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WO1997042816A1 - Lutte contre les ectoparasites - Google Patents

Lutte contre les ectoparasites Download PDF

Info

Publication number
WO1997042816A1
WO1997042816A1 PCT/IE1997/000038 IE9700038W WO9742816A1 WO 1997042816 A1 WO1997042816 A1 WO 1997042816A1 IE 9700038 W IE9700038 W IE 9700038W WO 9742816 A1 WO9742816 A1 WO 9742816A1
Authority
WO
WIPO (PCT)
Prior art keywords
concentrate
wetting solution
amount
present
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IE1997/000038
Other languages
English (en)
Inventor
Noreen Hanna
Vincent Mcnally
James Patrick Morgan
Kolazi S. Narayanan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zoetis Broomhill IP Ltd
ISP Investments LLC
Original Assignee
Bimeda Research and Development Ltd
ISP Investments LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bimeda Research and Development Ltd, ISP Investments LLC filed Critical Bimeda Research and Development Ltd
Priority to AU31869/97A priority Critical patent/AU718950B2/en
Priority to EP97927341A priority patent/EP0901321A1/fr
Priority to NZ332213A priority patent/NZ332213A/xx
Priority to GB9821315A priority patent/GB2326341B/en
Publication of WO1997042816A1 publication Critical patent/WO1997042816A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents

