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WO1998039358B1 - Lipides cationiques oligomeres - Google Patents

Lipides cationiques oligomeres

Info

Publication number
WO1998039358B1
WO1998039358B1 PCT/US1998/004344 US9804344W WO9839358B1 WO 1998039358 B1 WO1998039358 B1 WO 1998039358B1 US 9804344 W US9804344 W US 9804344W WO 9839358 B1 WO9839358 B1 WO 9839358B1
Authority
WO
WIPO (PCT)
Prior art keywords
cationic lipids
oligomeric cationic
oligomeric
present
compositions
Prior art date
Application number
PCT/US1998/004344
Other languages
English (en)
Other versions
WO1998039358A9 (fr
WO1998039358A1 (fr
Filing date
Publication date
Priority claimed from US08/812,775 external-priority patent/US5877220A/en
Application filed filed Critical
Priority to AU66879/98A priority Critical patent/AU6687998A/en
Publication of WO1998039358A1 publication Critical patent/WO1998039358A1/fr
Publication of WO1998039358B1 publication Critical patent/WO1998039358B1/fr
Publication of WO1998039358A9 publication Critical patent/WO1998039358A9/fr

Links

Abstract

La présente invention concerne de nouveaux lipides cationiques oligomères. La présente invention concerne également des compositions de ces nouveaux lipides cationiques avec des macromolécules anioniques, des méthodes d'interférence avec une expression de protéines dans une cellule faisant appel à ces compositions, ainsi qu'une trousse destinée à leur préparation.
PCT/US1998/004344 1997-03-06 1998-03-05 Lipides cationiques oligomeres WO1998039358A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU66879/98A AU6687998A (en) 1997-03-06 1998-03-05 Oligomeric cationic lipids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/812,775 US5877220A (en) 1997-03-06 1997-03-06 Amide-based oligomeric cationic lipids
US08/812,775 1997-03-06

Publications (3)

Publication Number Publication Date
WO1998039358A1 WO1998039358A1 (fr) 1998-09-11
WO1998039358B1 true WO1998039358B1 (fr) 1998-11-26
WO1998039358A9 WO1998039358A9 (fr) 1999-02-25

Family

ID=25210592

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/004344 WO1998039358A1 (fr) 1997-03-06 1998-03-05 Lipides cationiques oligomeres

Country Status (3)

Country Link
US (1) US5877220A (fr)
AU (1) AU6687998A (fr)
WO (1) WO1998039358A1 (fr)

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CN101041079A (zh) * 1999-12-30 2007-09-26 诺瓦提斯公司 用于基因治疗的新的胶体合成载体
US6686461B1 (en) * 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
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WO2001070685A2 (fr) * 2000-03-22 2001-09-27 Solulink, Incorporated Agents de reticulation bifonctionnels a base d'hydrazine et de carbonyle
JP2005508396A (ja) * 2001-11-02 2005-03-31 イントラディグム、コーポレイション 核酸送達ビヒクルのための治療方法
WO2004002453A1 (fr) 2002-06-28 2004-01-08 Protiva Biotherapeutics Ltd. Appareil liposomal et procedes de fabrication
CA2551022C (fr) 2003-09-15 2013-06-04 Protiva Biotherapeutics, Inc. Composes conjugues lipidiques polyethyleneglycol-dialkyloxypropyle et utilisations de ces composes
US7158353B2 (en) * 2003-11-06 2007-01-02 Seagate Technology Llc Magnetoresistive sensor having specular sidewall layers
EA010060B1 (ru) * 2003-12-17 2008-06-30 Вайет Конъюгаты иммуногенных пептидных носителей и способы их получения
DK2336147T3 (da) * 2003-12-17 2014-06-10 Wyeth Llc Beta-immunogen-peptid-bærerkonjugater og fremgangsmåder til fremstilling deraf
ATE536418T1 (de) * 2004-06-07 2011-12-15 Protiva Biotherapeutics Inc Lipidverkapselte interferenz-rna
EP1828219A4 (fr) * 2004-11-17 2008-07-23 Protiva Biotherapeutics Inc Silence arnsi de l'apolipoproteine b
JP5336853B2 (ja) 2005-11-02 2013-11-06 プロチバ バイオセラピューティクス インコーポレイティッド 修飾ｓｉＲＮＡ分子およびその使用法
JP5697988B2 (ja) * 2007-12-27 2015-04-08 プロチバ バイオセラピューティクス インコーポレイティッド 干渉ｒｎａを使用したポロ様キナーゼ発現のサイレンシング方法
JP5749494B2 (ja) * 2008-01-02 2015-07-15 テクミラ ファーマシューティカルズ コーポレイション 核酸の送達のための改善された組成物および方法
NZ588583A (en) 2008-04-15 2012-08-31 Protiva Biotherapeutics Inc Novel lipid formulations for nucleic acid delivery
PL2350043T3 (pl) 2008-10-09 2014-09-30 Tekmira Pharmaceuticals Corp Ulepszone aminolipidy i sposoby dostarczania kwasów nukleinowych
EP2405921A4 (fr) 2009-01-26 2013-05-22 Protiva Biotherapeutics Inc Compositions et procédés d'inactivation de l'expression de l'apolipoprotéine c-iii
US8569256B2 (en) 2009-07-01 2013-10-29 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
CA2767127A1 (fr) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Formulations lipidiques inedites permettant l'administration d'agents therapeutiques en direction de tumeurs solides
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
WO2011011447A1 (fr) 2009-07-20 2011-01-27 Protiva Biotherapeutics, Inc. Compositions et méthodes pour rendre silencieuse l’expression du gène du virus ebola
WO2011084721A2 (fr) * 2009-12-21 2011-07-14 Agave Pharma Inc Molécule cationique et procédé d'utilisation
US8455455B1 (en) 2010-03-31 2013-06-04 Protiva Biotherapeutics, Inc. Compositions and methods for silencing genes involved in hemorrhagic fever
US9006417B2 (en) 2010-06-30 2015-04-14 Protiva Biotherapeutics, Inc. Non-liposomal systems for nucleic acid delivery
US8466122B2 (en) 2010-09-17 2013-06-18 Protiva Biotherapeutics, Inc. Trialkyl cationic lipids and methods of use thereof
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
US11013905B2 (en) 2017-05-11 2021-05-25 Tci Llc Thermal interconnect for implantable blood pump
CA3200234A1 (fr) 2020-11-25 2022-06-02 Daryl C. Drummond Nanoparticules lipidiques utilisees pour l'administration d'acides nucleiques, et methodes d'utilisation associees
IL317109A (en) 2022-05-25 2025-01-01 Akagera Medicines Inc Lipid nanoparticles for the delivery of nucleic acids and methods of using them

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