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WO1998013007A8 - Methods and compositions for lipidization of hydrophilic molecules - Google Patents

Methods and compositions for lipidization of hydrophilic molecules

Info

Publication number
WO1998013007A8
WO1998013007A8 PCT/US1997/017282 US9717282W WO9813007A8 WO 1998013007 A8 WO1998013007 A8 WO 1998013007A8 US 9717282 W US9717282 W US 9717282W WO 9813007 A8 WO9813007 A8 WO 9813007A8
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
disulfide
fatty acid
lipidization
compositions
Prior art date
Application number
PCT/US1997/017282
Other languages
French (fr)
Other versions
WO1998013007A9 (en
WO1998013007A2 (en
Inventor
Wei-Chiang Shen
Jinghua Wang
Original Assignee
Univ Southern California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southern California filed Critical Univ Southern California
Priority to IL12917797A priority Critical patent/IL129177A0/en
Priority to BR9712128-2A priority patent/BR9712128A/en
Priority to JP51593398A priority patent/JP2002515883A/en
Priority to AU45967/97A priority patent/AU737865B2/en
Priority to EP97944483A priority patent/EP1023316A4/en
Priority to CA002267179A priority patent/CA2267179A1/en
Publication of WO1998013007A2 publication Critical patent/WO1998013007A2/en
Publication of WO1998013007A9 publication Critical patent/WO1998013007A9/en
Priority to NO991465A priority patent/NO991465L/en
Publication of WO1998013007A8 publication Critical patent/WO1998013007A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Fatty acid derivatives of disulfide-containing compounds (for example, disulfide-containing peptides or proteins) comprising fatty acid-conjugated products with a disulfide linkage are employed for delivery of the compounds to mammalian cells. This modification markedly increases the absorption of the compounds by mammalian cells relative to the rate of absorption of the unconjugated compounds, as well as prolonging blood and tissue retention of the compounds. Moreover, the disulfide linkage in the conjugate is quite labile in vivo and thus facilitates intracellular or extracellular release of the intact compounds from the fatty acid moieties.
PCT/US1997/017282 1996-09-26 1997-09-26 Methods and compositions for lipidization of hydrophilic molecules WO1998013007A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IL12917797A IL129177A0 (en) 1996-09-26 1997-09-26 Methods and compositions for lipidization of hydrophilic molecules
BR9712128-2A BR9712128A (en) 1996-09-26 1997-09-26 Methods and compositions for lipidization of hydrophilic molecules
JP51593398A JP2002515883A (en) 1996-09-26 1997-09-26 Methods and compositions for lipidation of hydrophilic molecules
AU45967/97A AU737865B2 (en) 1996-09-26 1997-09-26 Methods and compositions for lipidization of hydrophilic molecules
EP97944483A EP1023316A4 (en) 1996-09-26 1997-09-26 METHODS AND COMPOSITIONS FOR THE LIPIDATION OF HYDROPHILIC MOLECULES
CA002267179A CA2267179A1 (en) 1996-09-26 1997-09-26 Methods and compositions for lipidization of hydrophilic molecules
NO991465A NO991465L (en) 1996-09-26 1999-03-25 Methods and Preparations for Lipidization of Hydrophilic Molecules

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72130696A 1996-09-26 1996-09-26
US08/721,306 1996-09-26
US4949997P 1997-06-13 1997-06-13
US60/049,499 1997-06-13

Publications (3)

Publication Number Publication Date
WO1998013007A2 WO1998013007A2 (en) 1998-04-02
WO1998013007A9 WO1998013007A9 (en) 1998-08-13
WO1998013007A8 true WO1998013007A8 (en) 1999-05-20

Family

ID=26727231

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/017282 WO1998013007A2 (en) 1996-09-26 1997-09-26 Methods and compositions for lipidization of hydrophilic molecules

Country Status (10)

Country Link
EP (1) EP1023316A4 (en)
JP (1) JP2002515883A (en)
KR (1) KR100691315B1 (en)
CN (1) CN1127477C (en)
AU (1) AU737865B2 (en)
BR (1) BR9712128A (en)
CA (1) CA2267179A1 (en)
IL (1) IL129177A0 (en)
NO (1) NO991465L (en)
WO (1) WO1998013007A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169078B1 (en) * 1998-05-12 2001-01-02 University Of Florida Materials and methods for the intracellular delivery of substances
TWI242000B (en) 1998-12-10 2005-10-21 Univ Southern California Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use
GB0103877D0 (en) * 2001-02-16 2001-04-04 King S College London Novel Drug Delivery system
US20050054612A1 (en) * 2003-09-08 2005-03-10 Monahan Sean D. Delivery by labile hydrophobic modification of drugs
CN1902311A (en) * 2003-12-31 2007-01-24 森托科尔公司 Novel recombinant proteins with n-terminal free thiol
JP2010508271A (en) 2006-10-27 2010-03-18 ウェイ‐チャン シェン Lipidated interferon and uses thereof
JP2010520286A (en) * 2007-03-05 2010-06-10 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ Wnt composition and method of use thereof
AU2009217269B2 (en) * 2008-02-21 2014-10-02 Dermacare Neuroscience Institute Cosmetic and dermatological formulations of MNTF peptides
ES2859923T3 (en) * 2013-02-28 2021-10-04 Univ Tufts Disulfide compounds for the supply of pharmaceutical agents
WO2014186366A1 (en) * 2013-05-13 2014-11-20 Tufts University Nanocomplexes for delivery of saporin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5907030A (en) * 1995-01-25 1999-05-25 University Of Southern California Method and compositions for lipidization of hydrophilic molecules
NZ333562A (en) * 1996-06-25 2001-04-27 Stichting Inst Voor Dierhouder Vaccine comprising antigens bound by thioester or disulphide bonds to fatty acid carriers such palmitic acid, antigens bound in reversible and labile way

Also Published As

Publication number Publication date
CA2267179A1 (en) 1998-04-02
KR100691315B1 (en) 2007-03-12
CN1235594A (en) 1999-11-17
EP1023316A2 (en) 2000-08-02
BR9712128A (en) 2000-12-12
EP1023316A4 (en) 2004-06-09
AU4596797A (en) 1998-04-17
NO991465D0 (en) 1999-03-25
KR20000048608A (en) 2000-07-25
NO991465L (en) 1999-05-10
AU737865B2 (en) 2001-09-06
CN1127477C (en) 2003-11-12
JP2002515883A (en) 2002-05-28
WO1998013007A2 (en) 1998-04-02
IL129177A0 (en) 2000-02-17

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