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WO1998055126A3 - Use of anti-inflammatory steroids for the treatment of chronic inflammatory intestinal diseases - Google Patents

Use of anti-inflammatory steroids for the treatment of chronic inflammatory intestinal diseases Download PDF

Info

Publication number
WO1998055126A3
WO1998055126A3 PCT/EP1998/003473 EP9803473W WO9855126A3 WO 1998055126 A3 WO1998055126 A3 WO 1998055126A3 EP 9803473 W EP9803473 W EP 9803473W WO 9855126 A3 WO9855126 A3 WO 9855126A3
Authority
WO
WIPO (PCT)
Prior art keywords
inflammatory
treatment
group
intestinal diseases
steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1998/003473
Other languages
French (fr)
Other versions
WO1998055126A2 (en
Inventor
Johannes Hendriekus Meijerink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to PL98337458A priority Critical patent/PL337458A1/en
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Priority to KR19997011331A priority patent/KR20010013335A/en
Priority to BR9809551-0A priority patent/BR9809551A/en
Priority to JP50158399A priority patent/JP2002502409A/en
Priority to AU86252/98A priority patent/AU740005B2/en
Priority to HU0003354A priority patent/HUP0003354A3/en
Priority to EP98937458A priority patent/EP0984782A2/en
Priority to CA002290775A priority patent/CA2290775A1/en
Publication of WO1998055126A2 publication Critical patent/WO1998055126A2/en
Publication of WO1998055126A3 publication Critical patent/WO1998055126A3/en
Priority to NO995936A priority patent/NO995936L/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to the use of inflammatory compounds having general formula (I) wherein X is a member of the group consisting of H and halogen; Y is a member of the group consisting of H2, H(OH), H(O(C1-6)Acyl) and O; R1 is a member of the group consisting of H, CH3 and halogen; R2 is (C1-4)Alkyl; R3 is a member of the group consisting of H, O((C1-6)Acyl), O((C1-6)Alkyl) and CH3; R4 is a member of the group consisting of H and (C1-4)Alkyl, and C1-C2 and C6-C7 are saturated or unsaturated bonds, for the manufacture of a medicament for chronic inflammatory colon diseases.
PCT/EP1998/003473 1997-06-04 1998-06-02 Use of anti-inflammatory steroids for the treatment of chronic inflammatory intestinal diseases Ceased WO1998055126A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA002290775A CA2290775A1 (en) 1997-06-04 1998-06-02 Use of anti-inflammatory steroids for the treatment of chronic inflammatory intestinal diseases
KR19997011331A KR20010013335A (en) 1997-06-04 1998-06-02 Use of anti-inflammatory steroids for the treatment of chronic inflammatory intestinal diseases
BR9809551-0A BR9809551A (en) 1997-06-04 1998-06-02 Use of compounds and rimexolone, and, colitis improvement process.
JP50158399A JP2002502409A (en) 1997-06-04 1998-06-02 Use of anti-inflammatory steroids for the treatment of chronic inflammatory bowel disease
AU86252/98A AU740005B2 (en) 1997-06-04 1998-06-02 Use of anti-inflammatory steroids for the treatment of chronic inflammatory intestinal diseases
PL98337458A PL337458A1 (en) 1997-06-04 1998-06-02 Application of anti-inflammatory steroids in treating chronic intestinal inflammatory diseases
EP98937458A EP0984782A2 (en) 1997-06-04 1998-06-02 Use of anti-inflammatory steroids for the treatment of chronic inflammatory intestinal diseases
HU0003354A HUP0003354A3 (en) 1997-06-04 1998-06-02 Use of anti-inflammatory steroids for the preparation of pharmaceutical compositions of chronic inflammatory intestinal diseases
NO995936A NO995936L (en) 1997-06-04 1999-12-03 Use of anti-inflammatory steroids for the treatment of chronic inflammatory bowel disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97201690.1 1997-06-04
EP97201690 1997-06-04

Publications (2)

