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WO1998046277A2 - Compensation de l'humidite pour l'etalonnage a zero des cellules electrochimiques dans des dispositifs de mesure de gaz respiratoire - Google Patents

Compensation de l'humidite pour l'etalonnage a zero des cellules electrochimiques dans des dispositifs de mesure de gaz respiratoire Download PDF

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Publication number
WO1998046277A2
WO1998046277A2 PCT/US1998/006254 US9806254W WO9846277A2 WO 1998046277 A2 WO1998046277 A2 WO 1998046277A2 US 9806254 W US9806254 W US 9806254W WO 9846277 A2 WO9846277 A2 WO 9846277A2
Authority
WO
WIPO (PCT)
Prior art keywords
respiratory gas
gas
sample
respiratory
humidity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/006254
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English (en)
Other versions
WO1998046277A3 (fr
Inventor
Kathleen Bergeron Gull
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Datex Ohmeda Inc
Original Assignee
Ohmeda Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ohmeda Inc filed Critical Ohmeda Inc
Priority to AU68726/98A priority Critical patent/AU6872698A/en
Publication of WO1998046277A2 publication Critical patent/WO1998046277A2/fr
Publication of WO1998046277A3 publication Critical patent/WO1998046277A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption

Definitions

  • electrochemical fuel cells are used in conjunction with additional circuitry to measure the amount of a specific gas within a respiratory gas stream.
  • a monitor for measuring the concentration of nitric oxide and nitrogen dioxide electrochemical fuel cells are used to generate an electrical signal indicative of the respective concentrations of nitric oxide and nitrogen dioxide.
  • Such a monitor is useful during the administration of nitric oxide to a patient for medical purposes.
  • United States Patent No. 5,485,827, Zapol et al. which discusses the method of treating patients with nitric oxide and United States Patent No. 5,558,083, Bathe et al., which discloses a nitric oxide delivery system of which a gas monitor is one element.
  • the accuracy of respiratory gas measurements taken by electrochemical fuel cells is affected by changes in humidity. Such changes come more apparent after a monitoring bench containing fuel cells has been zeroed and then returned to the sampling mode where a measurement is taken of a respiratory gas sample. The difference in humidity between the sampling gas stream and the zeroing gas stream causes a zero drift in the fuel cell readings.
  • a six inch piece of Nafion® tubing is used in the present invention after the pneumatics manifold which switches between the two gas streams and the fuel cell bench in order to equilibrate the humidity in both the sample and zero gas streams. The addition of this Nafion® tubing eliminates the zero drift between the two gas sources allowing for an accurate zeroing of the nitrogen oxide and nitrogen dioxide fuel cells.
  • FIG. 1 is a diagram of the gas stream flow components of a respiratory gas monitor according to the present invention.
  • FIG. 1 depicts the major components of a respiratory gas monitor according to the present invention through which the sample and zero gases flow.
  • the pneumatic manifold 10 controls the source of the gas stream input to the bench 20 containing the electrochemical fuel cells for the measurement of nitric oxide, nitrogen dioxide and oxygen.
  • the manifold 10 enables the monitor control to select between inputting a sample of the respiratory gas stream into the sample inlet 40 or a sample of a calibration gas into scrubber 30.
  • a Nafion® tube or other hydrophilic tube 50 is placed between manifold 10 to bench 20 to reduce the amount of moisture in the gas stream.
  • Vacuum pump 60 provides the Vacuum necessary to draw the sample or calibration (zeroing) gases through the system.
  • the next configuration tested used humidified sample gas and dry room air gas.
  • the system was zeroed in each of four configurations: (1) no Nafion; (2) 4 inches of Nafion; (3) 6 inches of Nafion; and (4) 16 inches of Nafion. After zeroing the system was switched to humid sample gas and the variance in the relative humidity of the gas readings taken on the far side of the bench was recorded as set forth in the following Table 2.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Physiology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Fuel Cell (AREA)

