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WO1997039759A3 - Omega-3 fatty acids and omega-3 phosphatidylcholine in the treatment of bipolar disorder - Google Patents

Omega-3 fatty acids and omega-3 phosphatidylcholine in the treatment of bipolar disorder Download PDF

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Publication number
WO1997039759A3
WO1997039759A3 PCT/US1997/006712 US9706712W WO9739759A3 WO 1997039759 A3 WO1997039759 A3 WO 1997039759A3 US 9706712 W US9706712 W US 9706712W WO 9739759 A3 WO9739759 A3 WO 9739759A3
Authority
WO
WIPO (PCT)
Prior art keywords
omega
bipolar disorder
treatment
fatty acids
phosphatidylcholine
Prior art date
Application number
PCT/US1997/006712
Other languages
French (fr)
Other versions
WO1997039759A2 (en
Inventor
Andrew L Stoll
Wolfram E Severus
Original Assignee
Brigham & Womens Hospital
Andrew L Stoll
Wolfram E Severus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital, Andrew L Stoll, Wolfram E Severus filed Critical Brigham & Womens Hospital
Priority to AU27384/97A priority Critical patent/AU2738497A/en
Priority to US09/269,361 priority patent/US6344482B1/en
Publication of WO1997039759A2 publication Critical patent/WO1997039759A2/en
Publication of WO1997039759A3 publication Critical patent/WO1997039759A3/en
Priority to US10/068,035 priority patent/US20020091103A1/en
Priority to US11/052,533 priority patent/US20050267212A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention is directed to a method of treating patients with bipolar disorder by administering omega-3 fatty acids. These may be administered in a substantially purified form, as part of a pharmaceutical composition, or as part of a larger molecule, e.g. a triacylglycerol, which releases free fatty acid after ingestion by a patient. The present invention is also directed to triacylglycerols which are esterified at the gamma carbon of glycerol to phosphocholine and at either the alpha or beta carbon of glycerol to an omega-3 fatty acid. These 'omega-3 phosphatidylcholines' are also used in the treatment of patients with bipolar disorder.
PCT/US1997/006712 1996-04-24 1997-04-23 Omega-3 fatty acids and omega-3 phosphatidylcholine in the treatment of bipolar disorder WO1997039759A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU27384/97A AU2738497A (en) 1996-04-24 1997-04-23 Omega-3 fatty acids and omega-3 phosphatidylcholine in the treatment of bipolar disorder
US09/269,361 US6344482B1 (en) 1997-04-23 1997-04-23 Omega-3 fatty acids in the treatment of bipolar disorder
US10/068,035 US20020091103A1 (en) 1997-04-23 2002-02-05 Omega-3 fatty acids and omega-3 phosphatidylcholine in the treatment of bipolar disorder
US11/052,533 US20050267212A1 (en) 1997-04-23 2005-02-07 Omega-3 fatty acids in the treatment of depression

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1614096P 1996-04-24 1996-04-24
US60/016,140 1996-04-24

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US09/269,361 A-371-Of-International US6344482B1 (en) 1997-04-23 1997-04-23 Omega-3 fatty acids in the treatment of bipolar disorder
US09269361 A-371-Of-International 1997-04-23
US10/068,035 Continuation US20020091103A1 (en) 1997-04-23 2002-02-05 Omega-3 fatty acids and omega-3 phosphatidylcholine in the treatment of bipolar disorder
US10/083,913 Continuation-In-Part US6852870B2 (en) 1997-04-23 2002-02-27 Omega-3 fatty acids in the treatment of depression

Publications (2)

Publication Number Publication Date
WO1997039759A2 WO1997039759A2 (en) 1997-10-30
WO1997039759A3 true WO1997039759A3 (en) 1998-01-15

Family

ID=21775605

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/006712 WO1997039759A2 (en) 1996-04-24 1997-04-23 Omega-3 fatty acids and omega-3 phosphatidylcholine in the treatment of bipolar disorder

