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WO1998040470A3 - Cytochrome p450 monooxygenases - Google Patents

Cytochrome p450 monooxygenases Download PDF

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Publication number
WO1998040470A3
WO1998040470A3 PCT/EP1998/001253 EP9801253W WO9840470A3 WO 1998040470 A3 WO1998040470 A3 WO 1998040470A3 EP 9801253 W EP9801253 W EP 9801253W WO 9840470 A3 WO9840470 A3 WO 9840470A3
Authority
WO
WIPO (PCT)
Prior art keywords
monooxygenases
cytochrome
nitrils
dna molecules
conversion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1998/001253
Other languages
English (en)
Other versions
WO1998040470A2 (fr
Inventor
Barbara Ann Halkier
Soeren Bak
Rachel Alice Kahn
Birger Lindberg Moeller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Københavns Universitet
Original Assignee
Novartis AG
Københavns Universitet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG, Københavns Universitet filed Critical Novartis AG
Priority to PL98335643A priority Critical patent/PL335643A1/xx
Priority to IL13166298A priority patent/IL131662A0/xx
Priority to EP98912443A priority patent/EP0970191A2/fr
Priority to PCT/EP1998/001253 priority patent/WO1998040470A2/fr
Priority to KR1019997008133A priority patent/KR100583538B1/ko
Priority to AU67278/98A priority patent/AU723454C/en
Priority to BR9808825-4A priority patent/BR9808825A/pt
Priority to CA002282809A priority patent/CA2282809A1/fr
Priority to JP53918098A priority patent/JP2001514515A/ja
Priority to US09/380,420 priority patent/US6300544B1/en
Priority to UA99094957A priority patent/UA72185C2/uk
Publication of WO1998040470A2 publication Critical patent/WO1998040470A2/fr
Publication of WO1998040470A3 publication Critical patent/WO1998040470A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
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    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8285—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for nematode resistance
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8286—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for insect resistance
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Insects & Arthropods (AREA)
  • Pest Control & Pesticides (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

L'invention concerne des monooxygénases dépendantes du cytochrome P450II et des molécules d'ADN codant ces monooxygénases qui sont capables de catalyser la transformation biosynthéthique d'aldoximes en nitriles et la transformation desdits nitriles en cyanhydrines correspondantes qui sont les précurseurs des glucosides cyanogénétiques. En outre, l'invention concerne des procédés d'obtention de molécules d'ADN selon l'invention et des procédés d'obtention de plantes transgéniques qui résistent aux insectes, aux acariens ou aux nématodes ou de plantes à valeur nutritionnelle améliorée.
PCT/EP1998/001253 1997-03-07 1998-03-05 Cytochrome p450 monooxygenases Ceased WO1998040470A2 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
PL98335643A PL335643A1 (en) 1997-03-07 1998-03-05 P450 cytochrome mono-oxygenases
IL13166298A IL131662A0 (en) 1997-03-07 1998-03-05 Cytochrome p450 monooxygenases
EP98912443A EP0970191A2 (fr) 1997-03-07 1998-03-05 Cytochrome p450 monooxygenases
PCT/EP1998/001253 WO1998040470A2 (fr) 1997-03-07 1998-03-05 Cytochrome p450 monooxygenases
KR1019997008133A KR100583538B1 (ko) 1997-03-07 1998-03-05 사이토크롬 ｐ450 모노옥시게나제
AU67278/98A AU723454C (en) 1997-03-07 1998-03-05 Cytochrome P450 monooxygenases
BR9808825-4A BR9808825A (pt) 1997-03-07 1998-03-05 Monooxigenases do citocromo p450
CA002282809A CA2282809A1 (fr) 1997-03-07 1998-03-05 Monooxygenases de cytochrome p 450
JP53918098A JP2001514515A (ja) 1997-03-07 1998-03-05 チトクロームｐ４５０モノオキシゲナーゼ
US09/380,420 US6300544B1 (en) 1997-03-07 1998-03-05 Cytochrome P450 monooxygenases
UA99094957A UA72185C2 (en) 1997-12-08 1998-05-03 Cytochrome p450 monooxygenases

