WO1998003510B1 - - Google Patents
Info
- Publication number
- WO1998003510B1 WO1998003510B1 PCT/US1997/013072 US9713072W WO9803510B1 WO 1998003510 B1 WO1998003510 B1 WO 1998003510B1 US 9713072 W US9713072 W US 9713072W WO 9803510 B1 WO9803510 B1 WO 9803510B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- stereoisomeric forms
- ome
- isomers
- dimethyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- -1 2-methyl-4-methoxyphenyl Chemical group 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Chemical group 0.000 claims 2
- 150000003839 salts Chemical group 0.000 claims 2
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP50723398A JP4704521B2 (ja) | 1996-07-24 | 1997-07-23 | アゾロトリアジン類およびアゾロピリミジン類 |
| IL12787197A IL127871A0 (en) | 1996-07-24 | 1997-07-23 | Azolo triazines and pyrimidines |
| AU38942/97A AU747708B2 (en) | 1996-07-24 | 1997-07-23 | Azolo triazines and pyrimidines |
| HU0102187A HU228962B1 (en) | 1996-07-24 | 1997-07-23 | Azolo triazines, pharmaceutical compositions containing them and use of the compounds |
| SK97-99A SK286461B6 (sk) | 1996-07-24 | 1997-07-23 | [1,5-a]-Pyrazolo-1,3,5-triazíny, ich použitie a farmaceutické kompozície na ich báze |
| NZ333777A NZ333777A (en) | 1996-07-24 | 1997-07-23 | (1,5-a) pyrazolo and triazole triazines and pyrimidines |
| EP97936222A EP0915880B1 (fr) | 1996-07-24 | 1997-07-23 | Azolo triazines et pyrimidines |
| KR1019997000568A KR100548853B1 (ko) | 1996-07-24 | 1997-07-23 | 아졸로 트리아진 및 피리미딘 |
| IL15016397A IL150163A0 (en) | 1996-07-24 | 1997-07-23 | Azolo triazines and pyrimidines |
| UA99010100A UA73913C2 (en) | 1996-07-24 | 1997-07-23 | Azolo triazines and pyrimidines |
| DE69738197T DE69738197T2 (de) | 1996-07-24 | 1997-07-23 | Azolotriazine und pyrimidine |
| SI9720045A SI9720045B (sl) | 1996-07-24 | 1997-07-23 | Azolo triazini in pirimidini |
| RO99-00078A RO121272B1 (ro) | 1996-07-24 | 1997-07-23 | Azolotriazine şi pirimidine |
| EA199900158A EA004403B1 (ru) | 1996-07-24 | 1997-07-23 | Производные пиразолотриазинов, фармацевтические композиции, содержащие их, способы лечения |
| EEP199900019A EE04316B1 (et) | 1996-07-24 | 1997-07-23 | Asolotriasiinid ja -pürimidiinid, neid sisaldavadfarmatseutilised kompositsioonid ning nende kasutamine ravimite valmistamiseks |
| BR9710544A BR9710544A (pt) | 1996-07-24 | 1997-07-23 | M-todo de tratamento composto e composi-Æo farmac-utica |
| CA002259583A CA2259583C (fr) | 1996-07-24 | 1997-07-23 | Azolo triazines et pyrimidines |
| HU0500549A HU229024B1 (en) | 1996-07-24 | 1997-07-23 | Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof |
| PL97331523A PL195762B1 (pl) | 1996-07-24 | 1997-07-23 | Związki [1,5-a]pirazolo-1,3,5-triazynowe, środek farmaceutyczny i zastosowanie związków [1,5-a]pirazolo-1,3,5-triazynowych do wytwarzania leku |
| DK97936222T DK0915880T3 (da) | 1996-07-24 | 1997-07-23 | Azolotriaziner og pyrimidiner |
| IL127871A IL127871A (en) | 1996-07-24 | 1998-12-30 | PHARMACEUTICAL COMPOSITIONS CONTAINING CRF ANTAGONIST 3-ARYL-PYRAZOLO (AND 1,2,3-TRIAZOLO) [1,5-a]-1,3,5-TRIAZINE DERIVATIVES AND SOME NEW SUCH DERIVATIVES |
| LVP-99-13A LV12292B (en) | 1996-07-24 | 1999-01-20 | TRIANGLE AND PYRIMIDINES AZOL-DERIVATIVES |
