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WO1996015740A1 - Catheter a ballonnet pour le traitement par hyperthermie - Google Patents

Catheter a ballonnet pour le traitement par hyperthermie Download PDF

Info

Publication number
WO1996015740A1
WO1996015740A1 PCT/SE1995/001375 SE9501375W WO9615740A1 WO 1996015740 A1 WO1996015740 A1 WO 1996015740A1 SE 9501375 W SE9501375 W SE 9501375W WO 9615740 A1 WO9615740 A1 WO 9615740A1
Authority
WO
WIPO (PCT)
Prior art keywords
balloon
valve
central tube
outlet
catheter
Prior art date
Application number
PCT/SE1995/001375
Other languages
English (en)
Inventor
Hans I. Wallsten
Jerome Duc
Original Assignee
Wallsten Medical S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallsten Medical S.A. filed Critical Wallsten Medical S.A.
Priority to EP95938684A priority Critical patent/EP0853467B1/fr
Priority to US08/836,750 priority patent/US5957962A/en
Priority to JP8516774A priority patent/JPH10508778A/ja
Priority to DE69527313T priority patent/DE69527313T2/de
Publication of WO1996015740A1 publication Critical patent/WO1996015740A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • A61F7/123—Devices for heating or cooling internal body cavities using a flexible balloon containing the thermal element
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/08—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B2017/4216—Operations on uterus, e.g. endometrium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
    • A61F2007/0071—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating using a resistor, e.g. near the spot to be heated
    • A61F2007/0073—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating using a resistor, e.g. near the spot to be heated thermistor
    • A61F2007/0074—PTC