Definitions

  • the invention relates to the control of ectoparasites in animals and in particular to the prevention and control of blowfly strike and/or for the treatment and control of lice, keds and ticks and/or for the treatment and control of scab in animals, especially sheep.
  • insecticides for controlling ectoparasites in animals are formulated as emulsifiable concentrates.
  • emulsifiable concentrates On dispersion of such concentrates in water generally particles in the micron size range are produced. This particle size range adversely effects the spread of the insecticide on the animal.
  • known emulsifiable concentrates are generally formulated using hydrocarbon solvents which in some cases are not environmentally friendly.
  • This invention is therefore directed towards providing an improved method for preventing and controlling ectoparasites in animals and to an animal wetting solution used in the method which will overcome at least some of these difficulties.
  • the invention provides a method for preventing and controlling ectoparasites in animals by (a) diluting an aqueous emulsion concentrate containing 25 to 250 g/litre of a substantially water insoluble insecticide in a concentrate delivery system containing a surfactant system, and an co-solvent mixture of a N-Ci to C 4 alkyl pyrrolidone and a N-C 6 to C 14 alkyl pyrrolidone to form a homogenous, aqueous animal wetting solution containing from 25 to 500 mg/litre of the insecticide; and (b) wetting the animal with an effective insecticidal amount of said solution.
  • the emulsion concentrate is a macroemulsion, hydrogel concentrate or, most preferably an aqueous microemulsion concentrate.
  • the ectoparasites may be blowfly, lice, keds, ticks and/or scab.
  • the animals are sheep.
  • the animals are hooved animals such as cattle, goats, deer, horses or camels.
  • the animals may also be domesticated pets such as dogs and cats.
  • domesticated pets the concentrate may be formulated as in a standard pet shampoo formulation.
  • the animals may be feathered animals, especially poultry.
  • the insecticide is a pyrethroid insecticide, especially cypermethrin.
  • the concentrate contains from 50 to 150, especially approximately 100 g/1 of the insecticide.
  • the wetting solution contains from 80 to 120, especially approximately 100 mg/litre of insecticide. This concentration is particularly advantageous for preventing and controlling blowfly strike and/or for the treatment and control of lice, keds and ticks especially in sheep.
  • the wetting solution may contain from 180 to 220, especially approximately 200 mg/litre of insecticide. This concentration is particularly advantageous for the treatment and/or control of scab, especially in sheep.
  • the animals are wetted by plunge dipping animals in the wetting solution.
  • the method preferably includes the step after dipping a number of animals, of topping up the dipping solution with a solution formed by diluting the concentrate at a dilution ratio of from 1:250 to 1:1000, preferably 1:500.
  • the invention provides a method for preventing and controlling blowfly strike and/or for the treatment and control of lice, keds and ticks in sheep by diluting an aqueous microemulsion concentrate containing approximately 100 g/litre of cypermethrin to form a homogenous aqueous sheep dipping solution containing approximately 100 mg/litre of cypermethrin, and plunge dipping sheep in the dipping solution.
  • the invention provides a method for the treatment and/or control of scab in sheep by diluting an aqueous microemulsion concentrate containing approximately 100 g/litre of cypermethrin to form a homogenous aqueous sheep dipping solution containing approximately 200 mg/litre of cypermethrin, and plunge dipping sheep in the dipping solution.
  • the invention provides an animal wetting solution containing from 0.25 ppm to 50 ppm insecticide per kg body weight, derived from an ectoparasiticidal concentrate containing:
  • the ectoparasiticidal concentrate is a microemulsion concentrate.
  • the N-C; to Ct, alkyl pyrrolidone is preferably present in the concentrate in an amount of from 3 to 30, preferably 18 to 22 and ideally approximately 20 wt%.
  • the N-C ! to C 4 alkyl pyrrolidone is N-methyl-2-pyrrolidone.
  • one of the N- C 6 to C 14 alkyl pyrrolidone is present in the concentrate in an amount of from 2 to 15, preferably 8 to 10 and ideally approximately 9 wt% .
  • the N-C 6 to C 14 alkyl pyrrolidone is N-octyl-2-pyrrolidone.
  • the surfactant system is a mixture of surfactants.
  • the surfactant system includes an alkoxylated alkyl phenol which is preferably present in the concentrate in an amount of from 50 to 54, ideally approximately 52 wt%.
  • the alkoxylated alkyl phenol is ethoxylated nonyl phenol .
  • the surfactant system includes a non-ionic surfactant which is preferably present in the concentrate in an amount of from 5 to 80, preferably 8 to 10 and ideally approximately 9 wt%.
  • the non ionic surfactant is a difunctional block copolymer terminating in primary hydroxyl groups .
  • the concentrate includes a buffer.
  • the buffer is selected from one or more of a phosphated alkoxylated alkylphenol, a hydrophobic acid, or a hydrophobic base.
  • the buffer is present in the concentrate in an amount of from 0.025 to 2 wt%, preferably 0.5 to 1.5 wt%, and ideally approximately 1 wt% .
  • the buffer is preferably present in an amount to achieve a pH of from 3 to 6.5, preferably 3.5 to 5.5, and ideally approximately 4.
  • the buffer may be a phosphated ethoxylated nonylphenol .
  • the buffer is preferably present in an amount to achieve a pH of from 8 to 9.
  • the animal wetting solution may be in the form of an animal dipping solution, an animal pour-on solution, or in the form of a standard pet shampoo formulation.
  • the invention also provides an ectoparasiticidal concentrate for use in forming an animal wetting solution of the invention.
  • compositions of the present invention have numerous advantages including at least one of:-
  • N-Cj to C 4 pyrrolidones have coating and insecticide complexing properties.
  • N-C 6 to C 18 alkyl pyrrolidones have lanolin wetting and spreading properties and are capable of forming micelles when used in the present emulsion concentrates with the ethoxylated nonylphenol detergent and the ethylene oxide-propylene oxide-ethylene oxide block copolymer.
  • the formulation given in the Example includes the following branded chemicals:
  • Pluronic L31 (Trade Mark of BASF) is a difunctional block copolymer terminating in primary hydroxyl groups . It is a non-ionic surfactant.
  • IGEPAL CO-630 (Trade mark of Rhone Poulenc) is an ethoxylated nonylphenol detergent and acts as an emulsifier.
  • Rhodofac RE-610 (Trade Mark of Rhone Poulenc) is a phosphated ethoxylated nonylphenol buffer/emulsifier.
  • N-methyl-2-pyrrolidone used was AGSOL Exl available from ISP Europe.
  • N-octyl-2-pyrrolidone used was AGSOL Ex8 available from ISP Europe.
  • a microemulsion concentrate was prepared as follows.
  • the N-methyl 2-pyrrolidone is placed in a batch mixing vessel having a volume of 1200 litres and fitted with a propeller mixer.
  • the N-octyl-2-pyrrolidone is then added to the batch vessel and the contents are mixed.
  • the Igepal CO-630TM is then added to the vessel and mixing is continued.
  • Pluronic-LSlTM is added to the vessel with continuing mixing.
  • Rhodafac RE 610TM is then added and mixing is continued for 30 minutes.
  • Cypermethrin is prepared by liquifying at a temperature of from 37°C to 40°C. The liquified cypermethrin is added to the vessel and mixing is continued for 60 minutes.
  • the pale yellow liquid thus formed is poured into multi- layered plastics containers having an internal polyamide layer.
  • the containers are of 1 litre, 2 litre and 5 litre capacity.
  • N-methyl-2-pyrrolidone and N-octyl-2- pyrrolidone facilitate dissolution.
  • the two surfactants, Igepal 00-630TM and Pluronic-L31TM form micelles when the microemulsion concentrate is added to water. These micelles provide a means of incorporating the active into an aqueous vehicle at a concentration greater than the solubility of the active.
  • Rhodafac RE 610TM acts as a buffer.
  • Cypermethrin normally has a solubility of from 0.01 to 0.2 mg/1 at 20°C.
  • microemulsion concentrate of the invention Using the microemulsion concentrate of the invention, however, a solubility of greater than 100 mg/1 can be achieved.
  • the microemulsion concentrate has the following analysis:
  • Rhodafac RE 610TM 1.0% w/w
  • the microemulsion concentrate is used as follows. A dip bath was filled with the required quantity (typically 1000 litres) of clean water. A measured volume of the microemulsion concentrate is poured into the water at a rate of 10 ml of microemulsion concentrate per 10 litres of water to achieve the desired strength of 100 mg/1. After thorough stirring, sheep are immersed in the bath until the fleece is completely saturated with the dip wash. The sheep's head is plunged under at least twice.
  • the volume of dip in the bath may be replenished at a rate of 10 ml per 5 litres of added water.
  • the overall percentage strike rate was as follows:
  • the trial showed that the product is effective for 4-7 weeks in preventing the development of Blowfly myiasis of sheep.
  • untreated controls maintained moderate/high burdens of lice and keds for the trial duration.
  • the buffer may be selected from a hydrophobic acid or base alternatives such as nonylphenol phosphoric acid, tristearyl phenyl ethoxylated phosphonic acid and dodecylbenzene sulfonic acid.
  • the insecticide matrix may require buffering to a pH of 3 to 6.5, preferably 3.5 to 5.5 or as close to pH 4 as convenient for acid stable insecticides and as close to pH 8 to 9 for base stable insecticides.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