| NO19990264A NO315610B3 (no) | 1996-07-24 | 1999-01-21 | Azolotriaziner og -pyrimidiner |
| AU23236/02A AU773039C (en) | 1996-07-24 | 2002-03-12 | Azolo triazines and pyrimidines |
| IL150163A IL150163A (en) | 1996-07-24 | 2002-06-11 | PHARMACEUTICAL COMPOSITIONS COMPRISING PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AND SOME NOVEL SUCH COMPOUNDS |
| IL164513A IL164513A (en) | 1996-07-24 | 2004-10-12 | Pyrazolopyrimidines, pharmaceutical compositions containing them and their use in the preparation of medicaments |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2329096P | 1996-07-24 | 1996-07-24 | |
| US68604796A | 1996-07-24 | 1996-07-24 | |
| US08/686,047 | 1996-07-24 | ||
| US60/023,290 | 1996-07-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1998003510A1 WO1998003510A1 (fr) | 1998-01-29 |
| WO1998003510B1 true WO1998003510B1 (fr) | 1998-04-02 |
Family
ID=26696934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/013072 WO1998003510A1 (fr) | 1996-07-24 | 1997-07-23 | Azolo triazines et pyrimidines |
Country Status (17)
| Country | Link |
|---|---|
| EP (2) | EP0915880B1 (fr) |
| KR (1) | KR100548853B1 (fr) |
| AR (1) | AR007994A1 (fr) |
| AT (1) | ATE375344T1 (fr) |
| AU (1) | AU747708B2 (fr) |
| CZ (1) | CZ2005613A3 (fr) |
| DE (1) | DE69738197T2 (fr) |
| DK (1) | DK0915880T3 (fr) |
| EA (1) | EA006626B1 (fr) |
| ES (1) | ES2294800T3 (fr) |
| HK (1) | HK1052693A1 (fr) |
| HU (2) | HU228962B1 (fr) |
| LV (1) | LV12292B (fr) |
| PT (1) | PT915880E (fr) |
| RO (1) | RO121272B1 (fr) |
| TW (2) | TW542827B (fr) |
| WO (1) | WO1998003510A1 (fr) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7094782B1 (en) | 1996-07-24 | 2006-08-22 | Bristol-Myers Squibb Company | Azolo triazines and pyrimidines |
| JP2001511813A (ja) | 1997-02-18 | 2001-08-14 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | Crfレセプターアンタゴニストおよびそれらに関連する方法 |
| ES2218991T3 (es) * | 1998-01-28 | 2004-11-16 | Bristol-Myers Squibb Pharma Company | Pirazolotriazinas como antagonistas de crf. |
| WO1999045007A1 (fr) * | 1998-03-06 | 1999-09-10 | Janssen Pharmaceutica N.V. | Pyrazolo[4,3-b]pyridines antagonistes du facteur de liberation de la corticotropine (crf) |
| US6509338B1 (en) | 1998-06-22 | 2003-01-21 | Bristol-Myers Squibb Company | Pyrazolo[1,5-A]triazine corticotropin releasing factor antagonists |
| CN1217945C (zh) | 1998-11-12 | 2005-09-07 | 纽罗克里恩生物科学有限公司 | Crf受体拮抗剂以及与其有关的方法 |
| NZ511267A (en) | 1998-11-12 | 2002-12-20 | Neurocrine Biosciences Inc | Tricyclic heterocyclic CRF receptor antagonists and their use in treatment |
| AU4203500A (en) * | 1999-04-06 | 2000-10-23 | Du Pont Pharmaceuticals Company | Pyrazolopyrimidines as crf antagonists |
| AU4331500A (en) | 1999-04-06 | 2000-10-23 | Du Pont Pharmaceuticals Company | Pyrazolotriazines as crf antagonists |
| US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
| CA2379585C (fr) | 1999-09-30 | 2006-06-20 | James W. Darrow | Pyrazolo[1,5,-a]-1,5-pyrimidines a substitution alkylene-diamine et pyrazolo[1,5-a]-1,3,5-triazines |
| DE60032249T2 (de) * | 1999-09-30 | 2007-07-19 | Neurogen Corp., Branford | Amino-substituierte Pyrazolo-[1,5-a]-1,5-Pyrimidine und Pyrazolo-[1,5-a]-1,3,5-Triazine |
