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WO1998027058A3 - N-piperazin-1-ylphenyl-benzamide derivatives - Google Patents

N-piperazin-1-ylphenyl-benzamide derivatives Download PDF

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Publication number
WO1998027058A3
WO1998027058A3 PCT/EP1997/007160 EP9707160W WO9827058A3 WO 1998027058 A3 WO1998027058 A3 WO 1998027058A3 EP 9707160 W EP9707160 W EP 9707160W WO 9827058 A3 WO9827058 A3 WO 9827058A3
Authority
WO
WIPO (PCT)
Prior art keywords
ylphenyl
piperazin
benzamide derivatives
derivatives
benzamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1997/007160
Other languages
French (fr)
Other versions
WO1998027058A2 (en
Inventor
Steven Mark Bromidge
Francis David King
Paul Adrian Wyman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9626376.9A external-priority patent/GB9626376D0/en
Priority claimed from GBGB9700902.1A external-priority patent/GB9700902D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Priority to JP52734898A priority Critical patent/JP2001506995A/en
Priority to CA002274055A priority patent/CA2274055A1/en
Priority to EP97954435A priority patent/EP0946551A2/en
Publication of WO1998027058A2 publication Critical patent/WO1998027058A2/en
Publication of WO1998027058A3 publication Critical patent/WO1998027058A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Novel carboxamide derivatives having CNS activity, processes for their preparation and their use as medicaments.
PCT/EP1997/007160 1996-12-19 1997-12-15 N-piperazin-1-ylphenyl-benzamide derivatives Ceased WO1998027058A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP52734898A JP2001506995A (en) 1996-12-19 1997-12-15 N-piperazin-1-ylphenyl-benzamide derivatives
CA002274055A CA2274055A1 (en) 1996-12-19 1997-12-15 N-piperazin-1-ylphenyl-benzamide derivatives
EP97954435A EP0946551A2 (en) 1996-12-19 1997-12-15 N-piperazin-1-ylphenyl-benzamide derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9626376.9 1996-12-19
GBGB9626376.9A GB9626376D0 (en) 1996-12-19 1996-12-19 Novel compounds
GBGB9700902.1A GB9700902D0 (en) 1997-01-17 1997-01-17 Novel compounds
GB9700902.1 1997-01-17

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09331353 A-371-Of-International 1999-06-18
US66695700A Continuation 1996-12-19 2000-09-20

Publications (2)

Publication Number Publication Date
WO1998027058A2 WO1998027058A2 (en) 1998-06-25
WO1998027058A3 true WO1998027058A3 (en) 1998-08-20

Family

ID=26310680

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/007160 Ceased WO1998027058A2 (en) 1996-12-19 1997-12-15 N-piperazin-1-ylphenyl-benzamide derivatives

Country Status (4)

Country Link
EP (1) EP0946551A2 (en)
JP (1) JP2001506995A (en)
CA (1) CA2274055A1 (en)
WO (1) WO1998027058A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001526643A (en) * 1997-04-18 2001-12-18 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー Bicyclic aryl or heterocyclic rings, including compounds having combined 5HT1A, 5HT1B and 5HT1D receptor antagonist activity
WO1999002502A2 (en) * 1997-07-11 1999-01-21 Smithkline Beecham Plc Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation
GB9803411D0 (en) * 1998-02-18 1998-04-15 Smithkline Beecham Plc Novel compounds
US6194410B1 (en) 1998-03-11 2001-02-27 Hoffman-La Roche Inc. Pyrazolopyrimidine and pyrazolines and process for preparation thereof
CA2340952C (en) * 1998-09-10 2009-12-08 F. Hoffmann-La Roche Ag Dihydrobenzodioxine carboxamide and ketone derivatives as 5-ht4 receptor antagonists
GB9820113D0 (en) 1998-09-15 1998-11-11 Merck Sharp & Dohme Therapeutic agents
KR20020030126A (en) * 1999-09-25 2002-04-22 피터 기딩스 Piperazine Derivatives as 5-HT1B Antagonists
KR20030064852A (en) 2000-12-22 2003-08-02 이시하라 산교 가부시끼가이샤 Aniline Derivatives or Salts Thereof and Cytokine Production Inhibitors Containing the Same
KR100864356B1 (en) 2001-01-16 2008-10-17 아스트라제네카 아베 Therapeutic Heterocyclic Compounds
CN1592745A (en) 2001-01-16 2005-03-09 阿斯特拉曾尼卡有限公司 Therapeutic chromone compounds
GB0106586D0 (en) * 2001-03-16 2001-05-09 Smithkline Beecham Plc Novel compounds
SE0103644D0 (en) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic isoquinoline compounds
BR112012024380A2 (en) 2010-03-25 2015-09-15 Glaxosmithkline Llc chemical compounds

