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WO1997005267A3 - Mucosal delivery of polynucleotides - Google Patents

Mucosal delivery of polynucleotides Download PDF

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Publication number
WO1997005267A3
WO1997005267A3 PCT/US1996/012041 US9612041W WO9705267A3 WO 1997005267 A3 WO1997005267 A3 WO 1997005267A3 US 9612041 W US9612041 W US 9612041W WO 9705267 A3 WO9705267 A3 WO 9705267A3
Authority
WO
WIPO (PCT)
Prior art keywords
polynucleotide
animal
binding protein
polynucleotides
mucosal delivery
Prior art date
Application number
PCT/US1996/012041
Other languages
French (fr)
Other versions
WO1997005267A2 (en
Inventor
Dannie H King
Original Assignee
Maxim Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxim Pharmaceuticals filed Critical Maxim Pharmaceuticals
Priority to EP96924664A priority Critical patent/EP0840796A2/en
Priority to AU65057/96A priority patent/AU6505796A/en
Priority to CA002227871A priority patent/CA2227871A1/en
Priority to JP9507664A priority patent/JPH11510164A/en
Publication of WO1997005267A2 publication Critical patent/WO1997005267A2/en
Publication of WO1997005267A3 publication Critical patent/WO1997005267A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/118—Chlamydiaceae, e.g. Chlamydia trachomatis or Chlamydia psittaci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A composition for delivery of a polynucleotide to mucosal, neural, or other cells, comprising a GN1-binding protein and a polynucleotide in association with the binding protein; and a method for modulating immunity comprising administering the composition to an animal and expressing the polynucleotide whereby the animal generates an immune response to the product of the polynucleotide; and a method for gene therapy comprising administering to an animal a GM1-binding protein and a functional polynucleotide and expressing the polynucleotide in the animal whereby the function of the polynucleotide confers on the animal a therapeutic effect.
PCT/US1996/012041 1995-07-26 1996-07-19 Mucosal delivery of polynucleotides WO1997005267A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP96924664A EP0840796A2 (en) 1995-07-26 1996-07-19 Mucosal delivery of polynucleotides
AU65057/96A AU6505796A (en) 1995-07-26 1996-07-19 Mucosal delivery of polynucleotides
CA002227871A CA2227871A1 (en) 1995-07-26 1996-07-19 Mucosal delivery of polynucleotides
JP9507664A JPH11510164A (en) 1995-07-26 1996-07-19 Mucosal delivery of polynucleotides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US152795P 1995-07-26 1995-07-26
US60/001,527 1995-07-26

Publications (2)

Publication Number Publication Date
WO1997005267A2 WO1997005267A2 (en) 1997-02-13
WO1997005267A3 true WO1997005267A3 (en) 1997-04-24

Family

ID=21696500

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/012041 WO1997005267A2 (en) 1995-07-26 1996-07-19 Mucosal delivery of polynucleotides

Country Status (5)

Country Link
EP (1) EP0840796A2 (en)
JP (1) JPH11510164A (en)
AU (1) AU6505796A (en)
CA (1) CA2227871A1 (en)
WO (1) WO1997005267A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001527536A (en) * 1997-03-12 2001-12-25 ハイブライドン，インク． Down-regulation of gene expression by colorectal administration of synthetic oligonucleotides
GB9713122D0 (en) * 1997-06-20 1997-08-27 Chiron Spa Novel method of DNA transfer into cells
CA2344740C (en) * 1998-09-30 2011-11-22 American Cyanamid Company Mutant cholera holotoxin as an adjuvant
US7384640B1 (en) 1999-09-30 2008-06-10 Wyeth Holdings Corporation Mutant cholera holotoxin as an adjuvant
US7041296B1 (en) * 1999-11-12 2006-05-09 The United States Of America As Represented By The Department Of Health And Human Services Methods of treating inflammatory bowel disease using cholera toxin B subunit
DE60234695D1 (en) 2001-06-07 2010-01-21 Univ Colorado MUTANT TONS OF CHOLERA HOLOTOXIN AS ADJUVANS
BR0210216A (en) 2001-06-07 2004-06-08 Wyeth Corp Immunogenic cholera holotoxin, mutant (ct-crm), immunogenic composition, methods to increase the immune response of a vertebrate host to an antigen, and to produce an immunogenic, mutant cholera holotoxin, isolated and purified nucleic acid molecule, sequence host cell, and use of a mutant cholera holotoxin
CA2479212A1 (en) * 2002-03-15 2003-09-25 Brigham And Women's Hospital, Inc. Central airway administration for systemic delivery of therapeutics
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
US8680020B2 (en) 2008-07-15 2014-03-25 Academia Sinica Glycan arrays on PTFE-like aluminum coated glass slides and related methods
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
EP2885311B1 (en) 2012-08-18 2020-01-01 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
US10086054B2 (en) 2013-06-26 2018-10-02 Academia Sinica RM2 antigens and use thereof
US9981030B2 (en) 2013-06-27 2018-05-29 Academia Sinica Glycan conjugates and use thereof
CA2923579C (en) 2013-09-06 2023-09-05 Academia Sinica Human inkt cell activation using glycolipids with altered glycosyl groups
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
EP3094352B1 (en) 2014-01-16 2020-09-23 Academia Sinica Compositions and methods for treatment and detection of cancers
TWI797430B (en) 2014-03-27 2023-04-01 中央研究院 Reactive labelling compounds and uses thereof
AU2015267047A1 (en) 2014-05-27 2017-01-05 Academia Sinica Anti-CD20 glycoantibodies and uses thereof
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
EP4116329A1 (en) 2014-05-27 2023-01-11 Academia Sinica Anti-her2 glycoantibodies and uses thereof
KR20170005142A (en) 2014-05-27 2017-01-11 아카데미아 시니카 Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
CN106714829A (en) 2014-05-28 2017-05-24 中央研究院 anti-TNF-alpha carbohydrate antibodies and uses thereof
US9879042B2 (en) 2014-09-08 2018-01-30 Academia Sinica Human iNKT cell activation using glycolipids
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
TWI736523B (en) 2015-01-24 2021-08-21 中央研究院 Novel glycan conjugates and methods of use thereof
KR20180114210A (en) 2016-03-08 2018-10-17 아카데미아 시니카 Method for synthesizing N-glycan and its array
WO2018039274A1 (en) 2016-08-22 2018-03-01 CHO Pharma Inc. Antibodies, binding fragments, and methods of use

