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WO1999044622A1 - Composition topique antivirale faite d'une combinaison de nitrite non organique et d'un acide organique - Google Patents

Composition topique antivirale faite d'une combinaison de nitrite non organique et d'un acide organique Download PDF

Info

Publication number
WO1999044622A1
WO1999044622A1 PCT/GB1999/000605 GB9900605W WO9944622A1 WO 1999044622 A1 WO1999044622 A1 WO 1999044622A1 GB 9900605 W GB9900605 W GB 9900605W WO 9944622 A1 WO9944622 A1 WO 9944622A1
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutically acceptable
concentration
acid
use according
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1999/000605
Other languages
English (en)
Inventor
Anthony Ormerod
Nigel Benjamin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Aberdeen
Original Assignee
University of Aberdeen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HU0101374A priority Critical patent/HUP0101374A3/hu
Priority to JP2000534223A priority patent/JP2002505295A/ja
Priority to KR1020007009698A priority patent/KR20010041527A/ko
Priority to NZ506678A priority patent/NZ506678A/xx
Priority to AU32617/99A priority patent/AU758264B2/en
Priority to PL99342755A priority patent/PL342755A1/xx
Priority to BR9908617-4A priority patent/BR9908617A/pt
Priority to EP99937878A priority patent/EP1059928A1/fr
Priority to CA002322199A priority patent/CA2322199A1/fr
Priority to MXPA00008583A priority patent/MXPA00008583A/es
Application filed by University of Aberdeen filed Critical University of Aberdeen
Priority to US09/330,654 priority patent/US6709681B2/en
Publication of WO1999044622A1 publication Critical patent/WO1999044622A1/fr
Priority to NO20004302A priority patent/NO20004302L/no
Anticipated expiration legal-status Critical
Priority to US10/701,295 priority patent/US20040105898A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Definitions

  • the present invention relates to a complex of nitrogen oxides, arising from the interaction of nitrite and acid as an 5 antiviral composition for the treatment of viral diseases of the skin by topical application thereto.
  • nitrogen oxide include particular NO which is of the importance particularly if acidified.
  • US-A-5648101 provides a vaso-active composition comprising NO adapted for delivery to a body site inter alia by means of a 5 cream or ointment.
  • the NO is generated from an admixture of ferrous sulphate, an organic acid and an inorganic nitrite and caused to be reactive in the presence of moisture adjacent or at the site. Acidification is not discussed.
  • Another object of the invention is to provide a system for treatment of viral skin diseases which is less susceptible to mutation of viral DNA.
  • the pharmaceutically acceptable acidifying agent or the pharmaceutically acceptable donor of nitrogen oxides or a precursor therefor is disposed in a pharmaceutically acceptable carrier or diluent therefor.
  • the first and second waxy components comprise a paraffin.
  • the acidifying agent is preferably a reducing organic acid or salt such as ascorbic acid or ascorbyl palmitate.
  • the source of nitrogen oxides may be an alkali metal nitrite such as sodium nitrite.
  • a reducing acid or salt thereof results in a product at the environment of use which comprises a major amount of NO which has significant and therapeutic and immunological effects .
  • the antigen processing cells of the skin were seen to lose dendricity and drop from the epidermis so there were significantly fewer in the treated skin. As these cells behave in this way when activated and functioning to process a newly recognized antigen, this would seem to offer further evidence for an immunopotentiating role for the nitrogen oxide complex. Ki-67 staining for dividing cells did not differ in control or active sites. This would suggest that in warts, for example, the action is not one of reducing cell proliferation. - 20 -

