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WO1996023428A1 - Gant multicouche antimicrobien et antiviral - Google Patents

Gant multicouche antimicrobien et antiviral Download PDF

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Publication number
WO1996023428A1
WO1996023428A1 PCT/US1996/001387 US9601387W WO9623428A1 WO 1996023428 A1 WO1996023428 A1 WO 1996023428A1 US 9601387 W US9601387 W US 9601387W WO 9623428 A1 WO9623428 A1 WO 9623428A1
Authority
WO
WIPO (PCT)
Prior art keywords
glove
coating
latex
antimicrobial
fluoroelastomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1996/001387
Other languages
English (en)
Inventor
Sebastian S. Plamthottam
Bessie E. Callos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc filed Critical Baxter International Inc
Publication of WO1996023428A1 publication Critical patent/WO1996023428A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D19/00—Gloves
    • A41D19/0055—Plastic or rubber gloves
    • A41D19/0058—Three-dimensional gloves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B42/00—Surgical gloves; Finger-stalls specially adapted for surgery; Devices for handling or treatment thereof
    • A61B42/10—Surgical gloves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B25/00—Layered products comprising a layer of natural or synthetic rubber
    • B32B25/04—Layered products comprising a layer of natural or synthetic rubber comprising rubber as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B25/08—Layered products comprising a layer of natural or synthetic rubber comprising rubber as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B42/00—Surgical gloves; Finger-stalls specially adapted for surgery; Devices for handling or treatment thereof

Definitions

  • This invention relates to a multiple layered glove having antimicrobial or antiviral properties. More particularly, the multiple layered glove has an outer coating of a fluoroelastomer and a inner hydrophilic coating containing a antimicrobial or antiviral agent.
  • the glove has an outer layer of a fluorocarbon resin or a plasticized polyester resin which is flexible, solvent and abrasion resistant, a pin-hole free aluminum-foil middle layer and a inner heat sealable thermoplastic polymer material of polyethylene or polypropylene resin.
  • U.S. Patent No. 4,943,473 discloses fire and chemical resistant materials that can be used for gloves. These materials are produced by laminating a fluoropolymer containing film onto one or both sides of a flexible substrate. These materials retain their flexibility or suppleness and show enhanced resistance to chemical permeation and degradation.
  • U.S. Patent No. 5,194,335 discloses a coating or casting composition comprising a fluoroplastic resin
  • U.S. Patent Nos. 3,286,011 and 3,411,982 disclose a process for making a glove having a slip dip rubber-resin coating on the inside or outside surface of the glove.
  • the slip dip rubber-resin coating comprises a rubber and resin latex.
  • the resins disclosed as being suitable for use in the invention are: acrylic-type polymers and copolymers, vinyl acetate polymers and copolymers, polyethylene, polyvinyl acetals, polyvinyl chloride or copolymers of vinyl chloride, styrene-acrylonitrile resins and high styrene-butadiene copolymer resins.
  • U.S. Patent No. 3,856,561 discloses a rubber article having a slip coating.
  • the slip coating is a vinyl- chloride-alkyl acrylate copolymer or a vinylidene chloride-alkyl acrylate copolymer.
  • the slip coating comprises a first resin copolymer component consisting of a vinyl chloride- alkyl acrylate copolymer, a vinylidene chloride-alkyl acrylate copolymer and a vinyl acetate-alkyl acrylate copolymer and a second resin copolymer consisting of a vinyl chloride-vinyl ester copolymer and a vinylidene chloride-vinyl ester copolymer.
  • U.S. Patent No. 3,967,014 discloses a method for providing an essentially rubber free slip coating on a rubber surface by contacting a rubber surface with the slip coating disclosed in U.S. Patent No.
  • U.S. Patent No. 4,082,862 discloses a process for producing rubber articles having a slip coating wherein a form is first coated with a release agent, then coated with a slip coating composition deposited on the release agent and a rubber substrate deposited over the slip coating.
  • the slip coating comprises of a non-elastomeric synthetic polymer component exhibiting an elongation of below about 20% and a coefficient of friction of up to about 0.20.
