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WO1998045442A3 - Secreted f-spondin homologs - Google Patents

Secreted f-spondin homologs Download PDF

Info

Publication number
WO1998045442A3
WO1998045442A3 PCT/US1998/007117 US9807117W WO9845442A3 WO 1998045442 A3 WO1998045442 A3 WO 1998045442A3 US 9807117 W US9807117 W US 9807117W WO 9845442 A3 WO9845442 A3 WO 9845442A3
Authority
WO
WIPO (PCT)
Prior art keywords
secreted
zsig25
spondin
homologs
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/007117
Other languages
French (fr)
Other versions
WO1998045442A2 (en
Inventor
Paul O Sheppard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU69613/98A priority Critical patent/AU6961398A/en
Publication of WO1998045442A2 publication Critical patent/WO1998045442A2/en
Publication of WO1998045442A3 publication Critical patent/WO1998045442A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to a secreted zsig25 polypeptide expressed at very high level in prostate tissue and polynucleotides encoding the same. The zsig25 polypeptides are believed to be adhesion-modulating and may be used for diagnosis of prostate adenocarcinoma or for sorting cancerous from non-cancerous cells. The present invention also includes antibodies to the zsig25 polypeptides.
PCT/US1998/007117 1997-04-10 1998-04-10 Secreted f-spondin homologs Ceased WO1998045442A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU69613/98A AU6961398A (en) 1997-04-10 1998-04-10 Secreted f-spondin homologs

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4342197P 1997-04-10 1997-04-10
US60/043,421 1997-04-10
US4928897P 1997-06-11 1997-06-11
US60/049,288 1997-06-11

Publications (2)

Publication Number Publication Date
WO1998045442A2 WO1998045442A2 (en) 1998-10-15
WO1998045442A3 true WO1998045442A3 (en) 1999-01-14

Family

ID=26720414

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/007117 Ceased WO1998045442A2 (en) 1997-04-10 1998-04-10 Secreted f-spondin homologs

Country Status (2)

Country Link
AU (1) AU6961398A (en)
WO (1) WO1998045442A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1251139A3 (en) * 1998-04-08 2002-12-18 Genentech, Inc. Human mindin-like protein and nucleic acids encoding it
JP2002527757A (en) * 1998-10-19 2002-08-27 ダイアデクスアス・インコーポレーテッド Methods for diagnosing, monitoring, staging, imaging and treating prostate cancer
US6960433B1 (en) 1998-10-19 2005-11-01 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating prostate cancer
EP1466977A1 (en) * 1999-03-08 2004-10-13 Genentech, Inc. Methods and compositions for inhibiting neoplastic cell growth
US6682902B2 (en) 1999-12-16 2004-01-27 Schering Aktiengesellschaft DNA encoding a novel RG1 polypeptide
DE10050274A1 (en) * 2000-10-09 2002-04-18 Henkel Kgaa In vitro assays for skin stress and skin ageing includes determination of spondin 2, cathepsin L, actin gamma 1 and vimentin fragments secreted by skin fibroblasts
MXPA06000798A (en) 2003-07-22 2006-04-07 Schering Ag Rg1 antibodies and uses thereof.
US7294704B2 (en) * 2003-08-15 2007-11-13 Diadexus, Inc. Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020196A1 (en) * 1992-04-02 1993-10-14 The Trustees Of Columbia University In The City Of New York Cloning, expression and uses of a novel secreted protein, f-spondin
WO1997029189A1 (en) * 1996-02-12 1997-08-14 Human Genome Sciences, Inc. Human neuronal attachment factor-1

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020196A1 (en) * 1992-04-02 1993-10-14 The Trustees Of Columbia University In The City Of New York Cloning, expression and uses of a novel secreted protein, f-spondin
WO1997029189A1 (en) * 1996-02-12 1997-08-14 Human Genome Sciences, Inc. Human neuronal attachment factor-1

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GOBRON S ET AL: "SCO- spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation.", JOURNAL OF CELL SCIENCE, vol. 109, no. 5, May 1996 (1996-05-01), pages 1053 - 1061, XP002059006 *

Also Published As

Publication number Publication date
WO1998045442A2 (en) 1998-10-15
AU6961398A (en) 1998-10-30

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