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WO1997036917A1 - Chitotriosidase - Google Patents

Chitotriosidase Download PDF

Info

Publication number
WO1997036917A1
WO1997036917A1 PCT/US1997/005072 US9705072W WO9736917A1 WO 1997036917 A1 WO1997036917 A1 WO 1997036917A1 US 9705072 W US9705072 W US 9705072W WO 9736917 A1 WO9736917 A1 WO 9736917A1
Authority
WO
WIPO (PCT)
Prior art keywords
leu
gly
ala
chitotriosidase
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/005072
Other languages
English (en)
Inventor
Robert B. Kirkpatrick
Nageswara R. Thotakura
Jian Ni
Reiner Gentz
Arvind Chopra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
SmithKline Beecham Corp
Original Assignee
Human Genome Sciences Inc
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc, SmithKline Beecham Corp filed Critical Human Genome Sciences Inc
Priority to EP97917674A priority Critical patent/EP0828752A4/fr
Priority to AU25937/97A priority patent/AU2593797A/en
Priority to JP9535445A priority patent/JPH11508139A/ja
Publication of WO1997036917A1 publication Critical patent/WO1997036917A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01014—Chitinase (3.2.1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
    • C12N9/2442—Chitinase (3.2.1.14)

Definitions

  • polynucleotides encoding a polypeptide having the amino acid sequence of the chitotriosidase set out in Figure 1 or of the deposited clone
  • the polynucleotide may encode the polypeptide in a continuous region or in a plurality of two or more discontinuous exons, and it may compnse additional regions as well, which are unrelated to the coding region or regions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention porte sur des séquences d'acide nucléique codant pour la chitotriosidase, ainsi que sur des méthodes de détection de modifications de l'expression de protéines de remodelage de tissus, et de diagnostic de troubles du remodelage des tissus.
PCT/US1997/005072 1996-03-29 1997-03-21 Chitotriosidase Ceased WO1997036917A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP97917674A EP0828752A4 (fr) 1996-03-29 1997-03-21 Chitotriosidase
AU25937/97A AU2593797A (en) 1996-03-29 1997-03-21 Chitotriosidase
JP9535445A JPH11508139A (ja) 1996-03-29 1997-03-21 キトトリオシダーゼ

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1429596P 1996-03-29 1996-03-29
US60/014,295 1996-03-29

Publications (1)

Publication Number Publication Date
WO1997036917A1 true WO1997036917A1 (fr) 1997-10-09

Family

ID=21764619

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/005072 Ceased WO1997036917A1 (fr) 1996-03-29 1997-03-21 Chitotriosidase

Country Status (5)

Country Link
EP (1) EP0828752A4 (fr)
JP (1) JPH11508139A (fr)
AU (1) AU2593797A (fr)
WO (1) WO1997036917A1 (fr)
ZA (1) ZA972691B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999046390A1 (fr) * 1998-03-12 1999-09-16 Icos Corporation Fragments de chitinase liant la chitine
US6372212B1 (en) 1996-06-14 2002-04-16 Icos Corporation Chitinase materials and methods
US8679503B2 (en) 2001-07-24 2014-03-25 Yale University Methods, compositions and kits relating to chitnases and chitnase-like molecules and inflammation disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF BIOLOGICAL CHEMISTRY, 03 November 1995, Volume 270, No. 44, BOOT et al., "Cloning of a cDNA Encoding Chitotriodiase, a Human Chitinase Produced by Macrophages", pages 26252-26256. *
See also references of EP0828752A4 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372212B1 (en) 1996-06-14 2002-04-16 Icos Corporation Chitinase materials and methods
WO1999046390A1 (fr) * 1998-03-12 1999-09-16 Icos Corporation Fragments de chitinase liant la chitine
US6200951B1 (en) 1998-03-12 2001-03-13 Icos Corporation Chitinase chitin-binding fragments
US6399571B1 (en) 1998-03-12 2002-06-04 Icos Corporation Chitinase chitin-binding fragments
US8679503B2 (en) 2001-07-24 2014-03-25 Yale University Methods, compositions and kits relating to chitnases and chitnase-like molecules and inflammation disease

Also Published As

Publication number Publication date
EP0828752A4 (fr) 2000-07-26
EP0828752A1 (fr) 1998-03-18
AU2593797A (en) 1997-10-22
JPH11508139A (ja) 1999-07-21
ZA972691B (en) 1998-10-27

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