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WO1999044588A3 - Method for producing solid, spherical forms containing pharmaceutical active agents in a binder matrix - Google Patents

Method for producing solid, spherical forms containing pharmaceutical active agents in a binder matrix Download PDF

Info

Publication number
WO1999044588A3
WO1999044588A3 PCT/EP1999/001271 EP9901271W WO9944588A3 WO 1999044588 A3 WO1999044588 A3 WO 1999044588A3 EP 9901271 W EP9901271 W EP 9901271W WO 9944588 A3 WO9944588 A3 WO 9944588A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical active
forms containing
producing solid
active agents
spherical forms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1999/001271
Other languages
German (de)
French (fr)
Other versions
WO1999044588A2 (en
Inventor
Andreas Kleinke
Thomas Kessler
Joerg Rosenberg
Harald Krull
Gunther Berndl
Werner Maier
Joerg Breitenbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Priority to EP99911718A priority Critical patent/EP1059914A2/en
Priority to CA002322629A priority patent/CA2322629A1/en
Publication of WO1999044588A2 publication Critical patent/WO1999044588A2/en
Publication of WO1999044588A3 publication Critical patent/WO1999044588A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to a method for producing solid, spherical forms containing at least one pharmaceutical active agent homogeneously dispersed in an auxiliary matrix. According to this method, the constituents are mixed to form a melt which is then shaped. The invention is characterised in that at least one pharmaceutical active agent is processed with at least one thermoplastically processable matrix auxiliary to form a homogeneous melt with a viscosity of less than 5000 mPas and in that this melt is shaped into drops using a rotating perforated roll. These drops are then cooled so that they solidify.
PCT/EP1999/001271 1998-03-05 1999-02-26 Method for producing solid, spherical forms containing pharmaceutical active agents in a binder matrix Ceased WO1999044588A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99911718A EP1059914A2 (en) 1998-03-05 1999-02-26 Method for producing solid, spherical forms containing pharmaceutical active agents in a binder matrix
CA002322629A CA2322629A1 (en) 1998-03-05 1999-02-26 Method for producing solid, spherical forms containing pharmaceutical active agents in a binder matrix

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19809242A DE19809242A1 (en) 1998-03-05 1998-03-05 Process for the production of solid, spherical shaped articles containing pharmaceutical active substances in a binder matrix
DE19809242.3 1998-03-05

Publications (2)

Publication Number Publication Date
WO1999044588A2 WO1999044588A2 (en) 1999-09-10
WO1999044588A3 true WO1999044588A3 (en) 1999-10-28

Family

ID=7859688

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/001271 Ceased WO1999044588A2 (en) 1998-03-05 1999-02-26 Method for producing solid, spherical forms containing pharmaceutical active agents in a binder matrix

Country Status (4)

Country Link
EP (1) EP1059914A2 (en)
CA (1) CA2322629A1 (en)
DE (1) DE19809242A1 (en)
WO (1) WO1999044588A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19943501A1 (en) 1999-09-10 2001-03-15 Basf Ag Underwater granulation of melts containing active ingredients
US20010036959A1 (en) * 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
GB0113841D0 (en) * 2001-06-07 2001-08-01 Boots Co Plc Therapeutic agents
WO2004069138A2 (en) * 2003-02-03 2004-08-19 Novartis Ag Pharmaceutical formulation
KR101482922B1 (en) * 2004-08-12 2015-01-15 레킷트 벵키저 헬스케어(유케이)리미티드 Granules comprising a NSAID and a sugar alcohol made by melt extrusion
DE102007061408A1 (en) 2007-12-11 2009-06-18 Sandvik Materials Technology Deutschland Gmbh Method and drop former for producing pastilles and method for producing a sulfur-containing fertilizer

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3139920A1 (en) * 1981-10-08 1983-04-28 Nittner, Erich, Dr., 8280 Kreuzlingen Agent in the form of granules based on polysaccharide gums, process for the preparation thereof and use
US5013498A (en) * 1988-04-23 1991-05-07 Santrade Ltd. Method and apparatus for producing pastilles
WO1993025074A1 (en) * 1992-06-16 1993-12-23 E.I. Du Pont De Nemours And Company Water-dispersible granular agricultural compositions
EP0582186A1 (en) * 1992-08-04 1994-02-09 MERZ + CO. GmbH & Co. Process for producing solid pharmaceutical dosage forms with an extended two-stage release
WO1997012603A1 (en) * 1995-09-29 1997-04-10 Basf Aktiengesellschaft Solid medicaments obtained by extrusion of an isomalt-containing polymer-active substance melt
EP0922462A2 (en) * 1997-12-01 1999-06-16 Basf Aktiengesellschaft Process for preparation of solid dosage forms

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3139920A1 (en) * 1981-10-08 1983-04-28 Nittner, Erich, Dr., 8280 Kreuzlingen Agent in the form of granules based on polysaccharide gums, process for the preparation thereof and use
US5013498A (en) * 1988-04-23 1991-05-07 Santrade Ltd. Method and apparatus for producing pastilles
WO1993025074A1 (en) * 1992-06-16 1993-12-23 E.I. Du Pont De Nemours And Company Water-dispersible granular agricultural compositions
EP0582186A1 (en) * 1992-08-04 1994-02-09 MERZ + CO. GmbH & Co. Process for producing solid pharmaceutical dosage forms with an extended two-stage release
WO1997012603A1 (en) * 1995-09-29 1997-04-10 Basf Aktiengesellschaft Solid medicaments obtained by extrusion of an isomalt-containing polymer-active substance melt
EP0922462A2 (en) * 1997-12-01 1999-06-16 Basf Aktiengesellschaft Process for preparation of solid dosage forms

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCHAK J.A.: "Pelletizing, prilling or pastillating", PROC.-INST. BRIQUET. AGGLOM. , BIENN. CONF., vol. 2, 1991, pages 143 - 149, XP002113494 *

Also Published As

Publication number Publication date
EP1059914A2 (en) 2000-12-20
CA2322629A1 (en) 1999-09-10
WO1999044588A2 (en) 1999-09-10
DE19809242A1 (en) 1999-09-09

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