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WO1996022780B1 - Procedes d'amelioration de l'activite therapeutique de medicaments non steroides anti-inflammatoires (nsaids) et compositions de phospholipides zwitterioniques utiles a ces fins - Google Patents

Procedes d'amelioration de l'activite therapeutique de medicaments non steroides anti-inflammatoires (nsaids) et compositions de phospholipides zwitterioniques utiles a ces fins

Info

Publication number
WO1996022780B1
WO1996022780B1 PCT/US1996/000633 US9600633W WO9622780B1 WO 1996022780 B1 WO1996022780 B1 WO 1996022780B1 US 9600633 W US9600633 W US 9600633W WO 9622780 B1 WO9622780 B1 WO 9622780B1
Authority
WO
WIPO (PCT)
Prior art keywords
medicament
phospholipid
inflammatory agent
steroidal anti
zwitterionic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1996/000633
Other languages
English (en)
Other versions
WO1996022780A1 (fr
Filing date
Publication date
Priority claimed from US08/440,417 external-priority patent/US5763422A/en
Application filed filed Critical
Priority to DK01128271T priority Critical patent/DK1214940T3/da
Priority to DE69621773T priority patent/DE69621773T2/de
Priority to AT96902157T priority patent/ATE218872T1/de
Priority to EP96902157A priority patent/EP0805684B1/fr
Publication of WO1996022780A1 publication Critical patent/WO1996022780A1/fr
Publication of WO1996022780B1 publication Critical patent/WO1996022780B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

L'invention concerne des compositions comprenant des médicaments anti-inflammatoires non stéroïdes (NSAIDs) complexés avec des phospholipides zwitterioniques neutres, ou bien présentant en même temps des effets d'irritation gastrointestinale réduits et une meilleure activité antipyrétique, analgésique et anti-inflammatoire. L'invention se rapporte également à des procédés d'utilisation de ces complexes pour traiter la fièvre, les inflammations et prévenir l'agrégation plaquettaire. Dans certains modes de réalisation, l'activité antipyrétique de dosages sous-thérapeutiques des NSAIDs est améliorée de façon à obtenir une activité antipyrétique in vivo lorsqu'elle est associée (de manière non covalente) à des phospholipides zwitterioniques, tels que dipalmitoylphosphatidylcholine.
PCT/US1996/000633 1995-01-27 1996-01-24 Procedes d'amelioration de l'activite therapeutique de medicaments non steroides anti-inflammatoires (nsaids) et compositions de phospholipides zwitterioniques utiles a ces fins Ceased WO1996022780A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DK01128271T DK1214940T3 (da) 1995-01-27 1996-01-24 Fremgangsmåder til at foröge den terapeutiske aktivitet af NSAIDs og sammensætninger af zwitterioniske phospholipider anvendt heri
DE69621773T DE69621773T2 (de) 1995-01-27 1996-01-24 Verfahren zur erhöhung der therapeutischen wirkung von nsaids und dazu verwendbare zwitterionische phospholipidhaltige zusammensetungen
AT96902157T ATE218872T1 (de) 1995-01-27 1996-01-24 Verfahren zur erhöhung der therapeutischen wirkung von nsaids und dazu verwendbare zwitterionische phospholipidhaltige zusammensetungen
EP96902157A EP0805684B1 (fr) 1995-01-27 1996-01-24 Procedes d'amelioration de l'activite therapeutique de medicaments non steroides anti-inflammatoires (nsaids) et compositions de phospholipides zwitterioniques utiles a ces fins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US37969595A 1995-01-27 1995-01-27
US08/379,695 1995-01-27
US08/440,417 1995-05-12
US08/440,417 US5763422A (en) 1995-01-27 1995-05-12 Methods of enhancing the therapeutic activity of NSAIDS and compositions of zwitterionic phospholipids useful therein

Publications (2)

Publication Number Publication Date
WO1996022780A1 WO1996022780A1 (fr) 1996-08-01
WO1996022780B1 true WO1996022780B1 (fr) 1996-09-19

Family

ID=27008731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/000633 Ceased WO1996022780A1 (fr) 1995-01-27 1996-01-24 Procedes d'amelioration de l'activite therapeutique de medicaments non steroides anti-inflammatoires (nsaids) et compositions de phospholipides zwitterioniques utiles a ces fins

Country Status (5)

Country Link
EP (2) EP1214940B1 (fr)
AT (1) ATE218872T1 (fr)
DE (1) DE69621773T2 (fr)
ES (1) ES2176435T3 (fr)
WO (1) WO1996022780A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL127143A0 (en) 1998-11-19 1999-09-22 Dpharm Ltd Phospholipid terivatives of non-steroidal anti inflammatory drugs
JP4958381B2 (ja) * 2000-12-19 2012-06-20 ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システム 胃腸管保護および治療活性増強のためのレシチン油およびｎｓａｉｄｓの製剤を用いる方法および組成物
US20040077604A1 (en) 2001-12-19 2004-04-22 Lenard Lichtenberger Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
AU2004260696C1 (en) * 2003-07-31 2008-05-29 Board Of Regents Of The University Of Texas System Compositions and methods for treating, preventing and/or ameliorating cancers, the onset of cancers or the symptoms of cancers
AU2009290712A1 (en) 2008-09-09 2010-03-18 Astrazeneca Ab Method for delivering a pharmaceutical composition to patient in need thereof
CA2764963C (fr) 2009-06-25 2016-11-01 Astrazeneca Ab Procede pour le traitement d'un patient a risque de developer un ulcere associe a nsaid
CA2850187C (fr) 2011-09-29 2021-12-07 Plx Pharma Inc. Vecteurs dependant du ph pour liberation ciblee de produits pharmaceutiques dans le tube digestif, compositions preparees a partir de ceux-ci, et leur fabrication et leur utilisat ion
US9539214B2 (en) 2011-12-28 2017-01-10 Pozen Inc. Compositions and methods for delivery of omeprazole plus acetylsalicylic acid
WO2013152044A1 (fr) * 2012-04-02 2013-10-10 The Board Of Regents Of The University Of Texas System Utilisation d'anti-inflammatoires non stéroïdiens à base de phosphatidylcholine (pc-nsaid) pour traiter et/ou prévenir une inflammation pulmonaire
CA3172595A1 (fr) 2020-03-26 2021-09-30 Ronald Zimmerman Supports pharmaceutiques aptes a la reconstitution dependante du ph et leurs procedes de fabrication et d'utilisation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4369182A (en) * 1978-09-27 1983-01-18 A. Nattermann & Cie Gmbh Inflammation-preventing pharmaceutical composition of oral administration
US4421747A (en) * 1978-12-27 1983-12-20 A. Nattermann & Cie. Gmbh Inflammation-preventing pharmaceutical composition of oral administration
DE2914788A1 (de) * 1979-04-11 1980-10-16 Nattermann A & Cie Parenteral applizierbare, stabile arzneimittelloesungen mit entzuendungshemmender wirkung
DE2914789A1 (de) * 1979-04-11 1980-10-16 Nattermann A & Cie Injizierbare arzneimittel mit entzuendungshemmender wirkung
DE2951142C2 (de) * 1979-12-19 1983-11-03 A. Nattermann & Cie GmbH, 5000 Köln Suppositorium-Zubereitung von Indometacin oder Acemetacin
JP2844756B2 (ja) * 1989-12-01 1999-01-06 日本新薬株式会社 脂肪乳剤
JP3280071B2 (ja) * 1992-05-27 2002-04-30 ポーラ化成工業株式会社 消炎鎮痛外用剤

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