[go: up one dir, main page]

WO1997026016A3 - Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores - Google Patents

Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores Download PDF

Info

Publication number
WO1997026016A3
WO1997026016A3 PCT/EP1997/000208 EP9700208W WO9726016A3 WO 1997026016 A3 WO1997026016 A3 WO 1997026016A3 EP 9700208 W EP9700208 W EP 9700208W WO 9726016 A3 WO9726016 A3 WO 9726016A3
Authority
WO
WIPO (PCT)
Prior art keywords
application
gas bubble
contrast medium
ultrasound contrast
bubble suspensions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1997/000208
Other languages
German (de)
English (en)
Other versions
WO1997026016A2 (fr
Inventor
Martina Bergmann
Dieter Heldmann
Werner Weitschies
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to EP97902178A priority Critical patent/EP0874644A2/fr
Priority to AU15925/97A priority patent/AU1592597A/en
Priority to JP9525697A priority patent/JP2000504317A/ja
Publication of WO1997026016A2 publication Critical patent/WO1997026016A2/fr
Publication of WO1997026016A3 publication Critical patent/WO1997026016A3/fr
Priority to NO983332A priority patent/NO983332D0/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
    • C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
    • C08J9/14—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
    • C08J9/143—Halogen containing compounds
    • C08J9/147—Halogen containing compounds containing carbon and halogen atoms only
    • C08J9/148—Halogen containing compounds containing carbon and halogen atoms only perfluorinated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/04—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent
    • C08J9/12—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent
    • C08J9/14—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof using blowing gases generated by a previously added blowing agent by a physical blowing agent organic
    • C08J9/143—Halogen containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des matrices poreuses constituées de substances de faible poids moléculaire servant à générer des suspensions de bulles de gaz stables, leur utilisation sous forme d'agents de contraste ultrasonores et des procédés de production de ces matrices et agents de contraste.
PCT/EP1997/000208 1996-01-18 1997-01-16 Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores Ceased WO1997026016A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP97902178A EP0874644A2 (fr) 1996-01-18 1997-01-16 Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores
AU15925/97A AU1592597A (en) 1996-01-18 1997-01-16 Gas bubble suspensions and their application as an ultrasound contrast medium
JP9525697A JP2000504317A (ja) 1996-01-18 1997-01-16 気泡懸濁物と超音波造影剤への応用
NO983332A NO983332D0 (no) 1996-01-18 1998-07-17 Gassboblesuspensjoner og deres anvendelse som ultralydkontrastmiddel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602930.9 1996-01-18
DE19602930A DE19602930A1 (de) 1996-01-18 1996-01-18 Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung

Publications (2)

Publication Number Publication Date
WO1997026016A2 WO1997026016A2 (fr) 1997-07-24
WO1997026016A3 true WO1997026016A3 (fr) 1997-10-23

Family

ID=7783852

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/000208 Ceased WO1997026016A2 (fr) 1996-01-18 1997-01-16 Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores

Country Status (8)

Country Link
EP (1) EP0874644A2 (fr)
JP (1) JP2000504317A (fr)
AU (1) AU1592597A (fr)
CA (1) CA2243174A1 (fr)
DE (1) DE19602930A1 (fr)
NO (1) NO983332D0 (fr)
WO (1) WO1997026016A2 (fr)
ZA (1) ZA97414B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0904113T3 (da) 1996-03-05 2004-08-30 Acusphere Inc Mikroindkapslede fluorerede gasser til anvendelse som billeddannende midler
NZ568288A (en) * 2005-11-28 2012-02-24 Verrow Pharmaceuticals Inc Compositions comprising a a cyclodextrin and a nephrotoxic anticancer drug
JP5196896B2 (ja) * 2007-07-13 2013-05-15 花王株式会社 微細気泡前駆体の製造方法
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
KR101927614B1 (ko) 2017-03-30 2018-12-10 숭실대학교산학협력단 초음파 영상을 위한 안정한 생체적합 산소-나노버블 조영제 제조방법
JP7211699B2 (ja) * 2017-09-11 2023-01-24 バイエル ファーマ アクチエンゲゼルシャフト 超音波診断用造影剤
US20240226418A1 (en) * 2021-01-26 2024-07-11 Agitated Solutions Inc. Syringe-Based Microbubble Generator

