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WO1998048767A1 - Humectant, preparation cosmetique et produit medicinal contenant cet humectant - Google Patents

Humectant, preparation cosmetique et produit medicinal contenant cet humectant Download PDF

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Publication number
WO1998048767A1
WO1998048767A1 PCT/JP1998/001929 JP9801929W WO9848767A1 WO 1998048767 A1 WO1998048767 A1 WO 1998048767A1 JP 9801929 W JP9801929 W JP 9801929W WO 9848767 A1 WO9848767 A1 WO 9848767A1
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Prior art keywords
water
organic solvent
fraction
skin
moisturizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1998/001929
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English (en)
Japanese (ja)
Inventor
Yoshio Furusawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Priority to JP54682098A priority Critical patent/JP4424759B2/ja
Publication of WO1998048767A1 publication Critical patent/WO1998048767A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations

Definitions

  • the present invention relates to a novel humectant, a humidifying method using the humectant, and cosmetics and pharmaceuticals containing the humectant. More specifically, the present invention is a novel moisturizer that has excellent moisturizing properties, has high durability of moisturizing function, can impart moist feeling and smoothness to skin and hair, and is safe for the human body.
  • the present invention relates to a method for moisturizing skin and hair using the humectant, and to cosmetics and pharmaceuticals containing the humectant. Skill
  • Skin cosmetics are generally prepared by blending a hydrophilic skin moisturizer and an oily emollient to give the skin adequate moisture and oil to prevent the skin from drying out. You.
  • polyethers such as polyethylene glycol and polypropylene glycol, glycerin, and sorbitol have been used as the hydrophilic skin moisturizer, but in recent years, natural moisturizing factor (NMF) has been used.
  • NMF natural moisturizing factor
  • Amino acids, sodium pyrrolidonecarboxylate, urea, sodium lactate, etc., and natural high molecular weight compounds such as sodium hyaluronate and salivary gland mucin have been used.
  • moisturizers such as polyethers, glycerin, and sorbitol have the drawback of being dermatologically heterogeneous, and also have the disadvantage of removing water from the outermost layer of the skin, the stratum corneum. NMFs may be absorbed and rather cause skin to lose moisture. NMFs, which have been used in recent years, are substances derived from natural products, but they have a poor feeling on use and have a poor moisturizing effect. There are drawbacks such as On the other hand, sodium hyaluronate is currently used in many cosmetics and gives a skin a "moist feeling" and "smoothness" in a concentration range of about 0.02 to 0.1% by weight. Its usefulness has been highly evaluated. In addition, for safety testing In the range of 2 to 3% by weight, no local irritation or sensitization was observed in laboratory animals, and in human patch tests, it was safe even at a concentration of 1% by weight. Has been confirmed.
  • Salivary gland mucins also have an excellent moisturizing effect, and their "moistness” and “smoothness” on the skin are evaluated as being superior to sodium hyaluronate. It has been confirmed that salivary gland mucin has moisturizing and emulsifying effects and is highly safe for the human body, and can be said to be a fairly ideal moisturizer.
  • Salivary gland mucin is a glycoprotein that is biosynthesized and secreted by the salivary glands of mammals, for example, pests, pomas, bushes, and sheep, such as the submandibular, parotid, and sublingual glands. It has an inherent viscosity depending on the type of animal and is obtained as a macromolecule containing a large amount of sialic acid and having a molecular weight of about 100,000 to 100,000.
  • cosmetics containing sodium hyaluronate and salivary gland mucin improve the feeling of use, but because both components are easily decomposed, the molecular weight decreases over time, and the moisturizing property and viscosity decrease.
  • Another disadvantage is that the moisturizing film is easily removed by washing with water or hot water.
  • liquid oils such as liquid paraffin and petrolatum are used as emollients, but when these emollients are added to such an extent that they prevent normal evaporation of water from the epidermis, unpleasant feeling due to stickiness And lacks usefulness as a skin moisturizer. Disclosure of the invention
  • the first object of the present invention is to (1) exert a moisturizing property in an extremely small amount, and can be blended into various cosmetic bases and bases for external preparations for pharmaceuticals.