  • U.S. Patent 5,084,514 discloses a polymer latex for making gloves that has good donning and duffing characteristics.
  • the glove is a terpolymer of carboxylated butadiene/acrylonitrile and methacrylic acid.
  • hydrophilic coatings have been used to coat the inside surface of surgeon's gloves to facilitate donning.
  • Many hydrophilic monomers are known in the art such as hydroxy alkyl acrylates, hydroxy alkyl methacrylates, vinyl lactams (eg. vinyl pyrrolidone) , acrylamide and its derivatives, and ethylene oxide, just to name a few.
  • U.S. Patent No. 3,813,695 (the "Podell” patent) describes a surgeon's glove in which the glove material is formed of a laminate consisting of an outer layer of a flexible material and an inner layer of hydrophilic plastic material (such as a hydrogel polymer) , wherein the inner and outer layers are bonded together.
  • U.S. Patent No. 4,482,577 discloses a method of coating a vulcanized rubber article with a hydrophilic polymer. The process involves dipping the rubber glove into a high concentration (95-100%) of sulfuric acid, washing the glove and then immersing the glove in a hydrophilic polymer.
  • a surgeon's glove in which the glove material is formed of a laminate comprising of an outer flexible layer and a lubricating polymer.
  • a lubricating polymer examples include copolymers of 2-hydroxyethyl methacrylate (HEMA) with methacrylic acid (MAA) or with 2-ethylhexyl acrylate (EHA) or with both methacrylic acid and 2-ethylhexyl acrylate.
  • HEMA 2-hydroxyethyl methacrylate
  • MAA methacrylic acid
  • EHA 2-ethylhexyl acrylate
  • the hydrogel coating is further treated with a surfactant or long-chain fatty amine. It is believed that the surfactant or long-chain fatty amine enhances the lubricity of the innerlayer with respect to damp hands.
  • U.S. Patent No. 4,526,579 discloses a method of grafting a hydrophilic polymer onto the surface of a natural rubber article.
  • U.S. Patent No. 4,589,873 discloses a method for applying a hydrophilic polymer coating directly on to a substrate in order to provide a lubricous surface. Any polymeric substrate can be used. The substrate is contacted with a solution of the hydrophilic polymer in a suitable solvent. Any applying solvent in which the hydrophilic polymer is soluble can be used. The solvent is then removed from the substrate leaving only the hydrophilic coating.
  • U.S. Patent No. 5,069,965 describes rubber and vinyl articles having improved slip coatings. These rubber and vinyl articles have rubber-free extensible adherent slip coatings.
  • One of the slip coatings disclosed is composed or the reaction product of about 55 to 80 mole % of a vinyl halide, about 15 to 32 mole % of at least one copolymerizable ethylenically unsaturated hydrocarbon and about 3 to 10 mole % of at least one copolymerizable monomer containing a carboxyl or amido group.
  • the second adherent slip coating disclosed is the reaction product of about 76 to 94 mole % of a copolymerizable vinyl or vinylidene halide, about 8 to 11 mole % of acrylonitrile and about 2 to 12 mole % of at least one acrylic monomer.
  • the second adherent coating provides an inner coating on gloves that facilitates wet donning.
  • Antimicrobial and antiviral gloves are well known in the art. It is especially necessary that surgeon's gloves be free of bacteria or other microorganisms during surgery. Prior to donning his gloves, a surgeon scrubs his hands with a strong bactericidal soap using a brush and/or a sponge. Then, using sterile techniques, he dons his gloves which have been presterilized in the package. If these steps are strictly adhered to, the surgeon's gloves do not convey bacteria to the wound or incision site. However, regardless of the amount of scrubbing the surgeon undertakes, bacteria remain embedded deep within the pores of his hands and skin. Unfortunately, these bacteria cannot be removed via scrubbing.
  • the bacteria percolate out of the pores and reinfect the surgeon's hands.
  • the bacteria do not present a hazard to the surgeon, but rather a hazard to the patient if the glove were to rip, tear or puncture during surgery.