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122624A2 (fr) * 1983-04-15 1984-10-24 Schering Aktiengesellschaft Microparticules et milieu de contraste pour l'exploration ultrasonique contenant des bulles de gaz
EP0123235A2 (fr) * 1983-04-15 1984-10-31 Schering Aktiengesellschaft Microparticules et milieu de contraste pour l'exploration ultrasonique contenant des bulles de gaz
EP0365467A2 (fr) * 1988-10-07 1990-04-25 Schering Aktiengesellschaft Agent de contraste ultrasonique à base de bulles de gaz et de microparticules contenant des acides gras
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
US5160725A (en) * 1987-03-24 1992-11-03 Silica Gel Gesellschaft Mbh Adsorptions-Technik, Apparatebau Magnetic liquid compositions
WO1992021382A1 (fr) * 1991-06-03 1992-12-10 Holmes, Michael, John Ameliorations apportees a ou concernant des agents contrastants
WO1993000933A1 (fr) * 1991-07-05 1993-01-21 University Of Rochester Particules poreuses non agregees ultra-petites piegant des bulles gazeuses
WO1993013808A2 (fr) * 1992-01-09 1993-07-22 Holmes, Michael, John Perfectionnements apportes aux agents de contraste
WO1995003835A1 (fr) * 1993-07-30 1995-02-09 Alliance Pharmaceutical Corp. Compositions a mocrobulles stabilisees pour applications mettant en ×uvre des ultrasons
WO1995021631A1 (fr) * 1994-02-15 1995-08-17 Nycomed Imaging As Perfectionnements relatifs a des agents de contraste
WO1996026746A1 (fr) * 1995-02-28 1996-09-06 Alliance Pharmaceutical Corp. Emulsions gazeuses stabilisees contenant des phospholipides renforçant les contrastes dans les techniques d'imagerie par ultrasons

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
ES2103376T3 (es) * 1991-07-05 1997-09-16 Nycomed Imaging As Perfeccionamientos introducidos en los agentes de contraste.
ES2145011T5 (es) * 1991-09-17 2008-02-01 Ge Healthcare As Medios de contraste gaseoso para ecografias.
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
WO1995016467A1 (fr) * 1993-12-15 1995-06-22 Bracco Research S.A. Melanges gazeux utiles comme agents de contraste ultrasonores
DE4406474A1 (de) * 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122624A2 (fr) * 1983-04-15 1984-10-24 Schering Aktiengesellschaft Microparticules et milieu de contraste pour l'exploration ultrasonique contenant des bulles de gaz
EP0123235A2 (fr) * 1983-04-15 1984-10-31 Schering Aktiengesellschaft Microparticules et milieu de contraste pour l'exploration ultrasonique contenant des bulles de gaz
US5160725A (en) * 1987-03-24 1992-11-03 Silica Gel Gesellschaft Mbh Adsorptions-Technik, Apparatebau Magnetic liquid compositions
EP0365467A2 (fr) * 1988-10-07 1990-04-25 Schering Aktiengesellschaft Agent de contraste ultrasonique à base de bulles de gaz et de microparticules contenant des acides gras
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
WO1992021382A1 (fr) * 1991-06-03 1992-12-10 Holmes, Michael, John Ameliorations apportees a ou concernant des agents contrastants
WO1993000933A1 (fr) * 1991-07-05 1993-01-21 University Of Rochester Particules poreuses non agregees ultra-petites piegant des bulles gazeuses
WO1993013808A2 (fr) * 1992-01-09 1993-07-22 Holmes, Michael, John Perfectionnements apportes aux agents de contraste
WO1995003835A1 (fr) * 1993-07-30 1995-02-09 Alliance Pharmaceutical Corp. Compositions a mocrobulles stabilisees pour applications mettant en ×uvre des ultrasons
US5605673A (en) * 1993-07-30 1997-02-25 Alliance Pharmaceutical Corp. Stabilized microbubble compositions for ultrasound
WO1995021631A1 (fr) * 1994-02-15 1995-08-17 Nycomed Imaging As Perfectionnements relatifs a des agents de contraste
WO1996026746A1 (fr) * 1995-02-28 1996-09-06 Alliance Pharmaceutical Corp. Emulsions gazeuses stabilisees contenant des phospholipides renforçant les contrastes dans les techniques d'imagerie par ultrasons