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97810132.7 1997-03-07
EP97810954.4 1997-12-08
PCT/EP1998/001253 WO1998040470A2 (fr) 1997-03-07 1998-03-05 Cytochrome p450 monooxygenases

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/380,420 A-371-Of-International US6300544B1 (en) 1997-03-07 1998-03-05 Cytochrome P450 monooxygenases
US09/899,642 Division US6649814B2 (en) 1997-03-07 2001-07-05 Cytochrome P450 monooxygenases

Publications (2)

Publication Number Publication Date
WO1998040470A2 WO1998040470A2 (fr) 1998-09-17
WO1998040470A3 true WO1998040470A3 (fr) 1998-12-03

Family

ID=8166889

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/001253 Ceased WO1998040470A2 (fr) 1997-03-07 1998-03-05 Cytochrome p450 monooxygenases

Country Status (1)

Country Link
WO (1) WO1998040470A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1033405A3 (fr) * 1999-02-25 2001-08-01 Ceres Incorporated Fragments d'ADN avec des séquences déterminées et polypeptides encodées par lesdits fragments
EP1232268A2 (fr) * 1999-11-12 2002-08-21 Washington State University Research Foundation Oxygenases de cytochrome p450 et leurs utilisations
US6787343B2 (en) 1999-11-12 2004-09-07 Washington State University Research Foundation Cytochrome P450 oxygenases and their uses
US7122657B2 (en) 1999-12-01 2006-10-17 Moeller Birger Lindberg UDP-glucose aglycon-glucosytransferase
EP1246906A2 (fr) * 2000-01-13 2002-10-09 Syngenta Participations AG Monooxygenases p450 de la famille cyp79
GB0219723D0 (en) * 2002-08-23 2002-10-02 Syngenta Ltd Methods
AU2004260139A1 (en) 2003-07-22 2005-02-03 Washington State University Research Foundation P450 oxygenases and methods of use
ZA200602938B (en) * 2003-10-16 2008-06-25 Us Smokeless Tobacco Company Cloning of cytochrome p450 genes from Nicotiana
US8153862B2 (en) 2007-01-19 2012-04-10 Myongji University Industry And Academia Cooperation Cytochrome P450 gene for increasing seed size or water stress resistance of plant
WO2012126059A1 (fr) * 2011-03-22 2012-09-27 Monash University Nouvelle culture pour aliment pour animaux de ferme
CN110777157B (zh) * 2019-10-10 2023-07-04 广州中医药大学(广州中医药研究院) 催化香树脂醇c-28位氧化的cyp450基因及其编码产物与应用
CN113234739B (zh) * 2021-05-26 2023-12-26 云南中烟工业有限责任公司 烟草细胞色素p450亚家族cyp710a基因及应用
CN115161208B (zh) * 2022-01-15 2024-03-12 云南农业大学 酿酒酵母基因工程菌及其生产葫芦素中间体的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993022441A1 (fr) * 1992-04-23 1993-11-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Sequence d'adn d'un gene de resistance de plante
WO1995016041A1 (fr) * 1993-12-08 1995-06-15 Ciba-Geigy Ag Mono-oxygenases du cytochrome p-450

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993022441A1 (fr) * 1992-04-23 1993-11-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Sequence d'adn d'un gene de resistance de plante
WO1995016041A1 (fr) * 1993-12-08 1995-06-15 Ciba-Geigy Ag Mono-oxygenases du cytochrome p-450

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
B. KOCH ET AL.: "The biosynthesis of cyanogenic glucosides in seedlings of cassava (Manihot esculanta Crantz)", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 292, no. 1, January 1992 (1992-01-01), SAN DIEGO US, pages 141 - 150, XP002037259 *
KAHN R A ET AL: "ISOLATION AND RECONSTITUTION OF CYTOCHROME p450OX AND IN VITRO RECONSTITUTION OF THE ENTIRE BIOSYNTHETIC PATHWAY OF THE CYANOGENIC GLUCOSIDE DHURRIN FROM SORGHUM", PLANT PHYSIOLOGY (ROCKVILLE), vol. 115, no. 4, 1997, ROCKVILLE US, pages 1661 - 1670, XP002070833 *

Also Published As

Publication number Publication date
WO1998040470A2 (fr) 1998-09-17

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