  • Skin and (3) It can give a moist feeling and "smoothness” to hair and hair.
  • (3) It does not give a feeling of incongruity such as "stickiness” or “sharpness” like conventional oily emollients.
  • Moisturizing. The moisturizing film is not removed even after washing with water or hot water several times, (6) It is highly safe for the human body. Is to provide a suitable humectant.
  • a second object is to provide a method for moisturizing skin and hair using the humectant
  • a third object is to provide cosmetics and medicines containing the humectant. It is to be.
  • the present inventors have conducted intensive studies to achieve the above object, and as a result, many animals lick their bodies with their tongues and groom, and when saliva dries, beautiful and smooth shiny hair is obtained. Focusing on the fact that the wound is moisturized with the tongue, preventing dryness and accelerating the healing of the wound, a certain method is used from the parotid gland secretion of mammals.
  • the separated components are (a) extremely moist, and exhibit a moisturizing function, and are safe for the human body.
  • B) Even in powder form, they dissolve in water and apply to the skin to exert a moisturizing function.
  • C It can be used by blending it with various cosmetic bases and bases for external preparations for medicines. Lotion, base for external medicines, etc.
  • a moisturizer characterized by containing, as an active ingredient, a fraction that precipitates at a water-miscible organic solvent concentration of 60% (v / v) or higher in the parotid secretion of mammals.
  • a method for moisturizing the skin comprising applying the humectant of (1) to the skin
  • a moisturizing method for hair and scalp which comprises applying the moisturizing agent of (1) to the hair or scalp or both.
  • a cosmetic comprising a cosmetic base and a fraction that precipitates at a water-miscible organic solvent concentration of 60% (v / v) or higher in the parotid gland secretion of a mammal.
  • the humectant of the present invention contains, as an active ingredient, a substance derived from the parotid fluid of a mammal, and the mammal is not particularly limited. Although it is preferable to take the secretion fluid into consideration, such as ease of collection, amount of secretion (1 to 50 to 60 liters is secreted in one case), economy, etc. .
  • Saliva secreted into the mouth of mammals is a mixture of secretions from the parotid, submandibular and sublingual glands.
  • the ratio of salivary gland secretion to its secretion is about 70% by weight of parotid gland, 5% by weight of submandibular gland, and 25% by weight of sublingual gland.
  • the secretion of the mammal used in the present invention is limited to that secreted from the parotid gland, and is substantially free of the secretion secreted from other salivary glands, the submandibular gland and the sublingual gland Things.
  • Saliva as a mixture contains mucous and serous components, but the parotid gland secretion, which is the secretion from the parotid gland, is known to be serous and mostly water. ing. To date, only “all saliva” as a mixture has been studied for "saliva”, and little has been done on the secretions of the three glands described above. The present inventors have studied the secretions obtained from the salivary glands and found out that the parotid secretions contained a component having an extremely excellent moisturizing function.
  • an incision is made on the skin below the animal's parotid and the oral surface Expose the parotid gland duct near the skin and make a small incision in the parotid gland duct so that the tip of the forcenula can be inserted. Guide the force through the incision in the skin, and insert the tip of the force neuron from the incision in the parotid duct toward the parotid gland.
  • the incision wound on the skin is closed while the cannula is fixed with adhesive tape.
  • a receiver can be placed on the opposite end of the force neuron to collect the parotid gland fluid that flows off naturally.
  • the preservatives to be added include ordinary preservatives, for example, benzoic acids, paraoxybenzoic acids, dehydroacetic acids, sorbic acids, phenols, alcohols, sodium, rogens, glutaraldehydes,? -Probio Lactones and the like, or a mixture thereof.
  • it is odorless or one which can easily be removed in the subsequent step even if it has an odor, and paraoxy-benzoic acids are particularly preferred.
