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WO1998030680A3 - Special catalytic domains of CDC25C phosphatase - Google Patents

Special catalytic domains of CDC25C phosphatase Download PDF

Info

Publication number
WO1998030680A3
WO1998030680A3 PCT/US1998/000018 US9800018W WO9830680A3 WO 1998030680 A3 WO1998030680 A3 WO 1998030680A3 US 9800018 W US9800018 W US 9800018W WO 9830680 A3 WO9830680 A3 WO 9830680A3
Authority
WO
WIPO (PCT)
Prior art keywords
cdc25c
catalytic domains
special catalytic
cdc25c phosphatase
phosphatase
Prior art date
Application number
PCT/US1998/000018
Other languages
French (fr)
Other versions
WO1998030680A2 (en
Inventor
Martin R Deibel
Anne F Vosters
Anthony W Yem
Keith D Watenpaugh
Musiri N Janakiraman
Luis A Parodi
Original Assignee
Upjohn Co
Martin R Deibel
Anne F Vosters
Anthony W Yem
Keith D Watenpaugh
Musiri N Janakiraman
Luis A Parodi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Martin R Deibel, Anne F Vosters, Anthony W Yem, Keith D Watenpaugh, Musiri N Janakiraman, Luis A Parodi filed Critical Upjohn Co
Priority to AU60149/98A priority Critical patent/AU6014998A/en
Publication of WO1998030680A2 publication Critical patent/WO1998030680A2/en
Publication of WO1998030680A3 publication Critical patent/WO1998030680A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

This invention discloses novel forms of catalytic macro molecules that are related to cdc25C, a cell cycle specific phosphatase. These special domains of cdc25C, and the method of making them, are especially useful.
PCT/US1998/000018 1997-01-13 1998-01-09 Special catalytic domains of cdc25c phosphatase WO1998030680A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU60149/98A AU6014998A (en) 1997-01-13 1998-01-09 Special catalytic domains of cdc25c phosphatase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3518897P 1997-01-13 1997-01-13
US60/035,188 1997-01-13

Publications (2)

Publication Number Publication Date
WO1998030680A2 WO1998030680A2 (en) 1998-07-16
WO1998030680A3 true WO1998030680A3 (en) 1998-09-17

Family

ID=21881186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/000018 WO1998030680A2 (en) 1997-01-13 1998-01-09 Special catalytic domains of cdc25c phosphatase

Country Status (2)

Country Link
AU (1) AU6014998A (en)
WO (1) WO1998030680A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021771A2 (en) * 1999-09-22 2001-03-29 Canbas Co., Ltd. Compositions and methods for inhibiting g2 cell cycle arrest and sensitizing cells to dna damaging agents
WO2001044467A2 (en) * 1999-12-14 2001-06-21 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Method for obtaining human cdc25 phosphatases and method for identifying human cdc25 phosphatase modulators

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
B. BARATTE ET AL.: "Screening for antimitotic compounds using the cdc25 tyrosine phosphatase, an activator of the mitosis inducing p34cdc2/cyclin Bcdc13 protein kinase", ANTICANCER RESEARCH, vol. 12, 1992, pages 873 - 880, XP002069498 *
J.B.A MILLAR ET AL.: "p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast", EMBO JOURNAL, vol. 10, no. 13, 1991, pages 4301 - 4309, XP002069499 *
M.S. LEE ET AL: "cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2", MOLECULAR BIOLOGY OF THE CELL, vol. 3, 1992, pages 73 - 84, XP002069497 *
T. ORIGUCHI ET AL.: "Dnacin A1 and Dnacin B1 are antitmor antibiotics that inhibit cdc25B phosphatase activity", BIOCHEMICAL PHARMACOLOGY, vol. 48, no. 11, 1994, pages 2139 - 2141, XP002038482 *

Also Published As

Publication number Publication date
WO1998030680A2 (en) 1998-07-16
AU6014998A (en) 1998-08-03

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