Definitions

  • the present invention relates to a device for carry ⁇ ing out heat treatment, so called hyperthermia, in a body cavity or duct.
  • the device in question can be said to be a so called balloon catheter for carrying out thermal treatment of areas in a living body including man.
  • balloon catheters of this type heating of heat medium, frequently a liquid which after insertion of the catheter balloon into the organ to be treated, is used to expand the balloon.
  • the heating can take place by an ele ⁇ ment positioned in the. balloon for the transfer of heat to the liquid and further on to the inner walls of the cavity, and in certain designs the liquid is brought to circulate in the expanded balloon by means of some form of pumping system.
  • the heating medium can be externally heated and then introduced into the bal ⁇ loon.
  • a number of different types of balloon catheters for heat treatment of body cavities are known, and in certain cases it has been suggested that the heated liquid is circulated within the balloon for reaching an even heat distribution in the expanded balloon and effi ⁇ cient heat transfer to surrounding tissues.
  • a balloon catheter for hyperthermal treatment of body cavi ⁇ ties for example uterus
  • a balloon after inser ⁇ tion into the cavity, is expanded by means of a liquid heating medium injected into the rear or proximal end of the catheter by means of for example a syringe.
  • the hea ⁇ ting device consists of an auto-regulating material ha ⁇ ving a so called Curie point and the energy supply is carried out in an electric way.
  • This auto-controlling ma ⁇ terial may either be constituted by a ferromagnetic metal alloy which is wirelessly heated to the Curie point by a magnetic field affecting the material.
  • the Curie point has been selected for providing the desired therapeutic effect.
  • An alternative heating element is one wherein the auto-controlling material consists of a number of thin lamellae of so called PTC elements having a selected Curie point placed in the cy- lindric housing, heating taking place by means of an electric current under low voltage.
  • the liquid heat medium is circulated in the balloon so that efficient heat transfer to surrounding tissue is provi ⁇ ded, since otherwise the auto-controlling character of the material would result in shut down of the elements and thereby lack of release of sufficient power.
  • the circulation of the heat medium takes place by imparting to same a reciprocating movement which is then converted to circulation in the expanded balloon by the use of a system of counter-positioned back valves.
  • the circulation contributes to a more even heat transfer to the surrounding tissues, which is essential for providing the desired impact.
  • the known devices are associated with serious disadvantages.
  • the present invention has for its object to provide a new device for carrying out heat treatment, so called hyperthermia, while maintaining an efficient heat trans ⁇ fer from the heating medium.
  • Another object of the invention is to provide a de ⁇ vice for carrying out hyperthermia, where the arisal of air pockets in connection with the filling of the device with a liquid heating medium is essentially prevented.
  • Yet another object of the invention is to provide a device for carrying out hyperthermia in which the filling of liquid heat transferring medium takes place in one single operation in a simple manner.
  • a further object of the invention is to provide a device where the part which is contaminated in connection with the use thereof is suited for mass fabrication at a reasonable cost and can thus be disposed of after use.
  • a further object of the invention is to provide a device where there is arranged at the distal end of the catheter a central rigid part centered within the balloon so that contact between the outer walls thereof and the inner walls of the balloon is avoided.
  • an object of the invention is to provide a pul ⁇ sating pressure in the heat transferring medium so that uniform treatment and improved heat transfer will be ob- tained.
  • the invention provides for a de ⁇ vice for carrying out heat treatment, so called hyper ⁇ thermia, in a body cavity or duct, comprising a catheter with an elongate front part intended for insertion into said cavity or duct and provided with a central tube and a flexible and/or elastic balloon surrounding said cen ⁇ tral tube in a liquid-tight manner, further comprising an axially operating first inlet at the proximal end of the central tube for the supply of a heat transferring medium to the central tube, and at least one outlet from the central tube intended for supply of said medium under pressure to the balloon for the expansion thereof.
  • the device according to the invention is characteri- zed in that said central tube at its distal end extends at least up to the forward inner wall of the balloon to which it is fixed, said device in connection to the distal end of the central tube being provided with a val ⁇ ve enabling release of gas from the interior of the bal- loon through at least one gas outlet arranged at said ' distal end.
  • This valve through which remaining gas in the system can be discharged or evacuated is suitably some type of back valve, for example a so called fizz valve which can be exteriorly actuated, but may alternatively be consti ⁇ tuted by a valve with narrow ducts or capillaries al ⁇ lowing the passage of gas but preventing the passage of liquid.
  • a so called fizz valve which can be exteriorly actuated, but may alternatively be consti ⁇ tuted by a valve with narrow ducts or capillaries al ⁇ lowing the passage of gas but preventing the passage of liquid.