  • antiviral gloves are used by physicians, nurses and other healthcare professionals who may come in contact with viruses such as AIDS or
  • U.S. Patent No. 4,584,192 discloses a film-forming composition containing an antimicrobial agent.
  • the antimicrobial agent disclosed is a antimicrobial agent suitable for topical application such as chlorhexidine or a suitable derivative thereof.
  • the film comprises of three copolymerized monomers (A, B and C) .
  • Monomer A is a monomeric acrylic or methacrylic acid ester of an alkyl alcohol containing a single hydroxyl.
  • Monomer B is a monomeric methacrylic acid ester of an alkyl alcohol containing a single hydroxyl.
  • Monomer C is a N-vinyl lactam.
  • U.S. Patent No. 4,675,347 discloses a antimicrobial latex composition.
  • the antimicrobial latex composition contains at least one cationic latex component and a cationic antimicrobial agent incorporated into the latex.
  • the cationic latex component is either a cationic natural rubber latex or a cationic synthetic natural polymer.
  • U.S. Patent No. 4,853,978 discloses a antimicrobial multi-layered glove.
  • the glove comprises an outer elastomeric coating and a inner coating.
  • the inner coating has deposited on it a starch slurry containing antimicrobial agents thereby allowing the inner layer to slowly release the antimicrobial agent over time.
  • U.S. Patent 5,003,638 discloses a sterilized glove. Either the inside and/or outside layers of the glove contains an organic polymer film containing a antibacterial zeolite.
  • U.S. Patent 5,019,096 discloses a method for producing infection resistant materials. The infection resistant materials are prepared by: (1) preparing a coating vehicle by dissolving a matrix forming polymer (such as biomedical polyurethane, biomedical silicones, biodegradable polymers) into a solvent; (2) incorporating a antimicrobial agent such as a combination of chlorhexidine and its salts and silver and its salts; (3) coating a medical device with the coating composition; and (4) drying the coated medical device.
  • a matrix forming polymer such as biomedical polyurethane, biomedical silicones, biodegradable polymers
  • U.S. Patent Nos. 5,031,245 and 5,180,605 disclose a natural rubber latex glove and a method for making such a glove containing a antimicrobial effective amount of a non-ionic, sparingly water soluble antimicrobial agent, such as 2,4,4' -trichloro-2'hydroxy diphenyl ether.
  • a non-ionic, sparingly water soluble antimicrobial agent such as 2,4,4' -trichloro-2'hydroxy diphenyl ether.
  • the antimicrobial agent can be incorporated into a dispersion of aqueous natural rubber latex.
  • U.S. Patent No. 5,089,205 discloses a method for making a glove having antimicrobial properties. The method involves dipping a former into a gelled anionic natural latex to form a outer layer and then dipping the former into a second gelled anionic natural latex. The second anionic natural latex has incorporated into it a cationic antimicrobial agent. The cationic antimicrobial agent is stabilized in the anionic gelled latex through the use of a anionic surfactant . The glove is then cured and removed from the former.
  • U.S. Patent Nos. 5,128,168, 5,165,953, and 5,338,565 disclose a method for forming a latex membrane having a biocide barrier. In U.S. patent No.
  • U.S. Patent No. 5,165,953 is almost identical to U.S. Patent 5,128,168 however, the biocide does not function as a coagulant for the second coating.
  • U.S. Patent 5,338,565 is almost identical to U.S. Patent number 5,165,953, except that the first and second coatings are expanded to include polymeric latex, polymers dissolved in solvent and liquid polymers.
  • U.S. Patent 5,133,090 discloses an antimicrobial glove having an inner coating which contains a antiviral and lubricating agent.
  • the antiviral agent is any suitable salts of chlorhexidine such as chlorhexidine gluconate, chlorhexidine acetate and chlorhexidine chloride.
  • the lubricating agent facilitates donning but does not significantly absorb the antiviral agent.
  • the inner coating is formulated in such a manner that sufficient antiviral agent is released within 10 minutes after exposure to a fluid such as blood.