On peut éliminer les ectoparasites tels que les mouches à viande, les poux, les insectes responsables de la mélophagose, les tiques et les acariens responsables de la galle, chez les animaux tels que le mouton, en diluant un concentré en émulsion aqueuse d'un insecticide essentiellement insoluble dans l'eau dans un système d'apport, afin de former une solution homogène aqueuse impregnant l'animal, qui contient de 25 à 500 mg/litre d'un insecticide, et en impregnant l'animal avec une quantité d'insecticide efficace de cette solution. Le système d'apport du concentré contient un système de tensioactif et un mélange co-solvant d'une pyrrolidone alkyle N-C1 à C4 et d'une pyrrolidone alkyle N-C6 à C14. Cet insecticide peut être un insecticide au pyréthroïde, tel que la cyperméthrine.
PCT/IE1997/000038 1996-05-15 1997-05-14 Lutte contre les ectoparasites Ceased WO1997042816A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU31869/97A AU718950B2 (en) 1996-05-15 1997-05-14 Control of ectoparasites
EP97927341A EP0901321A1 (fr) 1996-05-15 1997-05-14 Lutte contre les ectoparasites
NZ332213A NZ332213A (en) 1996-05-15 1997-05-14 Control of ectoparasites with an aqueous solution of a pyrethroid (cypermethrin) an alkyl pyrrolidone and a surfactant used as an animal wetting solution to control blowfly ticks and scab
GB9821315A GB2326341B (en) 1996-05-15 1997-05-14 Control of ectoparasites

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IE960347A IE960347A1 (en) 1996-05-15 1996-05-15 Control of ectoparasites
IE960347 1996-05-15

Publications (1)

Publication Number Publication Date
WO1997042816A1 true WO1997042816A1 (fr) 1997-11-20