  • Conceivable fizz valves are valves in the form of a ball valve with a spring-actuated ball and a seat coope ⁇ rating therewith, but may also be constituted by a fizz valve with a so called flap and an associated seat, said flap being exteriorly releasable from the seat for dis ⁇ charge of gas from the interior of the balloon, and which in an unloaded condition reverts to sealing position, for example by inherent springing.
  • said outlet can simultaneously suitably constitute a gas outlet.
  • a particular embodiment of the device according to the present invention is characterized by means for pro- viding a pulsating pressure of the heat transferring me ⁇ dium, whereby a more uniform heat treatment and improved heat transfer can be obtained.
  • Said means suitably comprises a chamber of variable volume which via an outlet is connected to said first in- let and which is arranged to periodically be imparted a reduced and an enlarged volume, respectively, said cham ⁇ ber and any other chambers with inlet and outlet in the catheter being designed in such a way that the highest point of each chamber is positioned at the same level or lower than the highest point of the transition of the chamber to the outlet, whereby the leaving behind of air or other gas when the heat transferring medium is suppli ⁇ ed will be avoided.
  • said chamber is defined by a compressible and elasticly reverting container which can be brought to periodic compression from the outside.
  • Said means may further comprise a reciprocating element provi ⁇ ding periodic compression.
  • the device is further suitably provided with a safety valve arranged in the catheter which has for its function to eliminate the risk for too high overpressures in the system.
  • a heating element positioned inside the balloon said heating ele ⁇ ment may be of any type, particularly based on heating by the supply of electric power, but it is particularly pre- ferred to use heat releasing elements of the auto- controlling type, for example a so called PTC-type.
  • PTC-type heat releasing elements of the auto- controlling type
  • the ar ⁇ rangement for providing circulation of the heat transfer ⁇ ring medium and possibly other details reference is made to the above-mentioned PCT-application SE94/00208, the whole disclosure of which is incorporated herein by refe ⁇ rence.
  • distal and proximal are used in the meaning “forward” and “rear”, respectively, i.e. related to the operator of the instrument or device.
  • Figure 1 shows diagramatically an embodiment of the device according to the invention illustrating the prin ⁇ ciple design of the device;
  • Figure 2 shows in a section a detail of a valve for the evacuation of gas from the system;
  • Figure 3 shows an alternative valve design
  • Figure 4 shows an alternative embodiment of the ex ⁇ pandable balloon
  • Figure 5 shows an alternative embodiment of the de ⁇ vice according to the invention
  • Figures 6 and 7 show in sections a plan view and a side view, respectively, of a safety valve intended to be placed in the balloon catheter according to the inven- tion.
  • FIG. 1 shows diagramatically an embodiment of a balloon catheter according to the invention, said embodi- ment being shown in a very simplified form.
  • the balloon catheter generally designated 1 comprises a distal part 3 provided with an expandable balloon 7 of for example highly elastic silicon, a central tube 9 having an axial- ly proximal inlet 11, outlet openings 13, the two latter openings enabling introduction of a heat transferring me ⁇ dium to the balloon.
  • the distal part 3 further comprises suitable heating means, such as heat-releasing element not shown.
  • the catheter tube 15 comprises inter alia ducts for the supply of liquid medium to the balloon 7 and conduits for the supply of electric power to the element 10 and for the transmission of signals from any sensors for pressure and temperature which can be placed in associa- tion with the balloon.
  • a special cable 17 which, via a coupling box 19, can be connected to some type of control unit.
  • a closure valve 23 connected to the proximal end of the tube, said valve simultaneously constituting the proximal end of the catheter.
  • the procedure for introducing heat transferring liquid medium into the device shown in Fig. 1 is the fol ⁇ lowing.
  • the catheter with the balloon 7 in an unexpanded state in a sterile package is removed from the package, the syringe 25 is completely filled with the liquid to be used as a heat transferring pressure medium and is then connected to valve 23 via coupling 27.
  • the catheter fil ⁇ led with air is suitably held in a vertical position with the distal part pointing upward, as shown in Fig. 1.
  • the piston of syringe 25 is moved forward the liquid will progressively move forward and upward at the same time as the air enclosed in the catheter starts to fill the balloon without air remaining in the system.
  • the fil ⁇ ling is concluded when the liquid level has reached a certain position 10 in the balloon 7, as shown in Fig. 1. Above this level the air previously found in the catheter will be collected under a certain pressure around central tube 9.
  • a valve arranged in the distal end of balloon 7.
  • a valve arranged in the distal end of balloon 7.
  • a second val ⁇ ve 33 is arranged which has the form of a ball 35 which engages an associated seat 37 by a spring 39.
  • an outlet opening 41 is arranged in the seat 37 of valve 33.
  • valve 33 When all air has been collected under pressure at the distal part of the balloon in the manner described above valve 33 is opened by inserting a fine needle through opening 41 so that complete deairiation of bal- loon 7 can take place.
