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WO1998057144A1 - Dispositif pour determiner le temps de desagregation de corps moules medicamenteux comprimes, tels que des comprimes et des gelules, et procede a cet effet - Google Patents

Dispositif pour determiner le temps de desagregation de corps moules medicamenteux comprimes, tels que des comprimes et des gelules, et procede a cet effet Download PDF

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Publication number
WO1998057144A1
WO1998057144A1 PCT/DE1998/001397 DE9801397W WO9857144A1 WO 1998057144 A1 WO1998057144 A1 WO 1998057144A1 DE 9801397 W DE9801397 W DE 9801397W WO 9857144 A1 WO9857144 A1 WO 9857144A1
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WO
WIPO (PCT)
Prior art keywords
sensor
decay
test tube
basket
time
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1998/001397
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German (de)
English (en)
Inventor
Norbert Krämer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19739382A external-priority patent/DE19739382A1/de
Application filed by Individual filed Critical Individual
Priority to DE19880832D priority Critical patent/DE19880832D2/de
Priority to DE19880832A priority patent/DE19880832C1/de
Priority to AU84304/98A priority patent/AU8430498A/en
Publication of WO1998057144A1 publication Critical patent/WO1998057144A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/006—Dissolution of tablets or the like

Definitions

  • Device for determining the disintegration time of compressed medicament shaped articles such as tablets and capsules, and method therefor
  • the invention relates to a device for determining the disintegration time of compressed medicament shaped bodies, such as tablets or capsules, according to the preamble of claim 1 and to a method for determining the disintegration time of compressed medicament shaped bodies according to the preamble of claim 20.
  • the disintegration time measurement of compressed medicament shaped bodies is carried out in a standardized experimental setup in order to ensure the reproducibility of the measurement results, in particular according to DAB 10, 3rd supplement 1994 or European Pharmacopoeia or USP (USA).
  • the disintegration test determines whether the tablets or capsules disintegrate in a prescribed manner in a liquid medium under precisely executed conditions.
  • the main part of the repair consists of a rigid decay basket, which contains six cylindrical glass test tubes. Each tube is provided with a cylindrical disk made of transparent plastic material of precisely specified relative density and size, which has five through bores, one of which is guided through the central axis of the disk.
  • the test tubes are held vertically by an upper and a lower transparent plate made of plastic material, each with six holes.
  • All holes have the same distance from the center and the same distance from each other.
  • a metal column is attached in the middle of the plates in such a way that the apparatus can be suspended from this metal column in a hanging device and can be moved up and down evenly 28 to 32 times per minute by 50 to 60 mm.
  • the device is suspended in a suitable container that contains the prescribed liquid. After filling a tablet or capsule into each tube and placing the disc as a weight, the dissolution time of the tablets or capsules is determined by observing the measuring device and timing the disintegration time by the operator.
  • a disintegration device for test specimens in particular tablets, has become known from DE 35 20 034 C1, in which the test specimens are arranged in containers of a decay basket between a Hall generator and a disk provided with a magnet.
  • the containers of the decay basket are heated to a constant temperature by means of a heater.
  • the disk moves together with the magnet towards the Hall generator, so that it emits a signal which can be fed to a recording device and displayed after a switching shaft has been exceeded.
  • the energy for electrical circuits in the decay basket is transmitted via contacts or by a high-frequency transmitter and a high-frequency receiver.
  • the signals are transmitted to the recording device by optoelectric components.
  • an automatic disintegration time measuring device for the pharmaceutical quality and production control of tablets and dragees within a conductive test liquid which consists of a basket-like disintegration basket arranged in a beaker with a number of glass tubes arranged therein Bottoms are formed by circular sieve plates as standing surfaces for the glass tubes, each sieve plate consisting of two current-carrying, electrically forming wire mesh halves, which are arranged at a distance from one another to form a slot.
  • a test specimen is placed in each glass tube, which is covered by a float that rests on the test specimen.
  • the float has an embedded contact frame made of a metallic material on the underside.
  • a tablet disintegration time measuring device with moving tubes in a bath liquid is known from US Pat. No. 3,618,395 with a large number of mutually opposite, spaced electrodes on the bottom of the tubes containing the tablets.
  • the presence of a tablet disturbs an electromagnetic field applied to the electrodes, the disturbance influencing a timer whose signals can be evaluated.
  • WO 97/140 35 discloses a device for determining the disintegration time of pressed medicinal tablets, in which on the bottom of the Disintegration basket around each hole an electric coil is arranged as a single-layer or multi-layer coil, which is part of an electrical resonant circuit, a conductor loop for path-dependent damping of the electrical resonant circuit is arranged on the disc, which is connected together to an electrical evaluation device for generating vibrations and evaluating the measurement results are.