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0533267A1 (en) * 1991-09-18 1993-03-24 Glaxo Group Limited Benzanilide derivatives as 5-HT1D antagonists
EP0533266A1 (en) * 1991-09-18 1993-03-24 Glaxo Group Limited Benzanilide derivatives as 5-HT1D antagonists
WO1994001556A1 (en) * 1992-07-01 1994-01-20 Institut National De La Sante Et De La Recherche Medicale (Inserm) Polypeptides having serotoninergic receptor activity (5ht6), nucleic acids coding for said polypeptides, and uses thereof
FR2699533A1 (en) * 1992-12-21 1994-06-24 Mouhtaram Mohamed N-2-piperazinyl 4-amino:benzamide derivs. having antiemetic and antipsychotic activity
GB2273930A (en) * 1992-12-30 1994-07-06 Glaxo Group Ltd Benzanilide derivatives
WO1994015920A1 (en) * 1992-12-30 1994-07-21 Glaxo Group Limited Benzanilide derivatives as 5-ht1d-antagonists
GB2276165A (en) * 1993-03-17 1994-09-21 Glaxo Group Ltd Aniline and benzanilide compounds.
GB2276164A (en) * 1993-03-17 1994-09-21 Glaxo Group Ltd Aniline and benzanilide derivatives
WO1994021619A1 (en) * 1993-03-16 1994-09-29 Pfizer Inc. Naphthalene derivatives
WO1995004729A1 (en) * 1993-08-06 1995-02-16 Smithkline Beecham Plc Amide derivatives as 5ht1d receptor antagonists
WO1995011243A1 (en) * 1993-10-19 1995-04-27 Smithkline Beecham Plc Benzanilide derivatives as 5ht-1d receptor antagonists
EP0661266A1 (en) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituted cyclic amine compounds as 5HT2 antagonists
WO1995017888A1 (en) * 1993-12-30 1995-07-06 Smithkline Beecham Corporation Phenylmethyl hexanamides, and the use thereof

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0533266A1 (en) * 1991-09-18 1993-03-24 Glaxo Group Limited Benzanilide derivatives as 5-HT1D antagonists
EP0533267A1 (en) * 1991-09-18 1993-03-24 Glaxo Group Limited Benzanilide derivatives as 5-HT1D antagonists
WO1994001556A1 (en) * 1992-07-01 1994-01-20 Institut National De La Sante Et De La Recherche Medicale (Inserm) Polypeptides having serotoninergic receptor activity (5ht6), nucleic acids coding for said polypeptides, and uses thereof
FR2699533A1 (en) * 1992-12-21 1994-06-24 Mouhtaram Mohamed N-2-piperazinyl 4-amino:benzamide derivs. having antiemetic and antipsychotic activity
GB2273930A (en) * 1992-12-30 1994-07-06 Glaxo Group Ltd Benzanilide derivatives
WO1994015920A1 (en) * 1992-12-30 1994-07-21 Glaxo Group Limited Benzanilide derivatives as 5-ht1d-antagonists
WO1994021619A1 (en) * 1993-03-16 1994-09-29 Pfizer Inc. Naphthalene derivatives
GB2276165A (en) * 1993-03-17 1994-09-21 Glaxo Group Ltd Aniline and benzanilide compounds.
GB2276164A (en) * 1993-03-17 1994-09-21 Glaxo Group Ltd Aniline and benzanilide derivatives
WO1995004729A1 (en) * 1993-08-06 1995-02-16 Smithkline Beecham Plc Amide derivatives as 5ht1d receptor antagonists
WO1995011243A1 (en) * 1993-10-19 1995-04-27 Smithkline Beecham Plc Benzanilide derivatives as 5ht-1d receptor antagonists
EP0661266A1 (en) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituted cyclic amine compounds as 5HT2 antagonists
WO1995017888A1 (en) * 1993-12-30 1995-07-06 Smithkline Beecham Corporation Phenylmethyl hexanamides, and the use thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 100, no. 21, 21 May 1984, Columbus, Ohio, US; abstract no. 174780, XP002066493 *
CHEMICAL ABSTRACTS, vol. 121, no. 7, 15 August 1994, Columbus, Ohio, US; abstract no. 73080, XP002066494 *
DATABASE CHEM. ABS. REGISTRY American Chemical Society; *
J.W. CLITHEROW ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, no. 15, 1994, WASHINGTON US, pages 2253 - 2257 *
R. AGARWAL ET AL., INDIAN J. PHARMACOL., vol. 14, no. 2, 1982, pages 177 - 182 *

Also Published As

Publication number Publication date
JP2001506995A (en) 2001-05-29
CA2274055A1 (en) 1998-06-25
EP0946551A2 (en) 1999-10-06
WO1998027058A2 (en) 1998-06-25

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