATION ABOUT SEQ ID NO: 37:

(A) LENGTH: 170 amino acids

(B) TYPE: protein

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes

(vi) ORIGIN:

(A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 37:

ARAARAAQTP HLTLPADLQT LHLNRPTLSP ESKLEWNNDI PEVNHLNSEH WRKTEKWTGH 60

EETNHLETDF SGDGMTELEL GPSPRLQPIR RHPKELPQYG GPGKDIFEDQ LYLPVHSDGI120 SVHQMFTMAT AEHRSNSSIA GKMLTKVEKN HEKEKSQHLE GSASSSLSSD 170

(2) INFORMATION ABOUT SEQ ID NO: 38:

(A) LENGTH: 144 amino acids (B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF

(iii) HYPOTHETICAL: yes

(vi) ORIGIN: (A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 38: ARAPTLDMRF RRRLSADPHA TQRNSAEARG TMDGRVQLMK ALLAGPLRPA ARRWRNPIPF 60 PETFDGDTDR LPEFIVQTCS YMFVDENTFS NDALKVTFLI TRLTGKESALVRGLWNKKALQRFGLWNKPALQRGLWNKKALQRFGLWNKKALQRFGLWNKKALQRFGLWNKKALQRFGLWNKKALQRFGLWGKKALQRFGLFGKDALQRFGLWGKKALQRFGLFGKDALQRFGWLLGKKALQRGFG

(2) INFORMATION ABOUT SEQ ID NO: 39: (A) LENGTH: 178 amino acids

(B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes

(vi) ORIGIN:

(A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 39:

HSLGRAPVET LAVATGTANS SQSTRPQARG SPGLEVLVLL PSKDSLHLGQ KAPVIIEQGA 60

LLPDVGDHPL QGWPREAGDE ERHLQGVVGE RVLVHEHVGA RLHDELRESV GISVKRLGKG120 NRVPPATRRG PEGPGQEGLH QLHPTVHRAA RLRGVSLGCV GVSAKASPEA HVEGGGPG 178

(2) INFORMATION ABOUT SEQ ID NO: 40:

(A) LENGTH: 89 amino acids (B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes

(vi) ORIGIN: (A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 40: KLTGINTGCR NMLALCIRGH AQQIQEIYLA TFSRKGTLGI IHYILEVFLG FFFFFLRQSC60 CIAQAGSVVA QSQLIASSIT QGLSNPPTL 89

(2) INFORMATION ABOUT SEQ ID NO: 41:

(A) LENGTH: 95 amino acids

(B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF

(iii) HYPOTHETICAL: yes (vi) ORIGIN:

(A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 41:

IVTWRKVPMS LCQRPPPFVR IGIFRLLKGL AHIRCDLFIP VVMEGHICQS LESAKAGTRF60 PGPQWGCANP RELGCKFVKN QHHVWQLSIG ARSLP 95

(2) INFORMATION ABOUT SEQ ID NO: 42:

(A) LENGTH: 154 amino acids

(B) TYPE: Protein (C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes

(vi) ORIGIN:

(A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 42:

CQLVFRIQTD GSYWSLGLTS SGNITFSWAE MLLPALKQHS VLKTSWQAPG SNTQLPNMML 60 ILHEFATQFS RVCTPPLWAG EPGPGLRRLQ ALADVALHNN GNEKVTPYVR QALKESEYPN120

PHKRRGTLAK THGNFPPSND LDRRATQDSP SCSV 154

(2) INFORMATION ABOUT SEQ ID NO: 43: (A) LENGTH: 79 amino acids

(B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: ORF

(iii) HYPOTHETICAL: yes

(vi) ORIGIN:

(A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 43:

LASTLGVETC LPYVSEDMLS RSKRYIWQLF LEKAHWVSFI TFLSFFGFFF FFFETVLLYC60 PGWSVVAQSQ LIASSITQA 79

(2) INFORMATION ABOUT SEQ ID NO: 44: (A) LENGTH: 82 amino acids

(B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes

(vi) ORIGIN:

