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WO1998044900A1 - Compositions de dentifrice - Google Patents

Compositions de dentifrice Download PDF

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Publication number
WO1998044900A1
WO1998044900A1 PCT/IB1998/000485 IB9800485W WO9844900A1 WO 1998044900 A1 WO1998044900 A1 WO 1998044900A1 IB 9800485 W IB9800485 W IB 9800485W WO 9844900 A1 WO9844900 A1 WO 9844900A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition according
fluoride
toothpaste
compositions
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB1998/000485
Other languages
English (en)
Inventor
Robert Vincent Faller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of WO1998044900A1 publication Critical patent/WO1998044900A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • This invention relates to novel oral compositions which are exceptionally stable in terms of their ability to provide therapeutic amounts of soluble fluoride for treatment of dental tissue.
  • the improved fluoride stability is important since fluoride ions are believed to interact with dental enamel to reduce the enamel's acid solubility, as well as enhance remineralization and reversal of carious enamel, and to inhibit demineralization of enamel.
  • compositions containing fluoride salts and sodium bicarbonate are known, having been described, for example, in U.S. Patent 5,180,576, to Winston et al., issued January 19, 1993, the disclosure of which is incorporated herein by reference in its entirety.
  • This patent discloses compositions containing baking soda and a soluble fluoride source.
  • the patent in Column 6 at lines 4-12 discloses fluoride ion levels in the range of 25 - 5000 ppm, preferably 850 to 1500 ppm.
  • the present inventor has surprisingly found that if the fluoride ion level in the product is in the range of 200 - 800 ppm, preferably from about 500 to about 750 ppm, the anticaries effect of the product can be increased by adding from about 10 to about 30% of sodium bicarbonate.
  • the present invention relates to oral compositions comprising sodium bicarbonate and a soluble fluoride ion source capable of providing from about 200 to about 800 ppm of fluoride ions to the composition.
  • a part of this invention is to provide the effect of higher fluoride ion levels even though lower levels are actually present in the composition.
  • a method of enhancing the mineralization of teeth of a human in such need is also included.
  • Sodium bicarbonate also known as baking soda, is a household product with a variety of uses including use in dentifrices and mouthrinses. It is a white powder that is soluble in water and unless stabilized, tends to release carbon dioxide in an aqueous system.
  • the present compositions contain from about 10% to about 30%, preferably from about 15% to about 20%, sodium bicarbonate by weight of the composition. Soluble Fluoride Ion Source:
  • a soluble fluoride ion source is also incorporated into the present compositions.
  • the soluble fluoride ion source is used in amounts sufficient to provide from about 200 to about 800 ppm of the fluoride ion.
  • Preferred fluorides are sodium fluoride, stannous fluoride, indium fluoride, and sodium monofluorophosphate.
  • Norris et al., U.S. Patent 2,946,735, issued July 26, 1960 and Widder et al., U.S. Patent 3,678,154, issued July 18, 1972 disclose such salts as well as others. Both patents are incorporated herein by reference in their entirety. Carrier Materials
  • a preferred composition of the present invention is a toothpaste. Mouthwashes are also a preferred carrier.
  • dentifrice carrier materials means any material safe and effective for use in the toothpaste compositions prepared according to the present invention. Such materials are well known in the art and are readily chosen by one skilled in the art based on the physical and aesthetic properties desired for the dentifrice composition being prepared. Dentifrice carrier materials typically comprise from about 50% to about 94%, preferably from about 60% to about 80%, by weight of the present invention compositions.
  • the present invention toothpaste compositions typically contain some thickening material to provide a desirable consistency.
  • Preferred thickening agents are carboxyvinyl polymers, carrageenan, hydroxyethyl cellulose and water soluble salts of cellulose ethers such as sodium carboxymethyl cellulose and sodium carboxymethyl hydroxyethyl cellulose.
  • Natural gums such as gum karaya, xanthan gum, gum arabic, and gum tragacanth can also be used.
  • Colloidal magnesium aluminum silicate or finely divided silica can be used as part of the thickening agent to further improve texture.
  • Thickening agents can be used in an amount from about 0.2% to about 5% by weight of the total composition.
  • humectant material in a toothpaste to keep the composition from hardening upon exposure to air.
  • Certain humectants can also impart a desirable sweetness or flavor to toothpaste compositions and in certain cases provide an effect on bacteria in the mouth.
  • Suitable hu ectants include glycerin, sorbitol, xylitol other edible polyhydric alcohols, and mixtures thereof, at a level of from about 5% to about 70%, by weight of the compositions.
  • Titanium dioxide may also be added to the present compositions. Titanium dioxide is a white powder which adds pigment to the compositions. Titanium dioxide generally comprises from about 0.25% about 1% by weight of the compositions.
  • Water is also present in the toothpaste compositions of this invention.
  • Water employed in the preparation of commercially suitable toothpastes should preferably be deionized and free of organic impurities.
