WO1998001070A1 - METHOD FOR DETERMINING THE pH IN THE MUCOSA OF THE STOMACH OR THE GASTROINTESTINAL TRACT - Google Patents
METHOD FOR DETERMINING THE pH IN THE MUCOSA OF THE STOMACH OR THE GASTROINTESTINAL TRACT Download PDFInfo
- Publication number
- WO1998001070A1 WO1998001070A1 PCT/NL1997/000397 NL9700397W WO9801070A1 WO 1998001070 A1 WO1998001070 A1 WO 1998001070A1 NL 9700397 W NL9700397 W NL 9700397W WO 9801070 A1 WO9801070 A1 WO 9801070A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carbon dioxide
- stomach
- gastrointestinal tract
- factor
- correction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
- A61B5/4222—Evaluating particular parts, e.g. particular organs
- A61B5/4238—Evaluating particular parts, e.g. particular organs stomach
Definitions
- the invention relates to a method of determining the intramucosal pH of an animal or human stomach or gastrointestinal tract, comprising the determination of the carbon dioxide tension in the arterial blood and the determination of a carbon dioxide tension in the blood flowing through the wall of the stomach or gastrointestinal tract, by introducing into the stomach preferably a tube with a balloon which is permeable only for carbon dioxide and which is filled with a saline solution, and after a previously determined retention time of at least 30 minutes, removing said balloon for analysis of the carbon dioxide fraction present in the saline solution.
- pH of, for instance, a stomach wall is determined by the assumption that the partial carbon dioxide pressure in the surface layers of the stomach wall is in equilibrium with those of the deeper layers of the stomach wall.
- a further assumption is that the bicarbonate concentration in the tissue is the same as the bicarbonate concentration in the arterial blood.
- pHa and PaC0 2 in this formula relate to the arterial blood.
- the formula is modified by replacing PaC0 2 with PiC0 2 , that is to say the carbon dioxide pressure in the stomach wall, and to assume as mentioned above, that the concentration of the bicarbonate in the tissue is in equilibrium with the bicarbonate concentra- tion in the arterial blood.
- this latter assumption is not correct, particularly with patients who are critically ill and are in septic or anaphylactic shock.
- the pH measured according to the known method deviates from the actual pH, thus hindering a correct and timely treatment of the patient.
- measurement of the partial carbon dioxide pressure in the stomach is obtained by inserting a silicone balloon containing a saline solution into the gastrointestinal tract whereby the carbon dioxide pressure in the saline solution should equilibrate with the carbon dioxide pressure in the gastrointestinal tract. Then the time required to achieve equilibration is measured and the partial carbon dioxide pressure in the saline solution is determined using a blood gas analyzer while, if necessary, a nomogram is used for the determination of the stabilized carbon dioxide value, departing from the stabilisation time and the carbon dioxide pressure measured in the saline solution in combination with the bicarbonate concentration in a substantially simultaneously taken arterial blood sample.
- WO 94/21163 suggests to compare the carbon dioxide pressure relating to the respective organ with the arterial bicarbonate concentration and/or another direct or indirect measurement of a global or systematic physiologic value, such as the pH, the carbon dioxide pressure or oxygen pressure of arterial, venous or other kind of blood, mixed venous bicarbonate, the carbon dioxide pressure in the exhalation air or other values and, in order to determine whether the condition of the respective organ renders it desirable that a) a bicarbonate concentration should be determined and/or b) what kind of clinical therapy or interference is necessary or desirable with regard to the oxygen supply to the respective organ.
- a global or systematic physiologic value such as the pH, the carbon dioxide pressure or oxygen pressure of arterial, venous or other kind of blood, mixed venous bicarbonate, the carbon dioxide pressure in the exhalation air or other values
- the respiration rhythm is adjusted to maintain a partial carbon dioxide pressure of 40 ⁇ 5 Torr.