  • An alternative valve device allowing deairiation of balloon 7 can be constituted by a fibre plug provided with fine ducts or capillaries which has the ability of letting through only gas but not allowing passage of liquid.
  • a suitable material for such fibre plug is HDPE from POREX Technologies, Georgia, USA, ha ⁇ ving an average pore size of 60 ⁇ m, pore volume range 45- 55%.
  • a back valve for example a flap, can be arranged which allows flow out from the bal ⁇ loon but not in the opposite direction.
  • valve 33' which is provided with a so called flap 41 cooperating with a valve seat 43 containing a central opening 41.
  • this valve 33' can be opened from the out ⁇ side to the position of flap 41 shown in Fig. 3 with a pointed object, which enables air found in the upper end of balloon 7 to be evacuated.
  • the flap 41 is suitably ma ⁇ de of a spring material so that it returns to closed po- sition by the inherent elasticity of the material. How ⁇ ever, also here the closing position can be ensured by means of any sort of spring member, such as shown in Fig. 2.
  • the hyperthermia treatment is started by introducing the unexpanded but liquid-filled balloon into the cavity, for example uterus, whereafter the balloon is expanded to a suitable pressure by actuation of syringe 25 after ope ⁇ ning of valve 23. After the reclosure of valve 23 the course of treatment is started by actuation from the con- trol unit in that heating is started by supply of elect ⁇ ric current via cable 17 to the heating element in the central tube 9 until the correct temperature has been reached. Control of temperature and control of pressure can take place in a manner known per se by cooperation between sensors in the distal part of the catheter and the control unit via cable 17.
  • Fig. 4 shows an alternative embodiment of the bal ⁇ loon 7'.
  • the balloon is preshaped for adaptation to the intended use, for example for the treatment of urethra such as in connection with prostate problems.
  • the balloon 7' is as before made of a flexible thin material, for example PET, but in this case with a restricted stretchability since the adaptation to the surrounding walls primarily takes place by the fact that the balloon has been given the desired shape in advance.
  • Fig. 5 shows a device corresponding to that descri ⁇ bed above in connection with Fig. 1 but which in the em- bodiment in Fig. 5 contains an arrangement for providing a pulsating pressure of the heat transferring medium. This arrangement includes a container 55 placed in line with the catheter somewhere between valve 23 and inlet 11.
  • the container 55 is provided with an inlet 58 and an outlet 56 and is held between a fixed jaw 51 and a mov ⁇ able jaw 53.
  • the movable jaw is imparted a reciprocating movement by means of an excenter 57 as shown with arrows in the figure.
  • the balloon catheter according to Fig. 5 when used can be operated with a pulsating pressure of the heat transferring medium, which provides a certain periodically varying volume of balloon 7 (indicated with a dashed line in Fig. 5), and in view of this pulsation of the heat transferring medium a more efficient heat transfer to the surrounding of the balloon will be obtai ⁇ ned on the one hand and also a more uniform treatment re ⁇ sult on the other hand.
  • a volume change of about 2 mL per puls will be provided in the system.
  • FIGS 6 and 7 show in two sections diagramatically a safety valve intended to be positioned in the catheter in connection with the system containing heat transfer ⁇ ring medium.
  • the safety valve generally designated 61 may thus be positioned somewhere in the catheter circuit bet ⁇ ween the valve 23 and the inlet 58 of container 55, but this position is not of a critical importance.
  • FIG. 6 a section taken along line II-II in Fig. 7, where- as Fig. 7 shows a section taken along line I-I taken in Fig. 6.
  • the safety valve 61 shown comprises a valve hou ⁇ sing 63 provided with an inlet 65 and an outlet 67.
  • a vertical hub 69 is placed in the central part of valve housing 63 in the central part of valve housing 63 in the central part of valve housing 63 forming an annular zone for flow through valve housing 63.
  • Hub 69 contains a central vertical passage 71 which is open at the upper end for discharge of medium and which at the lower end normally is sealed by means of a membrane 75 closing a part 73 of valve housing 63 pro ⁇ truding downwardly.
  • back valves are ar- ranged which allow flow in only one direction and if said valves are placed counter to each other in openings 13 according to a certain system the pulsation obtained by the periodic change of volume of container 55 can provide circulation inside the central tube 9 and the balloon. Accordingly, if the three uppermost openings 13 in Fig. 5 are alloted back valves allowing flow only out from the central tube 9, and the three lowermost openings 13 are alloted back valves positioned in the opposite way there will be obtained in the pulsation of the medium a certain circulation inside the balloon in a manner indicated by the arrows in Fig. 5. It is also conceivable to arrange the back valves in connection with openings 13 so that they are pair-wise counteracting, whereby certain circu ⁇ lation in connection with adjacent pairs of openings 13 will be obtained.
  • Such back valves can be of a very simple kind, for example simple ball valves or valves with so called flaps which can provide sealing by inherent elasticity.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Otolaryngology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Thermal Sciences (AREA)
  • Vascular Medicine (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