Also Published As

Publication number Publication date
NO983332L (no) 1998-07-17
WO1997026016A2 (fr) 1997-07-24
DE19602930A1 (de) 1997-07-24
EP0874644A2 (fr) 1998-11-04
JP2000504317A (ja) 2000-04-11
NO983332D0 (no) 1998-07-17
AU1592597A (en) 1997-08-11
ZA97414B (en) 1997-07-17
CA2243174A1 (fr) 1997-07-24

Similar Documents

Publication Publication Date Title
AU1374797A (en) Adsorbent for phosphate from an aqueous medium, production and use of said adsorbent
CA2226221A1 (fr) Synthese de polycetides, exempte de cellule
AU6687396A (en) Strong, air permeable membranes of polytetrafluoroethylene
CA2224491A1 (fr) Produits de silice biogenique hautement purifies
WO2000040525A3 (fr) Ensembles de polymeres et techniques de production et d'utilisation
CA2069759A1 (fr) Liposomes utilises comme agents de contraste dans l'imagerie a ultrasons
WO1997026270A3 (fr) Synthese de methoxy nucleosides et de molecules d'acide nucleique enzymatique
WO1997032607A3 (fr) Segments de liaison actives et leurs procedes de fabrication et de purification
AU1091899A (en) Methods of making a molecular sieve containing catalyst
IL143670A0 (en) Methods for the expression of active protein-immunoglobulin fusions, active protein-immunoglobulin fusions obtained thereby and pharmaceutical compositions containing the same
AU3108099A (en) Membrane process for producing carbon dioxide
GC0000119A (en) Improved chromate ester catalyst and method of using same to produce high performance polyethylene products.
WO1997026016A3 (fr) Suspensions de bulles de gaz et leur utilisation sous forme d'agents de contraste ultrasonores
WO1996039512A3 (fr) Lignee cellulaire pour l'expression rapide de canaux a calcium fonctionnels
GR1002616B (el) Συνθεση και μεθοδος συνθεσης μοριου: τετραυδρο-ν,ν-διμεθυλο-2,2-διφαινυλο-3-φουρανομεθαναμινης (αε 37), αντισπασμωδικης, αντικαταθλιπτικης και νοοτροπικης δρασης.
WO1996007739A3 (fr) Recepteurs de type 3 de l'interleukine 1
EP2011503A3 (fr) Ligands d'acide nucléique à haute affinité de cytokines
AU4853297A (en) Container formed from copolyester composition, copolyester composition therefor and method of producing the same
WO1997012985A3 (fr) Agonistes multifonctionnels des recepteurs hematopoietiques
DE69233634D1 (de) Gasplasma behandeltes, poröses Medium und Trennungsmethode unter Verwendung des Mediums
WO2001064837A8 (fr) NETRINE β ET SES UTILISATIONS
ZA972627B (en) Process for the preparation of an intermediate useful in the synthesis of iodinated contrast media.
WO2002024343A3 (fr) Procede pour produire un revetement sur des materiaux poreux et/ou absorbants
ID19366A (id) Partikel-partikel arilpirol stabil, proses untuk pembuatannya dan komposisi-komposisi konsentrat suspensi yang mengandungnya
AU3037797A (en) Generation of replicative molecules in vivo

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AU AZ BB BG BR BY CA CN CZ EE GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LV MD MG MK MN MW MX NO NZ PL RO RU SD SG SI SK TJ TM TR TT UA UG US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AU AZ BB BG BR BY CA CN CZ EE GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LV MD MG MK MN MW MX NO NZ PL RO RU SD SG SI SK TJ TM TR TT UA UG US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

WWE Wipo information: entry into national phase

Ref document number: 1997902178

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2243174

Country of ref document: CA

Ref country code: CA

Ref document number: 2243174

Kind code of ref document: A

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 1997902178

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1997902178

Country of ref document: EP