  • the humectant of the present invention is obtained by mixing a mammalian parotid gland secretion with a water-miscible organic solvent, and a fraction that precipitates at an organic solvent concentration of 60% (v / v) or more (hereinafter, the humectant fraction). ) May be contained as an active ingredient.
  • the reason for setting the organic solvent concentration to 60% (v / v) or more is as follows. As the organic solvent is added to the parotid gland secretion, the solubility of the moisturizing components in the parotid gland secretion decreases and sedimentation begins to occur.
  • the effective amount of organic solvent added is defined as the amount at which this precipitate can be substantially recovered, which is about 60% (v / v) or more. Therefore, the amount of addition varies slightly depending on the type of organic solvent, but in the case of the present invention, if the amount of addition of the organic solvent is less than 60% (v / v), practical precipitation cannot be expected. .
  • the concentration of the organic solvent is not particularly limited as long as it is 60% (v / v) or more, but considering the amount of formed precipitate and the economics of using an excessive amount of the organic solvent,
  • the concentration of the organic solvent is preferably about 63 to 80% (v / v), and more preferably about 65 to 75% (v / v).
  • the parotid gland secretion collected as described above, or after filtration, is put into an extractor, and the water-miscible organic solvent is stirred preferably under cooling (about 0 to 15 ° C).
  • the obtained moisturizing fraction may be used as it is, but it is dehydrated and dried to obtain a powder. It is advantageous to use it.
  • As a method of dehydration there is a method of further adding a water-miscible organic solvent to the obtained fraction.
  • As a drying method there are an aeration method, a decompression method, and the like. These methods can be combined, and further heating can be applied.
  • water-miscible organic solvent examples include acetone, ethanol, methanol, and isopropanol. These may be used alone or in combination of two or more. Is particularly preferred.
  • the yield of the moisturizing fraction depends on the health of the animal from which the parotid gland secretion is collected, but is generally 0.1% as a dry fraction relative to the parotid gland secretion. It is about 5 to 0.7% by weight.
  • the nitrogen content and protein content in the dry and moisturizing fraction depend on animal health and the like, but are generally in the range of 0.05 to 0.4% by weight. And 0.4 to 3% by weight.
  • the substance having a moisturizing function of the moisturizing fraction has not yet been identified and is not necessarily a single substance.
  • mucopolysaccharides such as hyaluronic acid and salivary gland mucin It is considered to be a substance different from the above.
  • the moisturizing fraction separated from the parotid gland secretion of the mammal has the following properties.
  • the humectant of the present invention contains the humectant fraction as an active ingredient
  • the humectant may contain a conventionally known humectant component, if desired.
  • Known moisturizing components include, for example, polyethers such as polyethylene glycol and polypropylene glycol, polyhydric alcohols such as glycerin, 1,3-butylene glycol, propylene glycol, and sorbitol, and NMFs. Specific examples thereof include -amino acids, urea, sodium lactate, sodium borolidone carboxylate, mucopolysaccharides such as hyaluronic acid and chondroitin sulfate, and proteins such as collagen and elastin.
  • the moisturizing method of the present invention has two aspects. One is a method of applying the moisturizing agent of the present invention to the skin to moisturize the skin, whereby the skin has a “moist feeling” and “smoothness”. Is given.
  • the other is a method of applying the humectant of the present invention to the hair and / or scalp and moisturizing them, whereby the surface condition of the hair is improved and the slip on the hair surface (so-called comb) As expected), hair dressing is improved and drying of the scalp is improved, and itching and dandruff are suppressed.
  • the form of the humectant at the time of application is not particularly limited, and for example, a humectant can be used as a cosmetic in various forms described below or as an external preparation in various forms.
  • the cosmetic of the present invention contains a cosmetic base and the moisturizing fraction separated from the above-mentioned mammalian parotid secretion.