  • U.S. Patent No. 5,181,276 discloses an infection resistant glove made from a molten blend of at least one polymer and a compound having antioxidant, plasticizer and antiviral activity. This compound has a hydrophilic lipophilic balance of between 12 and 20.
  • An example of a suitable compound is nonoxynol-9.
  • U.S. Patent No. 5,236,703 discloses a polymeric substrate manufactured from latex incorporating povidone-iodine.
  • the povidone-iodine is capable of controlled release from the substrate.
  • a polar solution such as blood or mucous membranes
  • the povidone-iodine is released and functions as a biologically active agent.
  • the glove comprises an elastomeric body in the shape of a hand which is constructed from an elastomeric polymer or copolymer such as natural rubber latex, nitrile butadiene rubber, neoprene, butyl rubber, and polyurethane.
  • the glove has a inner and outer surface.
  • the inner surface is coated with a hydrophilic/hydrogel coating.
  • the hydrophilic coating is a skin friendly coating which has moisture absorbent properties.
  • the hydrophilic coating contains a antimicrobial or antiviral agent which protects the wearer of the glove from bacteria and viruses such as AIDS or Hepatitis.
  • the outer surface of the glove is coated with a fluoroelastomer.
  • the fluoroelastomer provides an effective barrier towards viruses and functions as an effective barrier towards body fluids due to the hydrophobic nature of its surface.
  • An example of a fluoroelastomer that can be used in this invention is TecnofIon IN latex available from Ausimont .
  • TecnofIon T ⁇ latex is a terpolymer of tetrafluoroethylene, hexa fluoropropylene and vinylidene fluoride.
  • the present invention involves a surgical or examination glove comprising an elastomeric body having an inner surface and an outer surface.
  • the inner surface comprises a hydrophilic coating and the outer surface comprises a fluoroelastomer coating.
  • the glove has plurality of superimposed layers which provide improved cleanliness, barrier properties, 'skin friendliness' and comfort.
  • the glove has very low particulates, ion extractable, non-volatile residues and surface contaminants.
  • the glove provides improved barrier protection against microorganisms and viruses with improved comfort and skin friendliness in medical use.
  • the elastomeric body of the glove is made of a material that provides integrity and strength to the glove and eventually becomes the middle layer of the glove between the two coatings.
  • the body of the glove could be made out of any elastomeric polymer or copolymer such as natural rubber latex, nitrile butadiene rubber (NBR) , neoprene (CR) , butyl rubber (IIR) , polyurethane and the like. If natural rubber latex is used the latex can be any coagulatable natural or synthetic latex compound, coagulatable natural or synthetic rubber latexes or styrenic block copolymer dispersions known in the art .
  • latex Conventional formulations for the preparation of latex are well known in the art and one skilled in the art would be readily able to vary the formulations and conditions of curing and the like to suit the particular latex being used as well as the final article desired. Precured, partially cured, or non-cured latex can be used. Additionally, the latex may contain conventional compounding ingredients commonly utilized. Specific examples are given in U.S. Patent 3,411,982, hereby incorporated by reference.
  • the inner surface of the glove which is the skin contacting surface, comprises a hydrophilic/hydrogel polymer coating.
  • Hydrophilic/hydrogel polymers are preferred because they provide greater comfort and moisture absorption properties then other polymers.
  • suitable hydrophilic coatings that can be used in this invention are disclosed in U.S. Patent Nos. 4,436,887, 4,499,154, 5,575,476, 4,889,664,
  • polymer compositions prepared from monomers comprising hydroxy alkyl acrylates, hydroxy alkyl methacrylates, vinyl lactams (eg. vinyl pyrrolidone) , acrylamide and its derivatives, ethylene oxide, and the like could be used. These monomers impart hydrophilic properties in the copolymer. Hydrophilic polymer blends prepared from polyvinyl alcohol, polyvinylpyrrolidone and the like could also be used. The hydrophilic/hydrogel polymer may or may not be cross-linked.