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne une formulation à usage local destinée à la fabrication d'un médicament à usage local permettant de stimuler le système immunitaire in vivo lors d'une infection virale cutanée provoquée par la reproduction d'un virus sur l'épiderme. Ladite formulation à usage local comprend une source d'oxydes d'azote, caractérisée en ce qu'elle est formée par la mise en contact étroit, sur un site d'action biologique, d'un agent acidifiant pharmaceutiquement acceptable et d'un donneur d'oxydes d'azote pharmaceutiquement acceptable ou d'un précurseur de celui-ci. L'invention concerne également des systèmes d'administration du médicament à usage local.
PCT/GB1999/000605 1994-02-21 1999-03-01 Composition topique antivirale faite d'une combinaison de nitrite non organique et d'un acide organique Ceased WO1999044622A1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CA002322199A CA2322199A1 (fr) 1998-03-02 1999-03-01 Composition topique antivirale faite d'une combinaison de nitrite non organique et d'un acide organique
KR1020007009698A KR20010041527A (ko) 1998-03-02 1999-03-01 국소적 항바이러스성 조성물로서 무기 아질산염 및유기산의 조성
NZ506678A NZ506678A (en) 1998-03-02 1999-03-01 Inorganic nitrite and organic acid in combination as topical antiviral composition
AU32617/99A AU758264B2 (en) 1998-03-02 1999-03-01 Inorganic nitrite and organic acid in combination as topical antiviral composition
PL99342755A PL342755A1 (en) 1998-03-02 1999-03-01 Inorganic nitrite and organic acid containing compositions as alocally acting antiviral preparations
BR9908617-4A BR9908617A (pt) 1998-03-02 1999-03-01 Nitroto inorgânico e ácido orgânico em combinação como uma composição antiviral tópica.
EP99937878A EP1059928A1 (fr) 1998-03-02 1999-03-01 Composition topique antivirale faite d'une combinaison de nitrite non organique et d'un acide organique
HU0101374A HUP0101374A3 (en) 1998-03-02 1999-03-01 Inorganic nitrite and organic acid in combination as topical antiviral composition
JP2000534223A JP2002505295A (ja) 1998-03-02 1999-03-01 局所抗ウイルス組成物として組み合わせた無機亜硝酸塩及び有機酸
MXPA00008583A MXPA00008583A (es) 1998-03-02 1999-03-01 Nitrito inorganico y acido organico en combinacion como una composicion antiviral topica.
US09/330,654 US6709681B2 (en) 1995-02-17 1999-06-11 Acidified nitrite as an antimicrobial agent
NO20004302A NO20004302L (no) 1998-03-02 2000-08-29 Kombinasjon av uorganisk nitritt og organisk syre som topisk antiviral sammensetning
US10/701,295 US20040105898A1 (en) 1994-02-21 2003-11-03 Acidified nitrite as an antimicrobial agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9804469.6 1998-03-02
GBGB9804469.6A GB9804469D0 (en) 1998-03-02 1998-03-02 Antiviral composition

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/GB1995/000338 Continuation-In-Part WO1995022335A1 (fr) 1994-02-21 1995-02-17 Nitrite acidifie en tant qu'agent antimicrobien
US69693096A Continuation-In-Part 1994-02-21 1996-08-21

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/330,654 Continuation-In-Part US6709681B2 (en) 1994-02-21 1999-06-11 Acidified nitrite as an antimicrobial agent
US09/330,654 Continuation US6709681B2 (en) 1994-02-21 1999-06-11 Acidified nitrite as an antimicrobial agent

Publications (1)

Publication Number Publication Date
WO1999044622A1 true WO1999044622A1 (fr) 1999-09-10

Family

ID=10827886

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/000605 Ceased WO1999044622A1 (fr) 1994-02-21 1999-03-01 Composition topique antivirale faite d'une combinaison de nitrite non organique et d'un acide organique

Country Status (14)

Country Link
EP (1) EP1059928A1 (fr)
JP (1) JP2002505295A (fr)
KR (1) KR20010041527A (fr)
CN (1) CN1270725C (fr)
AU (1) AU758264B2 (fr)
BR (1) BR9908617A (fr)
CA (1) CA2322199A1 (fr)
GB (1) GB9804469D0 (fr)
HU (1) HUP0101374A3 (fr)
MX (1) MXPA00008583A (fr)
NO (1) NO20004302L (fr)
NZ (1) NZ506678A (fr)
PL (1) PL342755A1 (fr)
WO (1) WO1999044622A1 (fr)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003013489A1 (fr) * 2001-08-03 2003-02-20 Aberdeen University Traitement des infections d'ongles avec de l'oxyde d'azote
WO2002017881A3 (fr) * 2000-08-30 2003-04-17 Queen Mary & Westfield College Composition d'administration transdermique d'agent pharmaceutique
US8557300B2 (en) 2005-05-19 2013-10-15 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite
WO2014031491A3 (fr) * 2012-08-23 2014-05-30 Nioxx Llc Production prolongée d'oxyde nitrique à partir de réactifs chimiques microencapsulés
US8795649B2 (en) 2007-02-28 2014-08-05 Invasive Animals Ltd. Nitrite salts as poisons in baits for omnivores
US8927030B2 (en) 2003-07-09 2015-01-06 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions
US8932650B2 (en) * 2011-01-11 2015-01-13 Kantian Skincare LLC Multifunctional topical formulation for the treatment of acne vulgaris and other skin conditions
EP3158990A1 (fr) 2015-10-21 2017-04-26 Glano Tech Ltd Formulation pour la libération d'oxyde nitrique
EP3166593A4 (fr) * 2014-07-11 2018-02-07 Novan, Inc. Compositions antivirales topiques et méthodes d'utilisation de celles-ci
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
US10716805B2 (en) 2018-03-19 2020-07-21 Glanotech Limited Formulation for release of nitric oxide
WO2020245573A1 (fr) 2019-06-04 2020-12-10 Thirty Holdings Limited Méthodes et compositions pour générer de l'oxyde nitrique et utilisations associées
WO2020245574A1 (fr) 2019-06-04 2020-12-10 Thirty Respiratory Limited Procédés et compositions pour générer de l'oxyde nitrique et leurs utilisations pour administrer de l'oxyde nitrique par l'intermédiaire des voies respiratoires
US11077194B2 (en) 2012-03-14 2021-08-03 Novan, Inc. Nitric oxide releasing pharmaceutical compositions
WO2021214440A1 (fr) 2020-04-23 2021-10-28 Thirty Respiratory Limited Oxyde nitrique ou compositions libérant de l'oxyde nitrique destinés à être utilisés dans le traitement du sars-cov et du sars-cov-2
WO2021214439A1 (fr) 2020-04-23 2021-10-28 Thirty Respiratory Limited Procédés et compositions pour le traitement et la lutte contre la tuberculose
US11285098B2 (en) 2013-02-28 2022-03-29 Novan, Inc. Topical compositions and methods of using the same
US11285171B2 (en) 2018-03-01 2022-03-29 Novan, Inc. Nitric oxide releasing suppositories and methods of use thereof
US11813284B2 (en) 2013-08-08 2023-11-14 Novan, Inc. Topical compositions and methods of using the same