  • a disadvantage of the known devices is, in particular, that the measuring methods used require such modifications to the test devices that they sometimes fail to meet the corresponding standards required by the pharmaceutical industry according to DAB 10 or USP. Sensors in the bottom area of the decay basket change the flow conditions within the test tube, for example. Furthermore, devices in which parts of the electronic components, e.g. Hall sensors or coils, located within the medium, often failures of these components.
  • Another disadvantage with known devices is that the decay time is caused by the entry of certain parameters, e.g. Falling below a certain thickness of the dissolving test specimen, that is to say determined by a switching process, the quality of the decay time cannot be checked in terms of its quality.
  • a non-contact displacement sensor with a measuring coil charged with alternating current is known from PCT / DE 93/00703, the measuring coil having at least two voltage taps, with an electrically and / or magnetically conductive measurement object and with an evaluation circuit for determining the position of the measurement object in relation output voltage of the measuring coil corresponding to the voltage taps, which is encapsulated in a housing.
  • the measurement object is a ring which surrounds the housing at a distance and can be moved along the housing wall.
  • the voltages that can be tapped at successive sections of the measuring coil are added up, subtotals each being formed that differ in the increasing number of voltage values taken into account. These subtotals are again added up to an output voltage, which can then be clearly related to the position of the ring.
  • the invention has for its object to provide a device of the type mentioned, the contactless detection of the movement of the perforated disc within the test tube and determine the disintegration time of the pressed drug body practically without changes to the prescribed parameters for the apparatus according to DAB 10 or USP . Furthermore, the device should be as repair and maintenance-prone as possible. Likewise, a possibility should be made available to evaluate the quality of the measurement of the decay time.
  • the object is achieved by a device of the type mentioned, in which, according to the invention, at least one spatially resolving sensor is introduced into the wall of the test tube, which sensor emits a sensor signal in the operating state due to the interaction with a hole disc within the same test tube, which is dependent on the height of the perforated disk above the bottom of the decay basket, the sensor signal being recorded as a function of time during the decay measurement and being evaluated in evaluation electronics for determining the decay time.
  • the evaluation of the sensor signals is preferably carried out according to the method of claim 21. In addition to determining the decay time, this method also allows the quality of the respective measurement to be assessed, since there is information about the course over time of the dissolution state of the medicament shaped body independently of the movement of the decay basket.
  • the spatially resolving sensor or the area in which the sensor can resolve the location of a target preferably extends from the side facing the bottom of the disintegrating basket to at a height H above the floor or above the sieve.
  • the height H should be greater than the thickness of possible drugs to be examined.
  • the sensor signal is transmitted via cables that lead out of the test tube or wirelessly, e.g. electro-optical, transmitted to an evaluation electronics.
  • the sensor signal is preferably continuously recorded in the evaluation electronics and evaluated to determine the decay time. Disturbance variables, in particular due to the up and down movement of the decay basket and thus the oscillating movement of the hole disc within the test tube, are eliminated by means of a suitable software algorithm. The underlying process is described below.
  • the cables are preferably melted within a flexible band.
  • the electronic elements of the device are preferably isolated from the medium in which the dissolution test is carried out in order to avoid short circuits and to increase the safety during operation and maintenance of the device, and do not come into contact with it .
  • the sensor can, for example, be melted into the cylindrical wall of the test tube, one or more cables being led out of the wall of the test tube, the cables preferably being surrounded by a flexible tape film.
  • the wall of the test tube is double-walled, the sensor being arranged between the partial walls and one or more cables being led out of the wall of the test tube.
  • the cables are used to transmit the sensor signal and, if necessary, to supply voltage or power to the sensor.
  • the evaluation electronics are also located in a sealed housing, e.g. together with the motor control for moving the decay basket within the vessel.
  • sensors can be used as sensors, the sensor signal of which can be evaluated to determine the position of a test specimen, here the perforated disk.
  • sensors can be used which operate on the capacitive, inductive, magnetic or optical principle. Both high-frequency and low-frequency sensors can be used as inductive sensors.
  • Hall sensors in question. The construction of a spatially resolving sensor as a sensor array from a plurality of individual sensors is also conceivable.
  • the strength of the sensor signal in response to the presence of the test specimen depends on its physical properties, e.g. Inductance, dielectric constant, magnetic field strength, and the type of sensor used. Since most sensors react only weakly to a standard hole disk, the signal-to-noise ratio is too bad for a reliable analysis of the sensor signal, it is usually necessary to equip the standard hole disk with a target that is from the Sensor has reliably detectable properties, which should differ as much as possible from the physical properties of the environment, in particular of the liquid medium. In order to improve the analysis of the current position of the hole disk, it is advantageous if the target does not extend over the entire hole disk, but is located in a small space. It is preferably located in the area of the underside, i.e. the side of the hole disc facing the bottom of the decay basket.