Country Status (2)

Country Link
AU (1) AU2738497A (en)
WO (1) WO1997039759A2 (en)

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US8691871B2 (en) 2009-04-29 2014-04-08 Amarin Pharmaceuticals Ireland Limited Methods of treating mixed dyslipidemia
US9028877B2 (en) 2007-03-28 2015-05-12 Aker Biomarine Antarctic As Bioeffective krill oil compositions
US9138415B2 (en) 2009-04-29 2015-09-22 Amarin Pharmaceuticals Ireland Limited Stable pharmaceutical composition and methods of using same
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy

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US6852870B2 (en) * 1999-03-22 2005-02-08 Andrew Stoll Omega-3 fatty acids in the treatment of depression
AU2006201772B2 (en) * 1999-01-27 2010-02-04 Amarin Neuroscience Limited Highly purified ethyl EPA and other EPA derivatives for psychiatric and neurological disorders
GB9901808D0 (en) * 1999-01-27 1999-03-17 Scarista Limited Drugs for treatment of psychiatric and brain disorders
GB9901809D0 (en) 1999-01-27 1999-03-17 Scarista Limited Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes
US7208180B2 (en) * 2000-05-08 2007-04-24 N.V. Nutricia Method and preparation for the preventing and/or treating vascular disorders and secondary disorders associated therewith
US7226916B1 (en) 2000-05-08 2007-06-05 N.V. Nutricia Preparation for the prevention and/or treatment of vascular disorders
WO2003011873A2 (en) 2001-07-27 2003-02-13 Neptune Technologies & Bioressources Inc. Natural marine source phospholipids comprising flavonoids, polyunsaturated fatty acids and their applications
US7935365B2 (en) 2003-10-22 2011-05-03 Enzymotec, Ltd. Glycerophospholipids for the improvement of cognitive functions
US8052992B2 (en) 2003-10-22 2011-11-08 Enzymotec Ltd. Glycerophospholipids containing omega-3 and omega-6 fatty acids and their use in the treatment and improvement of cognitive functions
US20050130937A1 (en) 2003-10-22 2005-06-16 Enzymotec Ltd. Lipids containing omega-3 and omega-6 fatty acids
IL158552A0 (en) * 2003-10-22 2004-05-12 Enzymotec Ltd Lipids containing omega-3 fatty acids
US20140343143A1 (en) * 2004-01-21 2014-11-20 Tiberio Bruzzese Use of highly concentrated compositions of selected n-3 fatty acids for the treatment of central nervous system disturbances
GB2421909A (en) * 2004-12-23 2006-07-12 Laxdale Ltd Pharmaceutical compositions comprising EPA and methods of use
US8697138B2 (en) 2007-03-28 2014-04-15 Aker Biomarine As Methods of using krill oil to treat risk factors for cardiovascular, metabolic, and inflammatory disorders
AU2008326800A1 (en) * 2007-11-16 2009-05-28 Baylor College Of Medicine Phospholipid compositions and uses thereof
EP3578177A1 (en) 2008-09-02 2019-12-11 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same
AU2010213899B2 (en) 2009-02-10 2014-02-06 Amarin Pharmaceuticals Ireland Limited Use of eicosapentaenoic acid ethyl ester for treating hypertriglyceridemia
US8372812B2 (en) 2009-02-26 2013-02-12 Aker Biomarine Asa Phospholipid and protein tablets
CN108096209A (en) 2009-06-15 2018-06-01 阿马里纳制药公司 Triglycerides, composition and method without increasing LDL-C levels are reduced in the object of associated Statins therapy
MX2012003555A (en) 2009-09-23 2012-07-03 Amarin Corp Plc Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same.
MX2012004977A (en) 2009-10-29 2012-11-06 Acasti Pharma Inc CONCENTRATED THERAPEUTIC PHOSPHOLIPID COMPOSITIONS.
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
