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WO1999049043A3 - Human rad17 cell cycle checkpoint - Google Patents

Human rad17 cell cycle checkpoint Download PDF

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Publication number
WO1999049043A3
WO1999049043A3 PCT/US1999/006782 US9906782W WO9949043A3 WO 1999049043 A3 WO1999049043 A3 WO 1999049043A3 US 9906782 W US9906782 W US 9906782W WO 9949043 A3 WO9949043 A3 WO 9949043A3
Authority
WO
WIPO (PCT)
Prior art keywords
rad17
polypeptides
polynucleotides
human
cell cycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/006782
Other languages
French (fr)
Other versions
WO1999049043A2 (en
Inventor
Antony Michael Carr
Daniel R Herendeen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Icos Corp
Original Assignee
Medical Research Council
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Research Council, Icos Corp filed Critical Medical Research Council
Priority to AU33683/99A priority Critical patent/AU3368399A/en
Publication of WO1999049043A2 publication Critical patent/WO1999049043A2/en
Publication of WO1999049043A3 publication Critical patent/WO1999049043A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed are novel checkpoint polynucleotides encoding polypeptides designated rad17, polypeptides encoded by the polynucleotides, expression constructs comprising the polynucleotides, host cells transformed or transfected with the polynucleotides, methods for producing the polypeptides, antibodies immunospecific for the polypeptides, methods to identify binding partners of the polypeptides, and methods to screen for modulators of rad17 biological activity.
PCT/US1999/006782 1998-03-27 1999-03-29 Human rad17 cell cycle checkpoint Ceased WO1999049043A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33683/99A AU3368399A (en) 1998-03-27 1999-03-29 Human rad17 cell cycle checkpoint

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4976098A 1998-03-27 1998-03-27
US09/049,760 1998-03-27

Publications (2)

Publication Number Publication Date
WO1999049043A2 WO1999049043A2 (en) 1999-09-30
WO1999049043A3 true WO1999049043A3 (en) 2000-03-02

Family

ID=21961571

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/006782 Ceased WO1999049043A2 (en) 1998-03-27 1999-03-29 Human rad17 cell cycle checkpoint

Country Status (2)

Country Link
AU (1) AU3368399A (en)
WO (1) WO1999049043A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674996A (en) * 1992-05-12 1997-10-07 University Of Washington Cell cycle checkpoint genes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674996A (en) * 1992-05-12 1997-10-07 University Of Washington Cell cycle checkpoint genes

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
A.E. PARKER ET AL.: "Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 29, 17 July 1998 (1998-07-17), pages 18340 - 18346, XP002125927 *
A.G. PAULOVICH ET AL.: "RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage.", GENETICS, vol. 145, no. 1, January 1997 (1997-01-01), pages 45 - 62, XP002125935 *
CIMPRICH K A ET AL: "CDNA CLONING AND GENE MAPPING OF A CONDIDATE HUMAN CELL CYCLE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 93, pages 2850-2855, XP002023632, ISSN: 0027-8424 *
D. LYDALL ET AL.: "G2/M checkpoint genes of Saccharomyces cerevisiae: further evidence for roles in DNA replication and/or repair.", MOLECULAR & GENERAL GENETICS, vol. 256, no. 6, November 1997 (1997-11-01), pages 638 - 651, XP002125932 *
D.J.F. GRIFFITHS ET AL.: "Fission yeast rad17: a homolgue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins.", THE EMBO JOURNAL, vol. 14, no. 23, 1995, pages 5812 - 5823, XP002125934 *
F.B. DEAN ET AL.: "cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1 and hus1 and cloning of homologs from mouse, Caenorhabditis elegans and Drosophilia melanogaster.", GENOMICS, vol. 54, no. 3, 15 December 1998 (1998-12-15), pages 424 - 436, XP002125929 *
H.A.R. BLUYSSEN ET AL.: "Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene.", GENOMICS, vol. 55, no. 2, 15 January 1999 (1999-01-15), pages 219 - 228, XP002125928 *
L. LI ET AL.: "hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation.", ONCOGENE, vol. 18, no. 9, 4 March 1999 (1999-03-04), pages 1689 - 1699, XP002125931 *
W. SIEDE ET AL.: "Cloning and characterization of RAD17, a gene controlling cell cycle responses to DNA damage in Saccharomyces cerevisiae.", NUCLEIC ACIDS RESEARCH, vol. 24, no. 8, 1996, pages 1669 - 1675, XP002125933 *

Also Published As

Publication number Publication date
WO1999049043A2 (en) 1999-09-30
AU3368399A (en) 1999-10-18

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