- the animals are kept on a core body temperature of
- Blood samples were taken from a femoral artery. After the placement of several catheters an abdominal incision is made and a tube is inserted into the right carotid for bleeding the animal. A needle probe is placed in the sto- mach wall for measuring the direct pH value, and the abdominal incision is covered with blankets to prevent dehydration. The animals are then left in peace for 60 min. to stabilize. A tube is placed in the stomach for measuring the partial carbon dioxide tension. The needle probe used is calibrated with buffer solutions which calibration is repeated after each experiment in order to determine the stability of the probe .
- the measuring protocol proceeded as follows :
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physiology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The carbon dioxide tension in the wall of the stomach or gastrointestinal tract is determined by inserting into the stomach a semipermeable balloon filled with a saline solution. The result obtained from analysing the carbon dioxide fraction in the saline solution is multiplied with a correction factor to obtain a stabilized measured value for the carbon dioxide fraction relating to the blood flowing through the wall of the stomach or the gastrointestinal tract, which stabilized measured value corresponds to a measured carbon dioxide fraction pertaining to a retention time of an hour or more, and by multiplying the carbon dioxide tension PaCO2 in the arterial blood with a first factor F to obtain a first correction product, and the stabilized value of the carbon dioxide tension PiCO2 in the blood flowing through the wall of the stomach or the gastrointestinal tract with a second factor F0 to obtain a second correction product, and by adding the first correction product to a basic factor F and subtracting the second product therefrom in accordance with the formula: pHi = F0 + F1 * PaCO2 - F2 * PiCO2, in which pHi forms a measure for the pH of the stomach or the gastrointestinal tract.
Description
Method for determining the pH in the mucosa of the stomach or the gastrointestinal tract
The invention relates to a method of determining the intramucosal pH of an animal or human stomach or gastrointestinal tract, comprising the determination of the carbon dioxide tension in the arterial blood and the determination of a carbon dioxide tension in the blood flowing through the wall of the stomach or gastrointestinal tract, by introducing into the stomach preferably a tube with a balloon which is permeable only for carbon dioxide and which is filled with a saline solution, and after a previously determined retention time of at least 30 minutes, removing said balloon for analysis of the carbon dioxide fraction present in the saline solution.
Such a method is known from the international patent application WO 94/21163. By the known method the pH of, for instance, a stomach wall is determined by the assumption that the partial carbon dioxide pressure in the surface layers of the stomach wall is in equilibrium with those of the deeper layers of the stomach wall. A further assumption is that the bicarbonate concentration in the tissue is the same as the bicarbonate concentration in the arterial blood. The pH in the tissue is then determined by applying a modified version of the known "Henderson-Hasselbalch" equation, which reads: pHa = 6.1 + logfHCO - log [PaC02] . The terms pHa and PaC02 in this formula relate to the arterial blood. For the present objective the formula is modified by replacing PaC02 with PiC02, that is to say the carbon dioxide pressure in the stomach wall, and to assume as mentioned above, that the concentration of the bicarbonate in the tissue is in equilibrium with the bicarbonate concentra- tion in the arterial blood. However, the problem is that this latter assumption is not correct, particularly with patients who are critically ill and are in septic or anaphylactic shock. As a result the pH measured according to the known method deviates from the actual pH, thus hindering a correct and timely treatment of the patient.
In the known method, measurement of the partial carbon dioxide pressure in the stomach is obtained by inserting a silicone balloon containing a saline solution into the gastrointestinal tract whereby the carbon dioxide pressure in the saline solution should equilibrate with the carbon dioxide pressure in the gastrointestinal tract. Then the time required to achieve equilibration is measured and the partial carbon dioxide pressure in the saline solution is determined using a blood gas analyzer while, if necessary, a nomogram is used for the determination of the stabilized carbon dioxide value, departing from the stabilisation time and the carbon dioxide pressure measured in the saline solution in combination with the bicarbonate concentration in a substantially simultaneously taken arterial blood sample. To speed up the pH determination of the organ to be examined, WO 94/21163 suggests to compare the carbon dioxide pressure relating to the respective organ with the arterial bicarbonate concentration and/or another direct or indirect measurement of a global or systematic physiologic value, such as the pH, the carbon dioxide pressure or oxygen pressure of arterial, venous or other kind of blood, mixed venous bicarbonate, the carbon dioxide pressure in the exhalation air or other values and, in order to determine whether the condition of the respective organ renders it desirable that a) a bicarbonate concentration should be determined and/or b) what kind of clinical therapy or interference is necessary or desirable with regard to the oxygen supply to the respective organ.
