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WO1998032469A3 - Polymeres - Google Patents

Polymeres Download PDF

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Publication number
WO1998032469A3
WO1998032469A3 PCT/GB1998/000270 GB9800270W WO9832469A3 WO 1998032469 A3 WO1998032469 A3 WO 1998032469A3 GB 9800270 W GB9800270 W GB 9800270W WO 9832469 A3 WO9832469 A3 WO 9832469A3
Authority
WO
WIPO (PCT)
Prior art keywords
linked
polymer backbone
compounds
polymers
therapeutic
Prior art date
Application number
PCT/GB1998/000270
Other languages
English (en)
Other versions
WO1998032469A2 (fr
Inventor
Henry Wolfe
Kenneth Kellar
Original Assignee
Nycomed Imaging As
Golding Louise
Henry Wolfe
Kenneth Kellar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9701813.9A external-priority patent/GB9701813D0/en
Application filed by Nycomed Imaging As, Golding Louise, Henry Wolfe, Kenneth Kellar filed Critical Nycomed Imaging As
Priority to AU58717/98A priority Critical patent/AU5871798A/en
Priority to EP98902085A priority patent/EP1011736A2/fr
Priority to JP53176198A priority patent/JP2001509796A/ja
Priority to CA002278200A priority patent/CA2278200A1/fr
Publication of WO1998032469A2 publication Critical patent/WO1998032469A2/fr
Publication of WO1998032469A3 publication Critical patent/WO1998032469A3/fr
Priority to NO993662A priority patent/NO993662L/no
Priority to US10/057,943 priority patent/US20020076378A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des composés renfermant un squelette polymère linéaire, ramifié ou dendrimère auquel est liée au moins une fraction reporter, ledit squelette polymère comprenant plusieurs acides contenant des amines. De tels composés peuvent être liés à un ou plusieurs agents de ciblage et sont utiles comme agents thérapeutiques et diagnostiques, en particulier dans les techniques d'imagerie médicale.
PCT/GB1998/000270 1997-01-29 1998-01-29 Polymeres WO1998032469A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU58717/98A AU5871798A (en) 1997-01-29 1998-01-29 Polymers
EP98902085A EP1011736A2 (fr) 1997-01-29 1998-01-29 Polymeres
JP53176198A JP2001509796A (ja) 1997-01-29 1998-01-29 重合体
CA002278200A CA2278200A1 (fr) 1997-01-29 1998-01-29 Polymeres
NO993662A NO993662L (no) 1997-01-29 1999-07-28 Polymerer
US10/057,943 US20020076378A1 (en) 1997-01-29 2002-01-29 Polymers

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9701813.9A GB9701813D0 (en) 1997-01-29 1997-01-29 Polymers
GB9701813.9 1997-01-29
US5707497P 1997-08-27 1997-08-27
US60/057,074 1997-08-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US36271199A Continuation 1997-01-29 1999-07-29

Publications (2)

Publication Number Publication Date
WO1998032469A2 WO1998032469A2 (fr) 1998-07-30
WO1998032469A3 true WO1998032469A3 (fr) 1998-11-05

Family

ID=26310882

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/000270 WO1998032469A2 (fr) 1997-01-29 1998-01-29 Polymeres

Country Status (8)

