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WO1998001125A3 - Isomeres dextrogyres d'oxybutynine et de desethyloxybutynine utilises dans le traitement de l'hyperactivite gastro-intestinale - Google Patents

Isomeres dextrogyres d'oxybutynine et de desethyloxybutynine utilises dans le traitement de l'hyperactivite gastro-intestinale Download PDF

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Publication number
WO1998001125A3
WO1998001125A3 PCT/US1997/012284 US9712284W WO9801125A3 WO 1998001125 A3 WO1998001125 A3 WO 1998001125A3 US 9712284 W US9712284 W US 9712284W WO 9801125 A3 WO9801125 A3 WO 9801125A3
Authority
WO
WIPO (PCT)
Prior art keywords
desethyloxybutynin
oxybutynin
treatment
dextrorotatory isomers
gastrointestinal hyperactivity
Prior art date
Application number
PCT/US1997/012284
Other languages
English (en)
Other versions
WO1998001125A2 (fr
Inventor
Gunnar Aberg
Original Assignee
Sepracor Inc
Gunnar Aberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc, Gunnar Aberg filed Critical Sepracor Inc
Priority to AU37999/97A priority Critical patent/AU3799997A/en
Publication of WO1998001125A2 publication Critical patent/WO1998001125A2/fr
Publication of WO1998001125A3 publication Critical patent/WO1998001125A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate

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  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Cette invention concerne un procédé permettant de traiter l'hyperactivité gastro-intestinale, le syndrome du côlon irrité, ainsi que d'autres troubles de motilité liés aux voies gastro-intestinales. Ce procédé consiste à administrer une quantité efficace sur le plan thérapeutique de (S)-oxybutynine, de (S)-déséthyloxybutynine ou d'un de leurs sels acceptable sur le plan pharmaceutique, ces éléments ne comprenant quasiment pas d'énantiomère R correspondant.
PCT/US1997/012284 1996-07-09 1997-07-09 Isomeres dextrogyres d'oxybutynine et de desethyloxybutynine utilises dans le traitement de l'hyperactivite gastro-intestinale WO1998001125A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37999/97A AU3799997A (en) 1996-07-09 1997-07-09 Dextrorotatory isomers of oxybutynin and desethyloxybutynin in the treatment of gastrointestinal hyperactivity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2140296P 1996-07-09 1996-07-09
US60/021,402 1996-07-09

Publications (2)

Publication Number Publication Date
WO1998001125A2 WO1998001125A2 (fr) 1998-01-15
WO1998001125A3 true WO1998001125A3 (fr) 1998-05-07

Family

ID=21804010

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/012284 WO1998001125A2 (fr) 1996-07-09 1997-07-09 Isomeres dextrogyres d'oxybutynine et de desethyloxybutynine utilises dans le traitement de l'hyperactivite gastro-intestinale

Country Status (2)

Country Link
AU (1) AU3799997A (fr)
WO (1) WO1998001125A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1191930A2 (fr) 1999-05-20 2002-04-03 Sepracor Inc. Procedes de traitement de l'asthme a l'aide de s-oxybutynine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB940540A (en) * 1960-07-26 1963-10-30 Mead Johnson & Co Aminoacetylenes and process for preparing the same
WO1996012477A1 (fr) * 1994-10-21 1996-05-02 Leiras Oy Systeme d'administration orale a liberation lente contenant de l'oxybutynine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB940540A (en) * 1960-07-26 1963-10-30 Mead Johnson & Co Aminoacetylenes and process for preparing the same
WO1996012477A1 (fr) * 1994-10-21 1996-05-02 Leiras Oy Systeme d'administration orale a liberation lente contenant de l'oxybutynine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HUGHES, K.M. ET AL: "Measurement of oxybutynin and its N-desethyl metabolite in plasma, and its application to pharmacokinetic studies in young, elderly and frail elderly volunteers", XENOBIOTICA, vol. 7, July 1992 (1992-07-01), pages 859 - 869, XP000572170 *
KACHUR, J.F. ET AL: "R and S enantiomers of Oxybutynin: Pharmacological effects in guinea pig bladder and intestine", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 247, no. 3, 1988, pages 867 - 872, XP000200584 *
NORONHA-BLOB, L. ET AL: "Enantiomers of Oxybutynin: In vitro pharmacological characterization at M1, M2 and M3 muscarinic receptors and in vivo effects on urinary bladder contraction, mydriasis and salivary secretion in guinea pigs", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 256, no. 2, 1991, pages 562 - 67, XP000572006 *

Also Published As

Publication number Publication date
AU3799997A (en) 1998-02-02
WO1998001125A2 (fr) 1998-01-15

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