  • the amount of the moisturizing fraction (dry state) contained in the cosmetic of the present invention depends on the form of the cosmetic and the presence or absence of other moisturizing components, but is usually 0.0 based on the total amount of the cosmetic. 0 to 2% by weight. If the content is less than 0.001% by weight, the moisturizing function may not be sufficiently exhibited, and if it exceeds 2% by weight, no improvement in the effect is recognized for the amount, and it is economically disadvantageous. Becomes Consider the moisturizing effect and economy The preferred content is in the range of 0.05 to 0.2% by weight.
  • the base used in the cosmetic of the present invention is not particularly limited, and is appropriately selected according to the desired form of the cosmetic from various components conventionally used as the base in cosmetics of various forms. You can choose.
  • the form of the cosmetic of the present invention is not particularly limited, for example, skin cosmetics such as lotion, milky lotion, creams, packs, lotions, lipsticks, foundations, skin cleansers, etc., hair conditioner, hair rinse, Hair cosmetics such as hair tonics, hair creams, and hair lotions can be mentioned, and the moisturizing fraction can be blended whether the base is aqueous or oily.
  • a hair cosmetic in which the moisturizing fraction is blended with a hair cosmetic base has an excellent effect of keeping the hair and the scalp healthy.
  • the hair By improving the surface condition of the hair, the slip on the hair surface (so-called comb-like) is improved and the riding of hair cosmetics is improved. It can also improve scalp drying and reduce itching and dandruff.
  • the cosmetic of the present invention may contain, if desired, various components conventionally used in cosmetics, for example, oils, surfactants, emulsifiers, alcohols, other moisturizing components, thickeners, preservatives, and antibacterial protection.
  • Cosmetics for example, oils, surfactants, emulsifiers, alcohols, other moisturizing components, thickeners, preservatives, and antibacterial protection.
  • oil component examples include liquid oils such as castor oil, olive oil, jojoba oil, camellia oil, solid oils such as hardened castor oil, lanolin, whale wax, beeswax, carnauba wax, waxes such as candelilla wax, squalane, Examples include hydrocarbons such as petrolatum, liquid paraffin, sericin, and paraffin.
  • surfactant examples include POE sorbin ester such as polyoxyethylene (POE) sorbin monooleate, sorbin ester such as sorbitan monooleate, P 0 E—P 0 E such as glyceryl monooleate.
  • POE sorbin ester such as polyoxyethylene (POE) sorbin monooleate
  • sorbin ester such as sorbitan monooleate
  • P 0 E—P 0 E such as glyceryl monooleate.
  • Glycery Glycerin fatty acid esters such as glycerin fatty acid esters and glycerin monooleate;
  • POE Polymers such as monooleate; POE—alkyl ethers such as lauryl ether; POE—branched alkyl ethers such as POE—octyldodecyl ether; POE—branched alkyl ethers such as POE—nonylphenyl ether P 0 E—glycerol esters such as alkylphenyl ether and glycerol monoisostearate; POE such as POE—glycerol monoisostearate—polyglycerin fatty acid esters such as diglyceryl monostearate Nonionic surfactants, fatty acid soaps such as sodium and sodium salts of higher fatty acids such as stearic acid, higher alkyl sulfates such as sodium lauryl sulfate, and alkyls such as POE-triethanolamine lauryl sulfate Ether sulfate, LA N-acyl sarcosine salts such as royl
  • alcohols include lower alcohols such as ethyl alcohol, propyl alcohol, and isopropyl alcohol, glycerin, polyglycerin, trimethylolpropane, pentaerythritol, dipentyl erythritol, ethylene glycol, propylene glycol, polypropylene glycol, polypropylene glycol, and the like.
  • the same components as those exemplified as the desired components in the description of the humectant of the present invention can be given.
  • the thickening agent examples include natural polymer substances such as sodium alginate, xanthan gum, malomelo seed extract, tragacanth gum, starch, and semi-synthetic polymers such as methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, soluble starch, and cationized cellulose. Substances, synthetic high molecular substances such as carboxyvinyl polymer and polyvinyl alcohol.