| NZ517575A (en) * | 1999-09-30 | 2004-04-30 | Neurogen Corp | Certain alkylene diamine-substituted heterocycles |
| KR20030016222A (ko) * | 2000-02-14 | 2003-02-26 | 니뽄 다바코 산교 가부시키가이샤 | 수술후 스트레스 예방ㆍ치료제 |
| CA2419626A1 (fr) * | 2000-07-14 | 2002-01-24 | Rajagopal Bakthavatachalam | Imidazo¬1,2-a|pyrazines destinees au traitement d'affections neurologiques |
| EP1305637A2 (fr) * | 2000-08-02 | 2003-05-02 | Malope Company Limited | Diagnostic et traitement de la dyspepsie non ulcereuse fondes sur l'anomalie de l'axe hypothalamo-hypophyso-surrenalien |
| KR100875595B1 (ko) | 2001-03-13 | 2008-12-23 | 브리스톨-마이어스 스퀴브 파마 컴파니 | 코르티코트로핀 방출인자 수용체 리간드로서4-(2-부틸아미노)-2,7-디메틸-8-(2-메틸-6-메톡시피리드-3-일) 피라졸로-[1,5-에이]-1,3,5-트리아진, 그의 거울상이성질체 및 약학적으로 허용가능한 염 |
| RU2003135424A (ru) | 2001-05-14 | 2005-05-20 | Бристол-Маерс Сквибб Фарма Компани (Us) | Замещенные пиразиноны, пиридины и пиримидины в качестве лигандов кортикотропин высвобождающего фактора |
| WO2003005969A2 (fr) | 2001-07-12 | 2003-01-23 | Bristol-Myers Squibb Pharma Company | Tetrahydropurinones et leurs derives en tant que ligands du recepteur du facteur de liberation de corticotropine |
| US7276526B2 (en) | 2001-07-13 | 2007-10-02 | Bristol-Myers Squibb Pharma Company | Substituted thiazoles and oxazoles as corticotropin releasing hormone ligands |
| US20030119831A1 (en) | 2001-11-20 | 2003-06-26 | Hartz Richard A. | 3,7-dihydro-purine-2,6-dione derivatives as CRF receptor ligands |
| ES2245772T3 (es) | 2002-03-07 | 2006-01-16 | Smithkline Beecham Corporation | Derivados de pirazolopirimidina y pirazolotriazina y composiciones farmaceuticas que los contienen. |
| DE60318697T2 (de) | 2002-04-26 | 2009-01-08 | Eli Lilly And Co., Indianapolis | Triazolderivate als tachykininrezeptor-antagonisten |
| FR2842809A1 (fr) * | 2002-07-26 | 2004-01-30 | Greenpharma Sas | NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
| FR2850653A1 (fr) * | 2003-02-04 | 2004-08-06 | Univ Pasteur | Derives de pyrazolotriazine, procede de preparation et utilisations |
| US7329658B2 (en) | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
| US7112585B2 (en) | 2003-04-18 | 2006-09-26 | Bristol-Myers Squibb Company | Pyrimidine derivatives as corticotropin releasing factor inhibitors |
| US7030145B2 (en) | 2003-04-18 | 2006-04-18 | Bristol-Myers Squibb Company | Pyridinyl derivatives for the treatment of depression |
| US7153961B2 (en) * | 2003-11-25 | 2006-12-26 | Bristol-Myers Squibb Pharma Co. | Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist |
| US7208596B2 (en) | 2003-11-25 | 2007-04-24 | Bristol-Myers Squibb Pharma Company | Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof |
| AR046967A1 (es) | 2003-12-22 | 2006-01-04 | Sb Pharmco Inc | Compuesto de pirazol[1,5-a]pirimidina, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion |
| GB0519957D0 (en) | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
| JP2009502734A (ja) * | 2005-07-29 | 2009-01-29 | アステラス製薬株式会社 | Lck阻害剤としての縮合複素環 |
| ES2428543T3 (es) | 2006-09-20 | 2013-11-08 | Eli Lilly And Company | Compuestos de tiofenopirazolopirimidina |