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201330871A (zh) * 2011-12-05 2013-08-01 Nioxx Taiwan Biotechnology Inc 局部產生一氧化氮的組合物和方法
CN109437134A (zh) * 2018-10-26 2019-03-08 中国核电工程有限公司 氮氧化物的制备方法及装置
CN116617254A (zh) * 2022-09-26 2023-08-22 杭州泽德医药科技有限公司 含硼酸、亚硝酸盐的抗病原微生物组合物及应用

Citations (3)

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Publication number Priority date Publication date Assignee Title
US4923899A (en) * 1987-12-22 1990-05-08 Cetylite Industries, Inc. Sterilant composition
WO1995022335A1 (fr) * 1994-02-21 1995-08-24 Aberdeen University Nitrite acidifie en tant qu'agent antimicrobien
US5573786A (en) * 1993-06-23 1996-11-12 Solco Basel Ag Preparation for skin and mucous membrane

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923899A (en) * 1987-12-22 1990-05-08 Cetylite Industries, Inc. Sterilant composition
US5573786A (en) * 1993-06-23 1996-11-12 Solco Basel Ag Preparation for skin and mucous membrane
WO1995022335A1 (fr) * 1994-02-21 1995-08-24 Aberdeen University Nitrite acidifie en tant qu'agent antimicrobien

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"Sodium Nitrite", MATERIAL SAFETY DATA SHEET, 12 August 1996 (1996-08-12), XP002111729, Retrieved from the Internet <URL:www.jtbaker.com/msds/s4466.htm> [retrieved on 19990803] *
HEATON C. L.: "The revival of nitric acid for the treatment of anogenital warts", CLINICAL PHARMACOLOGY &THERAPEUTICS, vol. 54, no. 1, July 1993 (1993-07-01), pages 107 - 111, XP002111731 *
WELLER R. ET AL: "A randomized trial of acidified nitrite cream in the treatment of tinea pedis", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 38, no. 4, April 1998 (1998-04-01), pages 559- - 563, XP002111730 *
YOSHIDA Y ET AL: "Induction and promotion of forestomach tumors by sodium nitrite in combination with ascorbic acid or sodium ascorbate in rats with or without N-methyl-N'-nitro-N-nitrosoguanidine pre-treatment.", INTERNATIONAL JOURNAL OF CANCER, (1994 JAN 2) 56 (1) 124-8., XP002111728 *