  • antibacterial and antifungal agents examples include methyl p-oxybenzoate, ethyl p-oxybenzoate, dehydroacetic acid, salicylic acid, benzoic acid, sorbic acid, and benzalkonium chloride. Examples thereof include dibutylhydroxytoluene, butylhydroxyanitool, provyl gallate, and ascorbic acid.
  • Examples of the chelating agent include disodium edetate, ethanehydroxydiphosphate, pyrophosphate, hexametaphosphate, citrate, tartaric acid, and gluconic acid
  • examples of the pH adjuster include sodium hydroxide, Triethanolamine, cunic acid, sodium citrate, boric acid, borax, sodium monohydrogen phosphate and the like.
  • examples of the ultraviolet absorber include 2-hydroxy-4-methoxybenzophenone, octyldimethyl p-aminobenzoate, and ethylhexyl p-methoxycinnamate
  • examples of the ultraviolet scattering agent include titanium oxide, kaolin, and talc. No.
  • vitamins include, for example, vitamin A, vitamin B, vitamin C, biyumin D, vitamin E, vitamin F, vitamin, vitamin P, vitamin U, power lunitine, ferulic acid, hi-orizanol, herlipoic acid, Orotic acid and its derivatives include amino acids such as glycine, alanine, norin, oral isin, isoleucine, serine, threonine, fenylalanine, tyrosine, triptophan, cystine, cystine, methionine, proline, and hydroxy. Examples include proline, aspartic acid, glutamic acid, arginine, histidine, lysine and derivatives thereof.
  • the medicament of the present invention contains the moisturizing fraction separated from the parotid gland secretion of the mammal as one component of the medicinal external preparation base.
  • the drug of the present invention can improve the function of retaining water on the skin surface by applying it to the skin as an external preparation.
  • urea-based compounds which are moisturizing components added to external preparations for pharmaceuticals, may cause skin crispness, pain, erythema, itching, burning, desquamation, hypersensitivity, etc. It can also occasionally cause eczema, skin cracks, rarely swelling and dryness.
  • the medicament of the present invention does not have the drawbacks of the above-mentioned urea compounds, and is effective for improving cracks, scabs and other diseases caused by dry skin, rough skin and dry skin. In addition, it improves the water retention function of the skin surface, which is advantageous in bringing out the therapeutic effect of the drug.
  • the amount of the moisturizing fraction (dry state) according to the present invention contained in the pharmaceutical of the present invention depends on the purpose of use, dosage form, presence or absence of other moisturizing components, and the like. It is in the range of 0.001-2% by weight based on the total amount of the chemical. If the content is less than 0.001% by weight, the moisturizing function may not be sufficiently exerted. If the content exceeds 2% by weight, no improvement in the effect is recognized for the amount, and economical efficiency is obtained. Disadvantaged. In consideration of the moisturizing effect and economy, the preferred content is in the range of 0.05 to 0.2% by weight.
  • the base used in the pharmaceutical product of the present invention can be appropriately selected according to the desired dosage form of the pharmaceutical from the various components conventionally used as the base in external preparations of various dosage forms. You can choose.
  • the dosage form of the drug of the present invention is not particularly limited, and includes, for example, creams, ointments, mouthwashes, etc., regardless of whether the base is hydrophilic or lipophilic.
  • the moisturizing fraction according to the present invention can be blended.
  • the drug that can be used in the pharmaceutical of the present invention is not particularly limited, and any drug that can be administered in the form of an external preparation can be used.
  • the medicine may contain, as desired, for example, each of the components exemplified as the desired components in the description of the cosmetic, an anti-inflammatory agent, an antipruritic agent, a bactericidal disinfectant, a feel improving agent, a hormonal agent and the like. Can be done.
  • an anti-inflammatory agent an antipruritic agent
  • a bactericidal disinfectant a feel improving agent
  • a hormonal agent a hormonal agent and the like.
  • the parotid gland secretion was collected, and 0.15% by weight of methyl paraoxybenzoate was added as a preservative and stored in a cool place.