  • the hydrophilic/hydrogel polymer contains a antimicrobial or antiviral agent.
  • antimicrobial is defined as " (1) killing microorganisms or suppressing their multiplication or growth; and (2) an agent that kills microorganisms or suppresses their multiplication or growth.”
  • Antiviral is defined as " (1) destroying viruses or suppressing their replication; and (2) an agent that destroys viruses or suppresses their growth.” Some antimicrobial agents can be used as antiviral agents. Id.
  • antimicrobial agents include: biguanides, including chlorhexidine and its salts, silver and its salts, polymyxin, tetracycline, aminoglycosides, rifampicin, bacitracin, neomycin, chloramphenicol, miconazole, quinolones, norfloxacin, nalidixic acid, perfloxacin, enoxacin and ciprofloxacin, pencillins, nonoxynol 9, fusidic acid, cephalosporins, and combinations thereof.
  • biguanides including chlorhexidine and its salts, silver and its salts, polymyxin, tetracycline, aminoglycosides, rifampicin, bacitracin, neomycin, chloramphenicol, miconazole, quinolones, norfloxacin, nalidixic acid, perfloxacin, enoxacin and ciprofloxacin
  • antiviral agents examples include biguanide, such as chlorhexidine or a salts thereof, silver salts, such as AgSD, silver acetate, silver benzoate, silver carbonate, silver chloride, silver iodate, silver iodide, silver lactate, silver laurate, silver nitrate, silver oxide, silver palmitate, and silver salts of proteins, iodine, nonoxynol-9 and combinations thereof.
  • biguanide such as chlorhexidine or a salts thereof
  • silver salts such as AgSD, silver acetate, silver benzoate, silver carbonate, silver chloride, silver iodate, silver iodide, silver lactate, silver laurate, silver nitrate, silver oxide, silver palmitate, and silver salts of proteins, iodine, nonoxynol-9 and combinations thereof.
  • the antiviral agent would help protect against contamination from viruses such AIDS and Hepatitis B.
  • Certain additives such as emulsion silicones can also be added or coated on to the hydrophilic/hydrogel polymer used to enhance the donning and the release of the glove from the former.
  • a silicone is generally defined as a compound that includes siloxane polymers which are based on a structure including alternate silicon and oxygen atoms, with organic groups attached to the silicon. Examples of suitable silicones that can be used include polydimethylsiloxane (PDMS) , Dow Corning Silicone Emulsion 365, and the like.
  • the outer surface of the glove comprises a fluoroelastomer coating.
  • Fluoroelastomers are any high polymer containing fluorine and can be homopolymers or copolymers . Fluoroelastomers exhibit elastomeric behavior or low flexural modulus.
  • fluoroelastomer encompasses hydrogen containing fluoroelastomers as well as hydrogen-free perfluoroelasto ers.
  • fluoroelastomers are homopolymers or copolymers of tetrafluoroethylene, hexafluoropropylene, pentafluoropropylene, chlorotrifluoroethylene, copolymers of vinylidene fluoride and hexafluoropropylene and tetrafluoroethylene and copolymers of vinylidene fluoride and chlorotrifluoroethylene.
  • a fluoroelastomer coating based on Tecnoflon TN latex produced by Ausimont could be used as the outer coating.
  • This coating would provide an effective barrier towards viruses and would function as an effective barrier towards bodily fluids due to the very hydrophobic nature of its surface .
  • Other materials which would function in a similar way include polytetrafluoroethylene (PTFE) /natural rubber latex blend, Tecnoflon TN/PTFE blend, and the like.
  • the elastomeric nature of the fluoroelastomer coating is beneficial because it provides deformability better than rigid plastics as well as improved frictional characteristics, such as a higher coefficient of friction, especially when compared with chlorinated natural rubber gloves.
  • the overall thickness of the glove could be reduced, thereby improving the tactile sensitivity and fit.
  • Another advantage is that particles will not stick and the coating will not shred during use.
  • another advantage of the fluoroelastomer coating is that the coating with prevent the inner layers from oxidation and ozone attack.