  • Water generally comprises from about 5% to about 40%, preferably from about 20% to about 35%, by weight of the compositions herein. These amounts of water include the free water which is added plus that which is introduced with other materials such as with sorbitol.
  • the pH of the present toothpaste compositions is preferably adjusted through the use of buffering agents.
  • Buffering agents refer to agents that can be used to maintain the pH of the present compositions to a range of above about pH 8 as desired for addition of the sodium bicarbonate. These agents include trisodium phosphate, sodium hydroxide and sodium carbonate. Sodium carbonate is preferred at a level of from about 0.5% to about 2% by weight of the present compositions.
  • the abrasive polishing material contemplated for use in the compositions of the present invention can be any material which does not excessively abrade dentin. These include, for example, silicas including gels and precipitates, calcium carbonate, dicalcium orthophosphate dihydrate, calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate, insoluble sodium polymetaphosphate, hydrated alumina, and resinous abrasive materials such as paniculate condensation products of urea and formaldehyde, and others such as disclosed by Cooley et al. in U.S. Patent 3,070,510, December 25, 1962, incorporated herein by reference. Mixtures of abrasives may also be used.
  • Silica dental abrasives of various types are preferred because of their unique benefits of exceptional dental cleaning and polishing performance without unduly abrading tooth enamel or dentin.
  • the silica abrasive polishing materials useful herein, as well as other abrasives generally have an average particle size ranging between about 0.1 and 30 microns, preferably 5 and 15 microns.
  • the silica abrasive can be precipitated silica or silica gels such as the silica xerogels described in Pader et al., U.S. Patent 3,538,230, issued March 2, 1970 and DiGiulio, U.S. Patent 3,862,307, June 21, 1975, both incorporated herein by reference.
  • the abrasive in the toothpaste compositions described herein is preferably present at a level of from about 6% to 70%, more preferably from about 10% to about 40% if including Calpyro abrasive.
  • the present toothpaste compositions can also contain surfactants.
  • Suitable surfactants are those which are reasonably stable and foam throughout a wide pH range, including non-soap anionic, nonionic, cationic, zwitterionic and amphoteric organic synthetic detergents. Many of these suitable agents are disclosed by Gieske et al. in U.S. Patent 4,051,234, September 27, 1977, incorporated herein by reference.
  • Sodium alkyl sulfate and polyethylene glycol are preferred for use in the present process and compositions at a level of from about 0.5% to about 5% by weight of the compositions.
  • Flavoring agents can also be added to the present compositions. Suitable flavoring agents include oil of wintergreen, oil of peppermint, oil of spearmint, oil of sassafras, and oil of clove. Sweetening agents which can be used include aspartame, acesulfame, saccharin, dextrose, levulose and sodium cyclamate. Flavoring and sweetening agents are generally used in toothpastes at levels of from about 0.005% to about 2% by weight of the composition.
  • compositions may also contain optional pharmaceutical agents (e.g., triclosan) and other tartar control agents.
  • optional pharmaceutical agents e.g., triclosan
  • additional tartar control agents include such known materials as synthetic anionic polymers [including polyacrylates and copolymers of maleic anhydride or acid and methyl vinyl ether (e.g., Gantrez), as described for example in U.S. Patent 4,627,977 to Gaffar et al., and U.S. Patent 4,515,772 to Parran et al.
  • polyamino propane sulfonic acid AMPS
  • polyphosphates e.g., pyrophosphates such as sodium pyrophosphate and others disclosed in the above '977 patent,tripolyphosphate, hexametaphosphate), diphos- phonates (e.g., EHDP; AHP), polypeptides (such as polyaspartic and polyglutamic acids), and mixtures thereof.
  • mouthwashes other than toothpastes may also be used. Included are mouthwashes, prophylaxis pastes, and the like. Conventional mouthwash composition components can comprise the carrier for the active agents of the present invention. Mouthwashes generally comprise from about 20:1 to about 2: 1 of a water/ethyl alcohol solution and preferably other ingredients such as flavor, sweeteners, humectants and sudsing agents such as those mentioned above for detnifrices. The humectants, such as glycerin and sorbitol give a moist feel to the mouth.
  • humectants such as glycerin and sorbitol give a moist feel to the mouth.
  • the mouthwashes of the invention comprise 0% to 60% (preferably 10% to 25%) ethyl alcohol, 0% to 20% (preferably 5% to 20%) of a humectant, 0% to 2% (preferably 0.01% to 0.15%) emulsifying agent, 0% to 0.5% (preferably 0.005% to 0.06%) sweetening agent such as saccharin, 0% to 0.3% (preferably 0.03% to 0.3%) flavoring agent, and the balance water.
  • compositions of the present invention are used in a manner consistent with regular oral care practices.
  • compositions of the present invention may be produced in any number of ways including those described in the U.S. Patents referred to above.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des compositions orales présentant des taux spécifiques d'ions fluorure et de bicarbonate de sodium.
PCT/IB1998/000485 1997-04-04 1998-04-02 Compositions de dentifrice Ceased WO1998044900A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83273597A 1997-04-04 1997-04-04
US08/832,735 1997-04-04