  • the target is, for example, a small magnet in the case of a spatially resolving sensor based on the magnetic principle or a conductor loop which runs peripherally around the hole disk.
  • the senor is a coil displacement sensor consisting of a coil wound in the wall of the glass tube around the tube axis with a plurality of coil taps with a constant turns ratio, similar to the coil of DE-196 50 657.4.
  • the coil is preferably supplied with alternating voltage and has at least two taps, preferably three or four or five taps.
  • the target is preferably a thin aluminum conductor loop running peripherally around the hole disk.
  • the coil has a certain total impedance as well as certain impedances of the coil sections, which change over time as the perforated disk with the closed aluminum loop sinks through the induction of eddy currents in the conductor loop.
  • These changes in the impedances can be measured as voltage signals, whereby a position-dependent sensor signal is available with a suitable evaluation, for example as known from DE 196 50 657.4.
  • two or three coils wound into one another namely bi- or trifilar wound, can be used. With a suitable design of the coil and target as well as the evaluation electronics, a spatial resolution of up to 50 ⁇ m can be achieved with such a structure.
  • a magnet as the target, it is therefore preferably a ring magnet, the bore of which is aligned with the central bore of the perforated disk.
  • aluminum is particularly suitable due to its low density.
  • the sensor signals of all test tubes arranged in the decay basket are fed to the evaluation electronics and preferably evaluated simultaneously. It is advantageous if the sensors are bus-compatible and can be configured via an interface.
  • the disintegration time of the drug tablet can be specified as the time until the sensor signal S 1 exceeds or falls below a predetermined threshold, in which case the threshold corresponds to a predetermined state of dissolution of the drug tablet.
  • the sensor signals S ,, ..., S n can be converted into height information x ,, ..., x n , ie height of the perforated disk relative to the bottom of the decay basket at a time corresponding to the upper reversal point or almost the upper reversal point of the decay basket , whereby a measurement is automatically rejected if several successive pairs of values S., S 1 + 1 are such that for the corresponding x ,, x 1+ ⁇ applies: x_ ⁇ x 1 + 1 .
  • FIG. 1 shows a side view of a device according to the invention, only two of the test tubes being shown;
  • FIG. 2 shows a longitudinal section of a test tube according to the invention; and
  • FIG. 3 shows a top view of the cover plate with the grooves, in which the flexible strips which enclose the electrical cables, up to
  • FIG. 4 shows a side view of a further device, only two of the test tubes being shown
  • Figure 5 shows a section of the device for representing the electrical contact between the sensor and the evaluation electronics Preferred embodiments:
  • FIG. 1 shows a device according to DAB 10, 3rd supplement 1994, as used in the present invention.
  • the device consists of a decay basket 1 with a circular cover plate 20 and a base 3, each of which has a plurality of holes 23, 23 ', usually six, in which cylindrical test tubes 2, 2', 2 "made of glass are arranged
  • the bottom 3 is covered on the underside with a sieve 14 made of stainless steel wire.
  • the cover plate 20 and the bottom 3 are rigidly held apart from one another by vertical spacing bars (not shown) on the outside of the decay basket 1, which is arranged above a vessel 5 in which a liquid medium is located, in which the disintegration time of the medicament shaped body 6 is to be determined.
  • the disintegration basket 1 is attached to a holding arm consisting of a head part 16 and a vertical column 19, which by means of a motor (not shown) periodically lowering and raising the Disintegration basket 1 into the vessel 5.
  • Data evaluation and control of the movement of the disintegration basket 1 takes place from the ID electronics 11, which together with the motor for moving the decay basket is located entirely within the head part 16.
  • the evaluation electronics 11 is able to work with external control units, e.g. other such devices or a central computer to communicate.
  • a tablet 6 or capsule is placed in each test tube 2, 2 'and a precisely defined perforated disc 4, 4' is placed on the tablet as a weight.
  • the perforated disk 4 preferably has a central bore which runs along the central axis of the perforated disk 4, 4 '.
  • the test tube 2, 2 ' has a spatially resolving sensor 8, 8' which extends within the cylindrical wall 7 over a large area from the opening of the test tube 2 facing the bottom 3 to a height H.
  • This sensor is any sensor which is able to emit sensor signals which are dependent on the height of the perforated disk 4, 4 'within the test tube 2, 2' and thus on the state of dissolution of the medicinal product body 6 to be tested. Since the movement of the perforated disk 4, 4 'in the lower area of the test tube 2, 2' is decisive for determining the decay time, it is sufficient if the sensor 8, 8 'is located in this area instead of the entire length of the Test tubes 2, 2 'to cover, which reduces the cost of a test tube equipped accordingly.
  • cables 9, 9' lead upwards within the wall 7 and out of the test tube 2, 2 'and to the evaluation electronics 11. These cables 9, 9' are used for current or. Power supply to the sensor 8, 8 'and to transmit the sensor signal to the evaluation electronics 11.
  • the cables 9, 9' belonging to all test tubes 2, 2 'within the decay basket 1 are within a tubular center column 15, which holds the decay basket 1, to the head part 16 out.
