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WO1997045841A1 - Dispositif de production de radionucleides steriles - Google Patents

Dispositif de production de radionucleides steriles Download PDF

Info

Publication number
WO1997045841A1
WO1997045841A1 PCT/RU1996/000137 RU9600137W WO9745841A1 WO 1997045841 A1 WO1997045841 A1 WO 1997045841A1 RU 9600137 W RU9600137 W RU 9600137W WO 9745841 A1 WO9745841 A1 WO 9745841A1
Authority
WO
WIPO (PCT)
Prior art keywords
elyuaτa
κοlοnκοy
iglοy
needle
eluate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU1996/000137
Other languages
English (en)
Russian (ru)
Inventor
Vasily Vladimirovich Basmanov
Nikolai Nikolaevich Khaveev
Roman Vladimirovich Judintsev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GOSUDARSTVENNY NAUCHNY TSENTR FIZIKO-ENERGETICHESKY INSTITUT
Original Assignee
GOSUDARSTVENNY NAUCHNY TSENTR FIZIKO-ENERGETICHESKY INSTITUT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GOSUDARSTVENNY NAUCHNY TSENTR FIZIKO-ENERGETICHESKY INSTITUT filed Critical GOSUDARSTVENNY NAUCHNY TSENTR FIZIKO-ENERGETICHESKY INSTITUT
Priority to PCT/RU1996/000137 priority Critical patent/WO1997045841A1/fr
Publication of WO1997045841A1 publication Critical patent/WO1997045841A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems

Definitions

  • the invention relates to the production of generators of radioactive elements used for the manufacture of radionuclides for medicine and technology.
  • the receiver has a radioactive element, for example, molybdenum-99, from the disassembled process, the disassembled E ⁇ ⁇ zhivuschy ⁇ adi ⁇ nu ⁇ lid izvle ⁇ ae ⁇ sya of ⁇ l ⁇ n- ⁇ i ⁇ u ⁇ em ⁇ ach ⁇ i che ⁇ ez sis ⁇ emu ⁇ ub ⁇ v ⁇ d elyuen ⁇ a - ⁇ l ⁇ n ⁇ a - ⁇ ub ⁇ v ⁇ d elyua ⁇ a s ⁇ ve ⁇ s ⁇ vuyuscheg ⁇ ⁇ as ⁇ v ⁇ a, na ⁇ ime ⁇ , iz ⁇ niches ⁇ g ⁇ ⁇ as ⁇ v ⁇ a ⁇ l ⁇ ida na ⁇ iya if gene ⁇ a ⁇ a ⁇ e ⁇ netsiya-99m.
  • the lack of access to the product from a medical device is a failure of the
  • the closest technical solution is the generatrix for receiving stable radionuclides [2], which saves the general cost-effectiveness and is fully protected.
  • the outer core of the pipe is connected to the vertical needle, the second secured second socket of the flange of the generator (pipe of the eluent).
  • a second vertical needle is installed, connected to the tube with an airborne bactericidal filter.
  • the authors recommend the installation of the circuit between the filter and the circuit breaker. With this switch, place the flange on the device and
  • LIS ⁇ ⁇ ⁇ ( ⁇ 26) supply an additional pipe with a needle secured in the automatic socket of the flange of the device. and plug the needle with a removable hermetic plug. Filter the eluate to mix together with the circle in the vertical socket of the radiation protection and forget to turn off the general protection of the receiver.
  • a basic hydraulic circuit is provided for the manufacture of a stable radionuclide, where 1 is a bit, and there is a little impairment.
  • ⁇ a ⁇ ub ⁇ v ⁇ de 3 ⁇ azmeschen ⁇ e ⁇ e ⁇ lyucha ⁇ el ⁇ a ⁇ e ⁇ n ⁇ l ⁇ giches ⁇ i ⁇ ⁇ eagen ⁇ v 4, and 5 ⁇ ub ⁇ v ⁇ de ⁇ azmeschen ⁇ il ⁇ 6 za ⁇ anchivayuschiysya igl ⁇ y 7 za ⁇ e ⁇ - lenn ⁇ y in ⁇ lantse 8.
  • ⁇ an 4 is provided ⁇ ub ⁇ v ⁇ d ⁇ m 9 ⁇ a ⁇ e ⁇ n ⁇ l ⁇ giches ⁇ i ⁇ ⁇ eagen ⁇ v, ⁇ y za ⁇ anchivae ⁇ sya 10.
  • a vertical device has been provided for use in order to obtain a stable radionuclide, where 23 is a device device; 24-socket flange device; 25 - Handle of control of enclosure 4 (optional additional radioactive protection); 26 - a vertical nest of radiation protection.
  • a diagram of the placement of needles on the flange of the device and the knobs of the operation of the switch is provided for a .5.
  • the device for receiving stable radionuclides is operated by the following process. At first, after discharging the device under stable conditions, it will discharge the charge of a 1 radionuclide player.
  • a consequence of this process may be that the device can be manufactured by the manufacturer in a wide range of times.
  • the content of impurities in the eluate increases with an increase in the load of the disease and at a lower rate of time.
  • the device In order to maintain the quality of the eluate in accordance with the described requirements, the device must be used with this device
  • the operating mode of the device is not subject to a change in the user.
  • the device is prepared for transport.
  • switch 4 is located in the "3/1 ⁇ " position, or "2 ⁇ ".
  • the needle 10 or the needle 7 is used in the process.
  • the needle that is used in the selected operating mode is muffled by the manufacturer's unused hermetic plug.
  • the operation of the generator has been described in the most difficult mode. For example.
  • ⁇ a needles 12 and 15 us ⁇ anavlivayu ⁇ ⁇ la ⁇ n elyuen ⁇ m 22 and the needle 7 us ⁇ anavlivayu ⁇ va ⁇ uumi ⁇ vanny 21.
  • ⁇ la ⁇ n on account ⁇ azn ⁇ s ⁇ i a ⁇ m ⁇ s ⁇ e ⁇ - pressure n ⁇ g ⁇ and va ⁇ uuma zhid ⁇ s ⁇ of ⁇ la ⁇ na 22 zasasyvae ⁇ sya che ⁇ ez needle 12 and ⁇ ⁇ ub ⁇ v ⁇ du January 1 ⁇ s ⁇ u ⁇ ae ⁇ in ⁇ l ⁇ n ⁇ u 1.
  • the use of the device will result in the failure of the process to operate the device in the event of a failure to operate.
  • Patent DG ⁇ 209171. ⁇ ⁇ 01 ⁇ 57/00. C21C 4/08. Generator for radiations for the receipt of a pure technology-99t. Publ. 04/25/84.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne un dispositif permettant de produire des radionucléides stériles, lequel comprend les éléments suivants: une colonne qui contient un sorbant ainsi qu'un radionucléide (1), et qui est entourée d'un protection (2) contre les rayonnements; un filtre (6) pour éluat qui est connecté à la colonne (1) par un conduit d'éluat (3); un conduit d'éluant (11) qui est connecté à la colonne (1) et à une aiguille (12) fixée dans un renfoncement du collet (8) du dispositif; un filtre bactéricide (13) comprenant un conduit (14) et une aiguille (15); et enfin, un conduit pour éluat (3) qui est connecté à la colonne (1) et à une aiguille (7) fixée dans un renfoncement du collet (8) du dispositif. Ce dispositif se caractérise par l'utilisation d'un commutateur à trois voies (4) qui est monté sur le conduit pour éluat (3) entre la colonne (1) et le filtre pour éluat (6). Ce dispositif comprend également un conduit additionnel (9) comprenant une aiguille complémentaire (10) qui est fixée dans un renfoncement distinct du collet (8) du dispositif, et qui est recouverte d'un capuchon hermétique et amovible (16). Le filtre pour éluat (6), qui est disposé avec la colonne (1) dans un renfoncement vertical de protection contre les radiations (26), est recouvert au niveau de son extrémité par un bouchon principal de protection contre les radiations (25).
PCT/RU1996/000137 1996-05-29 1996-05-29 Dispositif de production de radionucleides steriles Ceased WO1997045841A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/RU1996/000137 WO1997045841A1 (fr) 1996-05-29 1996-05-29 Dispositif de production de radionucleides steriles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU1996/000137 WO1997045841A1 (fr) 1996-05-29 1996-05-29 Dispositif de production de radionucleides steriles

