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WO1997018846A1 - Dispositif nebuliseur - Google Patents

Dispositif nebuliseur Download PDF

Info

Publication number
WO1997018846A1
WO1997018846A1 PCT/NL1996/000457 NL9600457W WO9718846A1 WO 1997018846 A1 WO1997018846 A1 WO 1997018846A1 NL 9600457 W NL9600457 W NL 9600457W WO 9718846 A1 WO9718846 A1 WO 9718846A1
Authority
WO
WIPO (PCT)
Prior art keywords
nebulizing
reservoir
control means
outlet opening
foregoing
Prior art date
Application number
PCT/NL1996/000457
Other languages
English (en)
Inventor
Johannes Hubertus Jozef Maria Kelders
Erwin Petrus Boes
Original Assignee
R + D Injector Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R + D Injector Ag filed Critical R + D Injector Ag
Publication of WO1997018846A1 publication Critical patent/WO1997018846A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • A61M15/025—Bubble jet droplet ejection devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0066—Inhalators with dosage or measuring devices with means for varying the dose size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41J—TYPEWRITERS; SELECTIVE PRINTING MECHANISMS, i.e. MECHANISMS PRINTING OTHERWISE THAN FROM A FORME; CORRECTION OF TYPOGRAPHICAL ERRORS
    • B41J2/00—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed
    • B41J2/005—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by bringing liquid or particles selectively into contact with a printing material
    • B41J2/01—Ink jet

