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WO1999040941A1 - Extrait d'ecailles de poissons utilise comme supplement calcique - Google Patents

Extrait d'ecailles de poissons utilise comme supplement calcique Download PDF

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Publication number
WO1999040941A1
WO1999040941A1 PCT/US1999/003371 US9903371W WO9940941A1 WO 1999040941 A1 WO1999040941 A1 WO 1999040941A1 US 9903371 W US9903371 W US 9903371W WO 9940941 A1 WO9940941 A1 WO 9940941A1
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WO
WIPO (PCT)
Prior art keywords
calcium
extract
bone
fish scale
fish
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/003371
Other languages
English (en)
Other versions
WO1999040941A8 (fr
Inventor
John Achkar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/025,003 external-priority patent/US5905093A/en
Application filed by Individual filed Critical Individual
Priority to AU32968/99A priority Critical patent/AU3296899A/en
Publication of WO1999040941A1 publication Critical patent/WO1999040941A1/fr
Publication of WO1999040941A8 publication Critical patent/WO1999040941A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/20—Fish extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A23L33/165—Complexes or chelates

Definitions

  • This invention relates to a novel material and composition useful as a calcium supplement for humans and other animals.
  • this invention relates to a fish scale extract containing a special form of calcium which can be applied topically to the skin and absorbed easily by the skin for strengthening bones or preventing other calcium deficiencies .
  • Calcium is the fifth most abundant element in the human body. It plays an important role in many physiological processes, including nerve and muscle functions. Not surprisingly, nutritional and metabolic deficiencies of calcium can have broad-ranging adverse effects. Since about 90% of the body's calcium is found in bone tissues, many of these adverse effects are manifested through deficiencies in the structure, function and integrity of the skeletal system.
  • Osteoporosis can be generally defined as the reduction in the quantity of bone, or the atrophy of skeletal tissue. In general, there are two types of osteoporosis: primary and secondary. "Secondary osteoporosis" is the result of an identifiable disease process or agent. However, approximately 90% of all osteoporosis cases is idiopathic "primary osteoporosis” . Such primary osteoporosis includes postmenopausal osteoporosis, age-associated osteoporosis (affecting a majority of individuals over the age of 70 to 80) , and idiopathic osteoporosis affecting middle-aged and younger men and women.
  • Bone fractures occur often, for example, in the wrist, hips and spine of women suffering from postmenopausal osteoporosis. Kyphosis (abnormally increased curvature of the thoracic spine) may also result.
  • the mechanism of bone loss in osteoporotics is believed to involve an imbalance in the process of "bone remodeling". Bone remodeling occurs throughout life, renewing the skeleton and maintaining the strength of bone . This remodeling occurs in a series of discrete pockets of activity in the bone, called “osteoclasts" and “osteoblasts” .
  • Osteoclasts are responsible for the resorption of a portion of bone within the bone matrix, during the resorption process. After resorption, the osteoclasts are followed by the appearance of osteoblasts (bone forming cells) , which then refill the resorbed portion with new bone.
  • osteoporotics In a healthy adult, the rate at which the osteoclasts and osteoblasts are formed maintains a balance of bone resorption and bone formation. However, in osteoporotics an imbalance in this remodeling process develops, resulting in loss of bone at a rate faster than the accretion of bone. This imbalance is much more severe, and occurs at a younger age, in osteoporotics as compared to healthy adults.
  • compositions and methods are described in the medical . literature for the prevention or "treatment” of osteoporosis. Many of these compositions and methods attempt to either slow the loss of bone or to produce a net gain in bone mass. See, for example, R. C. Haynes, Jr. et al . , "Agents affecting Calcification", The Pharmacological Basis of Therapeutics, 7th Edition (A. G. Gilman, L. S. Goodman et al . , Editors, 1985) ; and G. D. hedon et al . , "An Analysis of
  • Estrogen is often used to affect the metabolism of calcium.
  • an extract from fish scales contains a special form of calcium complex that is useful as food supplement or a portion of a food supplement to provide the users with more calcium than they otherwise have available from their normal diets.
  • This fish scale extract can be easily absorbed by the human body through the skin.
  • Many commercial calcium supplement preparations also contain vitamin D to facilitate calcium absorption, as in the instance of milk. It is well known that vitamin D plays an active role in calcium homeostasis and is a major regulator of the concentration of Ca 2+ in plasma.
  • topical application of calcium supplement can be unique and useful as an alternative route to provide the body with calcium supplementation, particularly if the calcium is in a form that can be readily absorbed by the skin.
  • the fish scale extract in the present invention is one of those forms.
  • vitamin D is also synthesized in the skin, suggesting that vitamin D may directly or indirectly interact with calcium to facilitate the absorption of calcium from the skin or otherwise participate calcium metabolism after the absorption.
  • An object of the present invention is to provide a calcium complex in which calcium is associated with one or more of other organic molecules.
