[go: up one dir, main page]

WO1998009951B1 - Intermediaires permettant la production d'inhibiteurs de la vih-protease et procedes de production d'inhibiteurs de la vih-protease - Google Patents

Intermediaires permettant la production d'inhibiteurs de la vih-protease et procedes de production d'inhibiteurs de la vih-protease

Info

Publication number
WO1998009951B1
WO1998009951B1 PCT/US1997/015468 US9715468W WO9809951B1 WO 1998009951 B1 WO1998009951 B1 WO 1998009951B1 US 9715468 W US9715468 W US 9715468W WO 9809951 B1 WO9809951 B1 WO 9809951B1
Authority
WO
WIPO (PCT)
Prior art keywords
group
formula
compound
aryl
alkyl
Prior art date
Application number
PCT/US1997/015468
Other languages
English (en)
Other versions
WO1998009951A2 (fr
WO1998009951A3 (fr
Filing date
Publication date
Priority to UA99041906A priority Critical patent/UA67727C2/uk
Priority to CA002264756A priority patent/CA2264756A1/fr
Priority to EEP199900109A priority patent/EE04465B1/xx
Priority to EA199900257A priority patent/EA002051B1/ru
Priority to SK282-99A priority patent/SK284899B6/sk
Priority to BR9713192-0A priority patent/BR9713192A/pt
Priority to AU43317/97A priority patent/AU740369B2/en
Priority to DK97941402T priority patent/DK0927165T3/da
Priority to SI9730719T priority patent/SI1361216T1/sl
Priority to DE69726298T priority patent/DE69726298T2/de
Priority to JP51283198A priority patent/JP4149000B2/ja
Priority to SI9730605T priority patent/SI0927165T1/xx
Priority to AT97941402T priority patent/ATE254603T1/de
Priority to EP97941402A priority patent/EP0927165B1/fr
Application filed filed Critical
Priority to IL12856797A priority patent/IL128567A/en
Priority to SK90-2005A priority patent/SK285278B6/sk
Priority to APAP/P/1999/001497A priority patent/AP1322A/en
Priority to APAP/P/2003/002938A priority patent/AP2003002938A0/en
Priority to PL331801A priority patent/PL198408B1/pl
Priority to NZ334909A priority patent/NZ334909A/en
Publication of WO1998009951A2 publication Critical patent/WO1998009951A2/fr
Publication of WO1998009951A3 publication Critical patent/WO1998009951A3/fr
Publication of WO1998009951B1 publication Critical patent/WO1998009951B1/fr
Priority to IS4982A priority patent/IS2030B/is
Priority to NO19991072A priority patent/NO313287B1/no
Priority to BG103305A priority patent/BG64793B1/bg
Priority to AU14736/02A priority patent/AU766155B2/en
Priority to JP2007280974A priority patent/JP2008056693A/ja

Links

Abstract

L'invention concerne des inhibiteurs de la VIH-protéase inhibant ou bloquant l'activité biologique de l'enzyme VIH-protéase, ce qui provoque la fin de la réplication du virus de l'immunodéficience humaine. On peut préparer ces composés grâce aux nouveaux procédés selon la présente invention, en utilisant les nouveaux composés et intermédiaires de l'invention.
PCT/US1997/015468 1995-09-26 1997-09-04 Intermediaires permettant la production d'inhibiteurs de la vih-protease et procedes de production d'inhibiteurs de la vih-protease WO1998009951A2 (fr)

Priority Applications (25)

