[go: up one dir, main page]

WO1997022972A3 - Method for the simultaneous detection of a therapeutic target for a disease state and its neutralizing antibody-like molecule - Google Patents

Method for the simultaneous detection of a therapeutic target for a disease state and its neutralizing antibody-like molecule Download PDF

Info

Publication number
WO1997022972A3
WO1997022972A3 PCT/US1996/019129 US9619129W WO9722972A3 WO 1997022972 A3 WO1997022972 A3 WO 1997022972A3 US 9619129 W US9619129 W US 9619129W WO 9722972 A3 WO9722972 A3 WO 9722972A3
Authority
WO
WIPO (PCT)
Prior art keywords
neutralizing antibody
molecule
disease state
therapeutic target
simultaneous detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1996/019129
Other languages
French (fr)
Other versions
WO1997022972A2 (en
Inventor
Paul K Tomich
David A Jones
Howard D Fischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Priority to AU11270/97A priority Critical patent/AU1127097A/en
Priority to EP96942111A priority patent/EP0880703A2/en
Priority to JP9522826A priority patent/JP2000502896A/en
Publication of WO1997022972A2 publication Critical patent/WO1997022972A2/en
Publication of WO1997022972A3 publication Critical patent/WO1997022972A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The specification discloses combinatorial libraries of recombinant antibody-like molecules used to identify both potential therapeutic targets and their corresponding neutralizing antibody(ies). The identification can be done either by in vitro (biochemical) means or in situ with established cell lines. No prior knowledge of either the antigen target or its corresponding antibody is required.
PCT/US1996/019129 1995-12-15 1996-12-04 Method for the simultaneous detection of a therapeutic target for a disease state and its neutralizing antibody-like molecule Ceased WO1997022972A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU11270/97A AU1127097A (en) 1995-12-15 1996-12-04 Method for the simultaneous detection of a therapeutic target for a disease state and its neutralizing antibody-like molecule
EP96942111A EP0880703A2 (en) 1995-12-15 1996-12-04 Method for the simultaneous detection of a therapeutic target for a disease state and its neutralizing antibody-like molecule
JP9522826A JP2000502896A (en) 1995-12-15 1996-12-04 Simultaneous detection of therapeutic targets for disease states and their neutralizing antibody-like molecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US868595P 1995-12-15 1995-12-15
US60/008,685 1995-12-15

Publications (2)

Publication Number Publication Date
WO1997022972A2 WO1997022972A2 (en) 1997-06-26
WO1997022972A3 true WO1997022972A3 (en) 1997-08-21

Family

ID=21733088

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/019129 Ceased WO1997022972A2 (en) 1995-12-15 1996-12-04 Method for the simultaneous detection of a therapeutic target for a disease state and its neutralizing antibody-like molecule

Country Status (4)

Country Link
EP (1) EP0880703A2 (en)
JP (1) JP2000502896A (en)
AU (1) AU1127097A (en)
WO (1) WO1997022972A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9700291D0 (en) * 1997-01-31 1997-01-31 Pharmacia & Upjohn Ab Selection method and prodcts resulting therefrom
EP1109897A1 (en) * 1998-09-07 2001-06-27 Eberhard-Karls-Universität Tübingen Universitätsklinikum Method for selecting peptides for the targeted transport of drugs and markers, and peptides discovered using said method
JP2002541818A (en) * 1999-04-14 2002-12-10 ザ ガヴァメント オブ ザ ユナイテッド ステイツ オブ アメリカ、アズ レプリゼンテッド バイ ザ セクレタリー、 デパートメント オブ ヘルス アンド ヒューマン サーヴィスィズ Highly sensitive phage display biomolecule detection
GB2360282A (en) * 2000-03-17 2001-09-19 Bioinvent Int Ab Making and using micro-arrays of biological materials
EP1394550A1 (en) * 2002-08-30 2004-03-03 Plant Research International B.V. A method of analysing relative epitope appearance in a plurality of samples

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011236A1 (en) * 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
US5264563A (en) * 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
WO1994026787A1 (en) * 1993-05-07 1994-11-24 The Board Of Trustees Of The Leland Stanford Junior University Method for generating cell type specific phage antibody libraries
WO1997006435A1 (en) * 1995-08-05 1997-02-20 Medical Research Council Improvements in or relating to methods of screening substances