  • the calcium complex is obtained by extracting it from fish scales with an acidic solution containing a mixture of a hydrocarboxylic acid and acetic acid.
  • Another object of the present invention is to provide a fish scale extract prepared by soaking the fish scales in a mixture of equal amounts of a hydrocarboxylic acid and acetic acid or a mixture of equal amounts of lemon juice and vinegar.
  • Another object of the present invention is to provide a fish scale extract prepared by soaking the fish scale in a mixture of a hydrocarboxylic acid and acetic acid or a mixture of lemon juice and vinegar at a ratio of 3 to 1.
  • a further object of the present invention is to provide a food supplement for preventing or reducing calcium deficiency or the risk of bone loss such as occurs in osteoporosis and related disorders .
  • the materials used in the extraction process comprise fish scales, a hydrocarboxylic acid or acetic acid, or preferably, a mixture of the two.
  • the fish scales may be collected from any type of fish in any amount. Preferably, for a preparation of 500 ml, 1 oz of fish scales are required.
  • the fish scales are first briefly, lightly sprayed with fresh water and then they are soaked in an organic acidic solution. Preferably, the substance coating each of the fish scales is not removed by spraying.
  • Any organic acidic solutions, preferably, acetic acid and a hydrocarboxylic acid such as citric acid or tartaric acid may be used for soaking the fish scales.
  • the acidic solution may be prepared at a concentration of about 0.
  • the fish scales are introduced into the solution in such a way that the fish scales are completely immersed in the solution.
  • the container that contains the fish scales soaked in the acidic solution is then covered and kept preferably at room temperature for at least 12 hours, preferably about 5 days, during which the calcium or calcium complex continuously comes out of the fish scales.
  • the fish scales may be maintained in the solution until an equilibrium of the calcium concentration between the fish scales and the acidic solution is established so that the calcium concentration is maintained at a constant level. This process may be accelerated by heating the solution.
  • the presence and concentration of the calcium in the solution can be readily determined by a person skilled in the art.
  • food products such as lemon or lime juice and vinegar may be used to substitute the hydrocarboxylic acid and acetic acid.
  • about 1 oz of the fish scales are soaked in about 500 ml of lemon or lime juice, or in about 500 ml of vinegar, preferably white vinegar or red wine vinegar, or in a mixture including about 200 ml of lemon or lime juice and about 300 ml of vinegar, for at least 12 hours, preferably about 5 days .
  • the extract so prepared is then suitable for an immediate use or may be further modified as a food supplement.
  • an extract cocktail may be formed by adding some other substances such as garlic and honey, etc. into the extract.
  • vitamin D may be added to the extract.
  • the extract may also serve as a major component for a pharmaceutical composition.
  • the fish scale extract may be dried by any suitable means, such as lyophilization for the purpose of storage or shipment. The dried fish scale extract may be resuspended or dissolved in a pH neutral solution, or manufactured in the form of capsules or tablets. In case of an immediate application after the extraction, the extract may be administered topically or orally.
  • the extract can be taken alone or combined with other foods .
  • At least a teaspoon of the extract or its modification may be employed daily depending on the user's needs and for as long as the user desires.
  • the extract or its modification is administered three times a day and preferably one tea spoon at each time.
  • the extract or its modification may be applied directly to various areas of the skin such as the face or the chest at least once a day or as often as the user desires or depending on the user's symptoms.
  • the extract when administered either orally or topically, may be useful to prevent, or reduce the risk of, the occurrence of bone loss such as osteoporosis or other calcium deficiencies .
  • containers 1 and 2 100 ml of lemon juice alone containers 3 and 4 75 ml of lemon juice + 25 ml of vinegar containers 5 and 6 50 ml of lemon juice + 50 ml of vinegar containers 7 and 8 25 ml of lemon juice + 75 ml of vinegar containers 9 and 10: 100 ml of vinegar alone
  • the containers containing fish scales and solutions as prepared above were covered and thoroughly mixed for a few minutes . Then the containers were allowed to stay for at least two days at room temperature to produce fish scale extracts. The fish scale extracts so prepared were then transferred into each of the ten empty containers by filtering out the fish scales, respectively, and properly labeling the corresponding containers. The filtered fish scale extracts were allowed to stand for at least one week until the insoluble particles precipitated.
  • any ratio of lemon juice and vinegar may be used to prepare the fish scale extracts, a mixture of equal amounts of lemon juice and vinegar is preferred.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne une préparation riche en calcium préparée en trempant des écailles de poissons dans un mélange d'acide carboxylique et d'acide acétique pendant un temps défini. On peut utiliser l'extrait d'écailles de poissons comme supplément alimentaire pour prévenir ou réduire le risque de perte osseuse ou d'autres carences calciques.
PCT/US1999/003371 1998-02-17 1999-02-17 Extrait d'ecailles de poissons utilise comme supplement calcique Ceased WO1999040941A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU32968/99A AU3296899A (en) 1998-02-17 1999-02-17 A fish scale extract as a calcium supplement