Country Link
EP (1) EP1011736A2 (fr)
JP (1) JP2001509796A (fr)
KR (1) KR20000070544A (fr)
CN (1) CN1246059A (fr)
AU (1) AU5871798A (fr)
CA (1) CA2278200A1 (fr)
NO (1) NO993662L (fr)
WO (1) WO1998032469A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE254137T1 (de) * 1998-09-29 2003-11-15 Statens Seruminstitut ßLIGAND PRESENTING ASSEMBLYß (LPA), VERFAHREN ZU DESSEN HERSTELLUNG UND VERWENDUNGEN
WO2001002861A1 (fr) * 1999-06-29 2001-01-11 Dako A/S Detection a l'aide de sondes et de marqueurs a dendrimeres
ITFO990015A1 (it) * 1999-07-23 2001-01-23 Verdini Antonio "dendrimeri polipeptidici quali trasportatori unimolecolari di farmaci e sostanze biologicamente attive".
KR100379720B1 (ko) * 2000-10-14 2003-04-11 주식회사 마크로젠 덴드리머 단일층 지지체 및 그의 제조방법
MX2007006050A (es) * 2004-11-22 2007-11-14 Ge Healthcare As Agentes de contraste.
JP4870941B2 (ja) * 2005-05-09 2012-02-08 公立大学法人大阪府立大学 高分子化合物
KR101334780B1 (ko) * 2010-08-13 2013-12-02 한국생명공학연구원 요오드를 함유한 방사형상의 고분자 화합물, 이의 제조방법 및 이를 포함하는 ｃｔ용 조영제 조성물
CN113939740A (zh) * 2019-01-03 2022-01-14 离子路径公司 用于离子束成像的组合物和试剂
CN113307863B (zh) * 2021-05-25 2022-12-16 华南农业大学 一种聚天冬氨酸及其盐类抗体的制备方法和应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985002611A1 (fr) * 1983-12-12 1985-06-20 Scripps Clinic And Research Foundation Polypeptide de synthese correspondant a une partie de l'enterotoxine thermolabile d'escherichia coli, compositions et procedes
EP0331616A2 (fr) * 1988-02-29 1989-09-06 Schering Aktiengesellschaft Formateur de complexe lié à un polymère, ces complexes, procédé de préparation et milieu pharmaceutique les contenant
EP0481526A1 (fr) * 1989-04-07 1992-04-22 Nycomed Salutar, Inc. Agents de chélation
WO1993006868A1 (fr) * 1991-10-07 1993-04-15 COCKBAIN, Jilian, Roderick, Michaelson Polychelateurs dendrimeres
WO1993010824A1 (fr) * 1991-12-04 1993-06-10 Guerbet S.A. Nouveau compose macromoleculaire polyamine iode, son procede de preparation et son utilisation comme agent de contraste
WO1994005203A1 (fr) * 1992-09-04 1994-03-17 The General Hospital Corporation Polymeres biocompatibles contenant des fractions therapeutiques ou de diagnostic
WO1996040816A1 (fr) * 1995-06-07 1996-12-19 Schering Aktiengesellschaft Polyamides et polyamines lineaires iodes
WO1996040760A2 (fr) * 1995-06-07 1996-12-19 Schering Aktiengesellschaft Peptides iodes et leur utilisation comme opacifiants radiologiques

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985002611A1 (fr) * 1983-12-12 1985-06-20 Scripps Clinic And Research Foundation Polypeptide de synthese correspondant a une partie de l'enterotoxine thermolabile d'escherichia coli, compositions et procedes
EP0331616A2 (fr) * 1988-02-29 1989-09-06 Schering Aktiengesellschaft Formateur de complexe lié à un polymère, ces complexes, procédé de préparation et milieu pharmaceutique les contenant
EP0481526A1 (fr) * 1989-04-07 1992-04-22 Nycomed Salutar, Inc. Agents de chélation
WO1993006868A1 (fr) * 1991-10-07 1993-04-15 COCKBAIN, Jilian, Roderick, Michaelson Polychelateurs dendrimeres
WO1993010824A1 (fr) * 1991-12-04 1993-06-10 Guerbet S.A. Nouveau compose macromoleculaire polyamine iode, son procede de preparation et son utilisation comme agent de contraste
WO1994005203A1 (fr) * 1992-09-04 1994-03-17 The General Hospital Corporation Polymeres biocompatibles contenant des fractions therapeutiques ou de diagnostic
WO1996040816A1 (fr) * 1995-06-07 1996-12-19 Schering Aktiengesellschaft Polyamides et polyamines lineaires iodes
WO1996040760A2 (fr) * 1995-06-07 1996-12-19 Schering Aktiengesellschaft Peptides iodes et leur utilisation comme opacifiants radiologiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RANGANATHAN, DARSHAN ET AL: "Synthesis of totally chiral, multiple armed, poly Glu and poly Asp scaffoldings on bifunctional adamantane core", TETRAHEDRON LETT., 1997, 38, 1265-1268, XP004034251 *

Also Published As

Publication number Publication date
AU5871798A (en) 1998-08-18
NO993662L (no) 1999-09-28
JP2001509796A (ja) 2001-07-24
KR20000070544A (ko) 2000-11-25
EP1011736A2 (fr) 2000-06-28
CN1246059A (zh) 2000-03-01
WO1998032469A2 (fr) 1998-07-30
CA2278200A1 (fr) 1998-07-30
NO993662D0 (no) 1999-07-28

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