Application Number Priority Date Filing Date Title
UA99041906A UA67727C2 (uk) 1996-09-05 1997-04-09 Проміжні сполуки для одержання інгібіторів віл-протеази і способи одержання інгібіторів віл-протеази
EP97941402A EP0927165B1 (fr) 1996-09-05 1997-09-04 Intermediaires permettant la production d'inhibiteurs de la vih-protease et procedes de production d'inhibiteurs de la vih-protease
EA199900257A EA002051B1 (ru) 1996-09-05 1997-09-04 Способ получения ингибиторов вич-протеазы
SK282-99A SK284899B6 (sk) 1996-09-05 1997-09-04 Medziprodukty na výrobu inhibítorov HIV-proteázy a spôsoby výroby inhibítorov HIV-proteázy
IL12856797A IL128567A (en) 1996-09-05 1997-09-04 Intermediates used to prepare Neplinavir HIV protease inhibitor, process for their preparation and methods for preparing naplinavir
AU43317/97A AU740369B2 (en) 1995-09-26 1997-09-04 Intermediates for making HIV-protease inhibitors and methods of making HIV-protease inhibitors
DK97941402T DK0927165T3 (da) 1996-09-05 1997-09-04 Mellemprodukter til fremstilling af HIV-protease inhibitorer og fremgangsmåde til fremstilling af HIV-protease inhibitorer
SI9730719T SI1361216T1 (sl) 1996-09-05 1997-09-04 Postopek za pripravo zaviralca proteaze hiv
DE69726298T DE69726298T2 (de) 1996-09-05 1997-09-04 Zwischenprodukte zur herstellung von hiv-protease-inhibitoren und verfharen zur herstellung hiv-protease-inhibitoren
JP51283198A JP4149000B2 (ja) 1996-09-05 1997-09-04 Ｈｉｖ―プロテアーゼ阻害剤製造の中間体及びｈｉｖ―プロテアーゼ阻害剤の製造方法
SI9730605T SI0927165T1 (en) 1996-09-05 1997-09-04 Intermediates for making hiv-protease inhibitors and methods of making hiv-protease inhibitors
AT97941402T ATE254603T1 (de) 1996-09-05 1997-09-04 Zwischenprodukte zur herstellung von hiv-protease-inhibitoren und verfharen zur herstellung hiv- protease-inhibitoren
NZ334909A NZ334909A (en) 1996-09-05 1997-09-04 Intermediates for making HIV protease inhibitors
CA002264756A CA2264756A1 (fr) 1996-09-05 1997-09-04 Intermediaires permettant la production d'inhibiteurs de la vih-protease et procedes de production d'inhibiteurs de la vih-protease
BR9713192-0A BR9713192A (pt) 1996-09-05 1997-09-04 Intermediários para fabricação de inibidores da protease de hiv e métodos de fabricação de inibidores para protease de hiv
SK90-2005A SK285278B6 (sk) 1996-09-05 1997-09-04 Spôsob výroby inhibítora HIV-proteázy
APAP/P/1999/001497A AP1322A (en) 1996-09-05 1997-09-04 Intermediates for making HIV- protease inhibitors and methods of making HIV protease inhibitors.
APAP/P/2003/002938A AP2003002938A0 (en) 1996-09-05 1997-09-04 Intermediates for making HIV- protease inhibitors and methods of making HIV protease inhibitors.
PL331801A PL198408B1 (pl) 1996-09-05 1997-09-04 Chlorek kwasu 3-acetoksy-2-metylobenzoesowego, sposób wytwarzania chlorku kwasu 3-acetoksy-2-metylobenzoesowego, sposób wytwarzania nelfinaviru i sposób wytwarzania mesylanu nelfinaviru
EEP199900109A EE04465B1 (et) 1996-09-05 1997-09-04 Vaheühendid HIV-proteaasi inhibiitorite valmistamiseks ja HIV-proteaasi inhibiitorite valmistamismeetodid
IS4982A IS2030B (is) 1996-09-05 1999-02-19 Milliefni til smíða á HIV-próteasatálmum og aðferðir til að smíða HIV-próteasatálma
NO19991072A NO313287B1 (no) 1996-09-05 1999-03-04 Fremgangsmåter for fremstilling av HIV-protease inhibitorer
BG103305A BG64793B1 (bg) 1996-09-05 1999-04-02 Междинни съединения за получаване на инхибитори на нiv-протеазата и методи за получаването на инхибитори на нiv-протеазата
AU14736/02A AU766155B2 (en) 1995-09-26 2002-01-31 Intermediates for making HIV-protease inhibitors and methods of making HIV-protease inhibitors
JP2007280974A JP2008056693A (ja) 1996-09-05 2007-10-29 Ｈｉｖ−プロテアーゼ阻害剤製造の中間体及びｈｉｖ−プロテアーゼ阻害剤の製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70841196A 1996-09-05 1996-09-05
US08/708,411 1996-09-05

Publications (3)

Publication Number Publication Date
WO1998009951A2 WO1998009951A2 (fr) 1998-03-12
WO1998009951A3 WO1998009951A3 (fr) 1998-07-09
WO1998009951B1 true WO1998009951B1 (fr) 1998-08-13

Family

ID=24845703

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/015468 WO1998009951A2 (fr) 1995-09-26 1997-09-04 Intermediaires permettant la production d'inhibiteurs de la vih-protease et procedes de production d'inhibiteurs de la vih-protease

Country Status (32)

