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WO1996020950A3 - Compositions and methods for treating rheumatoid arthritis - Google Patents

Compositions and methods for treating rheumatoid arthritis Download PDF

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Publication number
WO1996020950A3
WO1996020950A3 PCT/US1996/000206 US9600206W WO9620950A3 WO 1996020950 A3 WO1996020950 A3 WO 1996020950A3 US 9600206 W US9600206 W US 9600206W WO 9620950 A3 WO9620950 A3 WO 9620950A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
rheumatoid arthritis
methods
compositions
therapeutic compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1996/000206
Other languages
French (fr)
Other versions
WO1996020950A2 (en
Inventor
Jonathan Rothbard
Lars Henrik Fugger
Grete Sonderstrup-Mcdevitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immulogic Pharmaceutical Corp
Original Assignee
Immulogic Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immulogic Pharmaceutical Corp filed Critical Immulogic Pharmaceutical Corp
Priority to AU46952/96A priority Critical patent/AU4695296A/en
Publication of WO1996020950A2 publication Critical patent/WO1996020950A2/en
Publication of WO1996020950A3 publication Critical patent/WO1996020950A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides peptides, therapeutic compositions, and methods for treatment of rheumatoid arthritis in mammals, specifically in humans. The peptides of the invention comprise fragments of type II collagen which bind specifically with human major histocompatibility complex proteins known to be genetically linked to susceptibility to rheumatoid arthritis. The therapeutic compositions of the invention comprise the peptides, alone or in combination with other collagen peptides. In one method of the invention, therapeutic compositions of the peptides are administered by injection, transdermally, by inhalation, or orally to a patient in need of treatment.
PCT/US1996/000206 1995-01-06 1996-01-04 Compositions and methods for treating rheumatoid arthritis Ceased WO1996020950A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU46952/96A AU4695296A (en) 1995-01-06 1996-01-04 Compositions and methods for treating rheumatoid arthritis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36979295A 1995-01-06 1995-01-06
US08/369,792 1995-01-06

Publications (2)

Publication Number Publication Date
WO1996020950A2 WO1996020950A2 (en) 1996-07-11
WO1996020950A3 true WO1996020950A3 (en) 1996-09-12

Family

ID=23456941

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/000206 Ceased WO1996020950A2 (en) 1995-01-06 1996-01-04 Compositions and methods for treating rheumatoid arthritis

Country Status (2)

Country Link
AU (1) AU4695296A (en)
WO (1) WO1996020950A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6156535A (en) 1995-08-04 2000-12-05 University Of Ottawa Mammalian IAP gene family, primers, probes, and detection methods
US6737406B1 (en) 1996-03-21 2004-05-18 Circassia, Ltd. Cryptic peptides and method for their identification
SE9700301D0 (en) * 1997-01-31 1997-01-31 Astra Ab New compound
AUPO571297A0 (en) * 1997-03-19 1997-04-10 Montech Medical Developments Pty Ltd Method for the diagnosis of rheumatoid arthritis
EP1598370A3 (en) * 1999-10-27 2006-05-10 Cel-Sci Corporation Methods of preparation and composition of peptide constructs useful for treatment of autoimmune and transplant related host versus graft conditions
WO2003006603A2 (en) * 2001-07-12 2003-01-23 Arexis Ab Triple polypeptide complexes
NZ546807A (en) 2002-03-27 2007-03-30 Aegera Therapeutics Inc Antisense IAP nucleobase oligomers and uses thereof
US8012944B2 (en) 2003-10-30 2011-09-06 Pharmascience Inc. Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent
WO2010054446A1 (en) 2008-11-11 2010-05-20 Ademovic Zlatko Combination of two or more peptides in a single stable lyophilized pharmaceutical compound
EP2694530B1 (en) * 2011-04-05 2018-02-14 Curara AB Novel peptides that bind to types of mhc class ii and their use in diagnosis and treatment

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994007520A1 (en) * 1992-09-25 1994-04-14 Autoimmune, Inc. Method of treating rheumatoid arthritis with type ii collagen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994007520A1 (en) * 1992-09-25 1994-04-14 Autoimmune, Inc. Method of treating rheumatoid arthritis with type ii collagen

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
E.MICHAELSSON ET AL: "Identification of an immunodominant Type-II collagen peptide recognized by T cells in H-2q mice: self tolerance at the level of determinant selection", EUR.J.IMMUNOL., vol. 22, no. 7, 1992, pages 1819 - 25, XP002006497 *
L.K.MYERS ET AL.: "A synthetic peptide analogue of a determinant of type II collagen prevents the onset of collagen- induced arthritis", J.IMMUNOL., vol. 150, no. 10, 1993, pages 4652 - 8, XP002006498 *

Also Published As

Publication number Publication date
WO1996020950A2 (en) 1996-07-11
AU4695296A (en) 1996-07-24

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