  • the cable routing within the entire device is such that all cables 9, 9 'and other electronic components are isolated from the medium and protected against splashes.
  • the cables 9, 9 'for power supply and / or signal transmission are led out at the upper edge of the test tube 2, 2' from its wall 7 within the top surface, the exit point of the cables 9, 9 'from the wall 7 being sealed.
  • a computing processor can also be located within the head part 16 or the evaluation electronics 11, so that an external processor is no longer necessary.
  • the perforated disk 4, 4 ' preferably has at least one target 10, 10' to which the spatially resolving sensor 8, 8 'responds reliably, the weight, volume and shape of the perforated disk 4, 4' being unchanged in accordance with the standards.
  • the target 10, 10 ' is arranged in the region of the side of the perforated disk 4, 4' facing the base 3; the target 10, 10 'can preferably be a ring magnet.
  • FIG. 2 shows an enlarged view of a test tube 2 ", in the wall 7 of which the sensor 8 is integrated, which here as a coil 12, preferably an annular long coil encircling the wall, with a plurality of freely selectable electrical taps 21, 21 ', 21" , 21 '", namely four partial taps, which represent the cables 9 of the coil 12.
  • the partial taps 21, 21', 21", 21 '" are encased by a flexible band 22, which according to FIG extends from the test tube 2 "in a groove 24, 24 'which is milled into the surface of the cover plate 20.
  • All grooves 24, 24 'within the cover plate 20 are directed radially to the center of the cover plate 20 and extend to the point of attachment of the tubular center column 15 or into the base area The same, the flexible straps 22 in the interior of the center column 15 running upward into the head part 16 and being guided there into the evaluation electronics 11 '.
  • Peripherally arranged fastening holes 25 within the cover plate 20 serve to screw them onto the vertical spacer bars on the outside of the decay basket.
  • a perforated disk 4 "has a target 10", which is a peripheral aluminum band.
  • the number of partial taps of the coil gives the spatial resolution, and a measuring accuracy of less than 50 micrometers can be achieved with four partial taps; the measurement is preferably carried out shortly before the reversal point of the decay basket in the upward direction of movement.
  • the sensor signals S ,, ..., S n are converted into height information x,, ..., x n , ie the height of the perforated disk 4 "relative to the bottom of the decay basket 1 at a time corresponding to the upper reversal point of the decay basket 1, with a measurement is automatically discarded when a plurality of consecu- derêtde value pairs S;, S i + 1 in such a manner are that + ⁇ is true for the corresponding Xj, x i: Xi ⁇ x i + 1 makes it possible to detect whether a tablet placed transversely. or has erected so that such a value is discarded. "Sticking" of the tablet to the wall can also be detected become. In this way a complete chronological decay diagram of the tablet can be created.
  • the respective thicknesses of the tablet are preferably queried every two seconds while the decay basket is at the upper reversal point and the values are stored. This process is repeated until the tablet disintegrates or until a predetermined residual thickness is reached. In this way, the time course of the disintegration of the tablet is obtained, and the process can be displayed on a monitor.
  • the stored values of a measurement process can be evaluated statistically or locally in the device using graphs or tables, the values being able to be forwarded to a higher-level, integrating tablet test system for processing via data lines.
  • a light-sensitive sensor If a light-sensitive sensor is used as the sensor, it can be a high-speed opto-electronic, spatially resolving PSD component, the edge currents of which are evaluated, the ratio of which then provides information about the tablet's disintegration time.
  • FIG. 4 shows a side view of a further device, the illustration essentially corresponding to that of FIG. 1.
  • the connecting cables 9, 9 'from the sensor elements 8, 8' to the electronics 11 are completely enclosed in the material or in the central rod 15 and in the head part 16 and thus protected against spray liquid .
  • the connecting cables 9, 9 ' are melted into the wall 7 of the test tube 2, 2', emerge from the upper edge of the test tube and are guided inside the upper cover plate 20.
  • the guidance is implemented, for example, by grooves 24, 24 ', as shown in FIG. 3.
  • the connecting cables are guided radially in the direction of the center of the cover plate 20 via these grooves.
  • the evaluation electronics 11 arranged in the head part 16 further comprises a processor 26 for evaluating the measurement data at the location of the measurement.
  • a measuring head is therefore self-sufficient and independent of an external evaluation system, but can also be used in conjunction with an external evaluation system.
  • the interfaces 17, 18 evaluated data, but depending on the operating mode, raw data can also be transferred for later evaluation.
  • FIG. 5 shows an alternative to the realization of the electrical contact between the sensor 8 inserted into the wall 7 of the test tube 2 and the evaluation electronics in the head part of the measuring device.
  • Cable elements 9 are melted or otherwise introduced into the plate material in the cover plate and end on the underside of the cover plate in a plug element 27 with sockets or pins.
  • the upper edge of the test tube 2 is complementary to it, so it also has a plug element 27 'into which the cable 9 coming from the sensor 8 or the connecting strands of the partial taps open.
  • the object of the invention is particularly suitable for the production of a device according to DAB 10, 3rd addendum 1994, in order to automatically determine the disintegration time of pharmaceutical tablets and to record a disintegration time diagram.