| DE602007009305D1 (de) | 2006-09-20 | 2010-10-28 | Lilly Co Eli | Thiazolpyrazolopyrimidine als antagonisten des crf1-rezeptors |
| WO2008078091A1 (fr) | 2006-12-22 | 2008-07-03 | Astex Therapeutics Limited | Composés hétérocycliques bicycliques servant d'inhibiteurs des fgfr |
| JP5442449B2 (ja) | 2006-12-22 | 2014-03-12 | アステックス、セラピューティックス、リミテッド | 新規化合物 |
| EP2167094A2 (fr) * | 2007-06-13 | 2010-03-31 | Research Development Foundation | Procédés pour le traitement et la prévention de tauopathies et l'amyloïdose de bêta-amyloïde en modulant la signalisation de récepteur crf |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| WO2010118207A1 (fr) | 2009-04-09 | 2010-10-14 | Schering Corporation | Dérivés pyrazolo[1, 5-a]pyrimidine en tant qu'inhibiteurs de mtor |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| EP2264035A1 (fr) * | 2009-06-04 | 2010-12-22 | Merz Pharma GmbH & Co. KGaA | B antagonistes de la glycine |
| EP2723746A1 (fr) | 2011-06-22 | 2014-04-30 | Vertex Pharmaceuticals Inc. | Composés inhibiteurs de la kinase atr |
| UA113186C2 (xx) | 2011-09-30 | 2016-12-26 | Макроциклічні інгібітори lrrk2 кінази | |
| GB201210686D0 (en) | 2012-06-15 | 2012-08-01 | Holsboermaschmeyer Neurochemie Gmbh | V1B receptor antagonist for use in the treatment of patients having an elevated AVP level and/or an elevated copeptin level |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| US8871754B2 (en) | 2012-11-19 | 2014-10-28 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| LT2925757T (lt) | 2012-11-19 | 2017-12-27 | Novartis Ag | Junginiai ir kompozicijos, skirti parazitinių ligų gydymui |
| CN104903325B (zh) | 2012-12-07 | 2017-10-20 | 沃泰克斯药物股份有限公司 | 可用作atr激酶抑制剂的化合物 |
| EP2968237A4 (fr) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | Procédés et compositions pour améliorer la fonction cognitive |
| CA2904767C (fr) | 2013-03-15 | 2022-06-21 | Agenebio, Inc. | Procedes et compositions pour ameliorer la fonction cognitive |
| GB201310782D0 (en) | 2013-06-17 | 2013-07-31 | Max Planck Innovation Gmbh | Method for predicting a treatment response to a CRHR1 antagonist and/or V1B antagonist in a patient with depressive and/or anxiety symptoms |
| SI3077397T1 (sl) | 2013-12-06 | 2020-02-28 | Vertex Pharmaceuticals Inc. | 2-amino-6-fluoro-N-(5-fluoro-piridin-3-IL)pirazolo(1,5-A)pirimidin-3- karboksamidna spojina, koristna kot inhibitor kinaze ATR, njena priprava, različne trdne oblike in njeni radioaktivno označeni derivati |
| AU2015271030B2 (en) | 2014-06-05 | 2019-05-16 | Vertex Pharmaceuticals Incorporated | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo [1,5-a] pyrimidin-3-carboxamide compound useful as ATR kinase inhibitor, the preparation of said compound and different solid forms thereof |
| RU2736219C2 (ru) | 2014-06-17 | 2020-11-12 | Вертекс Фармасьютикалз Инкорпорейтед | Способ лечения рака с использованием комбинации ингибиторов снк1 и atr |
| SG11201701936WA (en) | 2014-09-17 | 2017-04-27 | Oncodesign Sa | Macrocyclic lrrk2 kinase inhibitors |
| MX2017005586A (es) | 2014-11-03 | 2017-06-19 | Bayer Pharma AG | Piperidinilpirazolopirimidinonas y utilización de las mismas. |
