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WO1998049165B1 - COMPOSES CYTOTOXIQUES: DERIVES DU SYSTEME CYCLIQUE PYRIDO[2,3,4-kl] ACRIDINE - Google Patents

COMPOSES CYTOTOXIQUES: DERIVES DU SYSTEME CYCLIQUE PYRIDO[2,3,4-kl] ACRIDINE

Info

Publication number
WO1998049165B1
WO1998049165B1 PCT/GB1998/001239 GB9801239W WO9849165B1 WO 1998049165 B1 WO1998049165 B1 WO 1998049165B1 GB 9801239 W GB9801239 W GB 9801239W WO 9849165 B1 WO9849165 B1 WO 9849165B1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
formula
group
compound according
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1998/001239
Other languages
English (en)
Other versions
WO1998049165A1 (fr
Filing date
Publication date
Priority claimed from GBGB9708751.4A external-priority patent/GB9708751D0/en
Application filed filed Critical
Priority to JP54674598A priority Critical patent/JP2001522370A/ja
Priority to AU72208/98A priority patent/AU7220898A/en
Priority to CA002287862A priority patent/CA2287862A1/fr
Priority to EP98919330A priority patent/EP0980372A2/fr
Publication of WO1998049165A1 publication Critical patent/WO1998049165A1/fr
Publication of WO1998049165B1 publication Critical patent/WO1998049165B1/fr
Anticipated expiration legal-status Critical
Priority to US09/962,013 priority patent/US6656948B2/en
Ceased legal-status Critical Current

Links

Abstract

L'invention concerne des composés de formule (I) (I) dans laquelle: X est choisi dans le groupe composé de O et NR3, R3 représentant un groupe alkyle inférieur; Y est choisi dans le groupe composé de CH et N; R1 et R2 sont choisis indépendamment dans le groupe composé de NH¿2?, NHR?4, et NR5¿2, R4 et R5 représentant chacun un groupe alkyle inférieur, ou R1 et R2 représentant ensemble un cycle choisi parmi a), b), et c): dans lesquels R?6, R7, et R8¿ sont choisis indépendamment dans le groupe composé des atomes d'hydrogène, des groupes alkyles inférieurs, des groupes hydroxy, et des groupes alkoxy inférieurs; et Z est choisi dans le groupe composé de O.
PCT/GB1998/001239 1997-04-29 1998-04-29 COMPOSES CYTOTOXIQUES: DERIVES DU SYSTEME CYCLIQUE PYRIDO[2,3,4-kl] ACRIDINE Ceased WO1998049165A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP54674598A JP2001522370A (ja) 1997-04-29 1998-04-29 ピリド［２，３，４−ｋ，ｌ］アクリジン環系の誘導体：細胞毒性化合物
AU72208/98A AU7220898A (en) 1997-04-29 1998-04-29 Cytotoxic compounds: derivatives of the pyrido{2,3,4-(kl)} acridine ring system
CA002287862A CA2287862A1 (fr) 1997-04-29 1998-04-29 Composes cytotoxiques: derives du systeme cyclique pyrido[2,3,4-kl] acridine
EP98919330A EP0980372A2 (fr) 1997-04-29 1998-04-29 COMPOSES CYTOTOXIQUES: DERIVES DU SYSTEME CYCLIQUE PYRIDO 2,3,4-$i(kl)] ACRIDINE
US09/962,013 US6656948B2 (en) 1998-04-29 2001-09-24 Cytotoxic compounds: derivatives of the pyrido[2,3,4-kl]acridine ring system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9708751.4A GB9708751D0 (en) 1997-04-29 1997-04-29 New cytotoxic analogues of marine natural products derivatives of the pyrido (2,3,4-K1) acridine ring systems
GB9708751.4 1997-04-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US42920499A Continuation 1998-04-29 1999-10-28

Publications (2)

Publication Number Publication Date
WO1998049165A1 WO1998049165A1 (fr) 1998-11-05
WO1998049165B1 true WO1998049165B1 (fr) 1998-12-10

Family

ID=10811575

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/001239 Ceased WO1998049165A1 (fr) 1997-04-29 1998-04-29 COMPOSES CYTOTOXIQUES: DERIVES DU SYSTEME CYCLIQUE PYRIDO[2,3,4-kl] ACRIDINE

Country Status (6)

Country Link
EP (1) EP0980372A2 (fr)
JP (1) JP2001522370A (fr)
AU (1) AU7220898A (fr)
CA (1) CA2287862A1 (fr)
GB (1) GB9708751D0 (fr)
WO (1) WO1998049165A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790954B1 (fr) * 1999-03-18 2003-08-08 Lafon Labor Composition pharmaceutique a base de composes polyaromatiques
GB9918079D0 (en) 1999-07-30 1999-10-06 Univ Barcelona New cytotoxic pyrido (2,3,4-kl) acridine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182287A (en) * 1989-11-03 1993-01-26 Harbor Branch Oceanographic Bioactive heterocycle alkaloids and methods of use

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