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Abstract

L'invention concerne un dispositif pour déterminer le temps de désagrégation de corps moulés médicamenteux comprimés (6, 6'), tels que des comprimés, dans un milieu liquide se trouvant à l'intérieur d'un récipient. Ce dispositif comporte une cage de désagrégation (1) que l'on fait descendre dans le milieu, cette cage étant pourvue d'un fond (3, 3'), recouvert d'un tamis, et d'une plaque de recouvrement supérieure (20) présentant une pluralité de trous dans lesquels des tubes à essai (2) sont disposés verticalement à l'intérieur de la cage de désagrégation (1) entre le fond (3, 3') et la plaque de recouvrement (20). Un disque perforé (4, 4', 4'') est introduit de manière mobile dans ces tubes à essai pour appliquer une pression sur chaque corps moulé médicamenteux (6, 6'), la cage de désagrégation (1) étant maintenue à une partie tête (21) à l'aide d'une colonne centrale (15, 15') raccordée au centre de la plaque de recouvrement (20). Dans la paroi (7, 7', 7'') du tube à essai (2) est placé au moins un capteur de position (8, 8') coopérant avec le disque perforé (4, 4', 4'') à l'intérieur du tube à essai (2, 2', 2'') de telle manière que le signal qu'il émet contient des informations concernant la hauteur du disque perforé par rapport au fond de la cage de désagrégation, en fonction du temps, et ainsi concernant le temps de désagrégation, les signaux du capteur étant évalués dans une électronique d'évaluation (11, 11').
PCT/DE1998/001397 1997-06-08 1998-05-22 Dispositif pour determiner le temps de desagregation de corps moules medicamenteux comprimes, tels que des comprimes et des gelules, et procede a cet effet Ceased WO1998057144A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE19880832D DE19880832D2 (de) 1997-06-08 1998-05-22 Vorrichtung zum Bestimmen der Zerfallszeit von verpreßten Arzneiformkörpern, wie Tabletten und Kapseln, und Verfahren hierzu
DE19880832A DE19880832C1 (de) 1997-06-08 1998-05-22 Vorrichtung zum Bestimmen der Zerfallszeit von verpreßten Arzneiformkörpern, wie Tabletten und Kapseln, und Verfahren hierzu
AU84304/98A AU8430498A (en) 1997-06-08 1998-05-22 Device for determining the decay time of compressed medicinal shaped bodies suchas tablets and capsules, and method therefor