It is the object of the invention to provide a method as described in the preamble which affords a simple manner for a quick and reliable determination of the intramu- cosal pH of an animal or human stomach or gastrointestinal tract .
This is achieved with the method according to the invention by multiplying the result obtained from analysing the carbon dioxide fraction in the saline solution with a correction factor to obtain a stabilized measured value for the carbon dioxide fraction relating to the blood flowing through the wall of the stomach or the gastrointestinal
tract, which stabilized measured value corresponds to a measured carbon dioxide fraction pertaining to a retention time of an hour or more, and by multiplying the carbon dioxide tension PaC02 in the arterial blood with a first factor F. to obtain a first correction product, and the stabilized value of the carbon dioxide tension PiC02 in the blood flowing through the wall of the stomach or the gastrointestinal tract with a second factor F2 to obtain a second correction product, and by adding the first correction product to a basic factor F0 and subtracting the second correction product therefrom in accordance with the formula : pHi = F0 + F2 * PaC02 - F2 * PiC02, in which pHi forms a measure for the pH of the stomach or the gastrointestinal tract. At a retention time of 30 minutes said correction factor is 1.24. At another retention time the correction factor is different, for instance 1.17 at a retention time of 45 minutes .
This new formula has proven to provide very reliable results. It has been shown that the most accurate measured values are obtained when the factors F0, Flf F2 are adjusted to about 7.511, 0.0482 and 0.061 respectively. Clearly, the method according to the invention lends itself very effectively for the realization in a device for the automatic pro- cessing of arterial blood samples and saline solutions which, as described above, have been in the stomach of the respective patient for a previously chosen length of time.
Consequently, the application is also for exclusive rights for a device which is provided with means for carrying out the method according to the invention.
The invention will now be further elucidated by means of an example .
According to the Example an experiment has been carried out for the validation of the method according to the invention and for the comparison of the results obtained thereby with regard to the results as they become available according to the prior art. To this end ten pigs weighing 30- 40 kg each were anaesthetized with intramuscular ketamine in an amount of 15 mg/kg. Sedation is maintained by means of
isoflurane (1.3%-1.5%) and pancuronium. After intubation the animals are connected to a respirator and maintained at 100%
02 in an amount of 15 ml/kg. The respiration rhythm is adjusted to maintain a partial carbon dioxide pressure of 40 ±5 Torr. The animals are kept on a core body temperature of
39 ±0.5°C. Blood samples were taken from a femoral artery. After the placement of several catheters an abdominal incision is made and a tube is inserted into the right carotid for bleeding the animal. A needle probe is placed in the sto- mach wall for measuring the direct pH value, and the abdominal incision is covered with blankets to prevent dehydration. The animals are then left in peace for 60 min. to stabilize. A tube is placed in the stomach for measuring the partial carbon dioxide tension. The needle probe used is calibrated with buffer solutions which calibration is repeated after each experiment in order to determine the stability of the probe .
The measuring protocol proceeded as follows :
1. After the operation the animals were left in peace for 60 min. to allow them to stabilize. After this period the first measurement was carried out, introducing into the stomach a balloon which is permeable only for carbon dioxide and which is filled with a saline solution, which solution is retained in the stomach for 30 minutes. In Table 1, the results from this first measurement are shown, indicated by T0.