  • the fluoroelastomer coating could be cured with a variety of curing agents. These include: aliphatic diamine derivatives, aromatic dihydroxy compounds with strong alkyl and aryl bases, or their suitable derivatives, basic metal oxides and hydroxides, and peroxides with suitable co-agents, such as trimethylol propane, trimethacrylate, triallyl tri-mellitate. Typical cure systems for fluoroelastomers are discussed in an article by D.S. Ogunniyi and C. Hepburn in Rubber Processing and Applications 6 (1986) pages 3-9.
  • a typical curing agent that could be used with the Tecnoflon latex coating includes triethylene tetramine (TETA) , triethylene diamine (TEDA) and the like. While the fluoroelastomer has been described as coating the outer surface of the glove, one skilled in the art would recognize that it can also be used to coat the inner surface of the glove as well.
  • the present invention has been described primarily in connection with gloves, it can also be used to form other skin-contacting articles such as catheters, ureters, sheets, condoms, etc.
  • EXAMPLE 1 Porcelain molds were washed and cleaned with soap and water to remove the smallest impurities such as minute specks of debris, oil, etc. because such debris can cause defects.
  • the molds were rinsed with water and dried. After drying, the molds were heated and then dipped into a coagulant mixture that had been previously prepared by mixing:
  • the molds were air dried under the hood approximately 5-7 minutes to evaporate the methanol in the coagulant.
  • the molds were then again dipped into the coagulant mixture which controls the latex thickness and helps release the glove from the mold later on.
  • the mold was air dried once again under the hood for methanol evaporation, 5-7 minutes.
  • the molds were dipped into General Latex (Vultex 1-N- 974) previously strained through a cloth sieve, gently and slowly to avoid bubbles and pinholes. When the mold emerged from the latex, an orchestrated waving motion was begun to distribute the latex evenly across the back to ensure a very thin filament coating. The mold is then leached in a water bath.
  • the mold was then placed in an oven for 15 minutes to dry and set the latex. Temperature: 250°F (121°C) . Once dried, the mold was allowed to cool down.
  • the latex glove was then dipped into a previously prepared dispersion of 50 parts of Tecnoflon TN latex and 50 parts of deionized water, wherein a 10-15 ml of amine
  • Tecnoflon TN latex is a water based emulsion of 68% fluorine terpolymer fluoroelastomer containing a minimum of 70% solids. Again, an orchestrated waving motion was used to evenly distribute. The mold was placed in the oven to cure at a temperature of 250°F (121°C) for 15 minutes. After cooling, cold tap water was run through the glove while stripping it off the mold. The water layer on the glove prevents the coating from sticking to itself during release. (Note: Triton X-100 was also used as an alternative to release the glove from the mold without sticking. ) The fluoroelastomer coating was clear, smooth and exhibited a glassy coating. The fluoroelastomer coating exhibited good anchorage to the latex and did not delaminate.
  • Latex glove was slipped in, flexed and stretched into a bisque finish glove mold.
  • Solutions of Teflon PTFE 30 and General Latex (Vultex l-N-974) were prepared in disposable plastic beakers at different proportions such as:
  • the glove mold was then dipped into the sample mixture slowly to avoid bubbles and pinholes, and orchestrated in a waving motion for even distribution when it emerges from the mixture.
  • the mold was placed in an oven to cure, typically, at 120°C (250°F) for approximately 10 - 15 minutes. The mold was then allowed to cool down.
  • the gloves were then inspected.
  • Glove (a) had a glossy, slightly sticky filament coating that was very strong and adhered well to the glove. The coating did not delaminate.
  • Glove (b) had a glossy, slightly sticky filament coating that adhered well to the glove and was very strong. The coating did not delaminate.
  • Glove (c) had a glossy, slightly sticky coating that stuck to itself. The coating was very strong and did not delaminate.
  • Glove (d) had a white, cracked coating. The coating exhibited poor anchorage and delaminated.