EP2646013A4 (en) 2010-11-29 2014-03-26 Amarin Pharma Inc LOW-ERUCATION COMPOSITION AND METHODS FOR TREATING AND / OR PREVENTING CARDIOVASCULAR DISEASE IN A SUBJECT HAVING FISH ALLERGY / HYPERSENSITIVITY
EP2685969A4 (en) * 2011-03-18 2014-08-06 Catabasis Pharmaceuticals Inc Use of intracellular enzymes for the release of covalently linked bioactives
WO2013033618A1 (en) 2011-09-02 2013-03-07 Arctic Nutrition As Lipid compositions with high dha content
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
EP2775837A4 (en) 2011-11-07 2015-10-28 Amarin Pharmaceuticals Ie Ltd Methods of treating hypertriglyceridemia
PE20142459A1 (en) 2012-01-06 2015-01-23 Omthera Pharmaceuticals Inc DPA-ENRICHED COMPOSITIONS OF POLYINSATURATED OMEGA 3 FATTY ACIDS IN FREE ACID FORM
WO2013103958A1 (en) 2012-01-06 2013-07-11 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject
JP6173437B2 (en) 2012-05-07 2017-08-02 オムセラ・ファーマシューティカルズ・インコーポレイテッド Statins and omega-3 fatty acid compositions
HUE069516T2 (en) 2012-06-29 2025-03-28 Amarin Pharmaceuticals Ie Ltd Methods to reduce the risk of cardiovascular events in subjects taking statins
WO2014074552A2 (en) 2012-11-06 2014-05-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
US9814733B2 (en) 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
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GB201400431D0 (en) 2014-01-10 2014-02-26 Aker Biomarine As Phospholipid compositions and their preparation
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
WO2015195662A1 (en) 2014-06-16 2015-12-23 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids
PL3256003T3 (en) 2015-02-11 2023-05-22 Aker Biomarine Antarctic As METHODS OF LIPID EXTRACTION
AU2016217566B2 (en) 2015-02-11 2019-02-14 Aker Biomarine Human Ingredients As Lipid compositions
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
US10966951B2 (en) 2017-05-19 2021-04-06 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject having reduced kidney function
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
SMT202400320T1 (en) 2018-09-24 2024-09-16 Amarin Pharmaceuticals Ie Ltd Methods of reducing the risk of cardiovascular events in a subject
CN116350616A (en) 2019-11-12 2023-06-30 阿马里纳药物爱尔兰有限公司 Method for reducing the risk of cardiovascular events in subjects with atrial fibrillation and/or atrial flutter
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US9028877B2 (en) 2007-03-28 2015-05-12 Aker Biomarine Antarctic As Bioeffective krill oil compositions
US9034388B2 (en) 2007-03-28 2015-05-19 Aker Biomarine Antartic As Bioeffective krill oil compositions
US9078905B2 (en) 2007-03-28 2015-07-14 Aker Biomarine Antarctic As Bioeffective krill oil compositions
US9320765B2 (en) 2007-03-28 2016-04-26 Aker Biomarine Antarctic As Bioeffective krill oil compositions
US9375453B2 (en) 2007-03-28 2016-06-28 Aker Biomarine Antarctic As Methods for producing bioeffective krill oil compositions
US8691871B2 (en) 2009-04-29 2014-04-08 Amarin Pharmaceuticals Ireland Limited Methods of treating mixed dyslipidemia
US9138415B2 (en) 2009-04-29 2015-09-22 Amarin Pharmaceuticals Ireland Limited Stable pharmaceutical composition and methods of using same
US9585856B2 (en) 2009-04-29 2017-03-07 Amarin Pharmaceuticals Ireland Limited Stable pharmaceutical composition and methods of using same
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy

Also Published As

Publication number Publication date
AU2738497A (en) 1997-11-12
WO1997039759A2 (en) 1997-10-30

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