2. After the measurement mentioned under 1, the animals are bled dry to a systolic blood pressure of 50 mmHg. After the bleeding period, which lasted at the most 30 min. , the next measurement is carried out. Said measurement being indicated in the Table by 11 .
3. The animals are then maintained for an hour in the shock condition associated with the activity carried out under 2. , at the end of which a subsequent measurement took place; said measurement is indicated in the Table by T2.
4. Subsequently, during a period of 30 min. the blood is retransfused and the another measurement is carried out, indicated in the Table by T3.
5. After retransfusion the animals stabilize again for an hour and a final measurement is carried out indicated in the Table by T4.
In all the above-mentioned measurements the reten- tion time of the balloon in the stomach of the laboratory animals, which balloon is permeable only for carbon dioxide and which is filled with a saline solution, is set at 30 minutes . To obtain the stabilized measurement for the carbon dioxide fraction corresponding to the measured carbon dioxide fraction pertaining to a retention time in the stomach of an hour or more, a correction factor 1.24 is applied. In addition to the anaesthetic, each animal received 50 mg raniti- dine to prevent acid production influencing the measurements. The results of the above-described experiment are shown in Table 1 below, in which the first figure always represents the mean value and the second figure the standard error of mean. In the first line of table 1 the pH value of the mucosa as measured directly is given. The second line gives that same value as measured according to the prior art , applying the modified "Henderson-Hasselbalch" equation as described above. The third line, finally, gives the results as obtained by the method according to the invention.
TABLE 1
Table 2 below gives the correlation analysis with respect to the results obtained.
TABLE 2
o Tx τ2 τ3 T
pHidir-pHi-
"Old" 0,6831 0,8468 0,781 0,86 0,905
pHidir-pHi- "New" 0,76 0,977 0,866 0,93 0,947
These Tables show that the pH of the stomach wall determined by the method according to the invention correlates better with the directly measured pH than when said pH is determined by the method according to the prior art. In particular in the essential haemodynamic periods, represented by the measurements Tλ (bleeding) , T2 (shock phase) and T3 (retransfusion) , the method according to the invention offers measuring results which correspond significantly better with the actual pH value than the pH values as determined according to the prior art .
Claims
1. The invention relates to a method of determining the intramucosal pH of an animal or human stomach or gastrointestinal tract, comprising the determination of the carbon dioxide tension in the arterial blood and the determi- nation of a carbon dioxide tension in the blood flowing through the wall of the stomach or gastrointestinal tract, by introducing into the stomach preferably a tube with a balloon which is permeable only for carbon dioxide and which is filled with a saline solution, and after a previously determined retention time of at least 30 minutes, removing said balloon for analysis of the carbon dioxide fraction present in the saline solution, wherein from these two values of the carbon dioxide tension a value is calculated which serves as a gauge for the pH of the mucosa of the stomach or the gastrointestinal tract, characterized in that the result obtained from analysing the carbon dioxide fraction in the saline solution is multiplied with a correction factor to obtain a stabilized measured value for the carbon dioxide fraction relating to the blood flowing through the wall of the stomach or the gastrointestinal tract, which stabilized measured value corresponds to a measured carbon dioxide fraction pertaining to a retention time of an hour or more, and by multiplying the carbon dioxide tension PaC02 in the arterial blood with a first factor Fx to obtain a first correction product, and the stabilized value of the carbon dioxide tension PiC02 in the blood flowing through the wall of the stomach or the gastrointestinal tract with a second factor F2 to obtain a second correction product, and by adding the first correction product to a basic factor F0 and subtracting the second correction product therefrom in accordance with the formula : pHi = F0 + Fx * PaCO- - F2 * PiC02, in which pHi forms a measure for the pH of the stomach or the gastrointestinal tract.
2. A method according to claim 1, characterized in that the correction factor is about 1.24.
3. A method according to claim 1 or 2, characterized in that the factors F0, Flf F2 are adjusted to about 7.511, 0.0482 and 0.061 respectively.