Dispositif permettant d'administrer un traitement thermique, appelé hyperthermie, dans une cavité ou un passage du corps, qui comprend un cathéter doté d'une partie avant allongée (3) destinée à être introduite dans la cavité ou le passage et pourvue d'un tube central (9) et d'un ballonnet (7) souple et/ou élastique qui entoure le tube central d'une manière étanche aux liquides. Ledit dispositif comprend en outre un premier orifice d'entrée (11) à fonctionnement axial à l'extrémité proximale du tube central et au moins un orifice de sortie du tube central, destiné à alimenter le ballonnet en milieu sous pression pour en provoquer l'expansion. Ledit dispositif est caractérisé par le fait que le tube central (9) s'étend, à son extrémité distale, au moins jusqu'à la paroi interne avant du ballonnet auquel il est fixé, le dispositif en connexion avec l'extrémité distale du tube central (9) étant doté d'une soupape (33, 33') permettant l'évacuation de gaz se trouvant à l'intérieur du ballonnet (7) à travers au moins un orifice de sortie de gaz ménagé au niveau de ladite partie distale.
PCT/SE1995/001375 1994-11-21 1995-11-20 Catheter a ballonnet pour le traitement par hyperthermie WO1996015740A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP95938684A EP0853467B1 (fr) 1994-11-21 1995-11-20 Catheter a ballonnet pour le traitement par hyperthermie
US08/836,750 US5957962A (en) 1994-11-21 1995-11-20 Balloon catheter for hyperthermia treatment
JP8516774A JPH10508778A (ja) 1994-11-21 1995-11-20 温熱療法用バルーンカテーテル
DE69527313T DE69527313T2 (de) 1994-11-21 1995-11-20 Ballonkatheter zur hypertermiebehandlung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9404022A SE508792C2 (sv) 1994-11-21 1994-11-21 Ballongkateter för att utföra värmebehandling i en kroppskavitet eller kroppskanal
SE9404022-7 1994-11-21

