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WO1999040097A8 - Process for making clarithromycin - Google Patents

Process for making clarithromycin

Info

Publication number
WO1999040097A8
WO1999040097A8 PCT/US1999/002497 US9902497W WO9940097A8 WO 1999040097 A8 WO1999040097 A8 WO 1999040097A8 US 9902497 W US9902497 W US 9902497W WO 9940097 A8 WO9940097 A8 WO 9940097A8
Authority
WO
WIPO (PCT)
Prior art keywords
clarithromycin
erythromycin
making
making clarithromycin
dialkylhydrazones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/002497
Other languages
French (fr)
Other versions
WO1999040097A1 (en
Inventor
David Leonov
Marko Kordova
Anchel Schwartz
Ilya Avrutov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Teva Pharmaceuticals USA Inc
Original Assignee
Teva Pharmaceutical Industries Ltd
Teva Pharmaceuticals USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd, Teva Pharmaceuticals USA Inc filed Critical Teva Pharmaceutical Industries Ltd
Priority to AU26588/99A priority Critical patent/AU2658899A/en
Publication of WO1999040097A1 publication Critical patent/WO1999040097A1/en
Publication of WO1999040097A8 publication Critical patent/WO1999040097A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

Clarithromycin is prepared from erythromycin A 9-alkylidenehydrazones, erythromycin A 9-alkyl- and arylsulfonylhydrazones, erythromycin A 9-N-alkylhydrazones or erythromycin A 9-N,N-dialkylhydrazones.
PCT/US1999/002497 1998-02-04 1999-02-04 Process for making clarithromycin Ceased WO1999040097A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU26588/99A AU2658899A (en) 1998-02-04 1999-02-04 Process for making clarithromycin

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1843298A 1998-02-04 1998-02-04
US09/018,432 1998-02-04
US17624198A 1998-10-21 1998-10-21
US09/176,241 1998-10-21

Publications (2)

Publication Number Publication Date
WO1999040097A1 WO1999040097A1 (en) 1999-08-12
WO1999040097A8 true WO1999040097A8 (en) 2000-04-20

Family

ID=26691116

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/002497 Ceased WO1999040097A1 (en) 1998-02-04 1999-02-04 Process for making clarithromycin

Country Status (2)

Country Link
AU (1) AU2658899A (en)
WO (1) WO1999040097A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7282221B2 (en) 2000-10-13 2007-10-16 Middlebrook Pharmaceuticals, Inc. Antiviral product, use and formulation thereof
US8889187B2 (en) 2000-02-24 2014-11-18 Shionogi Inc. Once a day amoxicillin product comprising immediate and delayed release dosage forms
US9144548B2 (en) 2003-08-12 2015-09-29 Shionogi Inc. Antibiotic product, use and formulation thereof

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL124084A0 (en) * 1998-04-14 1999-04-11 Chemagis Ltd Erythromycin a derivatives and methods for the preparation thereof
IL125372A0 (en) * 1998-07-15 1999-03-12 Chemagis Ltd Erythromycin derivatives and methods for the preparation thereof
KR100317907B1 (en) * 1998-11-24 2001-12-24 김 완 주 Novel Intermediates, process for preparing macrolide antibiotic agent therefrom
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
CN102382157B (en) * 2010-09-03 2015-04-08 上海医药工业研究院 Erythromycin A derivative and preparation method thereof
CN102786570B (en) * 2011-05-18 2016-02-10 上海医药工业研究院 Macrolides compound, its preparation method, application and intermediate
CN103130852B (en) * 2011-11-25 2016-03-16 上海医药工业研究院 A kind of erythromycin A derivant, its preparation method, intermediate and application

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8721165D0 (en) * 1987-09-09 1987-10-14 Beecham Group Plc Chemical compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889187B2 (en) 2000-02-24 2014-11-18 Shionogi Inc. Once a day amoxicillin product comprising immediate and delayed release dosage forms
US7282221B2 (en) 2000-10-13 2007-10-16 Middlebrook Pharmaceuticals, Inc. Antiviral product, use and formulation thereof
US9144548B2 (en) 2003-08-12 2015-09-29 Shionogi Inc. Antibiotic product, use and formulation thereof

Also Published As

Publication number Publication date
WO1999040097A1 (en) 1999-08-12
AU2658899A (en) 1999-08-23

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