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WO1999053910A3 - Compositions pharmaceutiques contenant de l'acide folique, procedes et systemes d'administration correspondants - Google Patents

Compositions pharmaceutiques contenant de l'acide folique, procedes et systemes d'administration correspondants Download PDF

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Publication number
WO1999053910A3
WO1999053910A3 PCT/US1999/008429 US9908429W WO9953910A3 WO 1999053910 A3 WO1999053910 A3 WO 1999053910A3 US 9908429 W US9908429 W US 9908429W WO 9953910 A3 WO9953910 A3 WO 9953910A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical compositions
folic acid
delivery systems
containing pharmaceutical
related methods
Prior art date
Application number
PCT/US1999/008429
Other languages
English (en)
Other versions
WO1999053910A2 (fr
WO1999053910A8 (fr
Inventor
Michael E Kafrissen
Original Assignee
Ortho Mcneil Pharm Inc
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc, Us Health filed Critical Ortho Mcneil Pharm Inc
Priority to EP99917591A priority Critical patent/EP1071428A2/fr
Priority to JP2000544315A priority patent/JP2002512185A/ja
Priority to CA002329005A priority patent/CA2329005C/fr
Priority to AU35676/99A priority patent/AU3567699A/en
Publication of WO1999053910A2 publication Critical patent/WO1999053910A2/fr
Publication of WO1999053910A3 publication Critical patent/WO1999053910A3/fr
Publication of WO1999053910A8 publication Critical patent/WO1999053910A8/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des compositions pharmaceutiques contenant de l'acide folique et, soit un contraceptif oral, soit une composition de substitution hormonale. Elle concerne également des procédés servant à administrer l'acide folique au moyen de ces compositions pharmaceutiques. Elle concerne enfin un système d'administration de médicaments utile pour administrer ces compositions pharmaceutiques.
PCT/US1999/008429 1998-04-17 1999-04-16 Compositions pharmaceutiques contenant de l'acide folique, procedes et systemes d'administration correspondants WO1999053910A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99917591A EP1071428A2 (fr) 1998-04-17 1999-04-16 Compositions pharmaceutiques contenant de l'acide folique, procedes et systemes d'administration correspondants
JP2000544315A JP2002512185A (ja) 1998-04-17 1999-04-16 葉酸を含有する製薬学的組成物並びに関連する方法及び送達系
CA002329005A CA2329005C (fr) 1998-04-17 1999-04-16 Compositions pharmaceutiques contenant de l'acide folique, procedes et systemes d'administration correspondants
AU35676/99A AU3567699A (en) 1998-04-17 1999-04-16 Folic acid-containing pharmaceutical compositions, and related methods and delivery systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8206898P 1998-04-17 1998-04-17
US60/082,068 1998-04-17

Publications (3)

Publication Number Publication Date
WO1999053910A2 WO1999053910A2 (fr) 1999-10-28
WO1999053910A3 true WO1999053910A3 (fr) 1999-12-29
WO1999053910A8 WO1999053910A8 (fr) 2001-07-05

Family

ID=22168860

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/008429 WO1999053910A2 (fr) 1998-04-17 1999-04-16 Compositions pharmaceutiques contenant de l'acide folique, procedes et systemes d'administration correspondants

Country Status (8)

Country Link
US (1) US6190693B1 (fr)
EP (2) EP2002839A1 (fr)
JP (3) JP2002512185A (fr)
CN (2) CN1240387C (fr)
AU (4) AU3567699A (fr)
CA (2) CA2522761C (fr)
TR (1) TR200002995T2 (fr)
WO (1) WO1999053910A2 (fr)