Publications (1)

Publication Number Publication Date
WO1996015740A1 true WO1996015740A1 (fr) 1996-05-30

Family

ID=20396054

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1995/001375 WO1996015740A1 (fr) 1994-11-21 1995-11-20 Catheter a ballonnet pour le traitement par hyperthermie

Country Status (7)

Country Link
US (1) US5957962A (fr)
EP (1) EP0853467B1 (fr)
JP (1) JPH10508778A (fr)
CA (1) CA2205552A1 (fr)
DE (1) DE69527313T2 (fr)
SE (1) SE508792C2 (fr)
WO (1) WO1996015740A1 (fr)

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US6066132A (en) * 1998-06-30 2000-05-23 Ethicon, Inc. Articulating endometrial ablation device
EP0955969B1 (fr) * 1995-07-07 2003-10-08 Prostalund Operations AB Dispositif de traitement thermique local des tissus
EP2327382A1 (fr) * 2009-11-26 2011-06-01 Hans I. Wallsten Dispositif de stérilisation

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US6589271B1 (en) 1998-04-21 2003-07-08 Alsius Corporations Indwelling heat exchange catheter
US6520977B2 (en) * 1999-12-06 2003-02-18 Hadi Piraka Uterine balloon apparatus and method
US6443947B1 (en) 2000-03-01 2002-09-03 Alexei Marko Device for thermal ablation of a cavity
US6716239B2 (en) 2001-07-03 2004-04-06 Scimed Life Systems, Inc. ePTFE graft with axial elongation properties
US6676680B1 (en) * 2001-07-17 2004-01-13 Polyzen, Inc. Tamponade device to control post-partum hemorrhage
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US7494477B2 (en) * 2003-09-02 2009-02-24 Pulsecath B.V. Catheter pump, catheter and fittings therefore and methods of using a catheter pump
JP4391221B2 (ja) * 2003-12-22 2009-12-24 有限会社日本エレクテル 高周波加温バルーンカテーテル
US7418464B2 (en) * 2004-01-27 2008-08-26 International Business Machines Corporation Method, system, and program for storing data for retrieval and transfer
US7727228B2 (en) * 2004-03-23 2010-06-01 Medtronic Cryocath Lp Method and apparatus for inflating and deflating balloon catheters
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US8672988B2 (en) 2004-10-22 2014-03-18 Medtronic Cryocath Lp Method and device for local cooling within an organ using an intravascular device
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US20080125765A1 (en) * 2006-11-24 2008-05-29 Berenshteyn A Microwave apparatus for ablation
BRPI0806361B8 (pt) * 2007-02-09 2021-06-22 B & D Medical Dev Llc dispositivo para controlar hemorragia genecológica e obstétrica em uma cavidade corporal de um paciente, e kit
EP2665433B1 (fr) 2011-01-19 2021-03-10 Fractyl Laboratories Inc. Dispositifs de traitement de tissus
EP2670328B1 (fr) 2011-02-01 2019-10-16 Channel Medsystems, Inc. Appareil pour traitement cryogénique d'un conduit ou d'une cavité corporelle
CA2865567C (fr) 2012-02-27 2022-10-11 Fractyl Laboratories, Inc. Systemes, dispositifs et methodes de thermoablation pour le traitement de tissu
EP3711810B1 (fr) 2012-04-19 2023-02-22 Fractyl Health, Inc. Systèmes d'expansion de tissus
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WO2014026055A1 (fr) 2012-08-09 2014-02-13 Fractyl Laboratories Inc. Systèmes, dispositifs et procédés d'ablation pour le traitement d'un tissu
EP2903626A4 (fr) 2012-10-05 2016-10-19 Fractyl Lab Inc Méthodes, systèmes et dispositifs pour la réalisation de traitements multiples sur un patient
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EP3003461B1 (fr) 2013-06-04 2019-05-01 Fractyl Laboratories, Inc. Systèmes et dispositifs pour réduire la surface luminale du tractus gastro-intestinal
EP3043732B1 (fr) * 2013-09-12 2021-04-07 Fractyl Laboratories, Inc. Systèmes et dispositifs pour traiter un tissu cible
KR102284469B1 (ko) 2013-11-22 2021-08-02 프랙틸 헬쓰, 인코포레이티드 위장관에 치료 제한부를 생성하기 위한 시스템, 장치 및 방법
US10959774B2 (en) 2014-03-24 2021-03-30 Fractyl Laboratories, Inc. Injectate delivery devices, systems and methods
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US9757535B2 (en) 2014-07-16 2017-09-12 Fractyl Laboratories, Inc. Systems, devices and methods for performing medical procedures in the intestine
EP4090282A4 (fr) 2020-01-15 2024-02-21 Fractyl Health, Inc. Dispositifs, systèmes et procédés automatiques de traitement de tissu
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US6066132A (en) * 1998-06-30 2000-05-23 Ethicon, Inc. Articulating endometrial ablation device
EP2327382A1 (fr) * 2009-11-26 2011-06-01 Hans I. Wallsten Dispositif de stérilisation
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US9283108B2 (en) 2009-11-26 2016-03-15 Hans I. Wallsten Sterilisation device

Also Published As

Publication number Publication date
US5957962A (en) 1999-09-28
SE508792C2 (sv) 1998-11-09
JPH10508778A (ja) 1998-09-02
DE69527313D1 (de) 2002-08-08
SE9404022D0 (sv) 1994-11-21
EP0853467B1 (fr) 2002-07-03
EP0853467A1 (fr) 1998-07-22
DE69527313T2 (de) 2003-02-20
CA2205552A1 (fr) 1996-05-30
SE9404022L (sv) 1996-05-22

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