(A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 44:

CQLVFRIQTD GSYWSLGLTS SGNITFSWAE MLLPALKQHS VLKTSWQAPG SNTQLPNMML60 ILHEFATSWL PRLQHSAVGT QS 62

(2) INFORMATION ABOUT SEQ ID NO: 45:

(A) LENGTH: 68 amino acids

(B) TYPE: Protein (C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes

(vi) ORIGIN:

(A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 45:

RGSKDRNSGQ GSGSYGQLSC RGFSDQFSRV CTPPLWAGEP GPGLRRLQAL ADVALHNNGN60 EKVTPYVR 68

(2) INFORMATION ABOUT SEQ ID NO: 46:

(A) LENGTH: 87 amino acids (B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes (vi) ORIGIN:

(A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 46:

DYVVSLRKKF VWGLWAVNAL GTIWKTGSCP QFLPKLDSLS GCPKSLIPGP ASPTPVTPPP60 APGPSLHPRS PPSGAHPPPE NSRRAAR 87 (2) INFORMATION ABOUT SEQ ID NO: 47:

(A) LENGTH: 51 amino acids

(B) TYPE: protein

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes

(vi) ORIGIN:

(A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 47:

QALESGFWDT PKVSPTWGET EGSSQFSILF PTHSLPTVPT QTSFAGSQHS P 51 (2) INFORMATION ABOUT SEQ ID NO: 48:

(A) LENGTH: 20 amino acids

(B) TYPE: protein

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes

(vi) ORIGIN:

(A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 48:

RRITYKWRRS RSPKAKLQEG 20 (2) INFORMATION ABOUT SEQ ID NO: 49:

(A) LENGTH: 36 amino acids

(B) TYPE: protein (C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes

(vi) ORIGIN: (A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 49: GESLINGAEA GARRLNCRRG ERMLCFHGPL TLMRQS 36

(2) INFORMATION ABOUT SEQ ID NO: 50:

(A) LENGTH: 26 amino acids (B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes

(vi) ORIGIN: (A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 50: KHSIRSPLLQ FSLRAPASAP FISDSP 26

(2) INFORMATION ABOUT SEQ ID NO: 51:

(A) LENGTH: 25 amino acids (B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF

(iii) HYPOTHETICAL: yes

(vi) ORIGIN: (A) ORGANISM: HUMAN (xi) SEQUENCE DESCRIPTION: SEQ ID NO 51:

EAHESTAFAH PSCNLAFGLL LRRHL 25 (2) INFORMATION ABOUT SEQ ID NO: 52:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3665 base pairs

(B) TYPE: nucleic acid (C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: partial cDNA made from individual ESTs by assembly and editing

(iii) HYPOTHETICAL: NO

(iii) ANTI-SENSE: NO

(vi) ORIGIN:

(A) ORGANISM: HUMAN

(C) ORGAN:

(vii) OTHER ORIGIN: (A) LIBRARY: cDNA library

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 52

GGCCATTTTG TGAAGAGACG AAGACTGAGC GGTTGTGGCC GCGTTGCCGA CCTCCAGCAG 60 CAGTCGGCTT CTCTACGCAG AACCCGGGAG TAGGAGACTC AGAAATCGAA TCTCTTCTCC 120

CTCCCCTTCT TGGGCAGCAA GGCGAACCCC ATCCCTACTC ACTGGAGCTC AGCTTTGATT 160

TTTAACCTCC CTTCCCCACC CTTCCAGAAC ACACACATTC CATTCCAAAA CTGATTTTAT 240

AAAGACATTT TAAACATAAT GATGCAACTT GGTGTGCACT ACAGCAAATG TACAGGTGTT 300

TTTTTTTTAA TTGTTTCCAA AACCGGGACC TGGATTTAAG ATGTAATTTT TAAAATTTCT 360 ATTTCTATTT TTTCTGCAGC AGTTGGGTTA GAGGAGGAGG AGCCTTTTAG CCTCTCATAA 420