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US20060281723A1 (en) * 1999-04-16 2006-12-14 Kafrissen Michael E Folic acid-containing pharmaceutical compositions, and related methods and delivery systems
US7297688B2 (en) 2000-06-08 2007-11-20 Wyeth Starter kit for low dose oral contraceptives
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US20040092494A9 (en) * 2000-08-30 2004-05-13 Dudley Robert E. Method of increasing testosterone and related steroid concentrations in women
US20040002482A1 (en) * 2000-08-30 2004-01-01 Dudley Robert E. Androgen pharmaceutical composition and method for treating depression
BRPI0116793B8 (pt) * 2000-12-14 2021-05-25 Johnson & Johnson produtos de hormônio de esteróide e métodos para prepará-los
CN1599606A (zh) 2001-07-31 2005-03-23 辉瑞产品公司 包含雌激素激动剂/拮抗剂、雌激素与孕激素组合的药物组合物、试剂盒和方法
US6911438B2 (en) * 2001-09-12 2005-06-28 Jonathan V. Wright Hormone replacement formulation
AU2002343249B2 (en) * 2002-02-21 2009-02-05 Bayer Schering Pharma Aktiengesellschaft Pharmaceutical compositions comprising one or more steroids one or more tetrahydrofolate components and vitamin B12
US20040024065A1 (en) * 2002-03-11 2004-02-05 Watkins Steven M. Novel metabolic targets and markers
CA2496618A1 (fr) * 2002-05-23 2003-12-04 Michael Holick Utilisation d'analogues peptidiques d'hormone parathyroide pour le traitement de l'atrophie vaginale
US20040162292A1 (en) * 2002-12-03 2004-08-19 Evenstad Kenneth L. Multivitamin formulations for promoting healthy collagen, and methods of their use
DE102004026679A1 (de) * 2004-05-28 2005-12-15 Grünenthal GmbH Hormonales Kontrazeptivum enthaltend eine Kombination aus Ethinylestradiol und Chlormadinonacetat
DE102004026669A1 (de) * 2004-05-28 2005-12-15 Grünenthal GmbH Verwendung einer Kombination aus Ethinylestradiol und Chlormadinonacetat zur Herstellung eines Arzneimittels
EP2263659A1 (fr) 2004-05-28 2010-12-22 Grünenthal GmbH Contraceptive comprenant de l'acide folique
DE102004026671A1 (de) * 2004-05-28 2005-12-15 Grünenthal GmbH Darreichungsform zur hormonalen Kontrazeption
DE102004026670A1 (de) * 2004-05-28 2005-12-15 Grünenthal GmbH Hormonales Kontrazeptivum enthaltend eine Kombination aus Ethinylestradiol und Chlormadinonacetat
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AU2012227235B2 (en) * 2005-05-13 2015-06-11 Bayer Intellectual Property Gmbh Pharmaceutical composition comprising progestogens and/or estrogens and 5-methyl-(6S)-tetrahydrofolate
DE102005034498A1 (de) * 2005-07-20 2007-01-25 Grünenthal GmbH Orale Kontrazeption mit Trimegeston
US8202546B2 (en) * 2005-08-04 2012-06-19 Vertical Pharmaceuticals, Inc. Nutritional supplement for use under physiologically stressful conditions
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US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
US20080039485A1 (en) * 2006-08-08 2008-02-14 Targetgen Biotechnology Co., Ltd. Low-dose-long-term pharmaceutical composition comprising camptothecin derivatives for the treatment of cancers
WO2009098279A1 (fr) * 2008-02-06 2009-08-13 Universiteit Antwerpen Effet protecteur de doses élevées de folate sur l'ischémie du myocarde
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GB2131292A (en) * 1982-12-01 1984-06-20 Dr Christopher H Mortimer Progestational pharmaceutical formulations
WO1988004927A1 (fr) * 1986-12-31 1988-07-14 Davirand, Inc. COMPOSITIONS ET FORMULATIONS CONTENANT DE l'ACIDE FOLIQUE ET MODE D'UTILISATION ET PROCEDE DE PREPARATION DE CELLES-CI
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Publication number Priority date Publication date Assignee Title
GB2131292A (en) * 1982-12-01 1984-06-20 Dr Christopher H Mortimer Progestational pharmaceutical formulations
WO1988004927A1 (fr) * 1986-12-31 1988-07-14 Davirand, Inc. COMPOSITIONS ET FORMULATIONS CONTENANT DE l'ACIDE FOLIQUE ET MODE D'UTILISATION ET PROCEDE DE PREPARATION DE CELLES-CI
WO1998004248A1 (fr) * 1996-07-30 1998-02-05 Energetics, Inc. Complements alimentaires

Non-Patent Citations (3)

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Title
BUTTERWORTH ET AL: "Improvement in Cervical Dysplasia Associated with Folic Acid Therapy in Users of Oral Contraceptives", AM. J. CLIN. NUTR., vol. 35, no. 1, 1982, pages 73 - 82, XP002114785 *
RHODE ET AL: "Effect of Orange Juice, Folic acid, and Oral Contraceptives on Serum Folate in Women taking a Folate-Restricted Diet", J. AM. COLL. NUTR., vol. 2, no. 3, 1983, pages 221 - 230, XP002114784 *
WHITEHEAD ET AL: "Megaloblastic Changes in the Cervical Epithelium. Association with Oral Contraceptive Therapy and Reversal with Folic acid", J. AMER. MED. ASS., vol. 226, no. 12, 1973, pages 1421 - 1424, XP002114786 *

Also Published As

Publication number Publication date
AU2009238379A1 (en) 2009-12-17
CA2522761A1 (fr) 1999-10-28
US6190693B1 (en) 2001-02-20
CA2329005C (fr) 2006-01-03
AU2003262426A1 (en) 2003-12-11
EP2002839A1 (fr) 2008-12-17
WO1999053910A2 (fr) 1999-10-28
EP1071428A2 (fr) 2001-01-31
AU3567699A (en) 1999-11-08
CA2329005A1 (fr) 1999-10-28
CN1240387C (zh) 2006-02-08
AU2003262426A8 (en) 2003-12-11
CA2522761C (fr) 2010-07-06
JP2002512185A (ja) 2002-04-23
AU2009238379B2 (en) 2013-01-10
JP2009298796A (ja) 2009-12-24
CN1644201A (zh) 2005-07-27
AU2003262426B2 (en) 2006-09-28
JP2009298797A (ja) 2009-12-24
AU2006213981A1 (en) 2006-10-19
CN1300218A (zh) 2001-06-20
TR200002995T2 (tr) 2001-01-22
WO1999053910A8 (fr) 2001-07-05

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