4. A device provided with means for carrying out the method according to any of the claims 1-4.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU33616/97A AU3361697A (en) | 1996-07-08 | 1997-07-08 | Method for determining the ph in the mucosa of the stomach or the gastrointestinal tract |
| US09/225,656 US6125293A (en) | 1996-07-08 | 1999-01-05 | Method for determining the pH in the mucosa of the stomach or the gastrointestinal tract |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1003533A NL1003533C2 (en) | 1996-07-08 | 1996-07-08 | Method for determining the acidity in the mucous membrane of the stomach or of the gastrointestinal tract. |
| NL1003533 | 1996-07-08 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US09/225,656 Continuation US6125293A (en) | 1996-07-08 | 1999-01-05 | Method for determining the pH in the mucosa of the stomach or the gastrointestinal tract |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1998001070A1 true WO1998001070A1 (en) | 1998-01-15 |
Family
ID=19763164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/NL1997/000397 Ceased WO1998001070A1 (en) | 1996-07-08 | 1997-07-08 | METHOD FOR DETERMINING THE pH IN THE MUCOSA OF THE STOMACH OR THE GASTROINTESTINAL TRACT |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU3361697A (en) |
| NL (1) | NL1003533C2 (en) |
| WO (1) | WO1998001070A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6462681B1 (en) | 1999-08-27 | 2002-10-08 | Koninklijke Philips Electronics N. V. | Scalable coding by scanning selected parts of respective bit-streams |
| WO2010125215A1 (en) * | 2009-04-29 | 2010-11-04 | Munoz Bonet Juan Ignacio | System for measuring, recording and continuously monitoring splanchnic tissue perfusion and physiological pulmonary dead space, and the use thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0089647A2 (en) * | 1982-03-22 | 1983-09-28 | FIDDIAN-GREEN, Richard G. | Hollow viscus tonometry |
| WO1990001893A1 (en) * | 1988-08-26 | 1990-03-08 | Mountpelier Investments S.A. | Remote sensing tonometric catheter apparatus and method |
| WO1994021163A1 (en) * | 1993-03-22 | 1994-09-29 | Instrumentarium Corporation | Remote sensing tonometric catheter apparatus and method |
-
1996
- 1996-07-08 NL NL1003533A patent/NL1003533C2/en not_active IP Right Cessation
-
1997
- 1997-07-08 AU AU33616/97A patent/AU3361697A/en not_active Abandoned
- 1997-07-08 WO PCT/NL1997/000397 patent/WO1998001070A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0089647A2 (en) * | 1982-03-22 | 1983-09-28 | FIDDIAN-GREEN, Richard G. | Hollow viscus tonometry |
| WO1990001893A1 (en) * | 1988-08-26 | 1990-03-08 | Mountpelier Investments S.A. | Remote sensing tonometric catheter apparatus and method |
| WO1994021163A1 (en) * | 1993-03-22 | 1994-09-29 | Instrumentarium Corporation | Remote sensing tonometric catheter apparatus and method |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6462681B1 (en) | 1999-08-27 | 2002-10-08 | Koninklijke Philips Electronics N. V. | Scalable coding by scanning selected parts of respective bit-streams |
| WO2010125215A1 (en) * | 2009-04-29 | 2010-11-04 | Munoz Bonet Juan Ignacio | System for measuring, recording and continuously monitoring splanchnic tissue perfusion and physiological pulmonary dead space, and the use thereof |
| ES2379817A1 (en) * | 2009-04-29 | 2012-05-04 | Juan Ignacio Muñoz Bonet | System for measuring, recording and continuously monitoring splanchnic tissue perfusion and physiological pulmonary dead space, and the use thereof |
| US9730614B2 (en) | 2009-04-29 | 2017-08-15 | Juan Ignacio Muñoz Bonet | System for continuous measuring, recording and monitoring of the splanchnic tissue perfusion and the pulmonary physiological dead space, and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| AU3361697A (en) | 1998-02-02 |
| NL1003533C2 (en) | 1998-01-12 |
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