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WO1999041374A3 - Human short-chain tnf-receptor family protein - Google Patents

Human short-chain tnf-receptor family protein Download PDF

Info

Publication number
WO1999041374A3
WO1999041374A3 PCT/US1999/002570 US9902570W WO9941374A3 WO 1999041374 A3 WO1999041374 A3 WO 1999041374A3 US 9902570 W US9902570 W US 9902570W WO 9941374 A3 WO9941374 A3 WO 9941374A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor family
family protein
human short
sctr
chain tnf
Prior art date
Application number
PCT/US1999/002570
Other languages
French (fr)
Other versions
WO1999041374A2 (en
Inventor
Y Tom Tang
Neil C Corley
Preeti Lal
Original Assignee
Incyte Pharma Inc
Y Tom Tang
Neil C Corley
Preeti Lal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc, Y Tom Tang, Neil C Corley, Preeti Lal filed Critical Incyte Pharma Inc
Priority to CA002321105A priority Critical patent/CA2321105A1/en
Priority to EP99905816A priority patent/EP1054961A2/en
Priority to AU25893/99A priority patent/AU2589399A/en
Priority to JP2000531555A priority patent/JP2002503464A/en
Publication of WO1999041374A2 publication Critical patent/WO1999041374A2/en
Publication of WO1999041374A3 publication Critical patent/WO1999041374A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides a human short-chain TNF-receptor family protein (SCTR) and polynucleotides which identify and encode SCTR. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of SCTR.
PCT/US1999/002570 1998-02-17 1999-02-05 Human short-chain tnf-receptor family protein WO1999041374A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002321105A CA2321105A1 (en) 1998-02-17 1999-02-05 Human short-chain tnf-receptor family protein
EP99905816A EP1054961A2 (en) 1998-02-17 1999-02-05 Human short-chain tnf-receptor family protein
AU25893/99A AU2589399A (en) 1998-02-17 1999-02-05 Human short-chain tnf-receptor family protein
JP2000531555A JP2002503464A (en) 1998-02-17 1999-02-05 Human short chain TNF receptor family protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2480898A 1998-02-17 1998-02-17
US09/024,808 1998-02-17

Publications (2)

Publication Number Publication Date
WO1999041374A2 WO1999041374A2 (en) 1999-08-19
WO1999041374A3 true WO1999041374A3 (en) 1999-09-23

Family

ID=21822505

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/002570 WO1999041374A2 (en) 1998-02-17 1999-02-05 Human short-chain tnf-receptor family protein

Country Status (5)

Country Link
EP (1) EP1054961A2 (en)
JP (1) JP2002503464A (en)
AU (1) AU2589399A (en)
CA (1) CA2321105A1 (en)
WO (1) WO1999041374A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003521242A (en) * 1999-11-12 2003-07-15 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド 19 human secreted proteins
WO2004004649A2 (en) * 2002-07-08 2004-01-15 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
EP2492281B1 (en) * 2009-10-19 2018-04-11 HanAll Biopharma Co., Ltd. Modified human tumor necrosis factor receptor-1 polypeptide or fragment thereof, and method for preparing same
JP2013512674A (en) 2009-12-02 2013-04-18 アクセルロン ファーマ， インコーポレイテッド Compositions and methods for increasing the serum half-life of an Fc fusion protein
KR101185310B1 (en) * 2010-12-23 2012-09-21 한올바이오파마주식회사 Modified human tumor necrosis factor receptor-1 polypeptides or fragments thereof and method for preparing the same
EP2718328A4 (en) 2011-06-08 2014-12-24 Acceleron Pharma Inc Compositions and methods for increasing serum half-life

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0784093A1 (en) * 1995-12-22 1997-07-16 Amgen Inc. Osteoprotegerin
WO1997033904A1 (en) * 1996-03-12 1997-09-18 Human Genome Sciences, Inc. Death domain containing receptors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0784093A1 (en) * 1995-12-22 1997-07-16 Amgen Inc. Osteoprotegerin
WO1997033904A1 (en) * 1996-03-12 1997-09-18 Human Genome Sciences, Inc. Death domain containing receptors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHINNAIYAN A M ET AL: "SIGNAL TRANSDUCTION BY DR3, A DEATH DOMAIN-CONTAINING RECEPTOR RELATED TO TNFR-1 AND CD95", SCIENCE, vol. 274, no. 5289, 8 November 1996 (1996-11-08), pages 990 - 992, XP000676685, ISSN: 0036-8075 *
DATABASE GENBANK 18 April 1997 (1997-04-18), "EST100127; H. sapiens pancreas tumor I", XP002110904 *
DATABASE GENBANK 18 April 1997 (1997-04-18), "EST12383; H. sapiens uterus tumor I", XP002110905 *
MACFARLANE M ET AL: "IDENTIFICATION AND MOLECULAR CLONING OF TWO NOVEL RECEPTORS FOR THE CYTOTOXIC LIGAND TRAIL", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 41, 10 October 1997 (1997-10-10), pages 25417 - 25420, XP002065148, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
CA2321105A1 (en) 1999-08-19
AU2589399A (en) 1999-08-30
EP1054961A2 (en) 2000-11-29
WO1999041374A2 (en) 1999-08-19
JP2002503464A (en) 2002-02-05

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