Publication Number Publication Date
WO1998055126A2 WO1998055126A2 (en) 1998-12-10
WO1998055126A3 true WO1998055126A3 (en) 1999-03-11

Family

ID=8228405

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/003473 Ceased WO1998055126A2 (en) 1997-06-04 1998-06-02 Use of anti-inflammatory steroids for the treatment of chronic inflammatory intestinal diseases

Country Status (12)

Country Link
EP (1) EP0984782A2 (en)
JP (1) JP2002502409A (en)
KR (1) KR20010013335A (en)
CN (1) CN1336824A (en)
AU (1) AU740005B2 (en)
BR (1) BR9809551A (en)
CA (1) CA2290775A1 (en)
HU (1) HUP0003354A3 (en)
NO (1) NO995936L (en)
PL (1) PL337458A1 (en)
TR (1) TR199902812T2 (en)
WO (1) WO1998055126A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI335819B (en) * 2002-12-24 2011-01-11 Alcon Inc Use of oculosurface selective glucocorticoid in the treatment of dry eye

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2301317A1 (en) * 1972-01-12 1973-07-26 Akzo Nv ALKYLATED 3.20-DIKETO-DELTA HIGH 4-STEROIDS OF THE PREGNAN SERIES
US3947478A (en) * 1972-01-12 1976-03-30 Akzona Incorporated Alkylated 3,20-diketo-Δ4 -steroids of the pregnane series
EP0014005A1 (en) * 1979-01-24 1980-08-06 Akzo N.V. Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same
WO1997039018A1 (en) * 1996-04-18 1997-10-23 Hoechst Marion Roussel New pregnane derivatives with no alpha-17 substitutent, their medicinal use, manufacturing method and its intermediaries and related compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2301317A1 (en) * 1972-01-12 1973-07-26 Akzo Nv ALKYLATED 3.20-DIKETO-DELTA HIGH 4-STEROIDS OF THE PREGNAN SERIES
US3947478A (en) * 1972-01-12 1976-03-30 Akzona Incorporated Alkylated 3,20-diketo-Δ4 -steroids of the pregnane series
EP0014005A1 (en) * 1979-01-24 1980-08-06 Akzo N.V. Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same
WO1997039018A1 (en) * 1996-04-18 1997-10-23 Hoechst Marion Roussel New pregnane derivatives with no alpha-17 substitutent, their medicinal use, manufacturing method and its intermediaries and related compounds

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CARPANI DE KASKI M ET AL: "FLUTICASONE PROPIONATE IN CROHN'S DISEASE", GUT, vol. 32, no. 6, June 1991 (1991-06-01), pages 657 - 660, XP002045555 *
JEWELL D P ET AL: "THE NEW STEROIDS: CLINICAL EXPERIENCE IN ULTERATIVE COLITIS", MOUNT SINAI JOURNAL OF MEDICINE, vol. 57, no. 5, October 1990 (1990-10-01), pages 293 - 296, XP002045554 *
ROTSZTEJN ET AL.: "Rapid glucocorticoid inhibition of vasoactive intestinal peptide-inducede cyclic AMP accumulation and prolactin release in rat pituitary cells in culture", PROC. NATL. ACAD. SCI. USA, vol. 78, no. 12, 1981, pages 7584 - 7588, XP002089115 *

Also Published As

Publication number Publication date
CA2290775A1 (en) 1998-12-10
HUP0003354A2 (en) 2001-03-28
NO995936D0 (en) 1999-12-03
AU740005B2 (en) 2001-10-25
NO995936L (en) 1999-12-03
CN1336824A (en) 2002-02-20
TR199902812T2 (en) 2000-06-21
HUP0003354A3 (en) 2001-09-28
EP0984782A2 (en) 2000-03-15
AU8625298A (en) 1998-12-21
JP2002502409A (en) 2002-01-22
KR20010013335A (en) 2001-02-26
WO1998055126A2 (en) 1998-12-10
BR9809551A (en) 2000-06-20
PL337458A1 (en) 2000-08-14

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