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/025,003 US5905093A (en) 1998-02-17 1998-02-17 Fish scale extract as a calcium supplement
US09/025,003 1998-02-17
US18717998A 1998-11-05 1998-11-05
US09/187,179 1998-11-05

Publications (2)

Publication Number Publication Date
WO1999040941A1 true WO1999040941A1 (fr) 1999-08-19
WO1999040941A8 WO1999040941A8 (fr) 1999-10-21

Family

ID=26699151

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/003371 Ceased WO1999040941A1 (fr) 1998-02-17 1999-02-17 Extrait d'ecailles de poissons utilise comme supplement calcique

Country Status (2)

Country Link
AU (1) AU3296899A (fr)
WO (1) WO1999040941A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342367B1 (en) * 1999-11-18 2002-01-29 Japan As Represented By Secretary Of Agency Of Industrial Science And Technology Method for the preparation of chondroitin sulfate compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6349057A (ja) * 1986-08-14 1988-03-01 Eikou Hiryo Kk カルシウム補給用溶液及びその製造方法
JPH02245167A (ja) * 1989-03-10 1990-09-28 Marutomo Kk 魚エキスの製造法
US5422099A (en) * 1990-06-21 1995-06-06 Trustees Of Boston University Compositions comprising vitamin D precursors and the use thereof
JPH08107771A (ja) * 1994-10-12 1996-04-30 M P G Kk 食品添加物
US5698222A (en) * 1995-04-07 1997-12-16 Abbott Laboratories Calcium supplement

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6349057A (ja) * 1986-08-14 1988-03-01 Eikou Hiryo Kk カルシウム補給用溶液及びその製造方法
JPH02245167A (ja) * 1989-03-10 1990-09-28 Marutomo Kk 魚エキスの製造法
US5422099A (en) * 1990-06-21 1995-06-06 Trustees Of Boston University Compositions comprising vitamin D precursors and the use thereof
JPH08107771A (ja) * 1994-10-12 1996-04-30 M P G Kk 食品添加物
US5698222A (en) * 1995-04-07 1997-12-16 Abbott Laboratories Calcium supplement

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342367B1 (en) * 1999-11-18 2002-01-29 Japan As Represented By Secretary Of Agency Of Industrial Science And Technology Method for the preparation of chondroitin sulfate compounds

Also Published As

Publication number Publication date
AU3296899A (en) 1999-08-30
WO1999040941A8 (fr) 1999-10-21

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