ACTGACCTCT CTACTTCCTC GTGTATTTTT AAGATTGÄTT GATGATGTGG AAAGGGCTTT 480

GCTTGTCTGC TACTGAAAAC TTTATCCTGC GGTTTTTGTG GAAACTGCTT TTGGAAAGAG 540

AAAAGAAATG AACTTTACTG ACTTGACATT TTTGCACCTC CCGTTTTTCT AATCTGGGCT 600

ATTTTTATTT TTGTTTTTTT ACAGTGAGAT TTTTTTGATC TTCAGCTTAC ATTTTCGGGC 660 TTTGTGAGGA AACCTTTACC CATCAAACAC GATGGCCAGC AACGTTACCA ACAAGACAGA 720

TCCTCGCTCC ATGAACTCCC GTGTATTCAT TGGGAATCTC AACACTCTTG TGGTCAAGAA 780

ATCTGATGTG GAGGCAATCT TTTCGAAGTA TGGCAAAATT GTGGGCTGCT CTGTTCATAA 840

GGGCTTTGCC TTCGTTCAGT ATGTTAATGA GAGAAATGCC CGGGCTGCTG TAGCAGGAGA 900

GGATGGCAGA ATGATTGCTG GCCAGGTTTT AGATATTAAC CTGGCTGCAG AGCCAAAAGT 960 GAACCGAGGA AAAGCAGGTG TGAAACGATC TGCAGCGGAG ATGTACGGCT CCTCTTTTGA1020

CTTGGACTAT GACTTTCAAC GGGACTATTA TGATAGGATG TACAGTTACC CAGCACGTGT1080

ACCTCCTCCT CCTCCTATTG CTCGGGCTGT AGTGCCCTCG AAACGTCAGC GTGTATCAGG1140

AAACACTTCA CGAAGGGGCA AAAGTGGCTT CAATTCTAAG AGTGGACAGC GGGGATCTTC1200

CAAGTCTGGA AAGTTGAAAG GAGATGACCT TCAGGCCATT AAGAAGGAGC TGACCCAGAT1260 AAAACAAAAA GTGGATTCTC TCCTGGAAAA CCTGGAAAAA ATTGAAAAGG AACAGAGCAA1320

ACAAGCAGTA GAGATGAAGA ATGATAAGTC AGAAGAGGAG CAGAGCAGCA GCTCCGTGAA1360

GAAAGATGAG ACTAATGTGA AGATGGAGTC TGAGGGGGGT GCAGATGACT CTGCTGAGGA1440

GGGGGACCTA CTGGATGATG ATGATAATGA AGATCGGGGG GATGACCAGC TGGAGTTGAT1500

CAAGGATGAT GAAAAAGAGG CTGAGGAAGG AGAGGATGAC AGAGACAAGG CCAATGGCGA1560 GGATGACTCT TAAGCACATA GTGGGGTTTA GAAATCTTAT CCCATTATTT CTTTACCTAG1620