Family

ID=11041162

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IE1997/000038 Ceased WO1997042816A1 (fr) 1996-05-15 1997-05-14 Lutte contre les ectoparasites

Country Status (8)

Country Link
EP (1) EP0901321A1 (fr)
AR (1) AR007143A1 (fr)
AU (1) AU718950B2 (fr)
GB (1) GB2326341B (fr)
IE (1) IE960347A1 (fr)
NZ (1) NZ332213A (fr)
WO (1) WO1997042816A1 (fr)
ZA (1) ZA974164B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007143298A3 (fr) * 2006-04-28 2009-04-30 Summit Vetpharm Llc Insecticides topiques à concentration élevée contenant des pyréthroïdes
EP1432315A4 (fr) * 2001-09-06 2009-07-15 Isp Investments Inc Preparation medicamenteuse stable pour le soin des animaux
US8178116B2 (en) 2002-04-29 2012-05-15 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation
AU2012203409B2 (en) * 2006-04-28 2012-09-06 Ceva Animal Health, Llc High concentration topical insecticides containing pyrethroids

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8752734B2 (en) 2009-02-11 2014-06-17 Ds Smith Plastics Limited Disposable assembly for a reusable urn or vessel
US10112820B1 (en) 2016-01-19 2018-10-30 Dss Rapak, Inc. Beverage dispensing system with disposable liner and faucet

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0388122A1 (fr) * 1989-03-13 1990-09-19 Scientific Chemicals (Proprietary) Limited Formulation pesticide
WO1991008665A1 (fr) * 1989-12-11 1991-06-27 Isp Investments Inc. Systeme de distribution pour produits chimiques destines a l'agriculture
WO1992013454A1 (fr) * 1991-02-12 1992-08-20 Isp Investments Inc. Stabilisation de microemulsions en utilisant des tampons d'acide hydrophobe
WO1993000809A1 (fr) * 1991-07-05 1993-01-21 Isp Investments Inc. Systeme de distribution de produits chimiques pour l'agriculture

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0388122A1 (fr) * 1989-03-13 1990-09-19 Scientific Chemicals (Proprietary) Limited Formulation pesticide
WO1991008665A1 (fr) * 1989-12-11 1991-06-27 Isp Investments Inc. Systeme de distribution pour produits chimiques destines a l'agriculture
WO1992013454A1 (fr) * 1991-02-12 1992-08-20 Isp Investments Inc. Stabilisation de microemulsions en utilisant des tampons d'acide hydrophobe
WO1993000809A1 (fr) * 1991-07-05 1993-01-21 Isp Investments Inc. Systeme de distribution de produits chimiques pour l'agriculture

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1432315A4 (fr) * 2001-09-06 2009-07-15 Isp Investments Inc Preparation medicamenteuse stable pour le soin des animaux
US8178116B2 (en) 2002-04-29 2012-05-15 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation
US8815270B2 (en) 2002-04-29 2014-08-26 Piedmont Pharmaceuticals, Llc Methods and compositions for treating ectoparasite infestation
WO2007143298A3 (fr) * 2006-04-28 2009-04-30 Summit Vetpharm Llc Insecticides topiques à concentration élevée contenant des pyréthroïdes
AU2007257076B2 (en) * 2006-04-28 2012-04-12 Ceva Animal Health, Llc High concentration topical insecticides containing pyrethroids
AU2012203409B2 (en) * 2006-04-28 2012-09-06 Ceva Animal Health, Llc High concentration topical insecticides containing pyrethroids
EP2015636A4 (fr) * 2006-04-28 2013-04-10 Summit Vetpharm Llc Insecticides topiques à concentration élevée contenant des pyréthroïdes

Also Published As

Publication number Publication date
NZ332213A (en) 2000-04-28
GB9821315D0 (en) 1998-11-25
EP0901321A1 (fr) 1999-03-17
GB2326341A (en) 1998-12-23
ZA974164B (en) 1998-05-14
AU3186997A (en) 1997-12-05
AR007143A1 (es) 1999-10-13
AU718950B2 (en) 2000-05-04
IE960347A1 (en) 1997-11-19
GB2326341B (en) 2000-04-12

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