Definitions

  • the invention relates to a device for dispensing a liquid such as for instance a pharmacon or prophylactic, provided with a reservoir for the liquid, an outlet opening connected to the reservoir and nebulizing means arranged between the reservoir and the outlet opening.
  • a device for dispensing a liquid such as for instance a pharmacon or prophylactic
  • a reservoir for the liquid such as for instance a pharmacon or prophylactic
  • nebulizing means arranged between the reservoir and the outlet opening.
  • Such a device is known and can be used for instance for administering active substances via the respiratory system to users or patients. What can be particularly envisaged here is the treatment or prophylaxis of respiratory disorders such as for instance asthma.
  • the known nebulizing devices can be sub-divided into four main types .
  • the most important known nebulizer is the so-called metered dose inhaler or MDI .
  • MDI metered dose inhaler
  • This is in fact an aerosol filled with the active substance having a dispensing cap and a mouthpiece, whereby each time the aerosol is operated a determined fixed dose of the active substance is nebulized and sprayed out via the mouthpiece.
  • the user herein places the mouthpiece in his mouth or nose or at a distance in front of them and operates the aerosol while simultaneously inhaling the spray flowing out of the aerosol .
  • This MDI has a number of drawbacks. Thus the size of the droplets forming the spray is not distributed relatively uniformly and i ⁇ difficult to control.
  • Another known nebulizing device which is suitable for nebulizing a dry substance consists of a housing in which can be received ampoules with the dry substance which can be carried in front of an outlet opening by the user, for instance by mutually rotating parts of the housing, whereafter the user can draw in the substance simply by inhaling.
  • This known device has the drawback that the operation greatly depends on the manner of breathing of the user, since a sufficient suction is required for nebulizing. Very young or very old users in particular can often not use this device properly.
  • nebulizing device the so-called jet nebulizer
  • a liquid active substance is sucked along and nebulized by the ejector action of an air stream under high pressure which is directed practically transversely of the inhaling direction of the user.
  • This device has the drawback that relatively voluminous and high-power equipment is required to generate sufficiently high air speeds to achieve the desired ejector action.
  • the ultrasonic nebulizer the liquid active substance is nebulized and carried in the air stream to the user by deforming the bottom of a reservoir with a piezoelectric element which receives an ultrasonic signal. This device also requires much power.
  • the droplet size can be determined within very narrow limits. It is thus known that due to variations in the droplet size the efficiency of administering of the active substance can be very adversely affected.
  • the mean efficiency of the above described systems amount to 10 to 20%. This implies that 80 to 90% of the supplied active substance does not reach the lungs of the user and is therefore has no effect, or hardly so.
  • the nebulizing device to form droplets of equal size, so-called monodispersed droplets, m order to thus increase the efficiency of the device
  • the invention has for its object to provide an improved nebulizing device of the above described type.
  • the nebulizing device is distinguished in that the nebulizing means are connected controllably to electronic control means and are adapted to distribute the substance in separate, very small droplets. Due to the electronic control of the nebulizing means a very precise nebulizing can be performed. Nebulizing is preferably performed with a precisely determined droplet size. Practically monodispersed droplets are herein obtained.
  • nebulizing means comprise at least one Inkjet printer element.
  • printer elements are commercially available on a large scale and operate very accurately and reliably.
  • a piezoelectric element as well as a bubble-jet element can be considered suitable as printer element.
  • the electronic control means are preferably adapted to adjust the droplet size.
  • the device can thus be adapted in simple manner to the substance required for a specific user.
  • a problem of known nebulizing devices is that many users have difficulty in coordinating their breathing with the operation of the nebulizing device. It is important that the user inhales at the moment the nebulized substance enters his oral cavity.
  • the nebulizing means can thus be operated automatically when the user inhales, whereby a determined pressure, generally an underpressure, is created.
  • the reservoir is preferably exchangeable and/or refillable.
  • the nebulizing means can be embodied compactly by applying a standard printer head
  • the reservoir, the nebulizing mean ⁇ and the control mean ⁇ can preferably be accommodated in a portable housing. Any user can thus carry with him his own nebulizing device.
  • the device herein has at least one battery connected to the nebulizing means and the control means, whereby the user is not dependent on the presence of a mains electricity power point .
  • a nebulizing device 1 is provided with a portable housing 2 in pocket format which ha ⁇ on one end a detachable mouthpiece 3 which defines an outlet opening 4. Situated in housing 2 is a reservoir 5 in which is arranged a liquid, for instance an active substance such as a pharmacon or prophylactic. The actual nebulizing means 6 are arranged between reservoir 5 and outlet opening 4.
  • the nebulizing means 6 are formed by one or more inkjet printer elements, for instance piezoelectric or bubble-jet elements. Such printer elements are commercially available on a large scale and at low cost and have already demonstrated their accuracy and reliability in practice. The principle of the inkjet printer is assumed known so that it need not be further discussed here.
  • the printer element distributes the active substance from the reservoir 5 in a large number of very small droplets, of which the droplet ⁇ ize, which lies for in ⁇ tance in the order of 5 ⁇ m, can be precisely determined.
  • the dispersion in the droplet ⁇ ize is therefore very small, whereby the formation of exces ⁇ ively large or ⁇ mall particle ⁇ , which, as stated, will generally not reach the lungs, is wholly or largely excluded.
  • the printer element 6 is provided in the example shown with a single discharge opening 15 whereby a stream of very fine droplets 16 can be sprayed via mouthpiece 3 into the oral or nasal cavity of the user.
  • the printer element 6 is controlled by an electronic control 8 connected via control line ⁇ 7 to the printer element 6.
  • the control 8 compri ⁇ e ⁇ for in ⁇ tance a microproce ⁇ sor 9 in which the most important control functions can be included.
  • the device 1 i ⁇ further provided with an on/off ⁇ witch 10, while mean ⁇ 11, here in the form of a rotatable knob, connected to the control means 8 are furthermore arranged to set the droplet size for dosing by the printer head 6 subject to the nature of the active substance arranged in the reservoir 5.
  • Two batteries 12 are accommodated in housing 2 for power supply to the control means 8 and the nebulizing means 6.
  • these are rechargeable, for instance nickel-cadmium batteries which, when device 1 is not in use, can be connected to a recharging apparatus, of which only a plug 14 is shown here.
  • a portable nebulizing device 1 which can be operated independently by the user, the principles of the invention can also be applied m large-scale stationary nebulizing devices such as can be found for instance m hospitals
  • Such a device often has one or more relatively large reservoirs and a plurality of mouthpieces connected over long conduits to the reservoirs
  • the nebulizing means can herein be arranged in the conduits or debouch therein
  • nebulizing mean ⁇ which are in any ca ⁇ e electronically controllable
  • a pressure sensor can then be arranged in the vicinity of the outlet opening which generates a control signal when a determined pressure occurs in the outlet opening as a result of the user inhaling
  • the nebulizing means are then actuated whereby the active substance is nebulized at precisely the correct moment
  • the control can also be set differently so that for instance the substance is nebulized at the end of exhalation or with some delay thereafter.
  • an active substance can be converted to a practically monodispersed spray which can reach the lungs practically in lt ⁇ entirety, the efficiency of the device is very high, whereby only a small dose of active substance has to be administered Treatment costs are hereby reduced considerably, while there is moreover les ⁇ danger of side effects.
  • the device is described above with reference to a nebulizing device for medical applications, it will be apparent that it is not limited thereto.
  • the device could thus for instance also be used to nebulize ink, thu ⁇ m the form of a pen or airbru ⁇ h
  • the line thicknes ⁇ can then easily be varied herein so that such a pen would be particularly suitable for drawing.
  • other applications are of course also conceivable.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Cette invention se rapporte à un dispositif (1) distributeur de liquide du type encre, médicament ou agent prophylactique. Ledit dispositif comporte un réservoir (5) destiné au liquide, un orifice de sortie (4) relié au réservoir (5) et un organe de nébulisation (6) disposé entre le réservoir (5) et l'orifice de sortie (4). L'organe de nébulisation (6) est relié de façon à pouvoir être régulé à un organe de régulation électronique (8) et est conçu pour distribuer la substance sous forme de gouttelettes (16) distinctes de très petite taille, la taille des gouttelettes étant de préférence précisément préétablie. L'organe de nébulisation (6) comporte un élément d'imprimante à jet d'encre, du type élément piézo-électrique ou élément d'imprimante à jet de bulles d'encre. L'utilisation d'un tel dispositif permet, dans une application médicale, d'administrer une substance active de manière pratiquement monodispersée, ce qui améliore considérablement l'efficacité de l'administration. Ce dispositif convient, par ailleurs, particulièrement bien en tant qu'instrument de dessin qui permette d'obtenir une épaisseur variable de tracé.
PCT/NL1996/000457 1995-11-17 1996-11-18 Dispositif nebuliseur WO1997018846A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1001682A NL1001682C2 (nl) 1995-11-17 1995-11-17 Vernevelingsinrichting.
NL1001682 1995-11-17

