WO1997030179B1 - Determination de l'exposition a un agent produisant des rayonnements ionisants a l'aide de marqueurs biologiques persistants - Google Patents
Determination de l'exposition a un agent produisant des rayonnements ionisants a l'aide de marqueurs biologiques persistantsInfo
- Publication number
- WO1997030179B1 WO1997030179B1 PCT/US1997/001972 US9701972W WO9730179B1 WO 1997030179 B1 WO1997030179 B1 WO 1997030179B1 US 9701972 W US9701972 W US 9701972W WO 9730179 B1 WO9730179 B1 WO 9730179B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gene
- cells
- ionizing radiation
- population
- exposure
- Prior art date
Links
- 230000005865 ionizing radiation Effects 0.000 title claims abstract 12
- 239000000090 biomarker Substances 0.000 title claims abstract 4
- 230000002085 persistent effect Effects 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 8
- 210000004027 cell Anatomy 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 239000012634 fragment Substances 0.000 claims 6
- 230000014509 gene expression Effects 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 5
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 241001529936 Murinae Species 0.000 claims 1
- 238000010240 RT-PCR analysis Methods 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Abstract
On peut utiliser des indicateurs biologiques persistants de l'exposition à un rayonnement ionisant, et particulièrement des indicateurs à base d'acide nucléique, pour déterminer si un sujet a été exposé à un rayonnement ionisant. Ces indicateurs biologiques peuvent être identifiés par la technique de l'affichage différentiel.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97905832A EP0880605A2 (fr) | 1996-02-15 | 1997-02-18 | Determination de l'exposition a un agent produisant des rayonnements ionisants a l'aide de marqueurs biologiques persistants |
| AU22629/97A AU2262997A (en) | 1996-02-15 | 1997-02-18 | Determining exposure to ionizing radiation agent with persistent biologic al markers |
| JP9529401A JP2000504583A (ja) | 1996-02-15 | 1997-02-18 | 持続的な生物学的マーカーによる電離放射線剤への暴露の判定 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/602,145 | 1996-02-15 | ||
| US08/602,145 US6025336A (en) | 1996-02-15 | 1996-02-15 | Determining exposure to ionizing radiation agent with persistent biological markers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1997030179A1 WO1997030179A1 (fr) | 1997-08-21 |
| WO1997030179B1 true WO1997030179B1 (fr) | 1997-11-06 |
Family
ID=24410152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/001972 WO1997030179A1 (fr) | 1996-02-15 | 1997-02-18 | Determination de l'exposition a un agent produisant des rayonnements ionisants a l'aide de marqueurs biologiques persistants |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6025336A (fr) |
| EP (1) | EP0880605A2 (fr) |
| JP (1) | JP2000504583A (fr) |
| KR (1) | KR19990082584A (fr) |
| CN (1) | CN1216069A (fr) |
| AU (1) | AU2262997A (fr) |
| CA (1) | CA2246387A1 (fr) |
| WO (1) | WO1997030179A1 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6172458B1 (en) | 1997-04-30 | 2001-01-09 | Tdk Corporation | Organic electroluminescent device with electrode of aluminum-lithium alloy |
| US7008768B1 (en) | 1999-02-26 | 2006-03-07 | The United States Of America As Represented By The Department Of Health And Human Services | Method for detecting radiation exposure |
| US20050014165A1 (en) * | 2003-07-18 | 2005-01-20 | California Pacific Medical Center | Biomarker panel for colorectal cancer |
| CA2552351A1 (fr) | 2004-01-30 | 2005-09-09 | Dana-Farber Cancer Institute, Inc. | Procedes pour determiner et quantifier l'exposition a des rayonnements ou a des genotoxines |
| KR100735731B1 (ko) | 2005-07-22 | 2007-07-06 | 이시혁 | 별늑대거미의 분자지표를 이용한 지표환경 내 중금속 오염평가방법 |
| US20080076122A1 (en) * | 2006-09-26 | 2008-03-27 | The Regents Of The University Of California | Characterizing exposure to ionizing radiation |
| US20080227130A1 (en) * | 2007-03-15 | 2008-09-18 | Tulsee Satish Doshi | Method for detecting exposure to ionizing radiation |
| CA2692382A1 (fr) | 2007-05-31 | 2008-12-11 | California Pacific Medical Center | Procede pour predire ou diagnostiquer un trouble ou une maladie gastro-intestinale |