GCGCTTGTCT AAGATCAAAT TTTTCACCAG ATCCTCTCCC CTAGTATCTT CAGCACATGC1660

TCACTGTTCT CCCCATCCTT GTCCTTCCCA TGTTCATTAA TTCATATTGC CCCGCGCCTA1740 GTCCCATTTT CACTTCCTTT GACGCTCCTA GTAGTTTTGT TAAGTCTTAC CCTGTAATTT1800 TTGCTTTTAA TTTTGATACC TCTTTATGAC TTAACAATAA AAAGGATGTA TGGTTTTTAT1660 CAACTGTCTC CAAAATAATC TCTTGTTATG CAGGGAGTAC AGTTCTTTTC ATTCATACAT1920 AAGTTCAGTA GTTGCTTCCC TAACTGCAAA GGCAATCTCA TTTAGTTGÄG TAGCTCTTGA1980 AAGCAGCTTT GAGTTAGÄAG TATGTGTGTT ACACCCTCAC ATTAGTGTGC TGTGTGGGGC2040 AGTTCAACÄC AAATGTAACA ATGTATTTTT GTGAATGAGA GTTGGCATGT CAAATGCATC2100 CTCTAGAAAA ATAATTAGTG TTATAGTCTT AAGATTTGTT TTCTAAAGTT GATACTGTGG2160 GTTATTTTTG TGAACAGCCT GATGTTTGGG ACCTTTTTTC CTCAAAATAA ACAAGTCCTT2220 ATTAAACCAG GAATTTGGAG AAAAAAAAAA AAAAAAATTT TTTATTTTTG TATTTTATTA2280 TTGTTTACTT CAAACTTTGT TTTACAGCGT CCTCCACAAA ACCTCTAGAA TGCACTAGAT2340 ATATTTTTCT TGGAGTCATA ATCATGATGC ATACCAACAC AACACTACTC AAATTATATT2400 TCATTGAGAT GCATGTTGCA TTGAGGAGTC AACTTGACAT AGAGTGGAGA CTTTTTCAAA2460 ATGGCTTTTA CATCCTAATG AAAGTTTGGG AAGTATATCC TCTCTGCCTT TTCATCAGTG2520 CTTTGTGGTC CAGCTGGCAC CCTTTCTGAG GTTTGTGTTT TGTGCTAAAT GGTTTTGTCC2580 TTAAATAGGA GAGGCT CAAA AACATCAAGA TTTCAGGAAA ATGGCGACAC TGGCATAATG2640 GAACCCCCCT GCTTCTATTT TGTTCTTTTA ATTACTATTT ATAGCCCCAG TTACCTTCTG2700 AATTCTGAAG TGTATATACC TCCATGTTCC TGAAAACAAG AAAACTCTTA CTTCCTGATA2760 TTCCATAGAC TGCCTTCCCA GGTGATTGAG AACATAGAGA ATGTTACACA TTTATTTTAC2820 TCTAAATGAT CTTTTACCCC TGTTAGCTAA TCTTTGTGTT TTCCTCAACT TTATTAATTA2880 CAGTGATTGC ATTTTTAGCA TCCAGTTGTA AGATGAATAT ATTAAACAGC TACCAGTGTT2940 GGTGATACCT CATCCTTGAA AGGCTTAGTT CATTTGTGTT TTATACTTCA GTTTTTCCAG3000 CATAGCAGAA AATGCCGCTT ATAATTTTTG TGCACACAAA CCTTGGAATC CCCCTGTAAA3060 GTTGCTATGG TTTCATAGCA TGCGGCACTG GCCCCTTTTT CATCCCACTC ATTACAGGCA3120 AAACCCATGT CTTATTTATG AGGATTTTAT AGATCATTTT CTGTAACAGG TGACAAAAGC3180 AGAAAAGAAT GAAGAGGCTG AAGTATGAAC TACCCTTGGA GCCCATATAC ATGATATAGG3240 CAATTTCTTT TGTATGTTAA TTCAGTCAAA AATACTACCC ACTTGATGTT TTCTAATCTG3300 ATGTGAGCTC ATGTTACACA GACTTTTAGT AAGTAACCCG TGACTAGAAA ATAAACTGGA3360 TGCTTAGGAG AGAGTGTCAG ATGTATAAGA TGCTAATAAA ACCTGTTTAA TATTATTGTT3420 AGCTGTAAGT TTTTGGGAAA TACTGAACAA ATTA GTCCAC AATCAAGTGT CTACTTTTCC3480 CTTCACTGTA GGGCCTCTCC CTGCACAGAG CAGTCTGTTT AGCTGTGAAC ACCACAATCT3540 GCAGATGTTC AAGTCCCTTA CATAAAATGG CATAGTATTAA ATATGTAACC TATGCATATATA3600 CTCCTAAAT3600