Abstract

La précision des mesures de gaz respiratoire effectuées par des cellules électrochimiques est affectée par les variations de l'humidité. Ces variations sont plus notables après qu'un banc de contrôle contenant des cellules électrochimiques a été étalonné à zéro, puis renvoyé au mode d'échantillonnage permettant la mesure d'un échantillon de gaz respiratoire. La différence d'humidité entre l'écoulement de gaz échantillon et l'écoulement de gaz d'étalonnage à zéro produit un écart du zéro dans les données produites par les cellules électrochimiques. Une longueur de tuyau en Nafion® est utilisée après le collecteur pneumatique qui commute entre les deux écoulements de gaz et le banc de cellules électrochimiques pour équilibrer l'humidité dans les écoulements de gaz échantillon et d'étalonnage à zéro.
PCT/US1998/006254 1997-04-16 1998-03-30 Compensation de l'humidite pour l'etalonnage a zero des cellules electrochimiques dans des dispositifs de mesure de gaz respiratoire Ceased WO1998046277A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU68726/98A AU6872698A (en) 1997-04-16 1998-03-30 Humidity compensation for fuel cell zeroing in respiratory gas measurement

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4325097P 1997-04-16 1997-04-16
US60/043,250 1997-04-16

Publications (2)

Publication Number Publication Date
WO1998046277A2 true WO1998046277A2 (fr) 1998-10-22
WO1998046277A3 WO1998046277A3 (fr) 1999-03-04

Family

ID=21926239

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/006254 Ceased WO1998046277A2 (fr) 1997-04-16 1998-03-30 Compensation de l'humidite pour l'etalonnage a zero des cellules electrochimiques dans des dispositifs de mesure de gaz respiratoire

Country Status (2)

Country Link
AU (1) AU6872698A (fr)
WO (1) WO1998046277A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003017837A1 (fr) * 2001-08-28 2003-03-06 Phase-In Ab Dispositif d'analyse quantitative de gaz respiratoires
WO2010030226A1 (fr) * 2008-09-15 2010-03-18 Phasein Ab Ligne d'échantillonnage de gaz pour gaz respiratoires
USD1057159S1 (en) 2022-03-29 2025-01-07 Masimo Corporation Electronic measurement device
USD1057160S1 (en) 2022-03-29 2025-01-07 Masimo Corporation Electronic measurement device

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5038792A (en) * 1988-06-29 1991-08-13 Mault James R Oxygen consumption meter
US5042500A (en) * 1990-06-18 1991-08-27 Medical Graphics Corporation Drying sample line
DE69133575T2 (de) * 1990-12-05 2008-04-17 The General Hospital Corp., Boston Verwendung von NO zur Behandlung der persistenten pulmonaren Hypertonie des Neugeborenen
US5284160A (en) * 1991-11-13 1994-02-08 Dryden Gale E Consolidated anesthesia circuit
US5558083A (en) * 1993-11-22 1996-09-24 Ohmeda Inc. Nitric oxide delivery system

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003017837A1 (fr) * 2001-08-28 2003-03-06 Phase-In Ab Dispositif d'analyse quantitative de gaz respiratoires
WO2010030226A1 (fr) * 2008-09-15 2010-03-18 Phasein Ab Ligne d'échantillonnage de gaz pour gaz respiratoires
US9861298B2 (en) 2008-09-15 2018-01-09 Masimo Corporation Gas sampling line
US10952641B2 (en) 2008-09-15 2021-03-23 Masimo Corporation Gas sampling line
US11564593B2 (en) 2008-09-15 2023-01-31 Masimo Corporation Gas sampling line
US12414711B2 (en) 2008-09-15 2025-09-16 Masimo Corporation Gas sampling line
USD1057159S1 (en) 2022-03-29 2025-01-07 Masimo Corporation Electronic measurement device
USD1057160S1 (en) 2022-03-29 2025-01-07 Masimo Corporation Electronic measurement device

Also Published As

Publication number Publication date
AU6872698A (en) 1998-11-11
WO1998046277A3 (fr) 1999-03-04

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