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WO1998023297A3 - Particulate compositions - Google Patents

Particulate compositions Download PDF

Info

Publication number
WO1998023297A3
WO1998023297A3 PCT/GB1997/003283 GB9703283W WO9823297A3 WO 1998023297 A3 WO1998023297 A3 WO 1998023297A3 GB 9703283 W GB9703283 W GB 9703283W WO 9823297 A3 WO9823297 A3 WO 9823297A3
Authority
WO
WIPO (PCT)
Prior art keywords
vesicles
particulate compositions
aqueous medium
contrast agent
ray contrast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1997/003283
Other languages
French (fr)
Other versions
WO1998023297A2 (en
Inventor
Liv Ingrid Oedegaardstuen
Kari Dyvik
Kathrin Bjerknes
Anne Kjersti Fahlvik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Priority to JP52444098A priority Critical patent/JP2001504837A/en
Priority to AU51293/98A priority patent/AU5129398A/en
Priority to EP97945974A priority patent/EP1009445A2/en
Publication of WO1998023297A2 publication Critical patent/WO1998023297A2/en
Publication of WO1998023297A3 publication Critical patent/WO1998023297A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention provides a contrast agent composition, preferably an X-ray contrast medium, comprising vesicles in suspension in an aqueous medium, said vesicles and optionally also said aqueous medium containing an iodinated X-ray contrast agent, characterised in that a dose of said composition containing 100 mgI entrapped in said vesicles contains no more than 8x1012 vesicles.
PCT/GB1997/003283 1996-11-29 1997-11-28 Particulate compositions Ceased WO1998023297A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP52444098A JP2001504837A (en) 1996-11-29 1997-11-28 Granular composition
AU51293/98A AU5129398A (en) 1996-11-29 1997-11-28 Particulate compositions
EP97945974A EP1009445A2 (en) 1996-11-29 1997-11-28 Particulate compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9624918.0 1996-11-29
GBGB9624918.0A GB9624918D0 (en) 1996-11-29 1996-11-29 Particulate components

Publications (2)

Publication Number Publication Date
WO1998023297A2 WO1998023297A2 (en) 1998-06-04
WO1998023297A3 true WO1998023297A3 (en) 1998-07-16

Family

ID=10803721

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/003283 Ceased WO1998023297A2 (en) 1996-11-29 1997-11-28 Particulate compositions

Country Status (5)

Country Link
EP (1) EP1009445A2 (en)
JP (1) JP2001504837A (en)
AU (1) AU5129398A (en)
GB (1) GB9624918D0 (en)
WO (1) WO1998023297A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO20004795D0 (en) 2000-09-26 2000-09-26 Nycomed Imaging As Peptide-based compounds
DK2029184T3 (en) * 2006-05-26 2011-05-02 Baxter Int Injectable fibrin composition for bone reinforcement
EP2550022B1 (en) * 2010-03-23 2020-12-09 GE Healthcare AS Preparation of stabilised x-ray diagnostic composition
EP2606912A1 (en) * 2011-12-23 2013-06-26 Central Medical Service Co., Ltd. Contrast medium composition with contrast enhancement effect by comprising highly concentrated agent

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989011272A1 (en) * 1988-05-20 1989-11-30 The Liposome Company, Inc. High ratio active agent:lipid complex
WO1992010166A1 (en) * 1990-12-11 1992-06-25 Sintetica S.A. Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated
WO1995026205A1 (en) * 1994-03-28 1995-10-05 Nycomed Imaging A/S Liposomes
WO1995026185A1 (en) * 1994-03-28 1995-10-05 Daiichi Pharmaceutical Co., Ltd. Liposome with increased retention volume
WO1996024381A2 (en) * 1995-02-09 1996-08-15 Schering Aktiengesellschaft Liposomes containing contrast media for blood pool imaging
WO1996025955A1 (en) * 1995-02-24 1996-08-29 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989011272A1 (en) * 1988-05-20 1989-11-30 The Liposome Company, Inc. High ratio active agent:lipid complex
WO1992010166A1 (en) * 1990-12-11 1992-06-25 Sintetica S.A. Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated
WO1995026205A1 (en) * 1994-03-28 1995-10-05 Nycomed Imaging A/S Liposomes
WO1995026185A1 (en) * 1994-03-28 1995-10-05 Daiichi Pharmaceutical Co., Ltd. Liposome with increased retention volume
EP0804925A1 (en) * 1994-03-28 1997-11-05 Daiichi Pharmaceutical Co., Ltd. Liposome with increased retention volume
WO1996024381A2 (en) * 1995-02-09 1996-08-15 Schering Aktiengesellschaft Liposomes containing contrast media for blood pool imaging
WO1996025955A1 (en) * 1995-02-24 1996-08-29 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HENZE A ET AL: "RADIO-OPAQUE LIPOSOMES FOR THE IMPROVED VISUALISATION OF FOCAL LIVER DISEASE BY COMPUTERIZED TOMOGRAPHY", COMPUTERIZED MEDICAL IMAGING AND GRAPHICS, vol. 13, no. 6, 1989, pages 455 - 462, XP002049028 *
KRAUSE, W. ET AL: "Liposomes in diagnostic imaging: comparison of modalities; in vivo visualization of liposomes", JOURNAL OF LIPOSOME RESEARCH, vol. 5, no. 1, 1995, pages 1 - 27, XP002063540 *
LEANDER P.: "Liver specific contrast media for MRI and CT. Experimental studies", ACTA RADIOLOGICA SUPPLEMENTUM, vol. 36, no. supp. 396, 1995, pages 1 - 36, XP002063541 *

Also Published As

Publication number Publication date
AU5129398A (en) 1998-06-22
GB9624918D0 (en) 1997-01-15
JP2001504837A (en) 2001-04-10
WO1998023297A2 (en) 1998-06-04
EP1009445A2 (en) 2000-06-21

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