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WO1998010795B1 - Molecules se logeant dans une tumeur, conjugues tires de ces molecules et leurs procedes d'utilisation - Google Patents

Molecules se logeant dans une tumeur, conjugues tires de ces molecules et leurs procedes d'utilisation

Info

Publication number
WO1998010795B1
WO1998010795B1 PCT/US1997/016086 US9716086W WO9810795B1 WO 1998010795 B1 WO1998010795 B1 WO 1998010795B1 US 9716086 W US9716086 W US 9716086W WO 9810795 B1 WO9810795 B1 WO 9810795B1
Authority
WO
WIPO (PCT)
Prior art keywords
tumor
page
new
molecule
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/016086
Other languages
English (en)
Other versions
WO1998010795A9 (fr
WO1998010795A3 (fr
WO1998010795A2 (fr
Filing date
Publication date
Application filed filed Critical
Priority to DE69734887T priority Critical patent/DE69734887T2/de
Priority to CA002265484A priority patent/CA2265484C/fr
Priority to JP10513856A priority patent/JP2001501600A/ja
Priority to AU44122/97A priority patent/AU4412297A/en
Priority to EP97942422A priority patent/EP0927045B1/fr
Publication of WO1998010795A2 publication Critical patent/WO1998010795A2/fr
Publication of WO1998010795A3 publication Critical patent/WO1998010795A3/fr
Publication of WO1998010795B1 publication Critical patent/WO1998010795B1/fr
Anticipated expiration legal-status Critical
Publication of WO1998010795A9 publication Critical patent/WO1998010795A9/fr
Ceased legal-status Critical Current

Links

Abstract

La présente invention concerne des molécules se logeant dans des tumeurs, capables de sélectionner la tumeur. Elle fournit également des procédés d'utilisation d'une molécule se logeant dans les tumeurs pour cibler un agent, tel qu'un médicament, sur une tumeur spécifique ou pour identifier la molécule cible exprimée par la tumeur. La présente invention concerne également des procédés de ciblage d'une tumeur contenant un système vasculaire angiogénique, lesdits procédés consistant à mettre en contact la tumeur avec une molécule se liant spécifiquement à une intégrine contenant αv. La présente invention concerne en outre des molécules pouvant sélectivement se loger dans un système vasculaire angiogénique. De plus, l'invention présente une molécule cible, liée spécifiquement par une molécule se logeant dans une tumeur et exprimée par un système vasculaire angiogénique. Elle présente enfin des anticorps se liant à la molécule cible, ainsi que des peptidomimétiques qui inhibent de façon compétitive la fixation d'un ligand sur la molécule cible.
PCT/US1997/016086 1996-09-10 1997-09-10 Molecules se logeant dans une tumeur, conjugues tires de ces molecules et leurs procedes d'utilisation Ceased WO1998010795A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE69734887T DE69734887T2 (de) 1996-09-10 1997-09-10 Tumor findende moleküle, davon abstammende konjugate und verfahren zu deren verwendung
CA002265484A CA2265484C (fr) 1996-09-10 1997-09-10 Molecules se logeant dans une tumeur, conjugues tires de ces molecules et leurs procedes d'utilisation
JP10513856A JP2001501600A (ja) 1996-09-10 1997-09-10 腫瘍ホーミング分子、それに由来する結合体、およびその使用方法
AU44122/97A AU4412297A (en) 1996-09-10 1997-09-10 Tumor homing molecules, conjugates derived therefrom, and methods of using sa me
EP97942422A EP0927045B1 (fr) 1996-09-10 1997-09-10 Molecules se logeant dans une tumeur, conjugues tires de ces molecules et leurs procedes d'utilisation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71006796A 1996-09-10 1996-09-10
US08/710,067 1996-09-10

Publications (4)

Publication Number Publication Date
WO1998010795A2 WO1998010795A2 (fr) 1998-03-19
WO1998010795A3 WO1998010795A3 (fr) 1998-05-22
WO1998010795B1 true WO1998010795B1 (fr) 1998-07-16
WO1998010795A9 WO1998010795A9 (fr) 2001-06-21

Family

ID=24852493

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/016086 Ceased WO1998010795A2 (fr) 1996-09-10 1997-09-10 Molecules se logeant dans une tumeur, conjugues tires de ces molecules et leurs procedes d'utilisation

Country Status (6)

Country Link
EP (1) EP0927045B1 (fr)
JP (1) JP2001501600A (fr)
AU (1) AU4412297A (fr)
CA (1) CA2265484C (fr)
DE (1) DE69734887T2 (fr)
WO (1) WO1998010795A2 (fr)

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US7186810B2 (en) 1998-10-23 2007-03-06 Amgen Inc. Modified peptides as therapeutic agents
US7442778B2 (en) 2004-09-24 2008-10-28 Amgen Inc. Modified Fc molecules
US9114175B2 (en) 2005-08-12 2015-08-25 Amgen Inc. Modified Fc molecules

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CN102558334B (zh) * 2004-09-07 2016-08-03 伯纳姆研究院 选择性锚定到心脏脉管系统上的肽和相关结合物和方法
WO2006067633A2 (fr) * 2004-12-23 2006-06-29 Molmed Spa Produit de conjugaison
ITMI20050328A1 (it) 2005-03-03 2006-09-04 Univ Degli Studi Milano Composti peptidomimetrici e preparazione di derivati biologicamente attivi
EP1968648B1 (fr) 2005-12-16 2015-05-06 Catherine M Shachaf Systeme diagnostic pour la detection et le diagnostic du cancer de la peau
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186810B2 (en) 1998-10-23 2007-03-06 Amgen Inc. Modified peptides as therapeutic agents
US7442778B2 (en) 2004-09-24 2008-10-28 Amgen Inc. Modified Fc molecules
US9114175B2 (en) 2005-08-12 2015-08-25 Amgen Inc. Modified Fc molecules

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