Country Link
EP (2) EP1361216B1 (fr)
JP (3) JP4149000B2 (fr)
KR (1) KR100563289B1 (fr)
CN (2) CN1305854C (fr)
AP (2) AP1322A (fr)
AT (2) ATE309990T1 (fr)
AU (2) AU740369B2 (fr)
BG (2) BG64793B1 (fr)
BR (1) BR9713192A (fr)
CA (1) CA2264756A1 (fr)
CZ (2) CZ298175B6 (fr)
DE (2) DE69734689T2 (fr)
DK (2) DK1361216T3 (fr)
EA (1) EA002051B1 (fr)
EE (1) EE04465B1 (fr)
ES (2) ES2252586T3 (fr)
GE (1) GEP20022799B (fr)
HU (1) HUP0000028A3 (fr)
IL (1) IL128567A (fr)
IS (1) IS2030B (fr)
NO (1) NO313287B1 (fr)
NZ (1) NZ334909A (fr)
OA (1) OA10988A (fr)
PL (2) PL198408B1 (fr)
PT (1) PT927165E (fr)
SG (1) SG94780A1 (fr)
SI (2) SI1361216T1 (fr)
SK (2) SK285278B6 (fr)
TR (1) TR199900473T2 (fr)
UA (1) UA67727C2 (fr)
WO (1) WO1998009951A2 (fr)
YU (1) YU11599A (fr)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0641038A (ja) * 1992-07-17 1994-02-15 Mitsubishi Kasei Corp カルボン酸誘導体
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
JPH07248183A (ja) * 1994-03-11 1995-09-26 Osaka Gas Co Ltd 浴室兼用衣類乾燥室
JP3298293B2 (ja) * 1994-03-14 2002-07-02 松下電器産業株式会社 厨芥処理機
WO1996028423A1 (fr) * 1995-03-15 1996-09-19 Sankyo Company, Limited Composes dipeptidiques de structure ahpba
EP0983999B8 (fr) * 1995-09-26 2005-06-08 Japan Tobacco Inc. Procede de production de derives amides et de leurs intermediaires
US5962704A (en) * 1995-09-26 1999-10-05 Japan Tobacco Inc. Production of amide derivatives and intermediate compounds therefor
PT984000E (pt) * 1995-09-26 2009-02-06 Agouron Pharma Processo para a produção de derivados amina e compostos intermediários
WO1997030993A1 (fr) * 1996-02-24 1997-08-28 Basf Aktiengesellschaft Derives de pyrazole-4-yle-hetaroyle utilises comme herbicides

Similar Documents

Publication Publication Date Title
EP0256982B1 (fr) Procédé pour la fabrication d'amines aryles secondaires optiquement actives
EP0496699B1 (fr) Disphosphines contenant des groupes silane, diphosphines immobilisées et leur utilisation comme catalyseurs d'hydrogenation
EP0496700A1 (fr) Diphosphines contenant des groupes silane, diphosphines immobilisées et leur utilisation comme catalyseurs d'hydrogenation
DE3141586A1 (de) 1,8-dihydroxy-9-anthron-derivate, verfahren zu ihrer herstellung und ihre verwendung in der pharmazie und kosmetik
Newcomb et al. N-Hydroxypyridine-2-thione carbamates. VII. Intermolecular addition and addition-cyclization reactions of aminium cation radicals
SU689615A3 (ru) Способ получени оптически активного алкилхризантемата
GB2066812A (en) 5'-acyl-uridine derivatives and processes for the preparation thereof
EP0233686A3 (fr) Bis phényléthanolamines et bis phénoxypropanolamines ayant une activité bêta-agoniste
KR860008973A (ko) 2-피롤리돈 유도체
EP0048501B1 (fr) Dérivés de diazabicyclooctane optiquement actifs ou racémiques
WO1998009951B1 (fr) Intermediaires permettant la production d'inhibiteurs de la vih-protease et procedes de production d'inhibiteurs de la vih-protease
US5723665A (en) Ethenyl amide compound production process
CA2261098A1 (fr) Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
ATE244224T1 (de) Verfahren zur umwandlung von 2,4-dichlorpyridinen in 2-aryloxy-4-chlorpyridine
DE2521347C3 (de) Hydroxylsubstituierte 2-Chlor- a, -(tertbutylaminomethyl)-benzylalkohole, Herstellungsverfahren und Arzneimittel
KR840000530A (ko) 신규 벤조트리아졸의 제조방법
KR940005806A (ko) 델타 발레로락톤의 라세미 혼합물을 분리하기 위한 효소적 방법
WO1997020946A1 (fr) Procede de production d'amines optiquement actives
US5210196A (en) Chiral sultams
EP1537095B1 (fr) Procede relatif a l'elaboration de gamma-butyrolactones fonctionnalisees a partir d'acide mucohalique
KR830001191A (ko) 살균제 조성물
US5688985A (en) Process for producing keto nitrile derivative
WO1994002443A2 (fr) PROCEDE DE PREPARATION DE DERIVES D'ACIDE AMINOBUTYRIQUE η β-SUBSTITUES A FORME ENANTIOMERE PURE, NOUVELLES ETAPES INTERMEDIAIRES DE CE PROCEDE A FORME ENANTIOMERE PURE ET LEUR UTILISATION
BG63895B1 (bg) Метод за количествен синтез на 3-[l-пироглутамил]-l- тиазолидин-4-карбоксилна киселина и на нейни производни
GB1390866A (en) Cycloalkanoyl-substituted pyrroles and pharmaceutical compo sitions containing them