Publications (1)

Publication Number Publication Date
WO1998044900A1 true WO1998044900A1 (fr) 1998-10-15

Family

ID=25262488

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1998/000485 Ceased WO1998044900A1 (fr) 1997-04-04 1998-04-02 Compositions de dentifrice

Country Status (2)

Country Link
PE (1) PE70399A1 (fr)
WO (1) WO1998044900A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0074082A2 (fr) * 1981-09-03 1983-03-16 Richardson-Vicks, Inc. Compositions orales stables contenant des composés de zinc et de fluorure
WO1993004663A1 (fr) * 1991-08-30 1993-03-18 Church & Dwight Company, Inc. Dentifrices anti-tartre
EP0712624A2 (fr) * 1994-11-14 1996-05-22 Colgate-Palmolive Company Dentifrice ayant des propriétés anti-tartre améliorées
EP0784971A2 (fr) * 1996-01-11 1997-07-23 The Procter & Gamble Company Compositions pour le traitement du tartre
EP0845258A2 (fr) * 1996-11-26 1998-06-03 The Procter & Gamble Company Procédé de fabrication d'un dentifrice contenant du fluoride et du peroxyde pour le traitement du tartre
EP0848943A1 (fr) * 1996-11-26 1998-06-24 The Procter & Gamble Company Procédé d'obtention d'un arÔme intensifié dans les produits pour soins bucaux

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0074082A2 (fr) * 1981-09-03 1983-03-16 Richardson-Vicks, Inc. Compositions orales stables contenant des composés de zinc et de fluorure
WO1993004663A1 (fr) * 1991-08-30 1993-03-18 Church & Dwight Company, Inc. Dentifrices anti-tartre
EP0712624A2 (fr) * 1994-11-14 1996-05-22 Colgate-Palmolive Company Dentifrice ayant des propriétés anti-tartre améliorées
EP0784971A2 (fr) * 1996-01-11 1997-07-23 The Procter & Gamble Company Compositions pour le traitement du tartre
EP0845258A2 (fr) * 1996-11-26 1998-06-03 The Procter & Gamble Company Procédé de fabrication d'un dentifrice contenant du fluoride et du peroxyde pour le traitement du tartre
EP0848943A1 (fr) * 1996-11-26 1998-06-24 The Procter & Gamble Company Procédé d'obtention d'un arÔme intensifié dans les produits pour soins bucaux

Also Published As

Publication number Publication date
PE70399A1 (es) 1999-10-06

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