| US10925834B2 (en) | 2015-05-22 | 2021-02-23 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| HK1258570A1 (zh) | 2015-09-30 | 2019-11-15 | Vertex Pharmaceuticals Inc. | 使用dna损伤剂及atr抑制剂的组合治疗癌症的方法 |
| SG11201909710XA (en) * | 2017-04-21 | 2019-11-28 | Kyn Therapeutics | Indole ahr inhibitors and uses thereof |
| AU2018317398A1 (en) | 2017-08-14 | 2019-11-21 | Spruce Biosciences, Inc. | Corticotropin releasing factor receptor antagonists |
| CA3089159A1 (fr) * | 2018-02-06 | 2019-08-15 | Jiangsu Hengrui Medicine Co., Ltd. | Derive de pyrazolo[1,5-a][1,3,5]triazine-2-amine, son procede de preparation et son utilisation medicale |
| AU2019370200B2 (en) | 2018-10-30 | 2024-12-19 | Kronos Bio, Inc. | Compounds, compositions, and methods for modulating CDK9 activity |
| JP2023537598A (ja) | 2020-08-12 | 2023-09-04 | スプルース バイオサイエンシーズ,インク. | 多嚢胞性卵巣症候群を処置するための方法および組成物 |
| US11708372B2 (en) | 2021-11-19 | 2023-07-25 | Spruce Biosciences, Inc. | Crystalline composition of tildacerfont and methods of use and preparation thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE786611A (fr) * | 1971-08-16 | 1973-01-22 | Int Chem & Nuclear Corp | Nouveaux inhibiteurs de xanthine-oxydase et leur procede de preparatio |
| US3910907A (en) * | 1973-07-09 | 1975-10-07 | Icn Pharmaceuticals | Pyrazolo(1,5-a)-1,3,5-triazines |
| US3995039A (en) * | 1975-05-27 | 1976-11-30 | Merck & Co., Inc. | Pyrazolo [1,5-a] [1,3,5] triazines |
| JPS6157587A (ja) * | 1984-08-29 | 1986-03-24 | Shionogi & Co Ltd | 縮合複素環誘導体および抗潰瘍剤 |
| US4824834A (en) * | 1986-10-31 | 1989-04-25 | Otsuka Pharmaceutical Company, Limited | Pyrazolotriazine compounds |
| DE3722072A1 (de) * | 1987-07-01 | 1989-01-12 | Schering Ag | 6,7-dihydro-pyrazolo(1,5-a)(1,3,5) triazin-2-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider und pflanzenwuchsregulierender wirkung |
| JP2585462B2 (ja) * | 1989-10-25 | 1997-02-26 | 株式会社大塚製薬工場 | ピラゾロ[1,5―a]ピリミジン誘導体 |
| KR927003595A (ko) * | 1990-10-09 | 1992-12-18 | 오츠카 아키히코 | 피리미딘 유도체, 이의 제조방법 및 안드로겐 저해제 |
| US5484760A (en) * | 1990-12-31 | 1996-01-16 | Monsanto Company | Herbicide antidotes as safeners for reducing phytotoxicity resulting from synergistic interaction between herbicides and other pesticides |
| EP0591528B1 (fr) * | 1991-04-22 | 1998-12-23 | Otsuka Pharmaceutical Factory, Inc. | DERIVE DE PYRAZOLO[1,5-a]PYRIMIDINE ET AGENT ANTI-INFLAMMATOIRECONTENANT CE DERIVE |
| US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
| WO1994013676A1 (fr) * | 1992-12-17 | 1994-06-23 | Pfizer Inc. | Pyrrolopyrimidines en tant qu'antagonistes du facteur liberateur de corticotrophine (crf) |
| PT714898E (pt) * | 1994-06-21 | 2002-04-29 | Otsuka Pharma Co Ltd | Derivado de pirazolo¬1,5-a|pirimidina |
| WO1996035689A1 (fr) * | 1995-05-12 | 1996-11-14 | Neurogen Corporation | Derives nouveaux de deazapurine; une nouvelle classe de ligands specifiques de crf1 |
| CZ244598A3 (cs) * | 1996-02-07 | 1998-10-14 | Janssen Pharmaceutica N.V. | Pyrazolopyrimidiny jako antagonisty CRF receptoru |
-
1997
- 1997-07-23 EA EA200301042A patent/EA006626B1/ru not_active IP Right Cessation
- 1997-07-23 AU AU38942/97A patent/AU747708B2/en not_active Expired