| WO2009015299A1 (fr) | 2007-07-26 | 2009-01-29 | California Pacific Medical Center | Procédé pour prédire ou diagnostiquer un trouble gastro-intestinal ou une maladie gastro-intestinale |
| EP2761294B1 (fr) | 2011-09-29 | 2019-02-27 | Meso Scale Technologies, LLC | Panels et procédés de biodosimétrie |
| CN105803049A (zh) * | 2014-12-29 | 2016-07-27 | 中国辐射防护研究院 | 电离辐射生物标志的筛选方法及由此确定的szt2蛋白的用途 |
| CN107090496A (zh) * | 2017-03-28 | 2017-08-25 | 南方医科大学 | 一种8Gy电离辐射的检测方法 |
| CN107015261A (zh) * | 2017-04-13 | 2017-08-04 | 南方医科大学 | 一种6.5Gy电离辐射的检测方法 |
| CN111621559A (zh) * | 2020-06-11 | 2020-09-04 | 北京市化工职业病防治院(北京市职业病防治研究院) | 关联转录组和蛋白组数据筛选低剂量电离辐射效应基因 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5346814A (en) * | 1992-10-14 | 1994-09-13 | Board Of Trustees Of The Leland Stanford Jr. University | Method of detecting cell response to cell-damaging energy |
-
1996
- 1996-02-15 US US08/602,145 patent/US6025336A/en not_active Expired - Fee Related
-
1997
- 1997-02-18 CN CN97193746A patent/CN1216069A/zh active Pending
- 1997-02-18 CA CA002246387A patent/CA2246387A1/fr not_active Abandoned
- 1997-02-18 KR KR1019980706322A patent/KR19990082584A/ko not_active Withdrawn
- 1997-02-18 WO PCT/US1997/001972 patent/WO1997030179A1/fr not_active Application Discontinuation
- 1997-02-18 JP JP9529401A patent/JP2000504583A/ja active Pending
- 1997-02-18 EP EP97905832A patent/EP0880605A2/fr not_active Withdrawn
- 1997-02-18 AU AU22629/97A patent/AU2262997A/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO1997030179B1 (fr) | Determination de l'exposition a un agent produisant des rayonnements ionisants a l'aide de marqueurs biologiques persistants | |
| JP2675774B2 (ja) | 単離された内部核マトリックス・タンパク質及びその利用方法 | |
| US20060211020A1 (en) | Methods for the diagnosis, prognosis and treatment of metabolic syndrome | |
| NZ331376A (en) | Methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening | |
| EP0057553B1 (fr) | Procédé de détection de DNA détérioré par fluorescence et trousse pour ledit procédé | |
| Dipali et al. | Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature | |
| US20150079609A1 (en) | Quick test for the diagnosis of alzheimer's disease | |
| US9068228B2 (en) | Method for screening ameliorants of dry skin caused by atopic dermatitis using bleomycin hydrolase activity as indicator | |
| KR19990082584A (ko) | 지속적인 생물학적 마커를 이용하여 이온화 방사제에 대한노출여부를 측정하는 방법 | |
| EP2521919B1 (fr) | Méthode de diagnostic et de surveillance de la schizophrénie et des tauopathies | |
| Laqqan et al. | Influence of variation in global sperm DNA methylation level on the expression level of protamine genes and human semen parameters. | |
| Testa et al. | Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24→ q25 and 1q32→ q41, respectively, by fluorescence in situ hybridization | |
| Braun et al. | Rapid and simple diagnosis of the two common α1-proteinase inhibitor deficiency alleles Pi* Z and Pi* S by DNA analysis | |
| EP1959022A1 (fr) | Detection d un leiomyosarcome uterin au moyen de lmp2 | |
| Okamoto et al. | Polymorphism of 5-methylcytosine-rich DNA in human acrocentric chromosomes | |
| Yamamoto et al. | Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants | |
| EP1159614A4 (fr) | Methodes diagnostiques de l'asthme | |
| JP2001346598A (ja) | Ｈｄｌ亜画分の分析方法 | |
| WO2007104724A2 (fr) | Identification de cellules osteoblastes, differentiation et marqueurs de tumeur osseuse et leur utilisation | |
| Yamada et al. | Lymphocyte metallothionein-mRNA as a sensitive biomarker of cadmium exposure | |
| RU2219186C2 (ru) | ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК, КОДИРУЮЩАЯ ПРЕПРОНЕЙРОПЕПТИД Y (препроNPY), ПОСЛЕДОВАТЕЛЬНОСТЬ РНК, СПОСОБ ОБСЛЕДОВАНИЯ СУБЪЕКТА, СИГНАЛЬНЫЙ ПЕПТИД, препроNPY, СПОСОБ ОПРЕДЕЛЕНИЯ ПЕПТИДА, СПОСОБ ДИАГНОСТИРОВАНИЯ ПРЕДРАСПОЛОЖЕННОСТИ К ПОВЫШЕННОМУ УРОВНЮ ОБЩЕГО ХОЛЕСТЕРИНА ИЛИ ХОЛЕСТЕРИНА LDL | |
| DE60028009T2 (de) | Verfahren zur diagnose und screening der unfruchtbarkeit bei männern | |
| Whitehouse et al. | Variation in alpha-1-antitrypsin phenotypes associated with penicillamine therapy | |
| EP0154917A2 (fr) | Essai enzymatique/immunofluorescent d'anticorps anti-virus d'Epstein-Barr | |
| JP4948768B2 (ja) | 精神障害に対する感受性の診断または予測方法 |