  • the antimicrobial glove of this invention could be prepared as follows: If the fluoroelastomer coating is to be on the outer surface after reversing, this can be accomplished by dipping the mold into a fluoroelastomer coating such as Tecnoflon TN latex. After withdrawal from the fluoroelastomer, the mold is dipped into a water or alcohol based coagulant. After the dip in the coagulant, the mold is dipped into natural rubber latex. The length of time the former is immersed in the latex determines the thickness of the glove. The longer the dwell time period, the greater the wall thickness of the article, and vice versa. The mold is removed from the latex with a coating of gelled latex adhering to it.
  • a fluoroelastomer coating such as Tecnoflon TN latex.
  • the mold is placed in a water bath to leach out water soluble components such as proteins, electrolytes, etc.
  • a hydrophilic/hydrogel polymer such as hydrophilic polyurethanes or acrylic such as copolymers of 2- hydroxyethyl methacrylate with methacrylic acid of 2- ethylhexyl acrylate or with both methacrylic acid and 2-ethylhexyl acrylate.
  • the hydrophic/hydrogel polymer contains an antimicrobial or antiviral agent.
  • the glove is cured or dried. Once dried, the glove can be stripped from the former. In order to enhance the release of the glove from the former, powder such as cornstarch or calcium carbonate, or silicones, such as polydimethyl siloxane can be added.

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Textile Engineering (AREA)
  • Gloves (AREA)
  • Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)

Abstract

L'invention concerne un gant chirurgical ou un gant d'examen antiviral ou antimicrobien. Le gant est constitué d'un corps en élastomère ayant la forme d'une main et pourvu d'une surface interne et d'une surface externe. La surface interne est constituée d'un revêtement polymère hydrophile/hydrogel qui contient un agent antiviral ou antimicrobien. La surface externe est constituée d'un revêtement en élastomère fluoré qui barre le passage aux bactéries et aux virus et qui est hydrophobe à l'égard des liquides biologiques.
PCT/US1996/001387 1995-02-02 1996-01-26 Gant multicouche antimicrobien et antiviral Ceased WO1996023428A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38261195A 1995-02-02 1995-02-02
US08/382,611 1995-02-02

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WO1996023428A1 true WO1996023428A1 (fr) 1996-08-08

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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999019006A1 (fr) * 1997-10-13 1999-04-22 Lrc Products Limited Articles elastiques a paroi mince
WO2000009590A1 (fr) * 1998-08-13 2000-02-24 Lrc Products Ltd. Gant resistant aux solvants
EP1060680A3 (fr) * 1999-06-16 2001-09-19 Mapa Pioneer Corporation Gant polymère comprenant une fine couche de fluoroélastomère et son procédé de fabrication
US6560782B2 (en) 2001-06-11 2003-05-13 Playtex Products, Inc. Antimicrobial glove and method of making same
WO2004098431A1 (fr) * 2003-05-02 2004-11-18 Kimberly-Clark Worldwide Inc. Procede de traitement des caracteristiques de surface d'un article elastomere
AT500558A1 (de) * 2004-06-07 2006-01-15 Semperit Ag Holding Handschuh
WO2006101934A1 (fr) * 2005-03-16 2006-09-28 Allegiance Corporation Article d'elastomere hydrophobe et lipophobe
US7175895B2 (en) 2003-11-19 2007-02-13 Kimberly-Clark Worldwide, Inc. Glove with medicated porous beads
EP1254002A4 (fr) * 2000-02-08 2007-05-23 Ansell Healthcare Prod Llc Production de gants et d'autres articles a partir d'un materiau polymere souple