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114442B2 (en) 2000-08-30 2012-02-14 Queen Mary & Westfield College Transdermal pharmaceutical delivery compositions
WO2002017881A3 (fr) * 2000-08-30 2003-04-17 Queen Mary & Westfield College Composition d'administration transdermique d'agent pharmaceutique
US8128964B2 (en) 2000-08-30 2012-03-06 Queen Mary & Westfield College Transdermal pharmaceutical delivery composition
RU2298403C2 (ru) * 2001-08-03 2007-05-10 Абердин Юниверсити Лечение инфекций ногтей при помощи no
HRP20040059B1 (en) * 2001-08-03 2008-05-31 Aberdeen University Treatment of nail infections with no
AU2002318001B2 (en) * 2001-08-03 2007-02-15 Aberdeen University Treatment of nail infections with NO
WO2003013489A1 (fr) * 2001-08-03 2003-02-20 Aberdeen University Traitement des infections d'ongles avec de l'oxyde d'azote
US9381381B2 (en) 2001-08-03 2016-07-05 Aberdeen University Treatment of nail infections with no
US9387224B2 (en) 2003-07-09 2016-07-12 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Treatment of specific cardiovascular conditions with nitrite
US9700578B2 (en) 2003-07-09 2017-07-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions
US8927030B2 (en) 2003-07-09 2015-01-06 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions
US9675637B2 (en) 2003-07-09 2017-06-13 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of nitrite salts for the treatment of cardiovascular conditions
US8557300B2 (en) 2005-05-19 2013-10-15 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite
US9750242B2 (en) 2007-02-28 2017-09-05 Invasive Animals Ltd. Nitrite salts as poisons in baits for omnivores
US8795649B2 (en) 2007-02-28 2014-08-05 Invasive Animals Ltd. Nitrite salts as poisons in baits for omnivores
US8932650B2 (en) * 2011-01-11 2015-01-13 Kantian Skincare LLC Multifunctional topical formulation for the treatment of acne vulgaris and other skin conditions
US11077194B2 (en) 2012-03-14 2021-08-03 Novan, Inc. Nitric oxide releasing pharmaceutical compositions
US9445996B2 (en) 2012-08-23 2016-09-20 Nioxx Llc Extended production of nitric oxide from a microencapsulated nitrite salt and an aqueous acidified gel
WO2014031491A3 (fr) * 2012-08-23 2014-05-30 Nioxx Llc Production prolongée d'oxyde nitrique à partir de réactifs chimiques microencapsulés
US11285098B2 (en) 2013-02-28 2022-03-29 Novan, Inc. Topical compositions and methods of using the same
US11813284B2 (en) 2013-08-08 2023-11-14 Novan, Inc. Topical compositions and methods of using the same
EP3698775A1 (fr) * 2014-07-11 2020-08-26 Novan Inc. Compositions antivirales topiques et méthodes d'utilisation
EP3166593A4 (fr) * 2014-07-11 2018-02-07 Novan, Inc. Compositions antivirales topiques et méthodes d'utilisation de celles-ci
US10736839B2 (en) 2014-07-11 2020-08-11 Novan, Inc. Topical antiviral compositions, delivery systems, and methods of using the same
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
US12403087B2 (en) 2014-07-11 2025-09-02 Ligand Pharmaceuticals Incorporated Topical antiviral compositions, delivery systems, and methods of using the same
US11723858B2 (en) 2014-07-11 2023-08-15 Novan, Inc. Topical antiviral compositions, delivery systems, and methods of using the same
US11040006B2 (en) 2014-07-11 2021-06-22 Novan, Inc. Topical antiviral compositions, delivery systems, and methods of using the same
US10322081B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
EP3158990A1 (fr) 2015-10-21 2017-04-26 Glano Tech Ltd Formulation pour la libération d'oxyde nitrique
US11285171B2 (en) 2018-03-01 2022-03-29 Novan, Inc. Nitric oxide releasing suppositories and methods of use thereof
US10716805B2 (en) 2018-03-19 2020-07-21 Glanotech Limited Formulation for release of nitric oxide
WO2020245574A1 (fr) 2019-06-04 2020-12-10 Thirty Respiratory Limited Procédés et compositions pour générer de l'oxyde nitrique et leurs utilisations pour administrer de l'oxyde nitrique par l'intermédiaire des voies respiratoires
WO2020245573A1 (fr) 2019-06-04 2020-12-10 Thirty Holdings Limited Méthodes et compositions pour générer de l'oxyde nitrique et utilisations associées
WO2021214440A1 (fr) 2020-04-23 2021-10-28 Thirty Respiratory Limited Oxyde nitrique ou compositions libérant de l'oxyde nitrique destinés à être utilisés dans le traitement du sars-cov et du sars-cov-2
WO2021214439A1 (fr) 2020-04-23 2021-10-28 Thirty Respiratory Limited Procédés et compositions pour le traitement et la lutte contre la tuberculose

Also Published As

Publication number Publication date
CN1291897A (zh) 2001-04-18
NO20004302D0 (no) 2000-08-29
CN1270725C (zh) 2006-08-23
PL342755A1 (en) 2001-07-02
NZ506678A (en) 2003-04-29
JP2002505295A (ja) 2002-02-19
AU758264B2 (en) 2003-03-20
NO20004302L (no) 2000-10-30
CA2322199A1 (fr) 1999-09-10
AU3261799A (en) 1999-09-20
HUP0101374A3 (en) 2003-07-28
MXPA00008583A (es) 2003-07-14
HUP0101374A2 (hu) 2001-08-28
GB9804469D0 (en) 1998-04-29
BR9908617A (pt) 2000-12-05
EP1059928A1 (fr) 2000-12-20
KR20010041527A (ko) 2001-05-25

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