(A) LENGTH: 301 amino acids

(B) TYPE: protein

(C) STRAND: single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes

(vi) ORIGIN:

(A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 53:

GNLYPSNTMA SNVTNKTDPR SMNSRVFIGN LNTLVVKKSD VEAIFSKYGK IVGCSVHKGF 60 AFVQYVNERN ARAAVAGEDG RMIAGQVLDI NLAAEPKVNR GKAGVKRSAA EMYGSSFDLD120 YDFQRDYYDR MYSYPARVPP PPPIARAVVP SKRQRVSGNT SRRGKSGFNS KSGQRGSSKS160 GKLKGDDLQÄ IKKELTQIKQ KVDSLLENLE KIEKEQSKQA VEMKNDKSEE EQSSSSVKKD240 ETNVKMESEG GADDSAEEGD LLDDDDNEDR GDDQLELIKD DEKEAEEGED DRDKANGEDD300 S 301 (2) INFORMATION ABOUT SEQ ID NO: 54:

(A) LENGTH: 1 12 amino acids

(B) TYPE: Protein (C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF

(iii) HYPOTHETICAL: yes

(vi) ORIGIN:

(A) ORGANISM: HUMAN:

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 54:

ESSSPLALSL SSSPSSASFS SSLINSSWSS PRSSLSSSSS RSPSSAESSA PPSDSIFTLV 60 SSFFTELLLC SSSDLSFFIS TACLLCSFSI FSRFSRREST FCFIWVSSFL MA 112

(2) INFORMATION ABOUT SEQ ID NO: 55:

(A) LENGTH: 107 amino acids (B) TYPE: protein

(C) STRAND: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: ORF (iii) HYPOTHETICAL: yes

(vi) ORIGIN: (A) ORGANISM: HUMAN

(xi) SEQUENCE DESCRIPTION: SEQ ID NO 55: TRNLEKKKKK NFLFLYFIIV YFKLCFTASS TKPLECTRYI FLGVIIMMHT NTTLLKLYFI 60 EMHVALRSQL DIEWRLFQNG FYILMKVWEV YPLCLFISAL WSSWHPF 107

