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WO1997039115B1 - Alliinase immobilisee et production continue d'allicine - Google Patents

Alliinase immobilisee et production continue d'allicine

Info

Publication number
WO1997039115B1
WO1997039115B1 PCT/IL1997/000124 IL9700124W WO9739115B1 WO 1997039115 B1 WO1997039115 B1 WO 1997039115B1 IL 9700124 W IL9700124 W IL 9700124W WO 9739115 B1 WO9739115 B1 WO 9739115B1
Authority
WO
WIPO (PCT)
Prior art keywords
alliinase
immobilized
chemically
allicin
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL1997/000124
Other languages
English (en)
Other versions
WO1997039115A1 (fr
Filing date
Publication date
Priority claimed from IL11793496A external-priority patent/IL117934A0/xx
Application filed filed Critical
Priority to EP97915666A priority Critical patent/EP0904361A1/fr
Priority to AU23058/97A priority patent/AU2305897A/en
Priority to IL12659697A priority patent/IL126596A/xx
Priority to US09/171,311 priority patent/US6689588B1/en
Priority to JP9536917A priority patent/JP2000508535A/ja
Publication of WO1997039115A1 publication Critical patent/WO1997039115A1/fr
Publication of WO1997039115B1 publication Critical patent/WO1997039115B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

L'invention a trait à de l'alliinase de l'ail immobilisée. Cette alliinase, qui a été immobilisée par voie chimique, physique ou biologique, est utilisée dans le cadre d'une technique de production continue d'allicine. Cette technique consiste à introduire une solution d'alliine comme substrat dans une colonne contenant ladite alliinase de l'ail immobilisée, puis à recueillir l'allicine pure dans les effluents. L'allicine pure ainsi produite est destinée à devenir un additif alimentaire ou à entrer dans la préparation de compositions à usage pharmaceutique pour le traitement d'infections d'origine virale et bactérienne ainsi que d'infections dues à des champignons et à des parasites, pour le traitement de teneurs élevées en cholestérol et en lipides du sang ainsi que de thromboses.
PCT/IL1997/000124 1996-04-16 1997-04-14 Alliinase immobilisee et production continue d'allicine Ceased WO1997039115A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP97915666A EP0904361A1 (fr) 1996-04-16 1997-04-14 Alliinase immobilisee et production continue d'allicine
AU23058/97A AU2305897A (en) 1996-04-16 1997-04-14 Immobilized alliinase and continuous production of allicin
IL12659697A IL126596A (en) 1996-04-16 1997-04-14 Immobilized alliinase and method for continuous production of allicin
US09/171,311 US6689588B1 (en) 1996-04-16 1997-04-14 Garlic alliinase covalently bound to carrier for continuous production of allician
JP9536917A JP2000508535A (ja) 1996-04-16 1997-04-14 固定化アリイナーゼおよびアリシンの連続生産

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11793496A IL117934A0 (en) 1996-04-16 1996-04-16 Continuous production of allicin
IL117934 1996-04-16

Publications (2)

Publication Number Publication Date
WO1997039115A1 WO1997039115A1 (fr) 1997-10-23
WO1997039115B1 true WO1997039115B1 (fr) 1997-11-27

Family

ID=11068775

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1997/000124 Ceased WO1997039115A1 (fr) 1996-04-16 1997-04-14 Alliinase immobilisee et production continue d'allicine

Country Status (7)

