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WO1999053945A8 - Molecules inhibant la croissance neuronale ou leurs derives utilises pour immuniser des mammiferes et ainsi favoriser la regeneration de l'axone - Google Patents

Molecules inhibant la croissance neuronale ou leurs derives utilises pour immuniser des mammiferes et ainsi favoriser la regeneration de l'axone

Info

Publication number
WO1999053945A8
WO1999053945A8 PCT/CA1999/000304 CA9900304W WO9953945A8 WO 1999053945 A8 WO1999053945 A8 WO 1999053945A8 CA 9900304 W CA9900304 W CA 9900304W WO 9953945 A8 WO9953945 A8 WO 9953945A8
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
growth inhibitory
axon regeneration
derivatives
neuron growth
Prior art date
Application number
PCT/CA1999/000304
Other languages
English (en)
Other versions
WO1999053945A1 (fr
Inventor
Samuel David
Lisa Joan Mckerracher
Peter Erich Braun
Original Assignee
Samuel David
Lisa Joan Mckerracher
Peter Erich Braun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samuel David, Lisa Joan Mckerracher, Peter Erich Braun filed Critical Samuel David
Priority to AU31347/99A priority Critical patent/AU3134799A/en
Publication of WO1999053945A1 publication Critical patent/WO1999053945A1/fr
Publication of WO1999053945A8 publication Critical patent/WO1999053945A8/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des compositions comprenant des agents immunogènes possédant des propriétés d'inhibition de croissance de neurones, ces compositions entraînant la génération d'anticorps polyréactifs se liant à des inhibiteurs de croissance de l'axone, ce qui favorise la régénération de l'axone. Ces agents comprennent de la glycoprotéine associée à la myéline (MAG), ainsi que des protéines arrétine ou protéoglycane. On peut utiliser ces compositions pour restaurer des transmissions nerveuses, notamment une fonction motrice et sensorielle après des lésions de la moelle épinière ou des lésions du nerf optique. On peut également les utiliser pour traiter des affections impliquant des lésions de l'axone telles qu'une sclérose en plaques et un accident vasculaire cérébral. On peut enfin utiliser les compositions selon l'invention comme vaccins prophylactiques avant que ne survienne une maladie ou une lésion du système nerveux central.
PCT/CA1999/000304 1998-04-16 1999-04-16 Molecules inhibant la croissance neuronale ou leurs derives utilises pour immuniser des mammiferes et ainsi favoriser la regeneration de l'axone WO1999053945A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU31347/99A AU3134799A (en) 1998-04-16 1999-04-16 Nevron growth inhibitory molecules or derivatives thereof used to immunize mammals thereby promoting axon regeneration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA2,234,921 1998-04-16
CA2234921 1998-04-16

Publications (2)

Publication Number Publication Date
WO1999053945A1 WO1999053945A1 (fr) 1999-10-28
WO1999053945A8 true WO1999053945A8 (fr) 2000-03-02

Family

ID=4162334

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1999/000304 WO1999053945A1 (fr) 1998-04-16 1999-04-16 Molecules inhibant la croissance neuronale ou leurs derives utilises pour immuniser des mammiferes et ainsi favoriser la regeneration de l'axone

Country Status (2)

Country Link
AU (1) AU3134799A (fr)
WO (1) WO1999053945A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020072493A1 (en) 1998-05-19 2002-06-13 Yeda Research And Development Co. Ltd. Activated T cells, nervous system-specific antigens and their uses
EP1080110A2 (fr) * 1998-05-19 2001-03-07 Yeda Research And Development Co. Ltd. Lymphocytes t actives, antigenes specifiques du systeme nerveux et leur utilisation
EP1248803B1 (fr) 2000-01-12 2010-05-05 Yale University Blocage de la croissance axonale a mediation assuree par le recepteur de nogo
AUPQ614200A0 (en) * 2000-03-10 2000-03-30 Department Of Human Physiology, Flinders University School Of Medicine Method for treating chronic spinal cord injury
GB0103174D0 (en) * 2001-02-08 2001-03-28 Smithkline Beecham Plc Novel method of treatment
AR040778A1 (es) * 2002-08-06 2005-04-20 Glaxo Group Ltd Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina).
GB0306309D0 (en) * 2003-03-19 2003-04-23 Glaxo Group Ltd Method of treatment
JP2009502138A (ja) 2005-07-21 2009-01-29 アルナイラム ファーマシューティカルズ インコーポレイテッド ＲｈｏＡ遺伝子のＲＮＡｉ調節及びその使用法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB191326535A (en) * 1913-11-19 1914-04-23 Charles Jules Henri Nicolle Improvements in and relating to Vaccines, Cultures and the like and the Preparation thereof.
GB9403250D0 (en) * 1994-02-21 1994-04-13 Univ Mcgill Therapeutic use of myelin-associated glycoprotein (mag)
US5962434A (en) * 1995-08-25 1999-10-05 The Johns Hopkins University School Of Medicine Compounds for stimulating nerve growth
CA2190418A1 (fr) * 1996-11-15 1998-05-15 Zhi-Cheng Xiao Systeme regulateur pour la croissance des neurones et des tumeurs neuronales; anticorps utilises a cette fin et applications

Also Published As

Publication number Publication date
AU3134799A (en) 1999-11-08
WO1999053945A1 (fr) 1999-10-28

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