WO2007070094A3 (fr) * 2005-12-14 2007-11-22 Kimberly Clark Co Article protecteur et therapeutique
WO2008053386A1 (fr) * 2006-10-31 2008-05-08 Kimberly-Clark Worldwide, Inc. Procédé de fabrication d'un appareil muni d'une couche élastique et d'une couche de protection pour administrer une composition
AT500557B1 (de) * 2004-06-07 2011-08-15 Semperit Ag Holding Tauchartikel
DE102011101800A1 (de) * 2011-05-17 2012-11-22 Mattias Finzelberg Schutzhandschuh
US8414547B2 (en) 2004-04-29 2013-04-09 C. R. Bard, Inc. Modulating agents for antimicrobial coatings
US9763453B2 (en) 2004-04-29 2017-09-19 Bacterin International, Inc. Antimicrobial coating for inhibition of bacterial adhesion and biofilm formation
CN111867375A (zh) * 2018-03-09 2020-10-30 富士胶片株式会社 抗菌膜、抗菌组合物、带抗菌膜的基材及赋予抗菌性的方法
US11167064B2 (en) 2016-07-14 2021-11-09 Hollister Incorporated Hygienic medical devices having hydrophilic coating
CN116941841A (zh) * 2023-07-26 2023-10-27 台州达顿安防科技有限公司 一种聚乙烯醇防化手套及其制作方法

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US8192834B2 (en) 2000-02-08 2012-06-05 Ansell Healthcare Products Llc Production of gloves and other articles of flexible polymer material
EP1254002A4 (fr) * 2000-02-08 2007-05-23 Ansell Healthcare Prod Llc Production de gants et d'autres articles a partir d'un materiau polymere souple
US6913758B2 (en) 2001-06-11 2005-07-05 Playtex Products, Inc. Antimicrobial glove and method of making same
US6560782B2 (en) 2001-06-11 2003-05-13 Playtex Products, Inc. Antimicrobial glove and method of making same
WO2004098431A1 (fr) * 2003-05-02 2004-11-18 Kimberly-Clark Worldwide Inc. Procede de traitement des caracteristiques de surface d'un article elastomere
US7175895B2 (en) 2003-11-19 2007-02-13 Kimberly-Clark Worldwide, Inc. Glove with medicated porous beads
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US8414547B2 (en) 2004-04-29 2013-04-09 C. R. Bard, Inc. Modulating agents for antimicrobial coatings
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AT500557B1 (de) * 2004-06-07 2011-08-15 Semperit Ag Holding Tauchartikel
US7767251B2 (en) 2005-03-16 2010-08-03 Shiping Wang Repellent elastomeric article
WO2006101934A1 (fr) * 2005-03-16 2006-09-28 Allegiance Corporation Article d'elastomere hydrophobe et lipophobe
AU2006227673B2 (en) * 2005-03-16 2011-11-17 Allegiance Corporation Repellent elastomeric article
JP2008537766A (ja) * 2005-03-16 2008-09-25 アレジアンス、コーポレイション 反発性弾性製品
US8530016B2 (en) 2005-03-16 2013-09-10 Allegiance Corporation Repellent elastomeric article
WO2007070094A3 (fr) * 2005-12-14 2007-11-22 Kimberly Clark Co Article protecteur et therapeutique
WO2008053386A1 (fr) * 2006-10-31 2008-05-08 Kimberly-Clark Worldwide, Inc. Procédé de fabrication d'un appareil muni d'une couche élastique et d'une couche de protection pour administrer une composition
KR101444669B1 (ko) 2006-10-31 2014-10-02 킴벌리-클라크 월드와이드, 인크. 탄성층 및 차단층을 갖는 조성물 전달용 기구의 제조방법
DE102011101800A1 (de) * 2011-05-17 2012-11-22 Mattias Finzelberg Schutzhandschuh
US9743694B2 (en) 2011-05-17 2017-08-29 Mattias Finzelberg Protective glove
US11167064B2 (en) 2016-07-14 2021-11-09 Hollister Incorporated Hygienic medical devices having hydrophilic coating
US12318511B2 (en) 2016-07-14 2025-06-03 Hollister Incorporated Hygienic medical devices having hydrophilic coatings and methods of forming the same
CN111867375A (zh) * 2018-03-09 2020-10-30 富士胶片株式会社 抗菌膜、抗菌组合物、带抗菌膜的基材及赋予抗菌性的方法
CN116941841A (zh) * 2023-07-26 2023-10-27 台州达顿安防科技有限公司 一种聚乙烯醇防化手套及其制作方法

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