  • the parotid gland secretion was filtered through filter paper No. 2 (Too Roshi Kaisha, Ltd.), and 100 liters thereof were stirred at 5 to 10 ° C in an extractor with a cooling device. While adding twice the amount (v / v) of acetone (acetone concentration: 66.6% (v / v)), a precipitate was formed, and the precipitate was collected.
  • the resulting precipitate was dehydrated by adding an appropriate amount of acetone, and the acetone was removed by filtration to obtain an acetone-dehydrated cake.
  • Test Example 1 Skin effect test A (sensory test)
  • test results were as follows: 8 subjects answered that the skin was “smooth” and “bulkyness” had disappeared, and 2 subjects had answered that “bulkyness” had disappeared. No subjects responded.
  • the moisturizing fraction according to the present invention has a low concentration of 0.01% by weight, Also, it can be seen that the powder has an excellent moisturizing function.
  • Test Example 2 Skin effect test B (sensory test)
  • the moisturizing fraction 5 O mg was kneaded into 500 g of white petrolatum to prepare an ointment treated with 0.01% by weight.
  • test results were as follows: 9 subjects answered that their skin was “smooth” and “bulkyness” had disappeared, and 1 subject had answered that “bulkyness” had disappeared. No subjects responded.
  • the cosmetic containing the moisturizing fraction according to the present invention gives moisture to the oil-deprived skin.
  • a test for evaluating the rough skin improving effect of the cosmetic containing the moisturizing fraction obtained in Production Example 1 above was performed in the following manner.
  • An ointment prepared by mixing the moisturizing fraction of 5 O mg in 500 g of white petrolatum and treating with 0.01% by weight was prepared.
  • test results were 8 valid, 2 valid, and 0 invalid.
  • the cosmetic containing the moisturizing fraction according to the present invention has the effect of improving rough skin and renewing the moisturizing function of the skin.
  • Test example 4 Cleaning resistance test
  • test results were as follows: 3 subjects who answered that the feeling of "smooth” did not disappear even after washing 5 times or more, 5 subjects who answered that the feeling of “smooth” did not disappear after 4 times, etc. None of the subjects answered one time and one subject answered twice, and none of the subjects answered that the feeling of “smoothness” disappeared by one washing.
  • the cosmetic containing the moisturizing fraction according to the present invention does not lose its moisturizing film even after several washings, and retains its moisturizing properties.
  • the lotion having the above-mentioned formula containing the moisturizing fraction according to the present invention moisturizes the skin and creates a "smooth" skin, and the following formulation examples make cosmetics extremely good on the skin. did.
  • 1,3-butylene glycol 3 0 squalane 2 0 stearic acid 2 0 liquid paraffin 6 0 sorbitan monostearate 1 5 polyoxyethylene (20) sorbitan monostearate 2 0 butyl parahydroxybenzoate 0 05 paraoxy Methyl benzoate 0 1 Moisturizing fraction from parotid gland secretion 0 01 Fragrance
  • Liquid paraffin 10 0 SENOLUNO 2 0 Cholesterin 0 5 Monoglyceride 1 0 Polyoxyethylene (6) sorbitan monohydrate 5.0 Moisturizing fraction derived from parotid gland secretion 0.02 Purified water Residue
  • the above-mentioned hair base conditioning water containing the moisturizing fraction according to the present invention takes a few milliliters after shampooing, and when applied to hair and scalp, the hair becomes ⁇ smooth '' and the hair styling material can be used thereafter.
  • the combing was greatly improved. It also moisturized the scalp, enhanced the water retention function, and improved drying.
  • Purified water Residue Formulation example 11 1 Skin cream
  • the humectant, cosmetic and pharmaceutical product of the present invention contain a moisturizing fraction derived from a parotid gland secretion of a mammal as an active ingredient, and the moisturizing fraction has a very small amount of a moisturizing function. It can exert and enhance the moisture retention function of the skin.