Publications (1)

Publication Number Publication Date
WO1997018846A1 true WO1997018846A1 (fr) 1997-05-29

Family

ID=19761874

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL1996/000457 WO1997018846A1 (fr) 1995-11-17 1996-11-18 Dispositif nebuliseur

Country Status (2)

Country Link
NL (1) NL1001682C2 (fr)
WO (1) WO1997018846A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1154815A4 (fr) * 1999-02-24 2002-04-24 Ponwell Entpr Ltd Inhalateur piezo-electrique
US6637430B1 (en) 2000-06-16 2003-10-28 Ponwell Enterprises Limited Respiratory delivery system with power/medicament recharge assembly
WO2005077446A1 (fr) * 2004-02-11 2005-08-25 Hewlett-Packard Development Company, L.P. Distributeur de medicament
AT503485B1 (de) * 2006-03-31 2009-03-15 Almak Vertrieb Gmbh Tascheninhalator
EP1415677B1 (fr) * 2002-10-31 2009-12-02 Hewlett-Packard Development Company, L.P. Dispositif d'inhalation pour distribution des quantites variables des composants differents
EP1211628A3 (fr) * 2000-11-30 2010-09-01 Canon Kabushiki Kaisha Terminal portable et méthode et système de gestion de santé utilisant un terminal portable
ES2594891A1 (es) * 2016-09-16 2016-12-23 Ingeniatrics Tecnologias, S.L. Dispositivo de impresión omnidireccional por chorro de tinta apto para su conexión a un brazo robótico
WO2018178605A1 (fr) * 2017-03-31 2018-10-04 Enovap Dispositif portable d'inhalation d'au moins une composition active
FR3064491A1 (fr) * 2017-03-31 2018-10-05 Enovap Dispositif portable d'inhalation d'au moins une composition active