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986006635A1 (en) * 1985-05-15 1986-11-20 Biotechnology Australia Pty. Ltd. Oral vaccines
JPS63258493A (en) * 1987-04-15 1988-10-25 Mitsui Toatsu Chem Inc Anti-ganglioside GM↓1 monoclonal antibody, cells producing it, and reagents comprising the same
EP0372928A2 (en) * 1988-12-07 1990-06-13 University Of Leicester Heat-labile toxin B subunit fusion proteins
EP0418626A2 (en) * 1989-09-08 1991-03-27 Takeda Chemical Industries, Ltd. Fused proteins and production thereof
WO1991007979A1 (en) * 1989-11-29 1991-06-13 Center For Innovative Technology Chimeric proteins
WO1993019183A1 (en) * 1992-03-23 1993-09-30 University Of Massachusetts Medical Center Immunization by inoculatioon of dna transcription unit
WO1994009823A1 (en) * 1992-11-03 1994-05-11 Oravax, Inc. Urease-based vaccine against helicobacter infection
WO1994023752A1 (en) * 1993-04-16 1994-10-27 University Of Portsmouth Enterprise Limited Drug delivery system
WO1995010301A1 (en) * 1993-10-08 1995-04-20 Duotol Ab Immunological tolerance-inducing agent
US5433946A (en) * 1991-10-11 1995-07-18 Health Research Inc. Synthesis and utilization of therapeutic agents for the treatment of lysosomal storage diseases

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986006635A1 (en) * 1985-05-15 1986-11-20 Biotechnology Australia Pty. Ltd. Oral vaccines
JPS63258493A (en) * 1987-04-15 1988-10-25 Mitsui Toatsu Chem Inc Anti-ganglioside GM↓1 monoclonal antibody, cells producing it, and reagents comprising the same
EP0372928A2 (en) * 1988-12-07 1990-06-13 University Of Leicester Heat-labile toxin B subunit fusion proteins
EP0418626A2 (en) * 1989-09-08 1991-03-27 Takeda Chemical Industries, Ltd. Fused proteins and production thereof
WO1991007979A1 (en) * 1989-11-29 1991-06-13 Center For Innovative Technology Chimeric proteins
US5433946A (en) * 1991-10-11 1995-07-18 Health Research Inc. Synthesis and utilization of therapeutic agents for the treatment of lysosomal storage diseases
WO1993019183A1 (en) * 1992-03-23 1993-09-30 University Of Massachusetts Medical Center Immunization by inoculatioon of dna transcription unit
WO1994009823A1 (en) * 1992-11-03 1994-05-11 Oravax, Inc. Urease-based vaccine against helicobacter infection
WO1994023752A1 (en) * 1993-04-16 1994-10-27 University Of Portsmouth Enterprise Limited Drug delivery system
WO1995010301A1 (en) * 1993-10-08 1995-04-20 Duotol Ab Immunological tolerance-inducing agent

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DATABASE MEDLINE XP002027270 *
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LYCKE ETAL.: "The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity", EUR. J. IMMUNOL., vol. 22, no. 9, September 1992 (1992-09-01), pages 2277 - 2281, XP002058448, DOI: doi:10.1002/eji.1830220915 *
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Also Published As

Publication number Publication date
EP0840796A2 (en) 1998-05-13
CA2227871A1 (en) 1997-02-13
JPH11510164A (en) 1999-09-07
WO1997005267A2 (en) 1997-02-13
AU6505796A (en) 1997-02-26

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