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264563A (en) * 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
WO1993011236A1 (en) * 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
WO1994026787A1 (en) * 1993-05-07 1994-11-24 The Board Of Trustees Of The Leland Stanford Junior University Method for generating cell type specific phage antibody libraries
WO1997006435A1 (en) * 1995-08-05 1997-02-20 Medical Research Council Improvements in or relating to methods of screening substances

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D. A. DANIELS ET AL.: "Phage peptide libraries.", METHODS: A COMPANION TO METHODS IN ENZYMOLOGY, vol. 9, no. 3, June 1996 (1996-06-01), NEW YORK, US., pages 494 - 507, XP000671255 *
F. FELICI ET AL.: "Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector.", JOURNAL OF MOLECULAR BIOLOGY, vol. 222, no. 2, 1991, LONDON, GB., pages 301 - 310, XP000373977 *
R. S. AMES ET AL.: "Neutralizing murine monoclonal antibodies to human IL-5 isolated from hybridomas and a filamentous phage Fab display library", THE JOURNAL OF IMMUNOLOGY, vol. 154, no. 12, 15 June 1995 (1995-06-15), BETHESDA, US, pages 6355 - 6364, XP002032743 *

Also Published As

Publication number Publication date
AU1127097A (en) 1997-07-14
EP0880703A2 (en) 1998-12-02
WO1997022972A2 (en) 1997-06-26
JP2000502896A (en) 2000-03-14

Similar Documents

Publication Publication Date Title
DE69835893T2 (en) DIAGNOSTIC TESTS AND KITS FOR CLOSTRIDIUM DIFFICILE
AU703468B2 (en) Competitive immunoassay device
US4689310A (en) Methods for attaching ligands or anti-ligands to a solid phase
WO2004055198A3 (en) Device and method for in-line blood testing using biochips
EP0969083A4 (en) Dna capillary
DE69028412D1 (en) METHOD FOR TRANSPORTING MOLECULES IN EUKARYOT CELLS
EP2100959A3 (en) Mammalian cytokine: interleukin-B30 and related reagents
WO1998025958A3 (en) Mammalian cell surface antigens comprising structural motifs characteristic of a member of the TNF ligand family
US4791069A (en) Methods for attaching ligands or anti-ligands to a solid phase
WO1997022972A3 (en) Method for the simultaneous detection of a therapeutic target for a disease state and its neutralizing antibody-like molecule
AU1259801A (en) Detection method by pcr
CA2555699C (en) Monoclonal antibody based biomarker discovery and development platform
CA2506197A1 (en) Detection of protease enzymes
WO1999024611A3 (en) Analyte detection process using dual labeled probes
CA2101166A1 (en) Method for detection of anti-rna-antibodies
CA2219947A1 (en) Monoclonal antibody reactive to human cetp and assay method for human cetp
DE69128639D1 (en) METHOD AND PHARMACEUTICAL SETS FOR DETECTING MICROORGANISMS ASSOCIATED WITH VAGINAL INFECTIONS
WO2001042503A3 (en) Apparatus and methods for drug screening based on nucleic acid analysis
LTIP1517A (en) Nucleic acids, proteins, organisms, cells, monoclonal antibody, methods of identification and diagnosis, analytical and model systems, pharmaceutical compositions
AU5121596A (en) Chlamydia pneumoniae antigens, method for production of the antigens, method and reagents for measurement of anti-chlamydia pneumoniae antibodies using the antigens
Subramanian et al. Characterization of a mutant form of ribosomal protein S1 from Escherichia coli.
EP0331514A3 (en) Assaying the duchenne muscular dystrophy protein deletion or defect
AU6045796A (en) Monoclonal antibody detection of proteins on sperm related to fertility
Abdurashidova et al. Determination of tRNA nucleotide residues directly interacting with proteins in the post‐and pretranslocated ribosomal complexes
Hofstetter et al. Detection of enantiomeric impurities in a simple membrane-based optical immunosensor

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG

AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref country code: JP

Ref document number: 1997 522826

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1996942111

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1996942111

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1996942111

Country of ref document: EP