  • the moisturizer, cosmetics and pharmaceuticals of the present invention can make the skin “moist” and improve the slip of the hair without causing discomfort such as "stickiness". Furthermore, the moisturizing function is highly durable, and even after several washings with water or hot water, the moisturizing film on the skin surface does not fall off.
  • the moisturizing fraction into an external preparation for medicine, the function of retaining moisture on the skin surface is improved, and it works advantageously to bring out the medicinal properties of the medicine.

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Abstract

Humectant contenant en tant qu'ingrédient actif une fraction de la sécrétion de la parotide d'un mammifère, qui se précipite dans un solvant organique miscible dans l'eau à une concentration égale ou supérieure à 60 % en volume; procédé d'humidification de la peau, de la chevelure et du crâne par application de cet humectant; préparation cosmétique contenant une base cosmétique et ladite fraction; produit médicinal comprenant une base pour des préparations médicinales et ladite fraction. Cette fraction humectante obtenue à partir de la sécrétion de la parotide d'un mammifère, utilisée dans l'humectant, dans la préparation cosmétique et dans le produit médicinal, peut jouer son rôle d'hydratation, même en quantités extrêmement limitées, non seulement pour améliorer la fonction de retenue de l'humidité de la peau, mais également pour amplifier les propriétés glissantes du cheveu. Elle est, de plus, sans danger pour le corps humain.
PCT/JP1998/001929 1997-04-28 1998-04-27 Humectant, preparation cosmetique et produit medicinal contenant cet humectant Ceased WO1998048767A1 (fr)

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JP54682098A JP4424759B2 (ja) 1997-04-28 1998-04-27 保湿剤、それを含む化粧料および医薬品

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JP11058697 1997-04-28
JP9/110586 1997-04-28

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WO1998048767A1 true WO1998048767A1 (fr) 1998-11-05

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53104714A (en) * 1977-01-25 1978-09-12 Teikoku Hormone Mfg Co Ltd Compound proteins having serum calcium decreasing, immunity promoting actions and their preparation
JPS57500562A (fr) * 1980-04-25 1982-04-01
JPS60115527A (ja) * 1983-11-25 1985-06-22 Teikoku Hormone Mfg Co Ltd 歯牙体液輸送促進物質及びその製造方法
JPS61129038A (ja) * 1984-11-28 1986-06-17 Iwase Kosufua Kk 乳化組成物
JPS61210013A (ja) * 1985-03-13 1986-09-18 Iwase Kosufua Kk 皮膚外用剤
JPS6289610A (ja) * 1985-06-05 1987-04-24 Pola Chem Ind Inc 化粧料
JPH05310799A (ja) * 1992-05-11 1993-11-22 Teikoku Hormone Mfg Co Ltd ムチンの精製方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53104714A (en) * 1977-01-25 1978-09-12 Teikoku Hormone Mfg Co Ltd Compound proteins having serum calcium decreasing, immunity promoting actions and their preparation
JPS57500562A (fr) * 1980-04-25 1982-04-01
JPS60115527A (ja) * 1983-11-25 1985-06-22 Teikoku Hormone Mfg Co Ltd 歯牙体液輸送促進物質及びその製造方法
JPS61129038A (ja) * 1984-11-28 1986-06-17 Iwase Kosufua Kk 乳化組成物
JPS61210013A (ja) * 1985-03-13 1986-09-18 Iwase Kosufua Kk 皮膚外用剤
JPS6289610A (ja) * 1985-06-05 1987-04-24 Pola Chem Ind Inc 化粧料
JPH05310799A (ja) * 1992-05-11 1993-11-22 Teikoku Hormone Mfg Co Ltd ムチンの精製方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"LECTURES ON BIOCHEMICAL EXPERIMENTS", CARBOHYDRATE CHEMISTRY, XX, XX, vol. 04, no. PART 01, 1 January 1976 (1976-01-01), XX, pages 155 - 170, XP002917123 *

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