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WO1997012963A3 - A paf-acetylhydrolase and use in therapy - Google Patents

A paf-acetylhydrolase and use in therapy Download PDF

Info

Publication number
WO1997012963A3
WO1997012963A3 PCT/EP1996/004268 EP9604268W WO9712963A3 WO 1997012963 A3 WO1997012963 A3 WO 1997012963A3 EP 9604268 W EP9604268 W EP 9604268W WO 9712963 A3 WO9712963 A3 WO 9712963A3
Authority
WO
WIPO (PCT)
Prior art keywords
acetylhydrolase
paf
therapy
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1996/004268
Other languages
French (fr)
Other versions
WO1997012963A2 (en
Inventor
Christopher Donald Southan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB1995/002320 external-priority patent/WO1997012984A1/en
Priority claimed from GBGB9617781.1A external-priority patent/GB9617781D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Priority to AU72169/96A priority Critical patent/AU7216996A/en
Priority to JP51396697A priority patent/JP2002515728A/en
Priority to EP96933431A priority patent/EP0859834A2/en
Publication of WO1997012963A2 publication Critical patent/WO1997012963A2/en
Publication of WO1997012963A3 publication Critical patent/WO1997012963A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

A PAF-acetylhydrolase of SEQ.ID.NO 1, for use in therapy.
PCT/EP1996/004268 1995-09-29 1996-09-26 A paf-acetylhydrolase and use in therapy Ceased WO1997012963A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU72169/96A AU7216996A (en) 1995-09-29 1996-09-26 A paf-acetylhydrolase and use in therapy
JP51396697A JP2002515728A (en) 1995-09-29 1996-09-26 New applications
EP96933431A EP0859834A2 (en) 1995-09-29 1996-09-26 A paf-acetylhydrolase and use in therapy

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/GB1995/002320 WO1997012984A1 (en) 1995-09-29 1995-09-29 COMPOUND HAVING SEQUENCE HOMOLOGY WITH LIPOPROTEIN ASSOCIATED PHOSPHOLIPASE A2 (Lp-PLA2)/PAF ACETYL HYDROLASE
GBPCT/GB95/02320 1995-09-29
GBGB9617781.1A GB9617781D0 (en) 1996-08-24 1996-08-24 New use
GB9617781.1 1996-08-24

Publications (2)

Publication Number Publication Date
WO1997012963A2 WO1997012963A2 (en) 1997-04-10
WO1997012963A3 true WO1997012963A3 (en) 1997-06-12

Family

ID=26306449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/004268 Ceased WO1997012963A2 (en) 1995-09-29 1996-09-26 A paf-acetylhydrolase and use in therapy

Country Status (5)

Country Link
EP (1) EP0859834A2 (en)
JP (1) JP2002515728A (en)
AU (1) AU7216996A (en)
CA (1) CA2233300A1 (en)
WO (1) WO1997012963A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009147A1 (en) * 1997-08-13 1999-02-25 Icos Corporation Truncated platelet-activating factor acetylhydrolase
NZ520752A (en) 2000-02-16 2004-03-26 Smithkline Beecham P Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors
TW201307324A (en) 2010-12-06 2013-02-16 Glaxo Group Ltd Compounds
EP2651403B1 (en) 2010-12-17 2020-12-02 Glaxo Group Limited Use of lp-pla2 inhibitors in the treatment and prevention of eye diseases
AU2012289492B2 (en) 2011-07-27 2016-02-04 Glaxo Group Limited 2,3-dihydroimidazo[1,2-c] pyrimidin-5(1H)-one compounds use as Lp-PLA2 inhibitors
AU2012288865B2 (en) 2011-07-27 2015-10-01 Glaxo Group Limited Bicyclic pyrimidone compounds
JP2016505053A (en) 2013-01-25 2016-02-18 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Bicyclic pyrimidone compounds as inhibitors of Lp-PLA2
UY35276A (en) 2013-01-25 2014-08-29 Glaxosmithkline Ip Dev Ltd New compounds that inhibit the activity of Lp-PLA2
EP2948457A4 (en) 2013-01-25 2016-09-07 Glaxosmithkline Ip Dev Ltd Compounds
WO2016012917A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012916A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
BR112022008786A2 (en) 2019-11-09 2022-07-26 Shanghai Simr Biotechnology Co Ltd COMPOUND, COMPOSITION, USE OF COMPOUND OR COMPOSITION, AND METHOD FOR TREATMENT OR PREVENTION OF A DIABETIC COMPLICATION, DISEASE RELATED TO NEUROINFLAMMATION OR ATHEROSCLEROSIS
CN115304620A (en) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 Pyrimidone derivatives, preparation method, pharmaceutical composition and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000649A1 (en) * 1993-06-25 1995-01-05 Smithkline Beecham Plc Lipoprotein associated phospholipase a2, inhibitors thereof and use of the same in diagnosis and therapy
WO1995009921A1 (en) * 1993-10-06 1995-04-13 Icos Corporation Platelet-activating factor acetylhydrolase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000649A1 (en) * 1993-06-25 1995-01-05 Smithkline Beecham Plc Lipoprotein associated phospholipase a2, inhibitors thereof and use of the same in diagnosis and therapy
WO1995009921A1 (en) * 1993-10-06 1995-04-13 Icos Corporation Platelet-activating factor acetylhydrolase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
D.G. TEW ET AL.: "Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins", ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol. 16, no. 4, April 1996 (1996-04-01), US, pages 591 - 599, XP000197167 *

Also Published As

Publication number Publication date
EP0859834A2 (en) 1998-08-26
WO1997012963A2 (en) 1997-04-10
AU7216996A (en) 1997-04-28
JP2002515728A (en) 2002-05-28
CA2233300A1 (en) 1997-04-10

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