Publications (1)

Publication Number Publication Date
WO1997045841A1 true WO1997045841A1 (fr) 1997-12-04

Family

ID=20130001

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU1996/000137 Ceased WO1997045841A1 (fr) 1996-05-29 1996-05-29 Dispositif de production de radionucleides steriles

Country Status (1)

Country Link
WO (1) WO1997045841A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000033322A1 (fr) * 1998-12-02 2000-06-08 Cedars-Sinai Medical Center Systeme et procede pour l'elusion et la concentration automatique d'un radio-isotope
GB2386743A (en) * 2002-04-11 2003-09-24 Amersham Plc Radioisotope generator
EP2011126A4 (fr) * 2006-01-12 2010-03-03 Draximage General Partership Systèmes et procédés pour la génération de radio-isotopes

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU479307A3 (ru) * 1972-07-26 1975-07-30 Хехст Аг (Фирма) Устройство дл получени дочерних радиоактивных веществ
WO1980002082A1 (fr) * 1979-03-26 1980-10-02 Byk Mallinckrodt Cil Bv Generateur de radio-isotopes
SU1702436A1 (ru) * 1984-05-18 1991-12-30 Институт Ядерных Исследований (Инопредприятие) Элюционный генератор технеци -99м и способ его изготовлени
WO1992007365A1 (fr) * 1990-10-12 1992-04-30 E.I. Du Pont De Nemours And Company Generateur de radionuclide sterilisable et procede de sterilisation dudit generateur

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU479307A3 (ru) * 1972-07-26 1975-07-30 Хехст Аг (Фирма) Устройство дл получени дочерних радиоактивных веществ
DE2236565B2 (de) * 1972-07-26 1978-09-07 Hoechst Ag, 6000 Frankfurt Vorrichtung zum Herstellen von sterilen, injizierbaren Eluaten durch Eluieren von Nuklidgeneratoren
WO1980002082A1 (fr) * 1979-03-26 1980-10-02 Byk Mallinckrodt Cil Bv Generateur de radio-isotopes
SU1702436A1 (ru) * 1984-05-18 1991-12-30 Институт Ядерных Исследований (Инопредприятие) Элюционный генератор технеци -99м и способ его изготовлени
WO1992007365A1 (fr) * 1990-10-12 1992-04-30 E.I. Du Pont De Nemours And Company Generateur de radionuclide sterilisable et procede de sterilisation dudit generateur

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000033322A1 (fr) * 1998-12-02 2000-06-08 Cedars-Sinai Medical Center Systeme et procede pour l'elusion et la concentration automatique d'un radio-isotope
GB2386743A (en) * 2002-04-11 2003-09-24 Amersham Plc Radioisotope generator
GB2386743B (en) * 2002-04-11 2004-02-11 Amersham Plc Radioisotope generator
US7091494B2 (en) 2002-04-11 2006-08-15 Ge Healthcare Ltd. Radioisotope generator
EP2011126A4 (fr) * 2006-01-12 2010-03-03 Draximage General Partership Systèmes et procédés pour la génération de radio-isotopes
EP2492920A3 (fr) * 2006-01-12 2012-12-12 DRAXIMAGE General Partnership Systèmes et procédés pour la génération de radio-isotopes

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