Country Link
US (1) US6689588B1 (fr)
EP (1) EP0904361A1 (fr)
JP (1) JP2000508535A (fr)
AU (1) AU2305897A (fr)
CA (1) CA2251532A1 (fr)
IL (1) IL117934A0 (fr)
WO (1) WO1997039115A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000032781A1 (fr) * 1998-11-30 2000-06-08 New Zealand Institute For Crop & Food Research Limited Gene de metabolisation du soufre issu de la racine de l'oignon
IL130325A0 (en) * 1999-06-07 2000-06-01 Yeda Res & Dev Pharmaceutical compositions comprising allicin
US7445802B2 (en) * 2000-12-26 2008-11-04 Yeda Research And Development Co. Ltd Site-specific in situ generation of allicin using a targeted alliinase delivery system for the treatment of cancers, tumors, infectious diseases and other allicin-sensitive diseases
US20040082479A1 (en) * 2001-01-17 2004-04-29 David Mirelman Method for soil sterilization from pathogens
ES2299280A1 (es) * 2001-03-01 2008-05-16 Industrial Farmaceutica Cantabria, S.A. Geles mixtos hidrofilicos como vehiculos de liberacion controlada o como dispersantes por flotacion y su preparacion y su uso por via oral.
AU2002305744B2 (en) 2001-05-30 2008-09-11 Yeda Research And Development Co. Ltd. Allylmercaptocaptopril compounds and uses thereof
GB2377219A (en) * 2001-07-04 2003-01-08 Neem Biotech Ltd Preparation of allicin
GB0122793D0 (en) * 2001-09-21 2001-11-14 Stone Island Holdings Ltd Allicin
US20040152880A1 (en) * 2002-11-22 2004-08-05 Carnegie Mellon University Compositions and methods for the reversible capture of biomolecules
GB0307079D0 (en) * 2003-03-27 2003-04-30 Stone Island Holdings Ltd Allicin
US20050112393A1 (en) * 2003-11-20 2005-05-26 Fliermans Carl B. Antifungal preservative composition for an environmentally friendly process
US20060122266A1 (en) * 2004-08-11 2006-06-08 Photini Sinnis Methods and compositions for malaria prophylaxis
EP1851544A4 (fr) * 2005-02-18 2008-12-10 Univ Carnegie Mellon Compositions et procedes de capture reversible de biomolecules
WO2009122404A2 (fr) * 2008-04-01 2009-10-08 Yeda Research And Development Co. Ltd Dispositif pour la production in situ et l'administration topique d'allicine
GB0903869D0 (en) 2009-03-05 2009-04-22 Neem Biotech Ltd Process for the preparation of ajoene
KR101188746B1 (ko) * 2009-09-23 2012-10-11 주식회사파마킹 에스-알릴-엘-시스테인을 유효성분으로 포함하는 위장질환 예방 또는 치료용 조성물
WO2011044113A1 (fr) * 2009-10-07 2011-04-14 Wisconsin Alumni Research Foundation Procédé de préparation de conjugués de composés organosoufrés d'allium avec des acides aminés, des peptides, et des protéines
US20120263719A1 (en) 2009-10-22 2012-10-18 Yeda Research And Development Co., Ltd. Compositions and methods for treating aspergillosis
CN102058527B (zh) * 2010-06-22 2012-05-23 新疆埃乐欣药业有限公司 一种抗肿瘤及抗感染的大蒜辣素注射液的制备方法及其低温连续搅拌超滤装置
KR20150041425A (ko) * 2013-10-08 2015-04-16 (주)태영에프에이 마늘 유래 알리이나아제의 제조방법
LU92793B1 (en) * 2015-08-07 2017-02-14 Luxembourg Inst Science & Tech List Preparation able to produce biopesticide and/or repellent for controlling plant pathogens
KR102333313B1 (ko) * 2019-09-27 2021-12-02 씨제이제일제당 (주) 풍미가 강화된 원물 농축액 및 이의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01289492A (ja) 1987-06-04 1989-11-21 Ajinomoto Co Inc アリイン又はメチルシステインスルホキサイドの製造法
US5244794A (en) 1989-03-17 1993-09-14 Cornell Research Foundation, Inc. Flavor compounds from allium root cultures
DE4012884A1 (de) 1990-04-23 1991-10-24 Lichtwer Pharma Gmbh Alliinhaltiger knoblauchtrockenextrakt und ein verfahren zu seiner herstellung
AU5358894A (en) 1992-10-08 1994-05-09 Yeda Research And Development Co. Ltd. Recombinant alliinase, its preparation and pharmaceutical compositions comprising it
US5350800A (en) * 1993-01-19 1994-09-27 Medtronic, Inc. Method for improving the biocompatibility of solid surfaces

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