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE19724008.9 1997-06-08
DE19724008 1997-06-08
DE19724303 1997-06-09
DE19724303.7 1997-06-09
DE19739382.9 1997-09-09
DE19739382A DE19739382A1 (de) 1997-06-08 1997-09-09 Vorrichtung zum Bestimmen der Zerfallszeit von verpreßten Arzneiformkörpern, wie Tabletten oder Kapseln, und Verfahren hierzu

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DE (1) DE19880832C1 (fr)
WO (1) WO1998057144A1 (fr)

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US7357046B2 (en) 2002-12-16 2008-04-15 N. V. Organon Method for dissolution testing of a pharmaceutical delivery device
US7956623B2 (en) 2007-02-16 2011-06-07 Countlab, Inc Container filling machine
DE102010012363A1 (de) 2010-03-22 2011-09-22 Erweka Gmbh Zerfallszeitmessgerät mit Spule und einem Modul zur drahtlosen Übertragung
US10577186B2 (en) 2011-08-18 2020-03-03 Countlab, Inc. Container filling machine
US10732162B2 (en) 2014-08-06 2020-08-04 Hexal Ag Method and device for determining the disintegration time of film-shaped pharmaceutical dosage forms
JP2022069332A (ja) * 2020-10-23 2022-05-11 富山産業株式会社 崩壊試験バスケット及び崩壊検出装置
CN120084960A (zh) * 2025-03-11 2025-06-03 苏州康纯医药科技有限公司 一种防折射干扰的崩解时限感应传感器

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EP1576189B1 (fr) * 2002-12-16 2007-09-12 N.V. Organon Recipient, procede et appareil pour tester la dissolution d'un dispositif annulaire de distribution pharmaceutique

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WO1997014035A1 (fr) * 1995-10-06 1997-04-17 Loeffler Hans Peter Dispositif pour la determination du temps de decomposition de medicaments sous forme de corps comprimes tels que pastilles, pilules ou capsules

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US7357046B2 (en) 2002-12-16 2008-04-15 N. V. Organon Method for dissolution testing of a pharmaceutical delivery device
US7956623B2 (en) 2007-02-16 2011-06-07 Countlab, Inc Container filling machine
DE102010012363A1 (de) 2010-03-22 2011-09-22 Erweka Gmbh Zerfallszeitmessgerät mit Spule und einem Modul zur drahtlosen Übertragung
WO2011117043A1 (fr) 2010-03-22 2011-09-29 Erweka Gmbh Appareil de mesure du temps de désintégration avec une bobine et un module pour le transfert sans fil
US10577186B2 (en) 2011-08-18 2020-03-03 Countlab, Inc. Container filling machine
US10732162B2 (en) 2014-08-06 2020-08-04 Hexal Ag Method and device for determining the disintegration time of film-shaped pharmaceutical dosage forms
JP2022069332A (ja) * 2020-10-23 2022-05-11 富山産業株式会社 崩壊試験バスケット及び崩壊検出装置
CN120084960A (zh) * 2025-03-11 2025-06-03 苏州康纯医药科技有限公司 一种防折射干扰的崩解时限感应传感器

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