- 1997-07-23 AT AT97936222T patent/ATE375344T1/de active
- 1997-07-23 HU HU0102187A patent/HU228962B1/hu unknown
- 1997-07-23 HU HU0500549A patent/HU229024B1/hu unknown
- 1997-07-23 ES ES97936222T patent/ES2294800T3/es not_active Expired - Lifetime
- 1997-07-23 KR KR1019997000568A patent/KR100548853B1/ko not_active Expired - Fee Related
- 1997-07-23 PT PT97936222T patent/PT915880E/pt unknown
- 1997-07-23 DK DK97936222T patent/DK0915880T3/da active
- 1997-07-23 EP EP97936222A patent/EP0915880B1/fr not_active Expired - Lifetime
- 1997-07-23 DE DE69738197T patent/DE69738197T2/de not_active Expired - Lifetime
- 1997-07-23 CZ CZ2005-613A patent/CZ2005613A3/cs unknown
- 1997-07-23 WO PCT/US1997/013072 patent/WO1998003510A1/fr active IP Right Grant
- 1997-07-23 RO RO99-00078A patent/RO121272B1/ro unknown
- 1997-07-23 EP EP07015514A patent/EP1908764A1/fr not_active Withdrawn
- 1997-07-24 AR ARP970103368A patent/AR007994A1/es unknown
- 1997-07-25 TW TW086110640A patent/TW542827B/zh not_active IP Right Cessation
- 1997-07-25 TW TW092105694A patent/TWI238164B/zh not_active IP Right Cessation
-
1999
- 1999-01-20 LV LVP-99-13A patent/LV12292B/en unknown
-
2003
- 2003-07-02 HK HK03104703.7A patent/HK1052693A1/zh unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO1998003510B1 (fr) | ||
| EP1008342A3 (fr) | Composés pharmaceutiquement actifs et liposomes, et leur application | |
| CA2165819A1 (fr) | Derives de dc-89 | |
| CA2017252A1 (fr) | Composes inhibiteurs de la protease des retrovirus | |
| CA2171275A1 (fr) | Derives du stilbene et compositions pharmaceutiques qui en renferment | |
| CA2079692A1 (fr) | Amino-6-demethyl-6-desoxytetracyclines substituees en 7 et en 9 | |
| CA2254833A1 (fr) | Produit pharmaceutique pour le traitement de troubles neurologiques et neuropsychiatriques | |
| CA2448602A1 (fr) | Derives de pyrimidine, triazine et pyrazine, recepteurs du glutamate | |
| PL323152A1 (en) | Derivatives of 1,3-propanodiole as biologically active compounds | |
| CA2195964A1 (fr) | Pesticides | |
| GB8929076D0 (en) | Treatment of shock by blocking agents of edrf effect or formation | |
| NO307181B1 (no) | Fremgangsmåte for fremstilling av N-[3(3-cyanopyrazol[1,5- a]pyrimidin-7-yl)fenyl]-N-etylacetamid | |
| CA2181665A1 (fr) | Melange stabilisateur synergiste | |
| AU3949889A (en) | The reductive amination of hydroxy-containing compounds | |
| ZA85327B (en) | Therapeutic compounds | |
| EP1026162A4 (fr) | Agent anti-rhumatismal | |
| CA2083361A1 (fr) | Production piscicole | |
| ATE192927T1 (de) | Neue cephem-derivate | |
| CA2229892A1 (fr) | Preparations liposomes de derives indolocarbazole | |
| EP0702014A4 (fr) | Derive dc-89 | |
| AU1925392A (en) | A process for the preparation of n-(2,6-dichlorophenyl)-n-phenyl-n-(chloroacetyl)-amine | |
| CA2193348A1 (fr) | Derives d'alkyldiamines substituees et leur utilisation en tant qu'antagonistes de la tachykinine | |
| CA2302412A1 (fr) | Derives d'amino-alkylphenols et composes associes | |
| EP0663816A4 (fr) | Classe nouvelle de derives de phosphocholine a activite fongicide. | |
| CA2353956A1 (fr) | Agent therapeutique pour le traitement de la dyserection |