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3812854A (en) * 1972-10-20 1974-05-28 A Michaels Ultrasonic nebulizer
JPS61272163A (ja) * 1985-05-28 1986-12-02 Nec Corp ミストバブルインクジエツト
EP0430087A2 (fr) * 1989-11-21 1991-06-05 Seiko Epson Corporation Imprimante à jet d'encre sans buses
JPH04299149A (ja) * 1991-03-28 1992-10-22 Seiko Epson Corp インクジェットヘッド
WO1995001137A1 (fr) * 1993-06-29 1995-01-12 Voges Innovation Pty. Ltd. Distributeur
EP0642802A2 (fr) * 1993-08-09 1995-03-15 Disetronic Ag Dispositif d'inhalation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3812854A (en) * 1972-10-20 1974-05-28 A Michaels Ultrasonic nebulizer
JPS61272163A (ja) * 1985-05-28 1986-12-02 Nec Corp ミストバブルインクジエツト
EP0430087A2 (fr) * 1989-11-21 1991-06-05 Seiko Epson Corporation Imprimante à jet d'encre sans buses
JPH04299149A (ja) * 1991-03-28 1992-10-22 Seiko Epson Corp インクジェットヘッド
WO1995001137A1 (fr) * 1993-06-29 1995-01-12 Voges Innovation Pty. Ltd. Distributeur
EP0642802A2 (fr) * 1993-08-09 1995-03-15 Disetronic Ag Dispositif d'inhalation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 011, no. 131 (M - 584) 24 April 1987 (1987-04-24) *
PATENT ABSTRACTS OF JAPAN vol. 017, no. 114 (M - 1377) 9 March 1993 (1993-03-09) *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1154815A4 (fr) * 1999-02-24 2002-04-24 Ponwell Entpr Ltd Inhalateur piezo-electrique
US6637430B1 (en) 2000-06-16 2003-10-28 Ponwell Enterprises Limited Respiratory delivery system with power/medicament recharge assembly
EP1211628A3 (fr) * 2000-11-30 2010-09-01 Canon Kabushiki Kaisha Terminal portable et méthode et système de gestion de santé utilisant un terminal portable
EP2384782A1 (fr) * 2000-11-30 2011-11-09 Canon Kabushiki Kaisha Terminal portable
EP1415677B1 (fr) * 2002-10-31 2009-12-02 Hewlett-Packard Development Company, L.P. Dispositif d'inhalation pour distribution des quantites variables des composants differents
WO2005077446A1 (fr) * 2004-02-11 2005-08-25 Hewlett-Packard Development Company, L.P. Distributeur de medicament
US7467630B2 (en) 2004-02-11 2008-12-23 Hewlett-Packard Development Company, L.P. Medicament dispenser
AT503485B1 (de) * 2006-03-31 2009-03-15 Almak Vertrieb Gmbh Tascheninhalator
ES2594891A1 (es) * 2016-09-16 2016-12-23 Ingeniatrics Tecnologias, S.L. Dispositivo de impresión omnidireccional por chorro de tinta apto para su conexión a un brazo robótico
WO2018178605A1 (fr) * 2017-03-31 2018-10-04 Enovap Dispositif portable d'inhalation d'au moins une composition active
FR3064491A1 (fr) * 2017-03-31 2018-10-05 Enovap Dispositif portable d'inhalation d'au moins une composition active

Also Published As

Publication number Publication date
NL1001682C2 (nl) 1997-05-21

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