Claims

claims 1. A nucleic acid sequence encoding a gene product or a part thereof, comprising a) a nucleic acid sequence selected from the group Seq ID No 14-18, 30, 31, 52. b) an allelic variation of the nucleic acid sequences mentioned under a) or c) a nucleic acid sequence which is complementary to the nucleic acid sequences mentioned under a) or b). 2. A nucleic acid sequence according to one of the sequences Seq ID Nos 14-18, 30, 31, 52 or a complementary or allelic variant thereof. 3. Nucleic acid sequence Seq. ID No. 1 to Seq. ID No. 31 and Seq.ID 52, characterized in that they are expressed in increased uterine fibroid tissue. BAC, PAC and cosmid clones containing functional genes and their chromosomal localization, according to the sequences Seq. ID. No. 1 to Seq. ID No. 31 and Seq. ID 52, for use as a vehicle for gene transfer. 5. A nucleic acid sequence according to claims 1 to 4, characterized in that it has a 90% homology to a human nucleic acid sequence. 6. A nucleic acid sequence according to claims 1 to 4, characterized in that it has a 95% homology to a human nucleic acid sequence. 7. A nucleic acid sequence comprising a part of the nucleic acid sequences mentioned in claims 1 to 6, in such a size that they hybridize with the sequences according to claims 1 to 6. 8. A nucleic acid sequence according to claims 1 to 7, characterized in that the size of the fragment has a length of at least 50 to 4500 bp. 9. A nucleic acid sequence according to claims 1 to 7, characterized in that the size of the fragment has a length of at least ^'50 to 4000 bp. 10. A nucleic acid sequence according to any one of claims 1 to 9, which encodes at least a partial sequence of a biologically active polypeptide. 1 1. An expression cassette comprising a nucleic acid fragment or a sequence according to any one of claims 1 to 9, together with at least one controil or regulatory sequence. 12. An expression cassette comprising a nucleic acid fragment or a sequence according to claim 1 1, wherein the control or regulatory sequence is a suitable promoter. 13. An expression cassette according to one of claims 1 1 and 12, characterized in that the DNA sequences on the cassette encode a fusion protein which comprises a known protein and a biologically active polypeptide fragment. 14. Use of the nucleic acid sequences according to claims 1 to 10 for the production of full-length genes. 15. A DNA fragment comprising a gene obtainable from the use according to claim 14. 16. Host cell containing, as a heterologous part of its expressible genetic information, a nucleic acid fragment according to one of claims 1 to 10. 17. Host cell according to claim 16, characterized in that it is a prokaryotic or eukaryotic cell system. 18. Host cell according to one of claims 16 or 17, characterized in that the prokaryotic cell system E. coli and the eukaryotic cell system is an animal, human or yeast cell system. 19. A method for producing a polypeptide or a fragment, characterized in that the host cells are cultivated according to claims 16 to 18. 20. An antibody which is directed against a polypeptide or a fragment which is derived from the nucleic acids of the sequences Seq. ID No. 1-31 and Seq.ID 52 is encoded ^' , which is obtainable according to claim 19. 21. An antibody according to claim 20, characterized in that it is monoclonal. 22. An antibody according to claim 20, characterized in that it is a phage display antibody. 23. partial polypeptide sequences, according to the sequences Seq. ID Nos. Seq. 32-51 and Seq. ID Nos. 53-55. 24. polypeptide partial sequences according to claim 23, with at least 80% homology to these sequences. 25. A polypeptide resulting from a phage display, which can bind to the polypeptide partial sequences according to claim 23. 26. polypeptide partial sequences according to claim 23, with at least 90% homology to these sequences. 27. Use of the partial polypeptide sequences according to the sequences Seq. ID No. 32 to 51 and Seq. ID Nos. 53-55, as tools for finding drugs against the uterine fibroid. 28. Use of the nucleic acid sequences according to the sequences Seq. ID No. 1- 31 and Seq ID No. 52 for the expression of polypeptides that can be used as tools for finding active substances against the uterine fibroid. 29. Use of the nucleic acid sequences Seq. ID No. 1-31 and and Seq ID No. 52 in sense or antisense form. 30. Use of the polypeptide partial sequences Seq. ID No. 32 to Seq. ID No. 51 and Seq. ID Nos. 53-55 as a drug in gene therapy for the treatment of Uterine fibroid. 31. Use of the polypeptide partial sequences Seq. ID No. 32 to Seq. ID No. 51 and Seq. ID Nos. 53-55, for the manufacture of a medicament for the treatment of uterine fibroids. 32. Medicament containing at least one polypeptide partial sequence Seq. ID No. 32 to Seq. ID No. 51 and Seq. ID Nos. 53-55. 33. A nucleic acid sequence according to claims 1 to 10, characterized in that it is a genomic sequence. 34. A nucleic acid sequence according to claims 1 to 10, characterized in that it is an mRNA sequence. 35. Genomic genes, their promoters, enhancers, silencers, exon structure, intron structure and their splice variants, obtainable from the cDNAs of the Sequences Seq. ID No. 1 to Seq. ID No. 31 and Seq. ID 52. 36. Use of the genomic genes according to claim 33, together with suitable regulatory elements. 37. Use according to claim 36, characterized in that the regulative element is a suitable promoter and / or enhancer. 38. A nucleic acid sequence according to claims 1 to 7, characterized in that the size of the fragment has a length of at least 300 to 3500 bp.